In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day...In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.展开更多
Objective To analyze the value of evaluating ovarian response to gonadotrophin stimulation according to patients basal FSH / LH ratio. Methods A total of 134 patients undergoing IVF-ET or ICSI were enrolled using shor...Objective To analyze the value of evaluating ovarian response to gonadotrophin stimulation according to patients basal FSH / LH ratio. Methods A total of 134 patients undergoing IVF-ET or ICSI were enrolled using short protocol. We studied their age, basal FSH, bFSH/LH ratio and some indexes which can represent ovarian response. Statistical evaluation was performed using logistic regression analysis and ROC curve to determine odds ratios（OR） and FSH/LH cutoffs. Results Among the patients whose bFSH were less than 8 IU/L, three odds ratios between the ovarian response index and their age, bFSH, bFSH/LH were no significant difference and bFSH/LH cutoff was 3.7. But among the patients those bFSH ≥ 8 IU/L, there were differences among the three OR and bFSH/LH cutoff was 3.3. The highest OR was between bFSH/LH ratio and ovarian response indexes, while the lowest was between bFSH and those indexes . Conclusions Among the patients who has lower ovary reserve （bFSH ≥8 IU/L）, the ratio of bFSH/LH has superior value to age and basal FSH on evaluating ovarian response.展开更多
文摘In Vitro Fertilization (IVF) is the treatment for many causes of infertility. Many studies were done to investigate different factors that can affect the success rate. This study was conducted to evaluate if cycle day 3 (CD3) follicle-stimulating hormone (FSH)/luteinizing hormone (LH) ratio can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years with normal baseline FSH. This is a retrospective case control study conducted at the Centre of Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women underwent IVF. Patients were grouped based on CD3 FSH/LH ratio. Group A consisted of ≤35-year-old women with FSH/LH ratio ≤35-year-old women with FSH/LH ratio ≥ 2. The primary outcomes include the fertilization rate, implantation rate and the clinical pregnancy rate. The secondary outcomes include duration and the total dose of gonadotrophin used. We found that, there was no significant difference in the total dose of gonadotropin used during the IVF cycle. Also, there was no significant difference in the number of retrieved and fertilized oocytes and the number of good embryos. Clinical pregnancy rate was the same in both groups. In conclusion, in patients younger than 35 years, CD3 FSH/LH ratio is not a predictor for IVF outcome.
文摘Objective To analyze the value of evaluating ovarian response to gonadotrophin stimulation according to patients basal FSH / LH ratio. Methods A total of 134 patients undergoing IVF-ET or ICSI were enrolled using short protocol. We studied their age, basal FSH, bFSH/LH ratio and some indexes which can represent ovarian response. Statistical evaluation was performed using logistic regression analysis and ROC curve to determine odds ratios（OR） and FSH/LH cutoffs. Results Among the patients whose bFSH were less than 8 IU/L, three odds ratios between the ovarian response index and their age, bFSH, bFSH/LH were no significant difference and bFSH/LH cutoff was 3.7. But among the patients those bFSH ≥ 8 IU/L, there were differences among the three OR and bFSH/LH cutoff was 3.3. The highest OR was between bFSH/LH ratio and ovarian response indexes, while the lowest was between bFSH and those indexes . Conclusions Among the patients who has lower ovary reserve （bFSH ≥8 IU/L）, the ratio of bFSH/LH has superior value to age and basal FSH on evaluating ovarian response.
