Four and a half LIM domains protein 1(FH L1),as the name suggests,contains four and a half LIM domains capable o f interacting with various molecules,including structural proteins,kinases,and transcriptional machinery...Four and a half LIM domains protein 1(FH L1),as the name suggests,contains four and a half LIM domains capable o f interacting with various molecules,including structural proteins,kinases,and transcriptional machinery.FHL1 contains a zinc-finger domain and performs diverse roles in regulation of gene transcription,cytoarchitecture,cell proliferation,and signal transduction.Several studies have validated the importance of FHL1 in muscle development,myopathy,and cardiovascular diseases.Mutations in the FHL1 gene are associated with various myopathies.Recently,FHL1 was identified as a major host factor for chikungunya virus(CHIKV)infection in both humans and mice.Based on more recent findings over the last decade,FHL1 is proposed to play a dual role in cancer progression.On the one hand,FHL1 expression is suppressed in several cancer types,which correlates with increased metastatic disease and decreased survival.Moreover,FHL1 is reported to inhibit tum or cell growth and migration by associating with diverse signals,such as TGF-P and ER,and therefore considered a tumor suppressor.On the other hand,FHL1 can function as an oncogenic protein that promotes tumor progression upon phosphorylation,reflecting complex roles in cancer.This review primarily focuses on the dual role and underlying mechanisms of action of FHL1 in human cancer progression and its clinical relevance.展开更多
基金grants from the National Natural Science Foundation of China(Grant No.81730071,81472734,and 81670626)Ministry of Science and Technology of China(Grant No.2016YFC1302103,and 2015CB553906)+1 种基金Beijing Natural Science Foundation grants(Grant No.7171005,7202084,and 7202080)Peking University grants(Grant No.BMU2018JC004 and BMU20120314)to H.Z.
文摘Four and a half LIM domains protein 1(FH L1),as the name suggests,contains four and a half LIM domains capable o f interacting with various molecules,including structural proteins,kinases,and transcriptional machinery.FHL1 contains a zinc-finger domain and performs diverse roles in regulation of gene transcription,cytoarchitecture,cell proliferation,and signal transduction.Several studies have validated the importance of FHL1 in muscle development,myopathy,and cardiovascular diseases.Mutations in the FHL1 gene are associated with various myopathies.Recently,FHL1 was identified as a major host factor for chikungunya virus(CHIKV)infection in both humans and mice.Based on more recent findings over the last decade,FHL1 is proposed to play a dual role in cancer progression.On the one hand,FHL1 expression is suppressed in several cancer types,which correlates with increased metastatic disease and decreased survival.Moreover,FHL1 is reported to inhibit tum or cell growth and migration by associating with diverse signals,such as TGF-P and ER,and therefore considered a tumor suppressor.On the other hand,FHL1 can function as an oncogenic protein that promotes tumor progression upon phosphorylation,reflecting complex roles in cancer.This review primarily focuses on the dual role and underlying mechanisms of action of FHL1 in human cancer progression and its clinical relevance.
