Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was adde...Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally "Ⅰ-type",meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite.展开更多
New,integrated petrographic,mineral chemistry,whole rock geochemical,zircon and titanite UPb geochronology,and zircon Hf isotopic data from the Montezuma granitoids,as well as new geochemical results for its host rock...New,integrated petrographic,mineral chemistry,whole rock geochemical,zircon and titanite UPb geochronology,and zircon Hf isotopic data from the Montezuma granitoids,as well as new geochemical results for its host rocks represented by the Corrego Tingui Complex,provides new insights into the late-to post-collisional evolution of the northeastern Sao Francisco paleocontinent.U-Pb zircon dates from the Montezuma granitoids spread along the Concordia between ca.2.2 Ga to 1.8 Ga and comprise distinct groups.Group I have crystallization ages between ca.2.15 Ga and 2.05 Ga and are interpreted as inherited grains.Group II zircon dates vary from 2.04 Ga to1.9 Ga and corresponds to the crystallization of the Montezuma granitoids,which were constrained at ca.2.03 Ga by the titanite U-Pb age.Inverse age zoning is common within the ca.1.8 Ga Group III zircon ages,being related to fluid isotopic re-setting during the Espinhaco rifiting event.ZirconεHf(t)analysis show dominantly positive values for both Group I(-4 to+9)andⅡ(-3 to+8)zircons and TDM2 model ages of 2.7-2.1 Ga and 2.5-1.95 Ga,respectively.Geochemically,the Montezuma granitoids are weakly peraluminous to metaluminous magnesian granitoids,enriched in LILES and LREE,with high to moderate Mg#and depleted in some of the HFSE.Their lithochemical signature,added to the juvenile signature of both inherited and crystallized zircons,allowed its classification as a shoshonitic high Ba-Sr granitoid related to a late-to post-collisional lithosphere delamination followed by asthenospheric upwelling.In this scenario,the partial melting of the lithospheric mantle interacted with the roots of an accreted juvenile intra-oceanic arc,being these hybrid magma interpreted as the source of the Montezuma granitoids.The Corrego Tingui Complex host rocks are akin to a syn-to late-collisional volcanic arc granitoids originated from the partial melting of ancient crustal rocks.The results presented in this study have revealed the occurrence of juvenile rocks,probably related to an island arc environment,that are exotic in relation to the Paleo-to Neoarchean crust from the Sao Francisco paleocontinent’s core.展开更多
Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric chemistry.Small ranges in Δ^(33)S that expanded into larger fractionations leading up to the G...Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric chemistry.Small ranges in Δ^(33)S that expanded into larger fractionations leading up to the Great Oxygenation Event(GOE;2.45–2.2 Ga)are disproportionately represented by sequences from the Kaapvaal and Pilbara Cratons.These patterns of S-MIF attenuation and enhancement may differ from the timing and magnitude of minor sulfur isotope fractionations reported from other cratons,thus obscuring local for global sulfur cycling dynamics.By expanding the Δ^(33)S record to include the relatively underrepresented São Francisco Craton in Brazil,we suggest that marine biogeochemistry affected S-MIF preservation prior to the GOE.In an early Neoarchean sequence(2763–2730 Ma)from the Rio das Velhas Greenstone Belt,we propose that low δ^(13)Corg(<-30‰)and dampened Δ^(33)S(-0.4‰to-0.7‰)in banded iron formation reflect the marine diagenetic process of anaerobic methane oxidation.The overlying black shale(TOC up to 7.8%)with higher δ^(13)Corg(-33.4‰to-19.2‰)and expanded Δ^(33)S(2.3‰±0.8‰),recorded oxidative sulfur cycling that resulted in enhance preservation of S-MIF input from atmospheric sources of elemental sulfur.The sequence culminates in a metasandstone,where concomitant changes to more uniform δCorg(-30‰to--25‰),potentially associated with the RuBisCO I enzyme,and near-zero Δ^(33)S(-0.04‰to 0.38‰)is mainly interpreted as evidence for local oxygen production.When placed in the context of other sequences worldwide,the Rio das Velhas helps differentiate the influences of global atmospheric chemistry and local marine diagenesis in Archean biogeochemical processes.Our data suggest that prokaryotic sulfur,iron,and methane cycles might have an underestimated role in pre-GOE sulfur minor isotope records.展开更多
The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the Archean.Howe...The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the Archean.However,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient rocks.Despite this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South America’s primitive crust.Therefore,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi Complex.The Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic composition.Our new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean rocks.Lu-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over time.In the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.展开更多
The late-to post-collisional stage in orogenic systems is characterized by the coeval existence of bimodal potassic to ultrapotassic magmatic activity related to partial melting of an enriched lithospheric mantle toge...The late-to post-collisional stage in orogenic systems is characterized by the coeval existence of bimodal potassic to ultrapotassic magmatic activity related to partial melting of an enriched lithospheric mantle together with crustal derived melts.In this paper,we present new whole rock geochemical analyses combined with zircon and titanite U–Pb and zircon Hf isotopic data from potassic to ultrapotassic rocks from six plutons that occur within the Archean Itacambira-Monte Azul block(BIMA),to discuss their petrogenesis and the tectonic implications for the São Francisco paleocontinent.The new U–Pb ages range from ca.2.06 Ga to 1.98 Ga and reveal long-lasting potassic magmatism within the BIMA,which is within the late-to-post-collisional stage of the São Francisco paleocontinent evolution.The ultrapotassic rocks are compatible with a fluid-related metasomatized mantle source enriched by previous subduction events,whereas the potassic rocks are bimodal and have a transitional shoshonitic to A-type affinity.These rocks have a hybrid nature,possible related to the mixing between the mafic potassic/ultrapotassic rocks and high temperature crustal melts of the Archean continental crust.Our results also show an increase of within-plate signature towards the younger potassic magmas.The participation of an important Archean crustal component in the genesis of these rocks is highlighted by the common and occasionally abundant occurrence of Archean inherited zircons.The Hf isotopic record shows that most of the zircon inheritance has dominantly subchondriticεHf(t)values,which fits a crustal reworking derivation from a similar Eo-to Paleoarchean precursor crust.However,the presence of juvenile 2.36 Ga zircon inheritance in an ultrapotassic sample reveal the existence of a hidden reservoir that is somewhat similar to the described for the Mineiro Belt in southern São Francisco paleocontinent.展开更多
Field observations and CA-LA-ICP-MS U–Pb zircon ages and Hf isotope compositions obtained from migmatitic orthogneisses and granitoids from the Belo Horizonte Complex,southern São Francisco Craton,indicate a maj...Field observations and CA-LA-ICP-MS U–Pb zircon ages and Hf isotope compositions obtained from migmatitic orthogneisses and granitoids from the Belo Horizonte Complex,southern São Francisco Craton,indicate a major period of partial melting and production of felsic rocks in the Neoarchean.Our observations show that the complex is an important site for studying partial melting processes of Archean crystalline crust.Much of the complex exposes fine-grained stromatic migmatites that are intruded by multiple leucogranitic veins and sheeted dikes.Both migmatites and leucogranite sheets are crosscut by several phases of granitoid batholiths and small granitic bodies;both of which are closely associated with the host banded gneisses.Chemical abrasion followed by detailed cathodoluminescence imaging revealed a wide variety of zircon textures that are consistent with a long-lived period of partial melting and crustal remobilization.Results of U-Pb and Hf isotopes disclose the complex as part of a much wider crustal segment,encompassing the entire southern part of the São Francisco Craton.Compilation of available U-Pb ages suggests that this crustal segment was consolidated sometime between 3000 Ma and 2900 Ma and that it experienced three main episodes of partial melting before stabilization at 2600 Ma.The partial melting episodes took place between 2750 Ma and 2600 Ma as a result of tectonic accretion and peeling off the lithospheric mantle and lower crust.This process is likely responsible for the emplacement of voluminous potassic granitoids across the entire São Francisco Craton.We believe that the partial melting of Meso-Archean crystalline crust and production of potassic granitoids are linked to a fundamental shift in the tectonics of the craton,which was also responsible for the widespread intrusion of large syenitic bodies in the northern part of the craton,and the construction of layered mafic–ultramafic intrusions to the south of the BHC.展开更多
The Campos Gerais Domain(CGD)in southeastern Brazil is an approximately 180 km×35 km area of Archean–Proterozoic rocks located southwest of the São Francisco Craton(SFC).The Archean–Paleopro terozoic evolu...The Campos Gerais Domain(CGD)in southeastern Brazil is an approximately 180 km×35 km area of Archean–Proterozoic rocks located southwest of the São Francisco Craton(SFC).The Archean–Paleopro terozoic evolution of the CGD—alongside its potential correlation with the SFC or other cratonic blocks in the region-is currently poorly-constrained.We present the results of systematic petrography,bulkrock geochemistry,mineral chemistry and geochronology for a suite of scarcely studied mafic–ultramafic rocks from the CGD.We also provide a compilation of previously reported bulk-rock geochemical and spinel group mineral chemical data for mafic–ultramafic rocks throughout the CGD,and geochronological information for various lithotypes in the region.The CGD records a protracted Mesoarchean to Statherian(3.1–1.7 Ga)crustal evolution,which we interpret to share a common history with the southern SFC and their related reworked segments,suggesting that it is a westward extension of this cratonic terrain.The metavolcano-sedimentary rocks of the Fortaleza de Minas and Alpinópolis segments represent a Mesoarchean greenstone belt that is stratigraphically and chemically comparable to Archean greenstone belts worldwide,and that is broadly coeval with a local suite of tonalite-trondhjemite-grano diorite(TTG)gneisses and migmatites.U-Pb SHRIMP zircon data from a subalkaline metagabbro yielded a concordia age of ca.2.96 Ga,revealing a previously unrecognized phase of Archean magmatism in the CGD that can be chrono-correlated with metakomatiite and TTG generation elsewhere in the São Francisco paleocontinent.Our data contradict a hypothesis whereby the metavolcano-sedimentary rocks of the Jacuí-Bom Jesus da Penha and Petúnia segments represent an ophiolite,as previously suggested,instead presenting features that point to formation in association with a continental arc.Coupled with a U-Pb(SHRIMP)crystallization age of ca.2.13 Ga recorded by zircon grains from a metaultramafic rock,these data highlight that a magmatic event was chrono-correlated with the main accretionary phase of the Minas Orogeny,and with the Pouso Alegre/Amparo and São Vicente complexes.Finally,a U-Pb(SHRIMP)concordia age of ca.590 Ma—obtained from metamorphic-textured zircon grains from a metaultramafic rock—points to a late metamorphic overprint related to upper amphibolite conditions,brittle fault activation and the juxtaposition of crustal blocks in association with the latest stages of western Gondwana’s assembly in the southern SFC,with later retrogression to greenschist-facies.展开更多
Greenstone belts contain several clues about the evolutionary history of primitive Earth.Here,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the No...Greenstone belts contain several clues about the evolutionary history of primitive Earth.Here,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the Northern Mundo Novo Greenstone Belt(N-MNGB),and present data collected with different techniques,including U–Pb–Hf–O isotopes of zircon and multiple sulfur isotopes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrite from this supracrustal sequence.A pillowed metabasalt situated in the upper section of the N-MNGB is 3337±25 Ma old and has zircon with ε_(Hf)(t)=2.47 to1.40,Hf model ages between 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰to+7.3‰.These isotopic data,together with compiled whole-rock trace element data,suggest that the mafic metavolcanic rocks formed in a subduction-related setting,likely a back-arc basin juxtaposed to a continental arc.In this context,the magma interacted with older Eoarchean crustal components from the Gavião Block.Detrital zircons from the overlying quartzites of the Jacobina Group are sourced from Paleoarchean rocks,in accordance with previous studies,yielding a maximum depositional age of 3353±22 Ma.These detrital zircons have ε_(Hf)(t)=5.40 to0.84,Hf model ages between 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰to+6.4‰.The pyrite multiple sulfur isotope investigation of the 3.3 Ga supracrustal rocks from the N-MNGB enabled a further understanding of Paleoarchean sulfur cycling.The samples have diverse isotopic compositions that indicate sulfur sourced from distinct reservoirs.Significantly,they preserve the signal of the anoxic Archean atmosphere,expressed by MIF-S signatures(Δ^(33)S between1.3‰to+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 that is indistinguishable from the so-called Archean array.A BIF sample has a magmatic origin of sulfur,as indicated by the limited Δ^(34)S range(0 to+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist shows positive Δ^(34)S(2.1‰–3.5‰)and elevated Δ^(33)S(1.2‰–1.4‰)values,with corresponding negative Δ^(36)S between1.2‰to0.2‰,which resemble the isotopic composition of Archean black shales and suggest a source from the photolytic reduction of elemental sulfur.The pillowed metabasalt displays heterogeneous Δ^(34)S,Δ^(33)S,and Δ^(36)S signatures that reflect assimilation of both magmatic sulfur and photolytic sulfate during hydrothermal seafloor alteration.Lastly,pyrite in a massive sulfide lens is isotopically similar to barite of several Paleoarchean deposits worldwide,which might indicate mass dependent sulfur processing from a global and well-mixed sulfate reservoir at this time.展开更多
Several generations of mafic dyke swarms(2.7 to 0.8Ga),highlighted by aeromagnetic data,petrography,geochemistry,isotope geology and mostly U-Pb baddeleyite ages,crosscut the Archean and
Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB (Northern Arizona Seismic ...Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB (Northern Arizona Seismic Belt) is the San Francisco volcanic field, classified by the United States Geological Survey as potentially active. The last volcanic event in the field was located at Sunset Crater and occurred less than 1,000 years ago. Eruption intervals in the volcanic field are of the same order of length of time. Seismic monitoring of the volcanic field area has improved greatly since 1985 with the establishment of new network seismic stations. This has allowed for a lowered threshold of detection of seismic events and improved location capabilities. As an example of the result of this improved ability to locate smaller tremors, two swarms have been identified in the field, the 2009 Halloween swarm near Sunset Crater volcano and the 2011 swarm near Flagstaff, the largest urban community in northern Arizona.展开更多
The objective of this study was to determine the contamination of OCPs (organochlorine pesticides) in sediments from the upper middle of Sao Francisco River (Bahia, Brazil) in order to evaluate their potential pol...The objective of this study was to determine the contamination of OCPs (organochlorine pesticides) in sediments from the upper middle of Sao Francisco River (Bahia, Brazil) in order to evaluate their potential pollution risks. Samples of surface sediments were collected using a Petersen dredge at 21 stations located between Sobradinho and Cura^i. The organochlorine compounds analyzed were: p,p'-DDT, p,p'-DDD, p,p'-DDE, dicofol, methoxychlor, HCHs, aldrin, endrin, endrin aldehyde, endrin ketone, dieldrin, heptachlor, heptachlor epoxide, endosulfan (ct, fl and sulfate) and chlordane (ct and ,/). Extractions were carried out using the MAE (microwave-assisted extraction) method and organochlorine pesticides determination was achieved by GC/MS (gas chromatography-mass spectrometry). Organochlorine concentrations ranged between 1.51-820.00 ng.gx, indicating very low to high levels. The most frequent OCPs were endrin aldehyde, -HCH, HCH, HCH, heptachlor and heptachlor epoxide.展开更多
Through a detailed analysis and documentation of relevant U.S.foreign relations and other official documents of the period around the Korean War,this paper aims to prove that in the early negotiation process of the 19...Through a detailed analysis and documentation of relevant U.S.foreign relations and other official documents of the period around the Korean War,this paper aims to prove that in the early negotiation process of the 1951 San Francisco peace treaty,the United States maintained that South Korea should participate in signing the treaty and that the U.S.changed its position because of the resilient British opposition to South Korean participation,which in turn was motivated strongly by the British concern over its strategic interests in East Asia and its diplomatic relations with the newly communized China.In particular,the Chinese intervention in the Korean War and the communist recapture of Seoul provided the impetus for this shift in the U.S.position that led to the exclusion of South Korea from the treaty.Because the substance of the San Francisco peace treaty was dictated by the exigencies under the Korean War and the Cold War and lacks the“Grotian spirit of international law”underlying the founding of the League of Nations and the United Nations,the San Francisco peace treaty does not contain sufficient merit to be worthy of permanent compliance,which leaves open the possibility of modification in the future.展开更多
In order to exploit native fish species for aquaculture, basic parameters of artificial reproducetion and estimates of reproductive potential for this fish must be determined to improve hatchery success. We analyze se...In order to exploit native fish species for aquaculture, basic parameters of artificial reproducetion and estimates of reproductive potential for this fish must be determined to improve hatchery success. We analyze seven Brazilian commercial fish. Spawning was induced using the hypophysation method, with injection of crude carp pituitary extract (CCPE). Characiformes species signaled the spawning time with behavioral alterations (usually circular movements). The time of oocyte extrusion varied from 5.3 ± 0.3 h in Salminus franciscanus to 8.6 ± 0.1 h in Prochilodus argenteus after the second CCPE injection. The greatest diameter of a vitellogenic oocyte was registered for P. argenteus (873.9 ± 122.2 μm) and the smallest was for Pimelodus maculates (465.4 ± 36.3 μm). The diameter of vitellogenic oocytes was very similar among species belonging to the same family. The highest ROI values were registered for Prochilodus costatus(27.0 ± 3.5 μm) and P. argenteus (23.4 ± 3.7 μm), while the lowest values were found in Pseudoplatystoma corruscans (4.6 ± 0.9 μm) and P. maculatus (6.0 ± 1.3 μm). Absolute fecundity (number of oocytes released at spawning) was lowest in P. maculatus and highest in P. corruscans. Relative fecundity (RF) presented a high correlation (r = 0.98 to 0.99) with gonad weight, indicating high efficiency of spawning. The RF also presented a high correlation with body weight (r = 0.88 to 0.97) and total length (r = 0.86 to 0.92). The highest RF was registered for Leporinus obtusidens, and the lowest was for P. corruscans. Released fecundity had a negative correlation with the diameter of vitellogenic oocytes and with the height of the follicular cells, and a positive correlation with the thickness of the zona pelucida. These results indicate that the species studied herein are suitable candidates for aquaculture due to their reproductive and zootechnical characteristics.展开更多
BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established worldwide.The cornerstone of this treatment lies in the various criteria formulated by expert con...BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established worldwide.The cornerstone of this treatment lies in the various criteria formulated by expert consensus and experience.The variations among the criteria are staggering,and the short-and long-term outcomes are controversial.AIM To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the future.METHODS We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were received.The centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was noted.RESULTS Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/year.Approximately 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the patients.Barring a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC lesion.Positron-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied indications.The alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the criteria.The criteria for successful downstaging varied,but most centers conformed to the UCSF or their center-specific criteria for LT,along with the AFP cutoff values.The wait time for LT from downstaging was at least 4–6 wk in all centers.Contrast-enhanced CT was the preferred imaging modality for post-LT surveillance in 52%of the centers.Approximately 65%of the centers preferred to start everolimus between 1 and 3 months post-LT.CONCLUSION The current predicted 5-year survival rate of HCC patients in India is less than 15%.The aim of transplantation is to achieve at least a 60%5-year disease free survival rate,which will provide relief to the prediction of an HCC surge over the next 20 years.The current worldwide criteria(Milan/UCSF)may have a higher 5-year survival(>70%);however,the majority of patients still do not fit these criteria and are dependent on other suboptimal modes of treatment,with much lower survival rates.To make predictions for 2040,we must prepare to arm ourselves with less stringent selection criteria to widen the pool of patients who may undergo transplantation and have a chance of a better outcome.With more advanced technology and better donor outcomes,LDLT will provide a cutting edge in the fight against liver cancer over the next two decades.展开更多
Chinese education in America is a cultural product of Chinese immigrants to the United States.In 1848,the California Gold Rush attracted many Chinese to the United States,and gradually formed Chinese communities in th...Chinese education in America is a cultural product of Chinese immigrants to the United States.In 1848,the California Gold Rush attracted many Chinese to the United States,and gradually formed Chinese communities in the local area,and then spontaneously produced Chinese education.At that time,San Francisco Chinatown was the largest Chinatown in the United States,and its Chinese education showed representative characteristics.By studying the origin and development of Chinese education in San Francisco,this paper analyzes the characteristics of Chinese education in the United States,in order to provide experience and reference for contemporary Chinese education in the United States.展开更多
19末至20世纪初,在美国学者恩内斯特·费诺罗萨(Ernest Francisco Fenollosa,1853—1908)的学术引领和号召力推动下,几大美国博物馆纷纷举办了中国美术展览。其间佛教题材的唐宋卷轴画被置于焦点之位,成为理解东方审美、文化的重要...19末至20世纪初,在美国学者恩内斯特·费诺罗萨(Ernest Francisco Fenollosa,1853—1908)的学术引领和号召力推动下,几大美国博物馆纷纷举办了中国美术展览。其间佛教题材的唐宋卷轴画被置于焦点之位,成为理解东方审美、文化的重要载体。这一时期,中国佛画的西传与鉴藏,是中学西渐的重要印证,亦是近代“中国观”嬗变的一个微观缩影。展开更多
基金CNPq (National Counsel of Technological and Scientific Development, Brazil) grant (234610/2014-0)CAPES (Brasília, Brazil)+4 种基金FAPEMIG (Belo Horizonte, Brazil)UFOP (Ouro Preto, Brazil)UPS/Laboratoire de Volcanologie-Pétrographie (Orsay, France)UQàM/GEOTOP (Montreal, Canada)APQ3793-16 project funding
文摘Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally "Ⅰ-type",meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite.
基金the financial support provided by FAPEMIG(CRA-APQ-00125-12)the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior(CAPES)by granting a PhD scholarship to S.M.Bersan(Process No.88881.188438/2018-01 of PDSE Program No.47/2017)。
文摘New,integrated petrographic,mineral chemistry,whole rock geochemical,zircon and titanite UPb geochronology,and zircon Hf isotopic data from the Montezuma granitoids,as well as new geochemical results for its host rocks represented by the Corrego Tingui Complex,provides new insights into the late-to post-collisional evolution of the northeastern Sao Francisco paleocontinent.U-Pb zircon dates from the Montezuma granitoids spread along the Concordia between ca.2.2 Ga to 1.8 Ga and comprise distinct groups.Group I have crystallization ages between ca.2.15 Ga and 2.05 Ga and are interpreted as inherited grains.Group II zircon dates vary from 2.04 Ga to1.9 Ga and corresponds to the crystallization of the Montezuma granitoids,which were constrained at ca.2.03 Ga by the titanite U-Pb age.Inverse age zoning is common within the ca.1.8 Ga Group III zircon ages,being related to fluid isotopic re-setting during the Espinhaco rifiting event.ZirconεHf(t)analysis show dominantly positive values for both Group I(-4 to+9)andⅡ(-3 to+8)zircons and TDM2 model ages of 2.7-2.1 Ga and 2.5-1.95 Ga,respectively.Geochemically,the Montezuma granitoids are weakly peraluminous to metaluminous magnesian granitoids,enriched in LILES and LREE,with high to moderate Mg#and depleted in some of the HFSE.Their lithochemical signature,added to the juvenile signature of both inherited and crystallized zircons,allowed its classification as a shoshonitic high Ba-Sr granitoid related to a late-to post-collisional lithosphere delamination followed by asthenospheric upwelling.In this scenario,the partial melting of the lithospheric mantle interacted with the roots of an accreted juvenile intra-oceanic arc,being these hybrid magma interpreted as the source of the Montezuma granitoids.The Corrego Tingui Complex host rocks are akin to a syn-to late-collisional volcanic arc granitoids originated from the partial melting of ancient crustal rocks.The results presented in this study have revealed the occurrence of juvenile rocks,probably related to an island arc environment,that are exotic in relation to the Paleo-to Neoarchean crust from the Sao Francisco paleocontinent’s core.
基金São Paulo Research Foundation(FAPESP grants2016/02933-2 to ABS,12/15824-6 to EPO and 2015/16235-2 to PP)the Agouron Institute(to WPG)for financial support。
文摘Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric chemistry.Small ranges in Δ^(33)S that expanded into larger fractionations leading up to the Great Oxygenation Event(GOE;2.45–2.2 Ga)are disproportionately represented by sequences from the Kaapvaal and Pilbara Cratons.These patterns of S-MIF attenuation and enhancement may differ from the timing and magnitude of minor sulfur isotope fractionations reported from other cratons,thus obscuring local for global sulfur cycling dynamics.By expanding the Δ^(33)S record to include the relatively underrepresented São Francisco Craton in Brazil,we suggest that marine biogeochemistry affected S-MIF preservation prior to the GOE.In an early Neoarchean sequence(2763–2730 Ma)from the Rio das Velhas Greenstone Belt,we propose that low δ^(13)Corg(<-30‰)and dampened Δ^(33)S(-0.4‰to-0.7‰)in banded iron formation reflect the marine diagenetic process of anaerobic methane oxidation.The overlying black shale(TOC up to 7.8%)with higher δ^(13)Corg(-33.4‰to-19.2‰)and expanded Δ^(33)S(2.3‰±0.8‰),recorded oxidative sulfur cycling that resulted in enhance preservation of S-MIF input from atmospheric sources of elemental sulfur.The sequence culminates in a metasandstone,where concomitant changes to more uniform δCorg(-30‰to--25‰),potentially associated with the RuBisCO I enzyme,and near-zero Δ^(33)S(-0.04‰to 0.38‰)is mainly interpreted as evidence for local oxygen production.When placed in the context of other sequences worldwide,the Rio das Velhas helps differentiate the influences of global atmospheric chemistry and local marine diagenesis in Archean biogeochemical processes.Our data suggest that prokaryotic sulfur,iron,and methane cycles might have an underestimated role in pre-GOE sulfur minor isotope records.
基金funded by the Fundação de AmparoàPesquisa do Estado de São Paulo(FAPESP)Grant(#2012/15824-6and#2018/25465-0 to EPO)the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Grant(#305099/2019-1 to EPO)the Institute of Geosciences of the University of Campinas and by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)PhD Scholarship(#001)to the senior author。
文摘The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the Archean.However,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient rocks.Despite this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South America’s primitive crust.Therefore,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi Complex.The Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic composition.Our new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean rocks.Lu-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over time.In the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.
基金financial support provided by FAPEMIG(CRAAPQ-00125-12)the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior(CAPES)+1 种基金by granting a PhD scholarship to S.M.Bersan(process n°88881.188438/2018-01 of PDSE program n°47/2017)granted a Fapemig scientific initiation scholarship(process PIBIC/Fapemig/UFOP N10/2017)。
文摘The late-to post-collisional stage in orogenic systems is characterized by the coeval existence of bimodal potassic to ultrapotassic magmatic activity related to partial melting of an enriched lithospheric mantle together with crustal derived melts.In this paper,we present new whole rock geochemical analyses combined with zircon and titanite U–Pb and zircon Hf isotopic data from potassic to ultrapotassic rocks from six plutons that occur within the Archean Itacambira-Monte Azul block(BIMA),to discuss their petrogenesis and the tectonic implications for the São Francisco paleocontinent.The new U–Pb ages range from ca.2.06 Ga to 1.98 Ga and reveal long-lasting potassic magmatism within the BIMA,which is within the late-to-post-collisional stage of the São Francisco paleocontinent evolution.The ultrapotassic rocks are compatible with a fluid-related metasomatized mantle source enriched by previous subduction events,whereas the potassic rocks are bimodal and have a transitional shoshonitic to A-type affinity.These rocks have a hybrid nature,possible related to the mixing between the mafic potassic/ultrapotassic rocks and high temperature crustal melts of the Archean continental crust.Our results also show an increase of within-plate signature towards the younger potassic magmas.The participation of an important Archean crustal component in the genesis of these rocks is highlighted by the common and occasionally abundant occurrence of Archean inherited zircons.The Hf isotopic record shows that most of the zircon inheritance has dominantly subchondriticεHf(t)values,which fits a crustal reworking derivation from a similar Eo-to Paleoarchean precursor crust.However,the presence of juvenile 2.36 Ga zircon inheritance in an ultrapotassic sample reveal the existence of a hidden reservoir that is somewhat similar to the described for the Mineiro Belt in southern São Francisco paleocontinent.
基金financial support from the CNPq(National Council for Scientific and Technological Development)under grant 141707/2016-0 to Lorena Martinsfinancial support provided by CNPq awarded to Cristiano Lana。
文摘Field observations and CA-LA-ICP-MS U–Pb zircon ages and Hf isotope compositions obtained from migmatitic orthogneisses and granitoids from the Belo Horizonte Complex,southern São Francisco Craton,indicate a major period of partial melting and production of felsic rocks in the Neoarchean.Our observations show that the complex is an important site for studying partial melting processes of Archean crystalline crust.Much of the complex exposes fine-grained stromatic migmatites that are intruded by multiple leucogranitic veins and sheeted dikes.Both migmatites and leucogranite sheets are crosscut by several phases of granitoid batholiths and small granitic bodies;both of which are closely associated with the host banded gneisses.Chemical abrasion followed by detailed cathodoluminescence imaging revealed a wide variety of zircon textures that are consistent with a long-lived period of partial melting and crustal remobilization.Results of U-Pb and Hf isotopes disclose the complex as part of a much wider crustal segment,encompassing the entire southern part of the São Francisco Craton.Compilation of available U-Pb ages suggests that this crustal segment was consolidated sometime between 3000 Ma and 2900 Ma and that it experienced three main episodes of partial melting before stabilization at 2600 Ma.The partial melting episodes took place between 2750 Ma and 2600 Ma as a result of tectonic accretion and peeling off the lithospheric mantle and lower crust.This process is likely responsible for the emplacement of voluminous potassic granitoids across the entire São Francisco Craton.We believe that the partial melting of Meso-Archean crystalline crust and production of potassic granitoids are linked to a fundamental shift in the tectonics of the craton,which was also responsible for the widespread intrusion of large syenitic bodies in the northern part of the craton,and the construction of layered mafic–ultramafic intrusions to the south of the BHC.
基金the Brazilian research institutions:National Council for Scientific and Technological Development(CNPqprocess n°206612/2014-1)+2 种基金the Fundação de AmparoàPesquisa de Minas Gerais(FAPEMIGprocess n°CRA 1.058/04)for the financial assistancethe Geological Survey of Brazil(SGB/CPRM)for the support。
文摘The Campos Gerais Domain(CGD)in southeastern Brazil is an approximately 180 km×35 km area of Archean–Proterozoic rocks located southwest of the São Francisco Craton(SFC).The Archean–Paleopro terozoic evolution of the CGD—alongside its potential correlation with the SFC or other cratonic blocks in the region-is currently poorly-constrained.We present the results of systematic petrography,bulkrock geochemistry,mineral chemistry and geochronology for a suite of scarcely studied mafic–ultramafic rocks from the CGD.We also provide a compilation of previously reported bulk-rock geochemical and spinel group mineral chemical data for mafic–ultramafic rocks throughout the CGD,and geochronological information for various lithotypes in the region.The CGD records a protracted Mesoarchean to Statherian(3.1–1.7 Ga)crustal evolution,which we interpret to share a common history with the southern SFC and their related reworked segments,suggesting that it is a westward extension of this cratonic terrain.The metavolcano-sedimentary rocks of the Fortaleza de Minas and Alpinópolis segments represent a Mesoarchean greenstone belt that is stratigraphically and chemically comparable to Archean greenstone belts worldwide,and that is broadly coeval with a local suite of tonalite-trondhjemite-grano diorite(TTG)gneisses and migmatites.U-Pb SHRIMP zircon data from a subalkaline metagabbro yielded a concordia age of ca.2.96 Ga,revealing a previously unrecognized phase of Archean magmatism in the CGD that can be chrono-correlated with metakomatiite and TTG generation elsewhere in the São Francisco paleocontinent.Our data contradict a hypothesis whereby the metavolcano-sedimentary rocks of the Jacuí-Bom Jesus da Penha and Petúnia segments represent an ophiolite,as previously suggested,instead presenting features that point to formation in association with a continental arc.Coupled with a U-Pb(SHRIMP)crystallization age of ca.2.13 Ga recorded by zircon grains from a metaultramafic rock,these data highlight that a magmatic event was chrono-correlated with the main accretionary phase of the Minas Orogeny,and with the Pouso Alegre/Amparo and São Vicente complexes.Finally,a U-Pb(SHRIMP)concordia age of ca.590 Ma—obtained from metamorphic-textured zircon grains from a metaultramafic rock—points to a late metamorphic overprint related to upper amphibolite conditions,brittle fault activation and the juxtaposition of crustal blocks in association with the latest stages of western Gondwana’s assembly in the southern SFC,with later retrogression to greenschist-facies.
基金the Brazilian National Council for Scientific and Technological Development(CNPq)for financial support(grants 163459/2013-4 and 202267/2014-8 for G.S Teles and 305053/2014-0 for F.Chemale Jr.)the Australian Research Council(ARC)(grant DP140103393 for T.R.Ireland)。
文摘Greenstone belts contain several clues about the evolutionary history of primitive Earth.Here,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the Northern Mundo Novo Greenstone Belt(N-MNGB),and present data collected with different techniques,including U–Pb–Hf–O isotopes of zircon and multiple sulfur isotopes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrite from this supracrustal sequence.A pillowed metabasalt situated in the upper section of the N-MNGB is 3337±25 Ma old and has zircon with ε_(Hf)(t)=2.47 to1.40,Hf model ages between 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰to+7.3‰.These isotopic data,together with compiled whole-rock trace element data,suggest that the mafic metavolcanic rocks formed in a subduction-related setting,likely a back-arc basin juxtaposed to a continental arc.In this context,the magma interacted with older Eoarchean crustal components from the Gavião Block.Detrital zircons from the overlying quartzites of the Jacobina Group are sourced from Paleoarchean rocks,in accordance with previous studies,yielding a maximum depositional age of 3353±22 Ma.These detrital zircons have ε_(Hf)(t)=5.40 to0.84,Hf model ages between 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰to+6.4‰.The pyrite multiple sulfur isotope investigation of the 3.3 Ga supracrustal rocks from the N-MNGB enabled a further understanding of Paleoarchean sulfur cycling.The samples have diverse isotopic compositions that indicate sulfur sourced from distinct reservoirs.Significantly,they preserve the signal of the anoxic Archean atmosphere,expressed by MIF-S signatures(Δ^(33)S between1.3‰to+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 that is indistinguishable from the so-called Archean array.A BIF sample has a magmatic origin of sulfur,as indicated by the limited Δ^(34)S range(0 to+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist shows positive Δ^(34)S(2.1‰–3.5‰)and elevated Δ^(33)S(1.2‰–1.4‰)values,with corresponding negative Δ^(36)S between1.2‰to0.2‰,which resemble the isotopic composition of Archean black shales and suggest a source from the photolytic reduction of elemental sulfur.The pillowed metabasalt displays heterogeneous Δ^(34)S,Δ^(33)S,and Δ^(36)S signatures that reflect assimilation of both magmatic sulfur and photolytic sulfate during hydrothermal seafloor alteration.Lastly,pyrite in a massive sulfide lens is isotopically similar to barite of several Paleoarchean deposits worldwide,which might indicate mass dependent sulfur processing from a global and well-mixed sulfate reservoir at this time.
文摘Several generations of mafic dyke swarms(2.7 to 0.8Ga),highlighted by aeromagnetic data,petrography,geochemistry,isotope geology and mostly U-Pb baddeleyite ages,crosscut the Archean and
文摘Seismicity in northern Arizona is concentrated in a northwest-southeast trending belt that stretches from the Utah border south to the edge of the Colorado Plateau. Located within this NASB (Northern Arizona Seismic Belt) is the San Francisco volcanic field, classified by the United States Geological Survey as potentially active. The last volcanic event in the field was located at Sunset Crater and occurred less than 1,000 years ago. Eruption intervals in the volcanic field are of the same order of length of time. Seismic monitoring of the volcanic field area has improved greatly since 1985 with the establishment of new network seismic stations. This has allowed for a lowered threshold of detection of seismic events and improved location capabilities. As an example of the result of this improved ability to locate smaller tremors, two swarms have been identified in the field, the 2009 Halloween swarm near Sunset Crater volcano and the 2011 swarm near Flagstaff, the largest urban community in northern Arizona.
文摘The objective of this study was to determine the contamination of OCPs (organochlorine pesticides) in sediments from the upper middle of Sao Francisco River (Bahia, Brazil) in order to evaluate their potential pollution risks. Samples of surface sediments were collected using a Petersen dredge at 21 stations located between Sobradinho and Cura^i. The organochlorine compounds analyzed were: p,p'-DDT, p,p'-DDD, p,p'-DDE, dicofol, methoxychlor, HCHs, aldrin, endrin, endrin aldehyde, endrin ketone, dieldrin, heptachlor, heptachlor epoxide, endosulfan (ct, fl and sulfate) and chlordane (ct and ,/). Extractions were carried out using the MAE (microwave-assisted extraction) method and organochlorine pesticides determination was achieved by GC/MS (gas chromatography-mass spectrometry). Organochlorine concentrations ranged between 1.51-820.00 ng.gx, indicating very low to high levels. The most frequent OCPs were endrin aldehyde, -HCH, HCH, HCH, heptachlor and heptachlor epoxide.
文摘Through a detailed analysis and documentation of relevant U.S.foreign relations and other official documents of the period around the Korean War,this paper aims to prove that in the early negotiation process of the 1951 San Francisco peace treaty,the United States maintained that South Korea should participate in signing the treaty and that the U.S.changed its position because of the resilient British opposition to South Korean participation,which in turn was motivated strongly by the British concern over its strategic interests in East Asia and its diplomatic relations with the newly communized China.In particular,the Chinese intervention in the Korean War and the communist recapture of Seoul provided the impetus for this shift in the U.S.position that led to the exclusion of South Korea from the treaty.Because the substance of the San Francisco peace treaty was dictated by the exigencies under the Korean War and the Cold War and lacks the“Grotian spirit of international law”underlying the founding of the League of Nations and the United Nations,the San Francisco peace treaty does not contain sufficient merit to be worthy of permanent compliance,which leaves open the possibility of modification in the future.
基金This study was conducted with funds granted by CNPq,FAPEMIG and CODEVASF.
文摘In order to exploit native fish species for aquaculture, basic parameters of artificial reproducetion and estimates of reproductive potential for this fish must be determined to improve hatchery success. We analyze seven Brazilian commercial fish. Spawning was induced using the hypophysation method, with injection of crude carp pituitary extract (CCPE). Characiformes species signaled the spawning time with behavioral alterations (usually circular movements). The time of oocyte extrusion varied from 5.3 ± 0.3 h in Salminus franciscanus to 8.6 ± 0.1 h in Prochilodus argenteus after the second CCPE injection. The greatest diameter of a vitellogenic oocyte was registered for P. argenteus (873.9 ± 122.2 μm) and the smallest was for Pimelodus maculates (465.4 ± 36.3 μm). The diameter of vitellogenic oocytes was very similar among species belonging to the same family. The highest ROI values were registered for Prochilodus costatus(27.0 ± 3.5 μm) and P. argenteus (23.4 ± 3.7 μm), while the lowest values were found in Pseudoplatystoma corruscans (4.6 ± 0.9 μm) and P. maculatus (6.0 ± 1.3 μm). Absolute fecundity (number of oocytes released at spawning) was lowest in P. maculatus and highest in P. corruscans. Relative fecundity (RF) presented a high correlation (r = 0.98 to 0.99) with gonad weight, indicating high efficiency of spawning. The RF also presented a high correlation with body weight (r = 0.88 to 0.97) and total length (r = 0.86 to 0.92). The highest RF was registered for Leporinus obtusidens, and the lowest was for P. corruscans. Released fecundity had a negative correlation with the diameter of vitellogenic oocytes and with the height of the follicular cells, and a positive correlation with the thickness of the zona pelucida. These results indicate that the species studied herein are suitable candidates for aquaculture due to their reproductive and zootechnical characteristics.
文摘BACKGROUND Liver transplantation(LT)for hepatocellular carcinoma(HCC)has been widely researched and is well established worldwide.The cornerstone of this treatment lies in the various criteria formulated by expert consensus and experience.The variations among the criteria are staggering,and the short-and long-term outcomes are controversial.AIM To study the differences in the current practices of LT for HCC at different centers in India and discuss their clinical implications in the future.METHODS We conducted a survey of major centers in India that performed LT in December 2022.A total of 23 responses were received.The centers were classified as high-and low-volume,and the current trend of care for patients undergoing LT for HCC was noted.RESULTS Of the 23 centers,35%were high volume center(>500 Liver transplants)while 52%were high-volume centers that performed more than 50 transplants/year.Approximately 39%of centers had performed>50 LT for HCC while the percent distribution for HCC in LT patients was 5%–15%in approximately 73%of the patients.Barring a few,most centers were divided equally between University of California,San Francisco(UCSF)and center-specific criteria when choosing patients with HCC for LT,and most(65%)did not have separate transplant criteria for deceased donor LT and living donor LT(LDLT).Most centers(56%)preferred surgical resection over LT for a Child A cirrhosis patient with a resectable 4 cm HCC lesion.Positron-emission tomography-computed tomography(CT)was the modality of choice for metastatic workup in the majority of centers(74%).Downstaging was the preferred option for over 90%of the centers and included transarterial chemoembolization,transarterial radioembolization,stereotactic body radiotherapy and atezolizumab/bevacizumab with varied indications.The alphafetoprotein(AFP)cut-off was used by 74%of centers to decide on transplantation as well as to downstage tumors,even if they met the criteria.The criteria for successful downstaging varied,but most centers conformed to the UCSF or their center-specific criteria for LT,along with the AFP cutoff values.The wait time for LT from downstaging was at least 4–6 wk in all centers.Contrast-enhanced CT was the preferred imaging modality for post-LT surveillance in 52%of the centers.Approximately 65%of the centers preferred to start everolimus between 1 and 3 months post-LT.CONCLUSION The current predicted 5-year survival rate of HCC patients in India is less than 15%.The aim of transplantation is to achieve at least a 60%5-year disease free survival rate,which will provide relief to the prediction of an HCC surge over the next 20 years.The current worldwide criteria(Milan/UCSF)may have a higher 5-year survival(>70%);however,the majority of patients still do not fit these criteria and are dependent on other suboptimal modes of treatment,with much lower survival rates.To make predictions for 2040,we must prepare to arm ourselves with less stringent selection criteria to widen the pool of patients who may undergo transplantation and have a chance of a better outcome.With more advanced technology and better donor outcomes,LDLT will provide a cutting edge in the fight against liver cancer over the next two decades.
文摘Chinese education in America is a cultural product of Chinese immigrants to the United States.In 1848,the California Gold Rush attracted many Chinese to the United States,and gradually formed Chinese communities in the local area,and then spontaneously produced Chinese education.At that time,San Francisco Chinatown was the largest Chinatown in the United States,and its Chinese education showed representative characteristics.By studying the origin and development of Chinese education in San Francisco,this paper analyzes the characteristics of Chinese education in the United States,in order to provide experience and reference for contemporary Chinese education in the United States.
文摘19末至20世纪初,在美国学者恩内斯特·费诺罗萨(Ernest Francisco Fenollosa,1853—1908)的学术引领和号召力推动下,几大美国博物馆纷纷举办了中国美术展览。其间佛教题材的唐宋卷轴画被置于焦点之位,成为理解东方审美、文化的重要载体。这一时期,中国佛画的西传与鉴藏,是中学西渐的重要印证,亦是近代“中国观”嬗变的一个微观缩影。