The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the ...The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on columns.The parametric vibration equation is established for the test model using the finite-element method.The auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent method.The effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test model.Compared with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental ones.For a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric resonance.Combined with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.展开更多
BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced N...BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant chemoradiotherapy.Therefore,precise prediction of metastasis in patients with NPC is crucial.AIM To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging(MRI)reports.METHODS This retrospective study included 792 patients with non-distant metastatic NPC.A total of 469 imaging variables were obtained from detailed MRI reports.Data were stratified and randomly split into training(50%)and testing sets.Gradient boosting tree(GBT)models were built and used to select variables for predicting DM.A full model comprising all variables and a reduced model with the top-five variables were built.Model performance was assessed by area under the curve(AUC).RESULTS Among the 792 patients,94 developed DM during follow-up.The number of metastatic cervical nodes(30.9%),tumor invasion in the posterior half of the nasal cavity(9.7%),two sides of the pharyngeal recess(6.2%),tubal torus(3.3%),and single side of the parapharyngeal space(2.7%)were the top-five contributors for predicting DM,based on their relative importance in GBT models.The testing AUC of the full model was 0.75(95%confidence interval[CI]:0.69-0.82).The testing AUC of the reduced model was 0.75(95%CI:0.68-0.82).For the whole dataset,the full(AUC=0.76,95%CI:0.72-0.82)and reduced models(AUC=0.76,95%CI:0.71-0.81)outperformed the tumor node-staging system(AUC=0.67,95%CI:0.61-0.73).CONCLUSION The GBT model outperformed the tumor node-staging system in predicting metastasis in NPC.The number of metastatic cervical nodes was identified as the principal contributing variable.展开更多
The 2-dimensional equivalent model used in helicopter ground resonance analysis is convenient for its simplicity and clarity. The equivalent body mass, the stiffness and the damping are derived from the modal charaCte...The 2-dimensional equivalent model used in helicopter ground resonance analysis is convenient for its simplicity and clarity. The equivalent body mass, the stiffness and the damping are derived from the modal charaCteristics. In this paper, a 3-dimensional space model is constructed to analyse the ground resonance.There is little difference between the calculated results of the 2-dimensional equivalent model and those of the 3-dimensional space model. Hence, the 2-dimensional model is verified for the practical application. Generally, the linear lead-lag damping of the equivalent rotor blade at the modal frequency is derived from the lead-lag damper characteristics by a procedure of iteration. The transformation of the imaginary part of the complex modulus of the viscoelastic damper into a linear velocity damping is complicated in analysis. A method to use the complex modulus directly in the ground resonance analysis is derived and verified.展开更多
Objective To investigate the role of peffusion-weighted magnetic resonance imaging (MRI) in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride ( 1 ml/kg) was selectively in...Objective To investigate the role of peffusion-weighted magnetic resonance imaging (MRI) in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride ( 1 ml/kg) was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side (SS), while the other half fiver without carbon tetrachloride injection was called as study control side (SCS). Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid (Gd-DTPA) dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase ( MRSI), peak time ( tp), and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit (au)/s, respectively. Three parameters of curves didn't show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis.展开更多
AIM: To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS: A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomograp...AIM: To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS: A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomography (CT) and magnetic resonance imaging (MRI) were used to observe tumorgrowth and metastasis at different phases. Pathological changes and spontaneous survival time of the rabbits were recorded.RESULTS: Two weeks after VX2 cell implantation, the tumor diameter ranged 4.1-5.8 mm and the success implantation rate was 81.8%. CT scanning showed low-density loci of the tumor in the rectum wail, while enhanced CT scanning demonstrated a symmetrical intensification in tumor loci. MRI scanning showed alow signal of the tumor on T1-weighted imaging anda high signal of the tumor on T2-weighted imaging.Both types of signals were intensified with enhanced MRI. Metastases to the liver and lung could beobserved 6 wk after VX2 cell implantation, and a largearea of necrosis appeared in the primary tumor. The spontaneous survival time of rabbits with cachexia and multiple organ failure was about 7 wk after VX2 cell implantation.CONCLUSION: The rabbit rectal VX2 carcinoma model we established has a high stability, and can be used in the study of rectal carcinoma.展开更多
To achieve high quality factor and high-sensitivity refractive index sensor,a slot micro-ring resonator(MRR)based on asymmetric Fabry-Perot(FP)cavity was proposed.The structure consisted of a pair of elliptical holes ...To achieve high quality factor and high-sensitivity refractive index sensor,a slot micro-ring resonator(MRR)based on asymmetric Fabry-Perot(FP)cavity was proposed.The structure consisted of a pair of elliptical holes to form an FP cavity and a microring resonator.The two different optical modes generated by the micro-ring resonator were destructively interfered to form a Fano line shape,which improved the system sensitivity while obtaining a higher quality factor and extinction ratio.The transmission principle of the structure was analyzed by the transfer matrix method.The transmission spectrum and mode field distribution of the proposed structure were simulated by the finite difference time domain(FDTD)method,and the key structural parameters affecting the Fano line shape in the device were optimized.The simulation results show that the quality factor of the device reached 22037.1,and the extinction ratio was 23.9 dB.By analyzing the refractive index sensing characteristics,the sensitivity of the structure was 354 nm·RIU−1,and the detection limit of the sensitivity was 2×10−4 RIU.Thus,the proposed compact asymmetric FP cavity slot micro-ring resonator has obvious advantages in sensing applications owing to its excellent performance.展开更多
Aiming at the problem that the intermediate potential part of the traditional bistable stochastic resonance model cannot be adjusted independently, a new composite stochastic resonance(NCSR) model is proposed by combi...Aiming at the problem that the intermediate potential part of the traditional bistable stochastic resonance model cannot be adjusted independently, a new composite stochastic resonance(NCSR) model is proposed by combining the Woods–Saxon(WS) model and the improved piecewise bistable model. The model retains the characteristics of the independent parameters of WS model and the improved piecewise model has no output saturation, all the parameters in the new model have no coupling characteristics. Under α stable noise environment, the new model is used to detect periodic signal and aperiodic signal, the detection results indicate that the new model has higher noise utilization and better detection effect.Finally, the new model is applied to image denoising, the results showed that under the same conditions, the output peak signal-to-noise ratio(PSNR) and the correlation number of NCSR method is higher than that of other commonly used linear denoising methods and improved piecewise SR methods, the effectiveness of the new model is verified.展开更多
The method of numerical analysis is employed to study the resonance mechanism of the lumped parameter system model for acoustic mine detection. Based on the basic principle of the acoustic resonance technique for mine...The method of numerical analysis is employed to study the resonance mechanism of the lumped parameter system model for acoustic mine detection. Based on the basic principle of the acoustic resonance technique for mine detection and the characteristics of low-frequency acoustics, the “soil-mine” system could be equivalent to a damping “mass-spring” resonance model with a lumped parameter analysis method. The dynamic simulation software, Adams, is adopted to analyze the lumped parameter system model numerically. The simulated resonance frequency and anti-resonance frequency are 151 Hz and 512 Hz respectively, basically in agreement with the published resonance frequency of 155 Hz and anti-resonance frequency of 513 Hz, which were measured in the experiment. Therefore, the technique of numerical simulation is validated to have the potential for analyzing the acoustic mine detection model quantitatively. The influences of the soil and mine parameters on the resonance characteristics of the soil–mine system could be investigated by changing the parameter setup in a flexible manner.展开更多
BACKGROUND Multiple linear stapler firings during double stapling technique(DST)after laparoscopic low anterior resection(LAR)are associated with an increased risk of anastomotic leakage(AL).However,it is difficult to...BACKGROUND Multiple linear stapler firings during double stapling technique(DST)after laparoscopic low anterior resection(LAR)are associated with an increased risk of anastomotic leakage(AL).However,it is difficult to predict preoperatively the need for multiple linear stapler cartridges during DST anastomosis.AIM To develop a deep learning model to predict multiple firings during DST anastomosis based on pelvic magnetic resonance imaging(MRI).METHODS We collected 9476 MR images from 328 mid-low rectal cancer patients undergoing LAR with DST anastomosis,which were randomly divided into a training set(n=260)and testing set(n=68).Binary logistic regression was adopted to create a clinical model using six factors.The sequence of fast spin-echo T2-weighted MRI of the entire pelvis was segmented and analyzed.Pure-image and clinical-image integrated deep learning models were constructed using the mask region-based convolutional neural network segmentation tool and three-dimensional convolutional networks.Sensitivity,specificity,accuracy,positive predictive value(PPV),and area under the receiver operating characteristic curve(AUC)was calculated for each model.RESULTS The prevalence of≥3 linear stapler cartridges was 17.7%(58/328).The prevalence of AL was statistically significantly higher in patients with≥3 cartridges compared to those with≤2 cartridges(25.0%vs 11.8%,P=0.018).Preoperative carcinoembryonic antigen level>5 ng/mL(OR=2.11,95%CI 1.08-4.12,P=0.028)and tumor size≥5 cm(OR=3.57,95%CI 1.61-7.89,P=0.002)were recognized as independent risk factors for use of≥3 linear stapler cartridges.Diagnostic performance was better with the integrated model(accuracy=94.1%,PPV=87.5%,and AUC=0.88)compared with the clinical model(accuracy=86.7%,PPV=38.9%,and AUC=0.72)and the image model(accuracy=91.2%,PPV=83.3%,and AUC=0.81).CONCLUSION MRI-based deep learning model can predict the use of≥3 linear stapler cartridges during DST anastomosis in laparoscopic LAR surgery.This model might help determine the best anastomosis strategy by avoiding DST when there is a high probability of the need for≥3 linear stapler cartridges.展开更多
The unfrozen water content of rock during freezing and thawing has an important influence on its physical and mechanical properties.This study presented a model for calculating the unfrozen water content of rock durin...The unfrozen water content of rock during freezing and thawing has an important influence on its physical and mechanical properties.This study presented a model for calculating the unfrozen water content of rock during freezing and thawing process,considering the influence of unfrozen water film and rock pore structure,which can reflect the hysteresis and super-cooling effects.The pore size distribution cu rves of red sandsto ne and its unfrozen water conte nt under different temperatures during the freezing and thawing process were measured using nuclear magnetic resonance(NMR) to validate the proposed model.Comparison between the experimental and calculated results indicated that the theoretical model accu rately reflected the water content change law of red sandstone during the freezing and thawing process.Furthermore,the influences of Hamaker constant and surface relaxation parameter on the model results were examined.The results showed that the appropriate magnitude order of Hamaker constant for the red sandstone was 10J to 10J;and when the relaxation parameter of the rock surface was within 25-30 μm/ms,the calculated unfrozen water content using the proposed model was consistent with the experimental value.展开更多
BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which ...BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which is assumed to be stable in normal, as well as many pathological, states. However, in vivo creatine levels do not remain constant. Therefore, absolute metabolite measurements, which provide the precise concentrations of certain chemical compounds, are superior to metabolite ratios for determining pathological and evolutional changes. OBJECTIVE: To investigate the feasibility of quantification analysis of brain metabolite changes caused by central analgesics nasal spray using the ^1H-MRS and linear combination model (LCModel) methods. DESIGN, TIME AND SETTING: This neuroimaging, observational, animal study was performed at the Laboratory of the Department of Medical Imaging, Second Affiliated Hospital, Medical College, Shantou University, China from July to December 2007. MATERIALS: Butorphanol tartrate nasal spray, as a mixed agonist-antagonist opioid analgesic, was purchased from Shanghai Hengrui Pharmacy, China. A General Electric Signa 1.5T System (General Electric Medical Systems, Milwaukee, WI, USA) and LCModel software (Stephen Provencher, Oakville, Ontario, Canada) were used in this study. METHODS: MRS images were acquired in ten healthy swine aged 2 weeks using single-voxel point-resolved spectroscopic sequence. A region of interest (2 cm × 2 cm × 2 cm) was placed in the image centers of maximum brain parenchyma. Repeated MRS scanning was performed 15-20 minutes after intranasal administration of 1 mg of butorphanol tartrate. Three settings of repetition time/echo time were selected before and after nasal spray administration 3 000 ms/30 ms,1 500 ms/30 ms, and 3 000 ms/50 ms. Metabolite concentrations were estimated by LCModel software. MAIN OUTCOME MEASURES: ^1H-MRS spectra was obtained using various repetition time/echo time settings. Concentrations of glutamate compounds (glutamate + glutamine), N-acetyl aspartate, and choline were detected in swine brain prior to and following nasal spray treatment. RESULTS: The glutamate compounds curve was consistent with original spectra, when a repetition time/echo time of 3 000 ms/30 ms was adopted. Concentrations of glutamate compounds, N-acetyl aspartate, and choline decreased following administration. The most significant reduction was observed in glutamate compound concentrations from (9.28 ± 0.54) mmol/kg to (7.28 ± 0.54) mmol/kg (P 〈 0.05). CONCLUSION: ^1H-MRS and LCModel software were effectively utilized to quantitatively analyze and measure brain metabolites. Glutamate compounds might be an important neurotransmitter in central analgesia.展开更多
AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pa...AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model.METHODS: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T MRI scanner. DWand TRIP-MRI were performed to determine if necrotic tumor core could be differentiated from viable tumor periphery. For each, we compared mean differences between tumor core/ periphery using a 2-tailed paired t-test (α = 0.05). Imaging was correlated with histopathology. RESULTS: Tumors were successfully grown in all rabbits, confirmed by necropsy. On DW-MRI, mean apparent diffusion coeffi cient (ADC) value was higher in necrotic tumor core (2.1 ± 0.3 mm2/s) than in viable tumor periphery (1.4 ± 0.5 mm2/s) (P < 0.05). On TRIP-MRI, mean perfusion values was higher in tumor periphery (110 ± 47 relative units) than in tumor core (66 ± 31 relative units) (P < 0.001). CONCLUSION: Functional MRI can be used to differentiate necrotic from viable tumor cells in an animal pancreatic cancer model using ADC (DW-MRI) and perfusion (TRIP-MRI) values.展开更多
This paper focuses on the state space modeling approach and output torques prediction of torsional vibrations for variable speed wind turbines. The multi-body system model under study is mainly comprised of a wind tur...This paper focuses on the state space modeling approach and output torques prediction of torsional vibrations for variable speed wind turbines. The multi-body system model under study is mainly comprised of a wind turbine, a three stage planetary gear box and an induction generator. The masses-springs approach of shaft system differential equations is developed from Newton's law and Lagrange formulas. For an easy comprehension for electrical engineers and tutorial purpose, an electrical equivalent circuit of the system is proposed by using mechanical and electrical components similarities. Extensive numerical simulations are performed to investigate system mechanical resonances and impacts of damping factors on the system dynamic and stability.展开更多
In this paper, by using harmonic-oscillator wave functions of different interaction models, i.e. OPE (onepion-exchange model), OPsE (only pseudoscalar meson exchange model), the extended GBE (Goldstone-boson-exchange ...In this paper, by using harmonic-oscillator wave functions of different interaction models, i.e. OPE (onepion-exchange model), OPsE (only pseudoscalar meson exchange model), the extended GBE (Goldstone-boson-exchange model including vector and scalar mesons), and OGE (one-gluon-exchange model), we calculate and compare the strong decays of negative parity N* resonances under 2 GeV. We find that the conventional mixing angles are correct, and GBE and OGE are obviously superior to OPE and OPsE.展开更多
The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or min...The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two lethal strains exhibited near ultraviolet (~230 nm) photon values while the two asymptomatic forms displayed near infrared (~1000 nm) values. Cross-correlations of spectral densities of the RRM values of the different classes of proteins associated with the genome of the viruses supported this dichotomy. The strongest coefficient occurred only between Sudan-Zaire strains but not for any of the other pairs of strains for sGP, the small glycoprotein that intercalated with the plasma cell membrane to promote insertion of viral contents into cellular space. A surprising, statistically significant cross-spectral correlation occurred between the “spike” glycoprotein component (GP1) of the virus that associated the anchoring of the virus to the mammalian cell plasma membrane and the Schumann resonance of the earth whose intensities were determined by the incidence of equatorial thunderstorms. Previous applications of the RRM to shifting photon wavelengths emitted by melanoma cells adapting to reduced ambient temperature have validated Cosic’s model and have demonstrated very narrowwave-length (about 10 nm) specificity. One possible ancillary and non-invasive treatment of people within which the fatal Ebola strains are residing would be whole body application of narrow band near-infrared light pulsed as specific physiologically-patterned sequences with sufficient radiant flux density to perfuse the entire body volume.展开更多
Magnetic resonance imaging(MRI)is a clinically relevant,real-time imaging modality that is frequently utilized to assess stroke type and severity.However,specific MRI biomarkers that can be used to predict long-term f...Magnetic resonance imaging(MRI)is a clinically relevant,real-time imaging modality that is frequently utilized to assess stroke type and severity.However,specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical need.Consequently,the present study sought to examine the prognostic value of commonly utilized MRI parameters to predict functional outcomes in a porcine model of ischemic stroke.Stroke was induced via permanent middle cerebral artery occlusion.At 24 hours post-stroke,MRI analysis revealed focal ischemic lesions,decreased diffusivity,hemispheric swelling,and white matter degradation.Functional deficits including behavioral abnormalities in open field and novel object exploration as well as spatiotemporal gait impairments were observed at 4 weeks post-stroke.Gaussian graphical models identified specific MRI outputs and functional recovery variables,including white matter integrity and gait performance,that exhibited strong conditional dependencies.Canonical correlation analysis revealed a prognostic relationship between lesion volume and white matter integrity and novel object exploration and gait performance.Consequently,these analyses may also have the potential of predicting patient recovery at chronic time points as pigs and humans share many anatomical similarities(e.g.,white matter composition)that have proven to be critical in ischemic stroke pathophysiology.The study was approved by the University of Georgia(UGA)Institutional Animal Care and Use Committee(IACUC;Protocol Number:A2014-07-021-Y3-A11 and 2018-01-029-Y1-A5)on November 22,2017.展开更多
BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic fibrosis.Although different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effect...BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic fibrosis.Although different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effective and reproducible for investigating cholestatic fibrosis.Magnetic resonance imaging(MRI)has made great advances for noninvasive assessment of liver fibrosis.More comprehensive liver fibrotic features of BDL on MRI are important.However,the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been assessed.AIM To evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse model.METHODS Twenty-eight healthy adult male balb/c mice were randomly divided into four groups:sham,week 2 BDL,week 4 BDL,and week 6 BDL.Multiparameter MRI sequences,included magnetic resonance cholangiopancreatography,T1-weighted,T2-weighted,T2 mapping,and pre-and post-enhanced T1 mapping,were performed after sham and BDL surgery.Peripheral blood and liver tissue were collected after MRI.For statistical analysis,Student’s t-test and Pearson’s correlation coefficient were used.RESULTS Four mice died after BDL surgery;seven,six,five and six mice were included separately from the four groups.Signal intensities of liver parenchyma showed no difference on TI-and T2-weighted images.Bile duct volume,ΔT1 value,T2 value,and the rate of liver fibrosis increased steadily in week 2 BDL,week 4 BDL and week 6 BDL groups compared with those in the sham group(P<0.01).Alanine aminotransferase and aspartate transaminase levels initially surged after surgery,followed by a gradual decline over time.Strong correlations were found between bile duct volume(r=0.84),T2 value(r=0.78),ΔT1 value(r=0.62),and hepatic fibrosis rate(all P<0.01)in the BDL groups.CONCLUSION The BDL mouse model induces changes that can be observed on MRI.The MRI parameters correlate with the hepatic fibrosis rate and allow for detection of cholestatic fibrosis.展开更多
The reaction of pp → pK^+A is a very good channel to study N^* resonances through their KA decay mode, because there is no mixing of isospin I = 1/2 and I = 3/2 due to isospin conservation. In this work, we extend ...The reaction of pp → pK^+A is a very good channel to study N^* resonances through their KA decay mode, because there is no mixing of isospin I = 1/2 and I = 3/2 due to isospin conservation. In this work, we extend a resonance model, which can reproduce the total cross section very well, to offer differential cross section information about this reaction. It can serve as a reference to build the scheduled hadron detector at Lanzhou Cooler Storage Ring (CSR). Experiment measurement of these differential cross sections in the future will supply us more constraints on the model and help us understanding the strangeness production dynamics better.展开更多
We discuss the dynamical behavior of a chemical network arising from the coupling of two Brusselators established by the relationship between products and substrates. Our interest is to investigate the coherence reson...We discuss the dynamical behavior of a chemical network arising from the coupling of two Brusselators established by the relationship between products and substrates. Our interest is to investigate the coherence resonance (CR) phenomena caused by noise for a coupled Brusselator model in the vicinity of the Hopf bifurcation, which can be determined by the signM-to-noise ratio (SNR). The CR in two coupled Brusselators will be considered in the presence of the Gaussian colored noise and two uncorrelated Gaussian white noises. Simulation results show that, for the case of single noise, the SNR characterizing the degree of temporal regularity of coupled model reaches a maximum value at some optimal noise levels, and the noise intensity can enhance the CR phenomena of both subsystems with a similar trend but in different resonance degrees. Meanwhile, effects of noise intensities on CR of the second subsystem are opposite for the systems under we find that CR might be a general phenomenon in coupled two uncorrelated Gaussian white noises. Moreover, systems.展开更多
The key problem to the calculation and optimization design of the helicopter 'Ground Resonance' is to correctly build up a mechanical model. In the past, the literature was only concerned with the lag modes of...The key problem to the calculation and optimization design of the helicopter 'Ground Resonance' is to correctly build up a mechanical model. In the past, the literature was only concerned with the lag modes of the rotor blade and the flap modes were neglected. But such approaches should be reconsidered now. In order to study the influences of rotating multiblades rotor on the degrees of freedom and also the flap ''Ground Resonance' of a helicopter, it is necessary to consider not only the lag degrees of freedom but also the flap degrees of freedom. Using Lagrangian equation a dynamical equation of the space model for helicopter 'Ground Resonance'is deduced for the first time. Some computation results show that the mechanical model including both lag DOF and flap DOF is more reasonable.展开更多
基金National Natural Science Foundation of China under Grant No.51879191。
文摘The auto-parametric resonance of a continuous-beam bridge model subjected to a two-point periodic excitation is experimentally and numerically investigated in this study.An auto-parametric resonance experiment of the test model is conducted to observe and measure the auto-parametric resonance of a continuous beam under a two-point excitation on columns.The parametric vibration equation is established for the test model using the finite-element method.The auto-parametric resonance stability of the structure is analyzed by using Newmark's method and the energy-growth exponent method.The effects of the phase difference of the two-point excitation on the stability boundaries of auto-parametric resonance are studied for the test model.Compared with the experiment,the numerical instability predictions of auto-parametric resonance are consistent with the test phenomena,and the numerical stability boundaries of auto-parametric resonance agree with the experimental ones.For a continuous beam bridge,when the ratio of multipoint excitation frequency(applied to the columns)to natural frequency of the continuous girder is approximately equal to 2,the continuous beam may undergo a strong auto-parametric resonance.Combined with the present experiment and analysis,a hypothesis of Volgograd Bridge's serpentine vibration is discussed.
文摘BACKGROUND Development of distant metastasis(DM)is a major concern during treatment of nasopharyngeal carcinoma(NPC).However,studies have demonstrated im-proved distant control and survival in patients with advanced NPC with the addition of chemotherapy to concomitant chemoradiotherapy.Therefore,precise prediction of metastasis in patients with NPC is crucial.AIM To develop a predictive model for metastasis in NPC using detailed magnetic resonance imaging(MRI)reports.METHODS This retrospective study included 792 patients with non-distant metastatic NPC.A total of 469 imaging variables were obtained from detailed MRI reports.Data were stratified and randomly split into training(50%)and testing sets.Gradient boosting tree(GBT)models were built and used to select variables for predicting DM.A full model comprising all variables and a reduced model with the top-five variables were built.Model performance was assessed by area under the curve(AUC).RESULTS Among the 792 patients,94 developed DM during follow-up.The number of metastatic cervical nodes(30.9%),tumor invasion in the posterior half of the nasal cavity(9.7%),two sides of the pharyngeal recess(6.2%),tubal torus(3.3%),and single side of the parapharyngeal space(2.7%)were the top-five contributors for predicting DM,based on their relative importance in GBT models.The testing AUC of the full model was 0.75(95%confidence interval[CI]:0.69-0.82).The testing AUC of the reduced model was 0.75(95%CI:0.68-0.82).For the whole dataset,the full(AUC=0.76,95%CI:0.72-0.82)and reduced models(AUC=0.76,95%CI:0.71-0.81)outperformed the tumor node-staging system(AUC=0.67,95%CI:0.61-0.73).CONCLUSION The GBT model outperformed the tumor node-staging system in predicting metastasis in NPC.The number of metastatic cervical nodes was identified as the principal contributing variable.
文摘The 2-dimensional equivalent model used in helicopter ground resonance analysis is convenient for its simplicity and clarity. The equivalent body mass, the stiffness and the damping are derived from the modal charaCteristics. In this paper, a 3-dimensional space model is constructed to analyse the ground resonance.There is little difference between the calculated results of the 2-dimensional equivalent model and those of the 3-dimensional space model. Hence, the 2-dimensional model is verified for the practical application. Generally, the linear lead-lag damping of the equivalent rotor blade at the modal frequency is derived from the lead-lag damper characteristics by a procedure of iteration. The transformation of the imaginary part of the complex modulus of the viscoelastic damper into a linear velocity damping is complicated in analysis. A method to use the complex modulus directly in the ground resonance analysis is derived and verified.
文摘Objective To investigate the role of peffusion-weighted magnetic resonance imaging (MRI) in evaluation of cirrhotic fiver. Methods With a 4F catheter, 1% diluted carbon tetrachloride ( 1 ml/kg) was selectively injected into fight or left hepatic artery of 12 dogs fortnightly. The half fiver into which carbon tetrachloride was injected was called as study side (SS), while the other half fiver without carbon tetrachloride injection was called as study control side (SCS). Conventional and peffusion-weighted MRI were performed in every 4 weeks. Via a 4F catheter, 5ml gadolinium diethylentriamine pentaaceti acid (Gd-DTPA) dilution was injected into superior mesenteric artery at the 5th scan. The signal intensity-thne curves of SS, SCS, and portal vein were completed in MR workstation. The maximal relative signal increase ( MRSI), peak time ( tp), and slope of the curves were measured. Results On conventional MR images, no abnormalities of externality and signal intensity were observed in both SS and SCS of fiver at each stage. The mean tp, MP, SI, and slope of intensity-time curves in normal fiver were 10. 56 seconds, 1.01, and 10. 23 arbitrary unit (au)/s, respectively. Three parameters of curves didn't show obvious change in SCS of fiver at every stage. Abnormal perfusion curves occurred in SS of fiver at the 12th week after the 1st injection. The abnormality of perfusion curve in SS was more and more serious as the times of injection increased. The mean tp, IVlRSI, and slope intensity-time curves in SS of fiver were 19.45 seconds, 0. 43, and 3. 60 au/s respectively at the 24th week. Conclusion Perfusion-weighted imaging can potentially provide information about portal peffusion of hepatic parenchyma, and to some degree, reflect the severity of cirrhosis.
文摘AIM: To establish a rabbit rectal VX2 carcinoma model for the study of rectal carcinoma.METHODS: A suspension of VX2 cells was injected into the rectum wall under the guidance of X-ray fluoroscopy. Computed tomography (CT) and magnetic resonance imaging (MRI) were used to observe tumorgrowth and metastasis at different phases. Pathological changes and spontaneous survival time of the rabbits were recorded.RESULTS: Two weeks after VX2 cell implantation, the tumor diameter ranged 4.1-5.8 mm and the success implantation rate was 81.8%. CT scanning showed low-density loci of the tumor in the rectum wail, while enhanced CT scanning demonstrated a symmetrical intensification in tumor loci. MRI scanning showed alow signal of the tumor on T1-weighted imaging anda high signal of the tumor on T2-weighted imaging.Both types of signals were intensified with enhanced MRI. Metastases to the liver and lung could beobserved 6 wk after VX2 cell implantation, and a largearea of necrosis appeared in the primary tumor. The spontaneous survival time of rabbits with cachexia and multiple organ failure was about 7 wk after VX2 cell implantation.CONCLUSION: The rabbit rectal VX2 carcinoma model we established has a high stability, and can be used in the study of rectal carcinoma.
基金supported by Natural Science Foundation of Gansu Province(No.22JR5RA320).
文摘To achieve high quality factor and high-sensitivity refractive index sensor,a slot micro-ring resonator(MRR)based on asymmetric Fabry-Perot(FP)cavity was proposed.The structure consisted of a pair of elliptical holes to form an FP cavity and a microring resonator.The two different optical modes generated by the micro-ring resonator were destructively interfered to form a Fano line shape,which improved the system sensitivity while obtaining a higher quality factor and extinction ratio.The transmission principle of the structure was analyzed by the transfer matrix method.The transmission spectrum and mode field distribution of the proposed structure were simulated by the finite difference time domain(FDTD)method,and the key structural parameters affecting the Fano line shape in the device were optimized.The simulation results show that the quality factor of the device reached 22037.1,and the extinction ratio was 23.9 dB.By analyzing the refractive index sensing characteristics,the sensitivity of the structure was 354 nm·RIU−1,and the detection limit of the sensitivity was 2×10−4 RIU.Thus,the proposed compact asymmetric FP cavity slot micro-ring resonator has obvious advantages in sensing applications owing to its excellent performance.
基金Project supported by the National Natural Science Foundation of China (Grant No.62371388)the Key Research and Development Projects in Shaanxi Province,China (Grant No.2023-YBGY-044)。
文摘Aiming at the problem that the intermediate potential part of the traditional bistable stochastic resonance model cannot be adjusted independently, a new composite stochastic resonance(NCSR) model is proposed by combining the Woods–Saxon(WS) model and the improved piecewise bistable model. The model retains the characteristics of the independent parameters of WS model and the improved piecewise model has no output saturation, all the parameters in the new model have no coupling characteristics. Under α stable noise environment, the new model is used to detect periodic signal and aperiodic signal, the detection results indicate that the new model has higher noise utilization and better detection effect.Finally, the new model is applied to image denoising, the results showed that under the same conditions, the output peak signal-to-noise ratio(PSNR) and the correlation number of NCSR method is higher than that of other commonly used linear denoising methods and improved piecewise SR methods, the effectiveness of the new model is verified.
基金Project supported,in part,by the National Natural Science Foundation of China(Grant No.41104065)the"Chen Guang"Program of Shanghai Municipal Ed-ucation Commission and Shanghai Education Development Foundation,China(Grant No.12CG047)+1 种基金the Scientific Research Innovation Program of Shanghai Municipal Education Commission,China(Grant No.13YZ022)the State Key Laboratory of Precision Measuring Technology and Instruments,China
文摘The method of numerical analysis is employed to study the resonance mechanism of the lumped parameter system model for acoustic mine detection. Based on the basic principle of the acoustic resonance technique for mine detection and the characteristics of low-frequency acoustics, the “soil-mine” system could be equivalent to a damping “mass-spring” resonance model with a lumped parameter analysis method. The dynamic simulation software, Adams, is adopted to analyze the lumped parameter system model numerically. The simulated resonance frequency and anti-resonance frequency are 151 Hz and 512 Hz respectively, basically in agreement with the published resonance frequency of 155 Hz and anti-resonance frequency of 513 Hz, which were measured in the experiment. Therefore, the technique of numerical simulation is validated to have the potential for analyzing the acoustic mine detection model quantitatively. The influences of the soil and mine parameters on the resonance characteristics of the soil–mine system could be investigated by changing the parameter setup in a flexible manner.
基金Shanghai Jiaotong University,No.YG2019QNB24This study was reviewed and approved by Ruijin Hospital Ethics Committee(Approval No.2019-82).
文摘BACKGROUND Multiple linear stapler firings during double stapling technique(DST)after laparoscopic low anterior resection(LAR)are associated with an increased risk of anastomotic leakage(AL).However,it is difficult to predict preoperatively the need for multiple linear stapler cartridges during DST anastomosis.AIM To develop a deep learning model to predict multiple firings during DST anastomosis based on pelvic magnetic resonance imaging(MRI).METHODS We collected 9476 MR images from 328 mid-low rectal cancer patients undergoing LAR with DST anastomosis,which were randomly divided into a training set(n=260)and testing set(n=68).Binary logistic regression was adopted to create a clinical model using six factors.The sequence of fast spin-echo T2-weighted MRI of the entire pelvis was segmented and analyzed.Pure-image and clinical-image integrated deep learning models were constructed using the mask region-based convolutional neural network segmentation tool and three-dimensional convolutional networks.Sensitivity,specificity,accuracy,positive predictive value(PPV),and area under the receiver operating characteristic curve(AUC)was calculated for each model.RESULTS The prevalence of≥3 linear stapler cartridges was 17.7%(58/328).The prevalence of AL was statistically significantly higher in patients with≥3 cartridges compared to those with≤2 cartridges(25.0%vs 11.8%,P=0.018).Preoperative carcinoembryonic antigen level>5 ng/mL(OR=2.11,95%CI 1.08-4.12,P=0.028)and tumor size≥5 cm(OR=3.57,95%CI 1.61-7.89,P=0.002)were recognized as independent risk factors for use of≥3 linear stapler cartridges.Diagnostic performance was better with the integrated model(accuracy=94.1%,PPV=87.5%,and AUC=0.88)compared with the clinical model(accuracy=86.7%,PPV=38.9%,and AUC=0.72)and the image model(accuracy=91.2%,PPV=83.3%,and AUC=0.81).CONCLUSION MRI-based deep learning model can predict the use of≥3 linear stapler cartridges during DST anastomosis in laparoscopic LAR surgery.This model might help determine the best anastomosis strategy by avoiding DST when there is a high probability of the need for≥3 linear stapler cartridges.
基金the support of the Second Tibetan Plateau Scientific Expedition and Research Program (STEP)of China (Grant No.2019QZKK0904)the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China (Grant No.51922104)+1 种基金Youth Innovation Promotion Association CASOpen Research Fund of State Key Laboratory of Geomechanics and Geotechnical Engineering,Institute of Rock and Soil Mechanics,Chinese Academy of Sciences (Grant No.Z018014)。
文摘The unfrozen water content of rock during freezing and thawing has an important influence on its physical and mechanical properties.This study presented a model for calculating the unfrozen water content of rock during freezing and thawing process,considering the influence of unfrozen water film and rock pore structure,which can reflect the hysteresis and super-cooling effects.The pore size distribution cu rves of red sandsto ne and its unfrozen water conte nt under different temperatures during the freezing and thawing process were measured using nuclear magnetic resonance(NMR) to validate the proposed model.Comparison between the experimental and calculated results indicated that the theoretical model accu rately reflected the water content change law of red sandstone during the freezing and thawing process.Furthermore,the influences of Hamaker constant and surface relaxation parameter on the model results were examined.The results showed that the appropriate magnitude order of Hamaker constant for the red sandstone was 10J to 10J;and when the relaxation parameter of the rock surface was within 25-30 μm/ms,the calculated unfrozen water content using the proposed model was consistent with the experimental value.
基金the National Natural Science Foundation of China,No. 3047051530570480
文摘BACKGROUND: In localized brain proton magnetic resonance spectroscopy (^1H-MRS), metabolite levels are often expressed as ratios, rather than absolute concentrations. Frequently, the denominator is creatine, which is assumed to be stable in normal, as well as many pathological, states. However, in vivo creatine levels do not remain constant. Therefore, absolute metabolite measurements, which provide the precise concentrations of certain chemical compounds, are superior to metabolite ratios for determining pathological and evolutional changes. OBJECTIVE: To investigate the feasibility of quantification analysis of brain metabolite changes caused by central analgesics nasal spray using the ^1H-MRS and linear combination model (LCModel) methods. DESIGN, TIME AND SETTING: This neuroimaging, observational, animal study was performed at the Laboratory of the Department of Medical Imaging, Second Affiliated Hospital, Medical College, Shantou University, China from July to December 2007. MATERIALS: Butorphanol tartrate nasal spray, as a mixed agonist-antagonist opioid analgesic, was purchased from Shanghai Hengrui Pharmacy, China. A General Electric Signa 1.5T System (General Electric Medical Systems, Milwaukee, WI, USA) and LCModel software (Stephen Provencher, Oakville, Ontario, Canada) were used in this study. METHODS: MRS images were acquired in ten healthy swine aged 2 weeks using single-voxel point-resolved spectroscopic sequence. A region of interest (2 cm × 2 cm × 2 cm) was placed in the image centers of maximum brain parenchyma. Repeated MRS scanning was performed 15-20 minutes after intranasal administration of 1 mg of butorphanol tartrate. Three settings of repetition time/echo time were selected before and after nasal spray administration 3 000 ms/30 ms,1 500 ms/30 ms, and 3 000 ms/50 ms. Metabolite concentrations were estimated by LCModel software. MAIN OUTCOME MEASURES: ^1H-MRS spectra was obtained using various repetition time/echo time settings. Concentrations of glutamate compounds (glutamate + glutamine), N-acetyl aspartate, and choline were detected in swine brain prior to and following nasal spray treatment. RESULTS: The glutamate compounds curve was consistent with original spectra, when a repetition time/echo time of 3 000 ms/30 ms was adopted. Concentrations of glutamate compounds, N-acetyl aspartate, and choline decreased following administration. The most significant reduction was observed in glutamate compound concentrations from (9.28 ± 0.54) mmol/kg to (7.28 ± 0.54) mmol/kg (P 〈 0.05). CONCLUSION: ^1H-MRS and LCModel software were effectively utilized to quantitatively analyze and measure brain metabolites. Glutamate compounds might be an important neurotransmitter in central analgesia.
基金Supported by A Society of Interventional Radiology Foundation Pilot Research Grant (to Lewandowski RJ) and a Howard Hughes Medical Institute Medical Research Training Fellow (to Eifler AC)
文摘AIM: To test the hypotheses that diffusion weighed (DW)and transcatheter intraarterial perfusion (TRIP)magnetic resonance imaging (MRI) can each be used to assess regional differences in tumor function in an animal pancreatic cancer model.METHODS: VX2 tumors were implanted in pancreata of 6 rabbits. MRI and digital subtraction angiography (DSA) were performed 3 wk following implantation. With a 2-French catheter secured in the rabbit's gastroduodenal artery, each rabbit was transferred to an adjacent 1.5T MRI scanner. DWand TRIP-MRI were performed to determine if necrotic tumor core could be differentiated from viable tumor periphery. For each, we compared mean differences between tumor core/ periphery using a 2-tailed paired t-test (α = 0.05). Imaging was correlated with histopathology. RESULTS: Tumors were successfully grown in all rabbits, confirmed by necropsy. On DW-MRI, mean apparent diffusion coeffi cient (ADC) value was higher in necrotic tumor core (2.1 ± 0.3 mm2/s) than in viable tumor periphery (1.4 ± 0.5 mm2/s) (P < 0.05). On TRIP-MRI, mean perfusion values was higher in tumor periphery (110 ± 47 relative units) than in tumor core (66 ± 31 relative units) (P < 0.001). CONCLUSION: Functional MRI can be used to differentiate necrotic from viable tumor cells in an animal pancreatic cancer model using ADC (DW-MRI) and perfusion (TRIP-MRI) values.
文摘This paper focuses on the state space modeling approach and output torques prediction of torsional vibrations for variable speed wind turbines. The multi-body system model under study is mainly comprised of a wind turbine, a three stage planetary gear box and an induction generator. The masses-springs approach of shaft system differential equations is developed from Newton's law and Lagrange formulas. For an easy comprehension for electrical engineers and tutorial purpose, an electrical equivalent circuit of the system is proposed by using mechanical and electrical components similarities. Extensive numerical simulations are performed to investigate system mechanical resonances and impacts of damping factors on the system dynamic and stability.
文摘In this paper, by using harmonic-oscillator wave functions of different interaction models, i.e. OPE (onepion-exchange model), OPsE (only pseudoscalar meson exchange model), the extended GBE (Goldstone-boson-exchange model including vector and scalar mesons), and OGE (one-gluon-exchange model), we calculate and compare the strong decays of negative parity N* resonances under 2 GeV. We find that the conventional mixing angles are correct, and GBE and OGE are obviously superior to OPE and OPsE.
文摘The Cosic Resonance Recognition Model (RRM) for amino acid sequences was applied to the classes of proteins displayed by four strains (Sudan, Zaire, Reston, Ivory Coast) of Ebola virus that produced either high or minimal numbers of human fatalities. The results clearly differentiated highly lethal and non-lethal strains. Solutions for the two lethal strains exhibited near ultraviolet (~230 nm) photon values while the two asymptomatic forms displayed near infrared (~1000 nm) values. Cross-correlations of spectral densities of the RRM values of the different classes of proteins associated with the genome of the viruses supported this dichotomy. The strongest coefficient occurred only between Sudan-Zaire strains but not for any of the other pairs of strains for sGP, the small glycoprotein that intercalated with the plasma cell membrane to promote insertion of viral contents into cellular space. A surprising, statistically significant cross-spectral correlation occurred between the “spike” glycoprotein component (GP1) of the virus that associated the anchoring of the virus to the mammalian cell plasma membrane and the Schumann resonance of the earth whose intensities were determined by the incidence of equatorial thunderstorms. Previous applications of the RRM to shifting photon wavelengths emitted by melanoma cells adapting to reduced ambient temperature have validated Cosic’s model and have demonstrated very narrowwave-length (about 10 nm) specificity. One possible ancillary and non-invasive treatment of people within which the fatal Ebola strains are residing would be whole body application of narrow band near-infrared light pulsed as specific physiologically-patterned sequences with sufficient radiant flux density to perfuse the entire body volume.
基金This work was supported by the National Institutes of Health,National Institute of Neurological Disorders and Stroke grant R01NS093314 as well as Small Business Innovation Research grant 1R43NS103596-01.
文摘Magnetic resonance imaging(MRI)is a clinically relevant,real-time imaging modality that is frequently utilized to assess stroke type and severity.However,specific MRI biomarkers that can be used to predict long-term functional recovery are still a critical need.Consequently,the present study sought to examine the prognostic value of commonly utilized MRI parameters to predict functional outcomes in a porcine model of ischemic stroke.Stroke was induced via permanent middle cerebral artery occlusion.At 24 hours post-stroke,MRI analysis revealed focal ischemic lesions,decreased diffusivity,hemispheric swelling,and white matter degradation.Functional deficits including behavioral abnormalities in open field and novel object exploration as well as spatiotemporal gait impairments were observed at 4 weeks post-stroke.Gaussian graphical models identified specific MRI outputs and functional recovery variables,including white matter integrity and gait performance,that exhibited strong conditional dependencies.Canonical correlation analysis revealed a prognostic relationship between lesion volume and white matter integrity and novel object exploration and gait performance.Consequently,these analyses may also have the potential of predicting patient recovery at chronic time points as pigs and humans share many anatomical similarities(e.g.,white matter composition)that have proven to be critical in ischemic stroke pathophysiology.The study was approved by the University of Georgia(UGA)Institutional Animal Care and Use Committee(IACUC;Protocol Number:A2014-07-021-Y3-A11 and 2018-01-029-Y1-A5)on November 22,2017.
基金the Natural Science Foundation of Hunan Province,No.2019JJ40444(to Xiao EH)and 2021JJ30945(to Luo YH).
文摘BACKGROUND Bile duct ligation(BDL)in animals is a classical method for mimicking cholestatic fibrosis.Although different surgical techniques have been described in rats and rabbits,mouse models can be more cost-effective and reproducible for investigating cholestatic fibrosis.Magnetic resonance imaging(MRI)has made great advances for noninvasive assessment of liver fibrosis.More comprehensive liver fibrotic features of BDL on MRI are important.However,the utility of multiparameter MRI to detect liver fibrosis in a BDL mouse model has not been assessed.AIM To evaluate the correlation between the pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse model.METHODS Twenty-eight healthy adult male balb/c mice were randomly divided into four groups:sham,week 2 BDL,week 4 BDL,and week 6 BDL.Multiparameter MRI sequences,included magnetic resonance cholangiopancreatography,T1-weighted,T2-weighted,T2 mapping,and pre-and post-enhanced T1 mapping,were performed after sham and BDL surgery.Peripheral blood and liver tissue were collected after MRI.For statistical analysis,Student’s t-test and Pearson’s correlation coefficient were used.RESULTS Four mice died after BDL surgery;seven,six,five and six mice were included separately from the four groups.Signal intensities of liver parenchyma showed no difference on TI-and T2-weighted images.Bile duct volume,ΔT1 value,T2 value,and the rate of liver fibrosis increased steadily in week 2 BDL,week 4 BDL and week 6 BDL groups compared with those in the sham group(P<0.01).Alanine aminotransferase and aspartate transaminase levels initially surged after surgery,followed by a gradual decline over time.Strong correlations were found between bile duct volume(r=0.84),T2 value(r=0.78),ΔT1 value(r=0.62),and hepatic fibrosis rate(all P<0.01)in the BDL groups.CONCLUSION The BDL mouse model induces changes that can be observed on MRI.The MRI parameters correlate with the hepatic fibrosis rate and allow for detection of cholestatic fibrosis.
基金The project partly supported by National Natural Science Foundation of China under Grant Nos. 10225525 and 10435080 and Knowledge Innovation Project of the Chinese Academy of Sciences under Grant No. KJCX2-SW-N02. We thank H.C. Chiang, G.M. Jin, X.G. Li, J.Y. Liu, P.N. Shen, J.J. Xie, H.S. Xu, and W.L. Zhan for useful discussions.
文摘The reaction of pp → pK^+A is a very good channel to study N^* resonances through their KA decay mode, because there is no mixing of isospin I = 1/2 and I = 3/2 due to isospin conservation. In this work, we extend a resonance model, which can reproduce the total cross section very well, to offer differential cross section information about this reaction. It can serve as a reference to build the scheduled hadron detector at Lanzhou Cooler Storage Ring (CSR). Experiment measurement of these differential cross sections in the future will supply us more constraints on the model and help us understanding the strangeness production dynamics better.
基金Supported by the National Natural Science Foundation of China under Grant No 61571365
文摘We discuss the dynamical behavior of a chemical network arising from the coupling of two Brusselators established by the relationship between products and substrates. Our interest is to investigate the coherence resonance (CR) phenomena caused by noise for a coupled Brusselator model in the vicinity of the Hopf bifurcation, which can be determined by the signM-to-noise ratio (SNR). The CR in two coupled Brusselators will be considered in the presence of the Gaussian colored noise and two uncorrelated Gaussian white noises. Simulation results show that, for the case of single noise, the SNR characterizing the degree of temporal regularity of coupled model reaches a maximum value at some optimal noise levels, and the noise intensity can enhance the CR phenomena of both subsystems with a similar trend but in different resonance degrees. Meanwhile, effects of noise intensities on CR of the second subsystem are opposite for the systems under we find that CR might be a general phenomenon in coupled two uncorrelated Gaussian white noises. Moreover, systems.
文摘The key problem to the calculation and optimization design of the helicopter 'Ground Resonance' is to correctly build up a mechanical model. In the past, the literature was only concerned with the lag modes of the rotor blade and the flap modes were neglected. But such approaches should be reconsidered now. In order to study the influences of rotating multiblades rotor on the degrees of freedom and also the flap ''Ground Resonance' of a helicopter, it is necessary to consider not only the lag degrees of freedom but also the flap degrees of freedom. Using Lagrangian equation a dynamical equation of the space model for helicopter 'Ground Resonance'is deduced for the first time. Some computation results show that the mechanical model including both lag DOF and flap DOF is more reasonable.