Three new isomers of FCH2CP system, F(H)CCPH (1), F-cCPC-H(H) (2) and F-cCC(H)P-H (3), are predicted by means of B3LYP and CCSD(T) (single-point) methods with 6-311++G(d,p) and 6-311++G(2df,2p) basis sets, respectivel...Three new isomers of FCH2CP system, F(H)CCPH (1), F-cCPC-H(H) (2) and F-cCC(H)P-H (3), are predicted by means of B3LYP and CCSD(T) (single-point) methods with 6-311++G(d,p) and 6-311++G(2df,2p) basis sets, respectively. The three calculated isomers can isomerize into thermodynamically the most stable species F-cPC(H)C-H, which has been suggested in previous theoretical studies, with relatively higher reaction barriers. In view of their higher thermodynamic and kinetic stability, we believe that the three species can be detected in future experiments.展开更多
通过对现有的合成模块进行改进,实现了(N-[18F]氟甲基)胆碱(18F-FCH)的半自动合成,并用其进行了无菌型炎症PET显像。以CH2Br2为前体,经过氟化反应制备甲基化试剂18FCH2Br,在柱与N,N-二甲基乙醇胺进行反应,并经过Sep Pak tC18和Sep Pak C...通过对现有的合成模块进行改进,实现了(N-[18F]氟甲基)胆碱(18F-FCH)的半自动合成,并用其进行了无菌型炎症PET显像。以CH2Br2为前体,经过氟化反应制备甲基化试剂18FCH2Br,在柱与N,N-二甲基乙醇胺进行反应,并经过Sep Pak tC18和Sep Pak CM小柱联用纯化的方法,得到放化纯度大于95%的18F-FCH注射液,放化产率为12%±2%(n=3,按18F-计算,未校正),放化合成时间为35min。PET显像表明,肌肉注射0.2mL松节油,4天后形成的炎症模型具有18F-FDG最高摄取,而18F-FCH在炎症处具有轻度的放射性浓聚,因此在18F-FCH肿瘤显像时应考虑炎症的可能性。展开更多
文摘Three new isomers of FCH2CP system, F(H)CCPH (1), F-cCPC-H(H) (2) and F-cCC(H)P-H (3), are predicted by means of B3LYP and CCSD(T) (single-point) methods with 6-311++G(d,p) and 6-311++G(2df,2p) basis sets, respectively. The three calculated isomers can isomerize into thermodynamically the most stable species F-cPC(H)C-H, which has been suggested in previous theoretical studies, with relatively higher reaction barriers. In view of their higher thermodynamic and kinetic stability, we believe that the three species can be detected in future experiments.
文摘通过对现有的合成模块进行改进,实现了(N-[18F]氟甲基)胆碱(18F-FCH)的半自动合成,并用其进行了无菌型炎症PET显像。以CH2Br2为前体,经过氟化反应制备甲基化试剂18FCH2Br,在柱与N,N-二甲基乙醇胺进行反应,并经过Sep Pak tC18和Sep Pak CM小柱联用纯化的方法,得到放化纯度大于95%的18F-FCH注射液,放化产率为12%±2%(n=3,按18F-计算,未校正),放化合成时间为35min。PET显像表明,肌肉注射0.2mL松节油,4天后形成的炎症模型具有18F-FDG最高摄取,而18F-FCH在炎症处具有轻度的放射性浓聚,因此在18F-FCH肿瘤显像时应考虑炎症的可能性。
