Following the High-Resolution Model Intercomparison Project(HighResMIP)Tier 2 protocol under the Coupled Model Intercomparison Project Phase 6(CMIP6),three numerical experiments are conducted with the Chinese Academy ...Following the High-Resolution Model Intercomparison Project(HighResMIP)Tier 2 protocol under the Coupled Model Intercomparison Project Phase 6(CMIP6),three numerical experiments are conducted with the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System Model,version f3-H(CAS FGOALS-f3-H),and a 101-year(1950–2050)global high-resolution simulation dataset is presented in this study.The basic configuration of the FGOALSf3-H model and numerical experiments design are briefly described,and then the historical simulation is validated.Forced by observed radiative agents from 1950 to 2014,the coupled model essentially reproduces the observed long-term trends of temperature,precipitation,and sea ice extent,as well as the large-scale pattern of temperature and precipitation.With an approximate 0.25°horizontal resolution in the atmosphere and 0.1°in the ocean,the coupled models also simulate energetic western boundary currents and the Antarctic Circulation Current(ACC),reasonable characteristics of extreme precipitation,and realistic frontal scale air-sea interaction.The dataset and supporting detailed information have been published in the Earth System Grid Federation.展开更多
Accurate preoperative prediction of lymph node metastasis(LNM)in esophageal cancer(EC)patients is of crucial clinical significance for treatment planning and prognosis.AIM To develop a clinical radiomics nomogram that...Accurate preoperative prediction of lymph node metastasis(LNM)in esophageal cancer(EC)patients is of crucial clinical significance for treatment planning and prognosis.AIM To develop a clinical radiomics nomogram that can predict the preoperative lymph node(LN)status in EC patients.METHODS A total of 32 EC patients confirmed by clinical pathology(who underwent surgical treatment)were included.Real-time fluorescent quantitative reverse transcription-polymerase chain reaction was used to detect the expression of B7-H3 mRNA in EC tissue obtained during preoperative gastroscopy,and its correlation with LNM was analyzed.Radiomics features were extracted from multi-modal magnetic resonance imaging of EC using Pyradiomics in Python.Feature extraction,data dimensionality reduction,and feature selection were performed using XGBoost model and leave-one-out cross-validation.Multivariable logistic regression analysis was used to establish the prediction model,which included radiomics features,LN status from computed tomography(CT)reports,and B7-H3 mRNA expression,represented by a radiomics nomogram.Receiver operating characteristic area under the curve(AUC)and decision curve analysis(DCA)were used to evaluate the predictive performance and clinical application value of the model.RESULTS The relative expression of B7-H3 mRNA in EC patients with LNM was higher than in those without metastasis,and the difference was statistically significant(P<0.05).The AUC value in the receiver operating characteristic(ROC)curve was 0.718(95%CI:0.528-0.907),with a sensitivity of 0.733 and specificity of 0.706,indicating good diagnostic performance.The individualized clinical prediction nomogram included radiomics features,LN status from CT reports,and B7-H3 mRNA expression.The ROC curve demonstrated good diagnostic value,with an AUC value of 0.765(95%CI:0.598-0.931),sensitivity of 0.800,and specificity of 0.706.DCA indicated the practical value of the radiomics nomogram in clinical practice.CONCLUSION This study developed a radiomics nomogram that includes radiomics features,LN status from CT reports,and B7-H3 mRNA expression,enabling convenient preoperative individualized prediction of LNM in EC patients.展开更多
The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMI...The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this paper.The FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled model.Then,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization experiments.The hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,respectively.The decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic variables.The preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean.展开更多
基金jointly funded by the Strategic Priority Research Program of Chinese Academy of Sciences grant number XDB40030205the National Natural Science Foundation of China grant numbers 91737306,41675100,and U1811464。
基金jointly supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.XDA19060102 and XDB42000000)National Natural Science Foundation of China(Grant Nos.91958201 and 42130608)+1 种基金the National Key Research and Development Program of China(Grant No.2020YFA0608800)supported by the National Key Scientific and Technological Infrastructure project“Earth System Numerical Simulation Facility”(EarthLab)。
文摘Following the High-Resolution Model Intercomparison Project(HighResMIP)Tier 2 protocol under the Coupled Model Intercomparison Project Phase 6(CMIP6),three numerical experiments are conducted with the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System Model,version f3-H(CAS FGOALS-f3-H),and a 101-year(1950–2050)global high-resolution simulation dataset is presented in this study.The basic configuration of the FGOALSf3-H model and numerical experiments design are briefly described,and then the historical simulation is validated.Forced by observed radiative agents from 1950 to 2014,the coupled model essentially reproduces the observed long-term trends of temperature,precipitation,and sea ice extent,as well as the large-scale pattern of temperature and precipitation.With an approximate 0.25°horizontal resolution in the atmosphere and 0.1°in the ocean,the coupled models also simulate energetic western boundary currents and the Antarctic Circulation Current(ACC),reasonable characteristics of extreme precipitation,and realistic frontal scale air-sea interaction.The dataset and supporting detailed information have been published in the Earth System Grid Federation.
基金The Yancheng Key Research and Development Program(Social Development),No.YCBE202324。
文摘Accurate preoperative prediction of lymph node metastasis(LNM)in esophageal cancer(EC)patients is of crucial clinical significance for treatment planning and prognosis.AIM To develop a clinical radiomics nomogram that can predict the preoperative lymph node(LN)status in EC patients.METHODS A total of 32 EC patients confirmed by clinical pathology(who underwent surgical treatment)were included.Real-time fluorescent quantitative reverse transcription-polymerase chain reaction was used to detect the expression of B7-H3 mRNA in EC tissue obtained during preoperative gastroscopy,and its correlation with LNM was analyzed.Radiomics features were extracted from multi-modal magnetic resonance imaging of EC using Pyradiomics in Python.Feature extraction,data dimensionality reduction,and feature selection were performed using XGBoost model and leave-one-out cross-validation.Multivariable logistic regression analysis was used to establish the prediction model,which included radiomics features,LN status from computed tomography(CT)reports,and B7-H3 mRNA expression,represented by a radiomics nomogram.Receiver operating characteristic area under the curve(AUC)and decision curve analysis(DCA)were used to evaluate the predictive performance and clinical application value of the model.RESULTS The relative expression of B7-H3 mRNA in EC patients with LNM was higher than in those without metastasis,and the difference was statistically significant(P<0.05).The AUC value in the receiver operating characteristic(ROC)curve was 0.718(95%CI:0.528-0.907),with a sensitivity of 0.733 and specificity of 0.706,indicating good diagnostic performance.The individualized clinical prediction nomogram included radiomics features,LN status from CT reports,and B7-H3 mRNA expression.The ROC curve demonstrated good diagnostic value,with an AUC value of 0.765(95%CI:0.598-0.931),sensitivity of 0.800,and specificity of 0.706.DCA indicated the practical value of the radiomics nomogram in clinical practice.CONCLUSION This study developed a radiomics nomogram that includes radiomics features,LN status from CT reports,and B7-H3 mRNA expression,enabling convenient preoperative individualized prediction of LNM in EC patients.
基金supported by National Key Research and Development Program of China(Grant No.2018YFA0606300)the NSFC(Grant No.42075163),the NSFC BSCTPES project(Grant No.41988101)+1 种基金the NSFC(Grant No.42205039)supported by the Jiangsu Collaborative Innovation Center for Climate Change and the National Key Scientific and Technological Infrastructure project“Earth System Science Numerical Simulator Facility”(EarthLab).
文摘The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this paper.The FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled model.Then,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization experiments.The hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,respectively.The decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic variables.The preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean.
