We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 p...We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.展开更多
Aiming at the problems of convergence-slow and convergence-free of Discrete Particle Swarm Optimization Algorithm(DPSO) in solving large scale or complicated discrete problem, this article proposes Intuitionistic Fuzz...Aiming at the problems of convergence-slow and convergence-free of Discrete Particle Swarm Optimization Algorithm(DPSO) in solving large scale or complicated discrete problem, this article proposes Intuitionistic Fuzzy Entropy of Discrete Particle Swarm Optimization(IFDPSO) and makes it applied to Dynamic Weapon Target Assignment(WTA). First, the strategy of choosing intuitionistic fuzzy parameters of particle swarm is defined, making intuitionistic fuzzy entropy as a basic parameter for measure and velocity mutation. Second, through analyzing the defects of DPSO, an adjusting parameter for balancing two cognition, velocity mutation mechanism and position mutation strategy are designed, and then two sets of improved and derivative algorithms for IFDPSO are put forward, which ensures the IFDPSO possibly search as much as possible sub-optimal positions and its neighborhood and the algorithm ability of searching global optimal value in solving large scale 0-1 knapsack problem is intensified. Third, focusing on the problem of WTA, some parameters including dynamic parameter for shifting firepower and constraints are designed to solve the problems of weapon target assignment. In addition, WTA Optimization Model with time and resource constraints is finally set up, which also intensifies the algorithm ability of searching global and local best value in the solution of WTA problem. Finally, the superiority of IFDPSO is proved by several simulation experiments. Particularly, IFDPSO, IFDPSO1~IFDPSO3 are respectively effective in solving large scale, medium scale or strict constraint problems such as 0-1 knapsack problem and WTA problem.展开更多
文摘We implemented a 3-3-1 algorithm in order to provide safe and simple self-titration in patients who newly initiated BOT as well as who were already on BOT and evaluated its utility in clinical setting. A total of 46 patients, 21 patients in the newly-initiated group and 25 patients in the existing BOT group performed dose adjustment using 3-3-1 algorithm. HbA1c was significantly improved 4 weeks after the initiation from 8.5% ± 1.2% at baseline to 7.3% ± 0.7% at the final evaluation (p 0.01, vs. Baseline). The average daily insulin units increased throughout the study period from 10.1 ± 6.7 at baseline to 14.6 ± 8.9 units at the final evaluation. Weight didn’t significantly change throughout the study (p = 0.12). The incidents of hypoglycemia were 0.8/month during the insulin dose self-adjustment period and 0.4/month during the follow-up period. The 3-3-1 algorithm using insulin glargine provided a safe and simple dose adjustment and demonstrated its utility in patients who were newly introduced to insulin treatment as well as who were already on BOT.
基金supported by The National Natural Science Foundation of China under Grant Nos.61402517, 61573375The Foundation of State Key Laboratory of Astronautic Dynamics of China under Grant No. 2016ADL-DW0302+2 种基金The Postdoctoral Science Foundation of China under Grant Nos. 2013M542331, 2015M572778The Natural Science Foundation of Shaanxi Province of China under Grant No. 2013JQ8035The Aviation Science Foundation of China under Grant No. 20151996015
文摘Aiming at the problems of convergence-slow and convergence-free of Discrete Particle Swarm Optimization Algorithm(DPSO) in solving large scale or complicated discrete problem, this article proposes Intuitionistic Fuzzy Entropy of Discrete Particle Swarm Optimization(IFDPSO) and makes it applied to Dynamic Weapon Target Assignment(WTA). First, the strategy of choosing intuitionistic fuzzy parameters of particle swarm is defined, making intuitionistic fuzzy entropy as a basic parameter for measure and velocity mutation. Second, through analyzing the defects of DPSO, an adjusting parameter for balancing two cognition, velocity mutation mechanism and position mutation strategy are designed, and then two sets of improved and derivative algorithms for IFDPSO are put forward, which ensures the IFDPSO possibly search as much as possible sub-optimal positions and its neighborhood and the algorithm ability of searching global optimal value in solving large scale 0-1 knapsack problem is intensified. Third, focusing on the problem of WTA, some parameters including dynamic parameter for shifting firepower and constraints are designed to solve the problems of weapon target assignment. In addition, WTA Optimization Model with time and resource constraints is finally set up, which also intensifies the algorithm ability of searching global and local best value in the solution of WTA problem. Finally, the superiority of IFDPSO is proved by several simulation experiments. Particularly, IFDPSO, IFDPSO1~IFDPSO3 are respectively effective in solving large scale, medium scale or strict constraint problems such as 0-1 knapsack problem and WTA problem.
