Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increase...Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increases in body weight can lead to reductions in pulmonary function, whether this is the case with the Japanese population and whether high body mass index （BMI） status alone represents an appropriate predictor of obstructive lung dysfunction remains unclear.The purpose of present study was to estimate the effect of BMI on lung function measured by spirometry of Japanese patients in general clinics. We measured BMI and performed spirometry on screening patients who had consulted general clinics.Methods Subjects comprised 1231 patients ≥40 years of age （mean age （65.0±12.0） years, 525 men, 706 women） who had consulted clinics in Nagasaki Prefecture, Japan, for non-respiratory disease. BMI was calculated and lung function was measured by spirometry.Results BMI was found to be positively correlated with forced expiratory volume in 1 second （FEV1）/forced vital capacity （FVC） in men and with maximum mid-expiratory flow （MMF） in all subjects. Following adjustment for relevant factors, a significant positive correlation between BMI and FEV1/FVC was identified for all subjects. Comparison between subjects with normal BMI （18.5-25.0） and higher BMI （25.1-30.0） also demonstrated that FEV1/FVC and percentage of predicted maximum mid-expiratory flow （%MMF） were significantly higher in the latter subjects.Conclusions In a population without marked respiratory disease, higher BMI subjects showed less obstructive pulmonary dysfunction compared to normal BMI subjects. High BMI status alone may be inappropriate as a predictor of obstructive lung dysfunction, particularly in populations with a low prevalence of obesity.展开更多
目的·探讨食品、药品和个人护理品中常用防腐剂对羟基苯甲酸酯类物质暴露与儿童肺功能指标的相关性。方法·以2019年8月—2020年1月于上海交通大学医学院附属儿童医院招募的136名5~7岁学龄前儿童为研究对象,收集儿童年龄、身...目的·探讨食品、药品和个人护理品中常用防腐剂对羟基苯甲酸酯类物质暴露与儿童肺功能指标的相关性。方法·以2019年8月—2020年1月于上海交通大学医学院附属儿童医院招募的136名5~7岁学龄前儿童为研究对象,收集儿童年龄、身高、体质量指数(body mass index,BMI)、家庭年收入等基线信息。留取尿液样本,采用高效液相色谱串联质谱法(high performance liquid chromatography-tandem mass spectrometry,HPLC-MS/MS)检测5种对羟基苯甲酸酯类物质的浓度,包括对羟基苯甲酸甲酯(methyl 4-hydroxybenzoate,MeP)、对羟基苯甲酸乙酯(ethyl 4-hydroxybenzoate,EtP)、对羟基苯甲酸丙酯(propyl 4-hydroxybenzoate,PrP)、对羟基苯甲酸丁酯(butyl 4-hydroxybenzoate,BuP)和对羟基苯甲酸苄酯(benzyl 4-hydroxybenzoate,BzP)。使用肺功能仪检测儿童用力肺活量(forced vital capacity,FVC)、1 s用力呼气容积(forced expiratory volume in one second,FEV_(1))、FEV_(1)/FVC、最大呼气流量(peak expiratory flow,PEF)和呼气中段流速(forced expiratory flow between the 25th and 75th percentile of forced vital capacity,FEF_(25-75))指标。通过多元线性回归评估儿童尿液中对羟基苯甲酸酯类物质暴露与儿童肺功能指标的相关性。结果·136名学龄前儿童的平均年龄和BMI分别为(5.76±0.84)岁和(15.78±2.86)kg/m2,男性59名(占43.4%),肥胖儿童13名(占9.6%)。学龄前儿童尿液MeP、EtP、PrP、BuP和BzP的检出率分别为97.8%、86.8%、99.3%、77.9%和11.8%;肌酐校正后MeP、EtP、PrP和BuP的中位数水平分别为36.12、3.88、1.50和0.06μg/g。经校正年龄、性别、身高、BMI、早产和家庭年收入等混杂因素后,多元线性回归结果提示,儿童尿液MeP与FVC(β=−0.018,95%CI−0.035~−0.001,P=0.044)、PrP与FEV_(1)(β=−0.032,95%CI−0.051~−0.013,P=0.013)、BuP与FVC(β=−0.018,95%CI−0.034~−0.002,P=0.038)以及BuP与FEV_(1)(β=−0.021,95%CI−0.041~−0.001,P=0.047)均呈显著负相关。结论·上海地区学龄前儿童可能普遍暴露于对羟基苯甲酸酯类物质,对羟基苯甲酸酯类物质暴露与儿童肺功能呈负相关。展开更多
文摘Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increases in body weight can lead to reductions in pulmonary function, whether this is the case with the Japanese population and whether high body mass index （BMI） status alone represents an appropriate predictor of obstructive lung dysfunction remains unclear.The purpose of present study was to estimate the effect of BMI on lung function measured by spirometry of Japanese patients in general clinics. We measured BMI and performed spirometry on screening patients who had consulted general clinics.Methods Subjects comprised 1231 patients ≥40 years of age （mean age （65.0±12.0） years, 525 men, 706 women） who had consulted clinics in Nagasaki Prefecture, Japan, for non-respiratory disease. BMI was calculated and lung function was measured by spirometry.Results BMI was found to be positively correlated with forced expiratory volume in 1 second （FEV1）/forced vital capacity （FVC） in men and with maximum mid-expiratory flow （MMF） in all subjects. Following adjustment for relevant factors, a significant positive correlation between BMI and FEV1/FVC was identified for all subjects. Comparison between subjects with normal BMI （18.5-25.0） and higher BMI （25.1-30.0） also demonstrated that FEV1/FVC and percentage of predicted maximum mid-expiratory flow （%MMF） were significantly higher in the latter subjects.Conclusions In a population without marked respiratory disease, higher BMI subjects showed less obstructive pulmonary dysfunction compared to normal BMI subjects. High BMI status alone may be inappropriate as a predictor of obstructive lung dysfunction, particularly in populations with a low prevalence of obesity.
文摘目的·探讨食品、药品和个人护理品中常用防腐剂对羟基苯甲酸酯类物质暴露与儿童肺功能指标的相关性。方法·以2019年8月—2020年1月于上海交通大学医学院附属儿童医院招募的136名5~7岁学龄前儿童为研究对象,收集儿童年龄、身高、体质量指数(body mass index,BMI)、家庭年收入等基线信息。留取尿液样本,采用高效液相色谱串联质谱法(high performance liquid chromatography-tandem mass spectrometry,HPLC-MS/MS)检测5种对羟基苯甲酸酯类物质的浓度,包括对羟基苯甲酸甲酯(methyl 4-hydroxybenzoate,MeP)、对羟基苯甲酸乙酯(ethyl 4-hydroxybenzoate,EtP)、对羟基苯甲酸丙酯(propyl 4-hydroxybenzoate,PrP)、对羟基苯甲酸丁酯(butyl 4-hydroxybenzoate,BuP)和对羟基苯甲酸苄酯(benzyl 4-hydroxybenzoate,BzP)。使用肺功能仪检测儿童用力肺活量(forced vital capacity,FVC)、1 s用力呼气容积(forced expiratory volume in one second,FEV_(1))、FEV_(1)/FVC、最大呼气流量(peak expiratory flow,PEF)和呼气中段流速(forced expiratory flow between the 25th and 75th percentile of forced vital capacity,FEF_(25-75))指标。通过多元线性回归评估儿童尿液中对羟基苯甲酸酯类物质暴露与儿童肺功能指标的相关性。结果·136名学龄前儿童的平均年龄和BMI分别为(5.76±0.84)岁和(15.78±2.86)kg/m2,男性59名(占43.4%),肥胖儿童13名(占9.6%)。学龄前儿童尿液MeP、EtP、PrP、BuP和BzP的检出率分别为97.8%、86.8%、99.3%、77.9%和11.8%;肌酐校正后MeP、EtP、PrP和BuP的中位数水平分别为36.12、3.88、1.50和0.06μg/g。经校正年龄、性别、身高、BMI、早产和家庭年收入等混杂因素后,多元线性回归结果提示,儿童尿液MeP与FVC(β=−0.018,95%CI−0.035~−0.001,P=0.044)、PrP与FEV_(1)(β=−0.032,95%CI−0.051~−0.013,P=0.013)、BuP与FVC(β=−0.018,95%CI−0.034~−0.002,P=0.038)以及BuP与FEV_(1)(β=−0.021,95%CI−0.041~−0.001,P=0.047)均呈显著负相关。结论·上海地区学龄前儿童可能普遍暴露于对羟基苯甲酸酯类物质,对羟基苯甲酸酯类物质暴露与儿童肺功能呈负相关。
文摘目的探讨平喘止咳汤治疗对慢阻肺急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者临床疗效及1 s用力呼气容积(forced expiratory volume in1 second,FEV_(1))、1 s用力呼气容积占用力肺活量比值(forced expiratory volume in 1 second to take up forced vital capacity ratio,FEV_(1)%)的影响效果。方法抽选2019年6月—2020年6月在枣阳市中医医院收治住院的108例AECOPD患者,随机数字表法分为对照组与研究组,各54例。对照组应用常规西药治疗,研究组应用平喘止咳汤治疗。对两组患者的临床治疗效果、肺功能改善情况(FEV_(1)、FEV_(1)%)以及不良反应发生率进行比较。结果研究组临床疗效(96.3%)高于对照组(77.8%),差异有统计学意义(P<0.05)。治疗前,两组FEV_(1)、FEV_(1)%比较,差异无统计学意义(P>0.05);研究组治疗后的肺功能优于对照组(P<0.05)。研究组不良反应发生率为5.6%,低于对照组的20.4%,差异有统计学意义(P<0.05)。结论AECOPD患者应用平喘止咳汤治疗,具有显著疗效,使患者的相关肺功能指标得到更加显著改善,降低患者治疗过程中出现相关不良反应的风险与发生率。
