AIM: To investigate the effects of a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols diet (LFD) and the probiotic Lactobacillus rhamnosus GG (LGG) in irritable bowel syndrome (IBS).
Despite little evidence for the therapeutic benefits of a high-fiber diet for diverticulitis, it is commonly recommended as part of the clinical management. The ongoing uncertainty of the cause(s) of diverticulitis co...Despite little evidence for the therapeutic benefits of a high-fiber diet for diverticulitis, it is commonly recommended as part of the clinical management. The ongoing uncertainty of the cause(s) of diverticulitis confounds attempts to determine the validity of this therapy. However, the features of a high-fiber diet represent a logical contradiction for colon diverticulitis. Considering that Bernoulli’s principle, by which enlarged diameter of the lumen leads to increased pressure and decreased fluid velocity, might contribute to development of the diverticulum. Thus, theoretically, prevention of high pressure in the colon would be important and adoption of a low FODMAP diet (consisting of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) may help prevent recurrence of diverticulitis.展开更多
Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, blo...Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, bloating, pain, flatulence and constipation may sometimes be misleading. Once diagnosed of CD, patients must adhere to Gluten Free Diet, which consists in the lifelong avoidance of gluten containing foods and of those naturally gluten free but at risk of contamination. This dietary approach is considered the only therapy in order to avoid symptoms exacerbation and to reduce the digestive mucosa inflammation, which has been related to higher risks of lymphoproliferative malignancy and other immunological disorders. However, being on a Gluten Free Diet is not as resolving as it may seem since it has several criticalities. First of all, excluding gluten means limiting food variety so that coeliac patients may have unbalanced intake of several nutrients and develop clinical or subclinical deficiencies. This can be due to scarce attention to qualitative and quantitative composition of diets and poor information about gluten-containing foods, which only patient-tailored dietetic protocol and long-term follow-up can achieve. Secondly, Gluten Free Diet may not result in complete remission of mucosal damage or in resolution of symptoms. Unintentional contamination of gluten or poor adherence to diet are the main culprits of the incomplete mucosal healing but other triggers may be involved. Recent research has focused on the role of FODMAPs in changing gut microbiota and on the improvement of Irritable Bowel Syndrome (IBS) symptoms after their dietary avoidance or reduction. Since CD and IBS may share many clinical presentations, further studies are needed to evaluate if a subgroup of CD patients whose symptoms are not improved by Gluten Free Diet could benefit from a new therapeutic approach consisting in both gluten/wheat and FODMAPs avoidance.展开更多
目的:总结FODMAP研究的文献计量学分布规律。方法:以Web of Science(WOS)数据库为基础检索从1990年1月1日—2020年6月30日发表FODMAP研究的文献,借助文献计量学分析软件Histcite,对FODMAP研究的语种、研究者、研究机构、国家、检索词、...目的:总结FODMAP研究的文献计量学分布规律。方法:以Web of Science(WOS)数据库为基础检索从1990年1月1日—2020年6月30日发表FODMAP研究的文献,借助文献计量学分析软件Histcite,对FODMAP研究的语种、研究者、研究机构、国家、检索词、期刊、参考文献、引文关系的分布规律进行统计。结果:对FODMAP研究的高产作者是Gibson P R(61篇),最重要的研究者是Gibson P R;该领域刊发FODMAP研究最多的期刊是Gastroenterology(胃肠病学)(76篇),重要的期刊是Gastroenterology,重要参考文献是Halmos E P发表于2014年的文献(被引频次223次),重要检索词是FODMAP(336次,可发酵的低聚糖、二糖、单糖和多元醇),重要的检索词是bowel(2156次,肠);FODMAP研究的语种以英语为主体;高产机构是Monash Univ(81篇),重要的研究机构是Monash Univ(81次),高产的国家是美国(128篇),引文关系时序图发现Whelan K发表于2018年的研究是FODMAP研究的最新进展。结论:FODMAP的研究群体主要集中于发达国家,这些研究为FODMAP领域的认识提供了便利,对于研究者快速定位本领域的研究内容有指导意义。展开更多
文摘AIM: To investigate the effects of a low fermentable, oligosaccharides, disaccharides, monosaccharides and polyols diet (LFD) and the probiotic Lactobacillus rhamnosus GG (LGG) in irritable bowel syndrome (IBS).
文摘Despite little evidence for the therapeutic benefits of a high-fiber diet for diverticulitis, it is commonly recommended as part of the clinical management. The ongoing uncertainty of the cause(s) of diverticulitis confounds attempts to determine the validity of this therapy. However, the features of a high-fiber diet represent a logical contradiction for colon diverticulitis. Considering that Bernoulli’s principle, by which enlarged diameter of the lumen leads to increased pressure and decreased fluid velocity, might contribute to development of the diverticulum. Thus, theoretically, prevention of high pressure in the colon would be important and adoption of a low FODMAP diet (consisting of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) may help prevent recurrence of diverticulitis.
文摘Coeliac Disease (CD) is a permanent gluten intolerance, whose pathogenesis involves multiple factors including genetics and environment. CD has different representations and non-specific symptoms such as diarrhea, bloating, pain, flatulence and constipation may sometimes be misleading. Once diagnosed of CD, patients must adhere to Gluten Free Diet, which consists in the lifelong avoidance of gluten containing foods and of those naturally gluten free but at risk of contamination. This dietary approach is considered the only therapy in order to avoid symptoms exacerbation and to reduce the digestive mucosa inflammation, which has been related to higher risks of lymphoproliferative malignancy and other immunological disorders. However, being on a Gluten Free Diet is not as resolving as it may seem since it has several criticalities. First of all, excluding gluten means limiting food variety so that coeliac patients may have unbalanced intake of several nutrients and develop clinical or subclinical deficiencies. This can be due to scarce attention to qualitative and quantitative composition of diets and poor information about gluten-containing foods, which only patient-tailored dietetic protocol and long-term follow-up can achieve. Secondly, Gluten Free Diet may not result in complete remission of mucosal damage or in resolution of symptoms. Unintentional contamination of gluten or poor adherence to diet are the main culprits of the incomplete mucosal healing but other triggers may be involved. Recent research has focused on the role of FODMAPs in changing gut microbiota and on the improvement of Irritable Bowel Syndrome (IBS) symptoms after their dietary avoidance or reduction. Since CD and IBS may share many clinical presentations, further studies are needed to evaluate if a subgroup of CD patients whose symptoms are not improved by Gluten Free Diet could benefit from a new therapeutic approach consisting in both gluten/wheat and FODMAPs avoidance.
文摘目的:总结FODMAP研究的文献计量学分布规律。方法:以Web of Science(WOS)数据库为基础检索从1990年1月1日—2020年6月30日发表FODMAP研究的文献,借助文献计量学分析软件Histcite,对FODMAP研究的语种、研究者、研究机构、国家、检索词、期刊、参考文献、引文关系的分布规律进行统计。结果:对FODMAP研究的高产作者是Gibson P R(61篇),最重要的研究者是Gibson P R;该领域刊发FODMAP研究最多的期刊是Gastroenterology(胃肠病学)(76篇),重要的期刊是Gastroenterology,重要参考文献是Halmos E P发表于2014年的文献(被引频次223次),重要检索词是FODMAP(336次,可发酵的低聚糖、二糖、单糖和多元醇),重要的检索词是bowel(2156次,肠);FODMAP研究的语种以英语为主体;高产机构是Monash Univ(81篇),重要的研究机构是Monash Univ(81次),高产的国家是美国(128篇),引文关系时序图发现Whelan K发表于2018年的研究是FODMAP研究的最新进展。结论:FODMAP的研究群体主要集中于发达国家,这些研究为FODMAP领域的认识提供了便利,对于研究者快速定位本领域的研究内容有指导意义。
