PPI与CPI的协整检验

本文在分析PPI对CPI的传导机制及制约因素的基础上，以我国1996年10月到2008年5月的PPI和CPI的数据为样本，对PPI与CPI的关系进行实证分析。结果发现，CPI和PPI均有单位根，协整检验表明CPI与PPI具有协整关系。这说明了CPI与PPI之间有着密切的关系。

FiPy在地下水数值模拟中的应用分析

FiPy是美国国家标准与技术研究所(NIST)[1,2]开发的一套通用求解程序。基于标准的有限体积(FV)方法,FiPy采用先进的python语言和面向对象策略开发通用偏微分方程组(PDEs)求解器。依托python强大的程序设计、前后处理、可视化能力,实现了FiPy对各种不同类型PDE问题的高效、稳定求解,提供了一个可扩展、强大且免费的工具。通过现有地下水数值模拟软件特点分析,简单介绍FiPy程序的功能及使用,并结合具体算例讨论FiPy在地下水模拟中的应用潜力。

Preparation, characterization and evaluation of multi-component-loaded liposomes containing Tat-TOS, phospholipase D inhibitor and doxorubicinPreparation, characterization and evaluation of multi-component-loaded liposomes containing Tat-TOS, phospholipase

In the present study, we aimed to co-load the α-TOS conjugate Tat-TOS with the phospholipase D inhibitor FIPI and the antitumor drug doxorubicin（DOX） in a liposome delivery system for antitumor metastasis. Firstly, Tat-TOS was synthesized by solid-phase synthesis, and its structure was confirmed. The ability of free and liposomal Tat-TOS to induce apoptosis in vitro was evaluated by flow cytometry. Biodistribution of Tat-TOS-loaded liposomes was investigated by a molecular imaging system. Multi-component-loaded liposomes modified with Tat-TOS containing FIPI and DOX was prepared by thin film dispersion method in combination with p H gradient method and post-insertion method. Physicochemical properties were determined, and the in vitro uptake ability of the formulations was evaluated. The results showed that the prepared liposomes were characterized by a uniform particle size distribution and small particle size. The encapsulation efficiency of FIPI and DOX exceeded 85%. Both free and liposomal Tat-TOS significantly improved the activity of inducing apoptosis of tumor cells. The liposomes modified with Tat-TOS were apparently accumulated in normal lung tissue and tumor metastasized lung. Multi-component-loaded liposomes exhibited the strongest cell uptake capacity, suggesting a stronger anti-metastatic effect and anti-tumor activity in vivo.

健脾通络汤治疗慢性阻塞性肺疾病合并抑郁症的效果研究

目的观察健脾通络汤对慢性阻塞性肺疾病合并抑郁症(肺脾气虚痰瘀阻肺证)患者呼吸道症状、肺通气功能及心理状态的影响。方法采用随机数字表法将浙江普陀医院呼吸与危重症医学科2019年9月—2020年9月收治的84例慢性阻塞性肺疾病合并抑郁症患者分为观察组(42例)和对照组(42例),对照组给予祛痰、解痉等常规西药治疗,观察组在对照组基础上联合健脾通络汤治疗,2组1个疗程均为4周,共治疗3个疗程。比较治疗前后2组呼吸道症状、CAT评分、BODE指数评分、HAMD评分、SDS评分及肺通气功能指标(FEV_(1)、FEV_(1)/FVC、MIP、MEP)的改善状况,并评估2组临床疗效及不良反应。结果观察组和对照组总有效率分别为92.86%、76.19%,观察组明显高于对照组(P<0.05);治疗后,观察组呼吸道症状积分、CAT评分和BODE指数评分,SDS评分和HAMD评分均明显低于对照组(均P<0.05),FEV_(1)、FEV_(1)/FVC、MIP、MEP水平均明显高于对照组(均P<0.05);2组均无明显不良反应。结论健脾通络汤能够改善慢性阻塞性肺疾病合并抑郁症患者肺通气功能,缓解呼吸道症状,改善患者抑郁状态。