Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have brui...Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have bruising in the vicinity of the umbilicus (Cullen’s sign). She had pronounced ovarian enlargement on ultrasonography and it was hypothesised that this profound phenotype might reflect an abnormal FSH receptor.However sequencing of the FSH receptor was normal.The ovarian enlargement resolved with thyroxine replacement.Physicians and surgeons should consider longstanding hypothyroidismin patients presenting with Cullen’s sign.展开更多
The FSH isomers,both produced by the anterior pituitary gland in vivo and pharmaceutical preparations,have variable biological properties,which can affect the ovarian function through interaction with FSH receptors.Ov...The FSH isomers,both produced by the anterior pituitary gland in vivo and pharmaceutical preparations,have variable biological properties,which can affect the ovarian function through interaction with FSH receptors.Ovarian response to FSH stimulation also depends on FSH receptor genotype.展开更多
文摘Ovarian hyperstimulation is a recognised complication of longstanding hypothyroidism. A 12 year old girl with atrophicthyroiditis who presented with abdominal pain and distensionis reported. She was noted to have bruising in the vicinity of the umbilicus (Cullen’s sign). She had pronounced ovarian enlargement on ultrasonography and it was hypothesised that this profound phenotype might reflect an abnormal FSH receptor.However sequencing of the FSH receptor was normal.The ovarian enlargement resolved with thyroxine replacement.Physicians and surgeons should consider longstanding hypothyroidismin patients presenting with Cullen’s sign.
文摘The FSH isomers,both produced by the anterior pituitary gland in vivo and pharmaceutical preparations,have variable biological properties,which can affect the ovarian function through interaction with FSH receptors.Ovarian response to FSH stimulation also depends on FSH receptor genotype.
