Virtual reality training improves accommodative facility and accommodative range

AIM: To evaluate the effects of virtual reality(VR) training on different parameters of vision.METHODS: Sixty individuals ranged 18-60 years old with asthenopia were randomly divided into short-term(n=40) and long-term(n=20) treatment groups. They were given a specially designed VR training device only once for 15 min or 3-4 times a day for 15 min each time for 1 mo. The visual acuity, spherical equivalent, accommodative range, accommodative facility, pupil size, and visual fatigue were evaluated before(control) and after VR training. RESULTS: The visual acuity, accommodative range, and accommodative facility increased in subjects of the shortterm treatment group, whereas their pupil size contracted significantly. No significant changes in spherical equivalent and visual fatigue were observed. The changes in distant vision and corrected visual acuity were positively correlated with those in pupil size, but not with spherical equivalent. The accommodative range and accommodative facility improved significantly in subjects of the long-term treatment group. No significant changes in visual acuity, spherical equivalent, pupil size, and visual fatigue were noted. CONCLUSION: VR training can improve the accommodative range and accommodative facility of human eyes. Although short-term VR training can transiently improve vision, which probably due to bright light adaptation, there is no evidence that it can improve myopia.

Evaluation of corneal parameter changes under different accommodative stimuli with Scheimpflug imaging-based tomography

AIM:To evaluate the reliability of measurements of corneal changes with accommodation in healthy eyes using a Scheimpflug imaging-based system and how these measurements distribute in the normal population.METHODS:Prospective,non-randomized,comparative study including 27 healthy subjects(54 eyes),including emmetropia(13 eyes),myopia(17 eyes),hyperopia(4 eyes)and astigmatism(20 eyes)groups.In all cases,a complete eye examination was performed,including the analysis of corneal changes with different accommodative stimuli(+2.00,0.00 and-3.00 D)using the Pentacam AXL system.The investigation was structured in 2 phases:repeatability analysis and characterization of accommodation-related corneal changes in healthy populations.RESULTS:In the repeatability analysis,the index of height asymmetry(IHA)showed the greatest variability with the three accommodative stimuli,being the results for the rest of parameters acceptable.The group of emmetropes showed significant differences with accommodative changes in the position of maximum keratometry(Kmax;P<0.05),whereas in the astigmatism group,significant changes were not only observed in the position of Kmax,but also in minimum corneal thickness(MCT),corneal spherical aberration,and total and low order aberration root mean square(all P<0.05).Likewise,a significant difference was found in the displacement of the X position of Kmax with+2.00 D and-3.00 D in the myopia group(P=0.033)as well as in changes with+2.00 D and-3.00 D in the magnitude of the position vector of Kmax in the emmetropia group(P<0.05).No significant changes were found between accommodative stimuli in the displacement of coordinates of MCT(P≥0.109).CONCLUSION:The position of Kmax and MCT in healthy corneas can change significantly when presenting different accommodative stimuli using the accommodation mode of the Pentacam system,with different trends in these accommodation-related corneal changes between refractive errors.Likewise,the consistency of the measurements obtained with Scheimpflug has been confirmed.

Biocompatibility of light responsive materials prepared for accommodative intraocular lenses manufacturing

AIM:To investigate the biocompatibility and bacterial adhesion properties of light responsive materials(LRM)and analyze the feasibility and biosafety of employing LRM in the preparation of accommodative intraocular lenses(AIOLs).METHODS:Employing fundamental experimental research techniques,LRM with human lens epithelial cells(hLECs)and human retinal pigment epithelium cells(ARPE-19 cells)were co-cultured.Commercially available intraocular lenses(IOLs)were used as controls to perform cell counting kit-8(CCK-8),cell staining under varying light intensities,cell adhesion and bacterial adhesion experiments.RESULTS:LRM exhibited a stronger inhibitory effect on the proliferation of ARPE19 cells than commercially available IOLs when co-cultured with the undiluted extract for 96h(P<0.05).Under other culturing conditions,the effects on the proliferation of hLECs and ARPE-19 cells were not significantly different between the two materials.Under the influence of light irradiation at intensities of 200 and 300 mW/cm^(2),LRM demonstrated a markedly higher inhibitory effect on the survival of hLECs compared to commercially available IOLs(P<0.0001).They also showed a stronger suppressive effect on the survival rate of ARPE-19 cells,with significant differences observed at 200 mW/cm^(2)(P<0.001)and extremely significant differences at 300 mW/cm^(2)(P<0.0001).Additionally,compared to commercially available IOLs,LRM had a higher number of cells adhering to their surface(P<0.05),as well as a significantly greater number of adherent bacterium(P<0.0001).CONCLUSION:LRM,characterized by their excellent non-contact tunable deformability and low cytotoxicity to ocular tissues,show considerable potential for use in the fabrication of AIOLs.These materials demonstrate strong cell adhesion;however,during photothermal conversion processes involving shape deformation under various light intensities,the resultant temperature rise may harm surrounding cells.These factors suggest that while the material plays a positive role in reducing the incidence of posterior capsule opacification(PCO),it also poses potential risks for retinal damage.Additionally,the strong bacterial adhesion of these materials indicates an increased risk of endophthalmitis.

The biosafety level-2 macromolecular crystallography beamline(BL10U2)at the Shanghai Synchrotron Radiation Facility

BL10U2 is an undulator-based macromolecular crystallography(MX)beamline located at the 3.5-GeV Shanghai Synchrotron Radiation Facility.BL10U2 is specifically designed for conducting routine and biosafety level-2(BSL-2)MX experiments utilizing high-flux tunable X-rays with energies from 7 to 18 keV,providing a beam spot size of 20μm(horizontal)×10μm(vertical)at the sample point.Certification by the Shanghai Pudong Municipal Health Commission confirmed the capability to perform BSL-2 MX experiments.The beamline is currently equipped with an Eiger X 16 M detector and two newly developed in-house high-precision diffractometers that can be switched to perform conventional or in situ crystal diffraction experiments.An automatic sample changer developed in-house allows fast sample exchange in less than 30 s,supporting high-throughput MX experimentation and rapid crystal screening.Data collection from both the diffractometer and detector was controlled by an in-house developed data collection software(Finback)with a user-friendly interface for convenient operation.This study presents a comprehensive overview of the facilities,experimental methods,and performance characteristics of the BL10U2 beamline.

BL02U1:the relocated macromolecular crystallography beamline at the Shanghai Synchrotron Radiation Facility

Macromolecular crystallography beamline BL17U1 at the Shanghai Synchrotron Radiation Facility has been relocated,upgraded,and given a new ID(BL02U1).It now delivers X-rays in the energy range of 6–16 keV,with a focused beam of 11.6μm×4.8μm and photon flux greater than 1012 phs/s.The high credibility and stability of the beam and good timing synchronization of the equipment significantly improve the experimental efficiency.Since June 2021,when it officially opened to users,over 4200 h of beamtime have been provided to over 200 research groups to collect data at the beamline.Its good performance and stable operation have led to the resolution of several structures based on data collected at the beamline.

Study on Control Techniques of Virus Diseases in Facility Cherry

The diseases of sweet cherry caused by viruses and viroids have occurred in the main cherry producing areas of China and are increasing year by year, which has become an important factor affecting the yield and quality of sweet cherry. For this reason, this paper elaborated the prevention and countermeasures of virus diseases from six aspects, including soil treatment, cultivation of disease-free seedlings, prevention of disease and pest damage, reasonable pruning, water management, and treatment of virus diseases, in order to provide technical guidance for the disease resistance, high quality and high yield of facility cherry, as well as information reference for the further improvement of the technical system of virus disease prevention and cultivation of facility cherry.

Improved Adaptive Differential Evolution Algorithm for the Un-Capacitated Facility Location Problem

The differential evolution algorithm is an evolutionary algorithm for global optimization and the un-capacitated facility location problem (UFL) is one of the classic NP-Hard problems. In this paper, combined with the specific characteristics of the UFL problem, we introduce the activation function to the algorithm for solving UFL problem and name it improved adaptive differential evolution algorithm (IADEA). Next, to improve the efficiency of the algorithm and to alleviate the problem of being stuck in a local optimum, an adaptive operator was added. To test the improvement of our algorithm, we compare the IADEA with the basic differential evolution algorithm by solving typical instances of UFL problem respectively. Moreover, to compare with other heuristic algorithm, we use the hybrid ant colony algorithm to solve the same instances. The computational results show that IADEA improves the performance of the basic DE and it outperforms the hybrid ant colony algorithm.

Minimum dose path planning for facility inspection based on the discrete Rao-combined ABC algorithm in radioactive environments with obstacles

Workers who conduct regular facility inspections in radioactive environments will inevitably be affected by radiation.Therefore,it is important to optimize the inspection path to ensure that workers are exposed to the least amount of radiation.This study proposes a discrete Rao-combined artificial bee colony(ABC)algorithm for planning inspection paths with minimum exposure doses in radioactive environments with obstacles.In this algorithm,retaining the framework of the traditional ABC algorithm,we applied the directional solution update rules of Rao algorithms at the employed bee stage and onlooker bee stage to increase the exploitation ability of the algorithm and implement discretion using the swap operator and swap sequence.To increase the randomness of solution generation,the chaos algorithm was used at the initialization stage.The K-opt operation technique was introduced at the scout bee stage to increase the exploration ability of the algorithm.For path planning in an environment with complex structural obstacles,an obstacle detour technique using a recursive algorithm was applied.To evaluate the performance of the proposed algorithm,we performed experimental simulations in three hypothetical environments and compared the results with those of improved particle swarm optimization,chaos particle swarm optimization,improved ant colony optimization,and discrete Rao’s algorithms.The experimental results show the high performance of the proposed discrete Rao-combined ABC algorithm and its obstacle detour capability.

Effects of Meteorological Conditions on Yield and Quality of Facility Hami Melon

With different varieties of facility Hami melon(Cucumis melo var. sacchairinus) as test materials, the effects of meteorological conditions on the yield and quality of different varieties of facility Hami melon were analyzed. The results showed that among the yield and quality traits of melon, the variation degree of average single melon weight was the highest, and the coefficient of variation was 33.05%. The variation degree of leaf area index was the lowest, and the coefficient of variation was 11.00%. Through the correlation analysis of meteorological factors with the yield and quality of facility Hami melon, it was found that the quality traits of facility Hami melon were significantly positively correlated with maximum temperature and sunshine duration, and significantly negatively correlated with precipitation. The yield traits were positively correlated with maximum temperature, sunshine duration and precipitation.

Study on Soilless Culture of Facility Strawberry

[Objective] The aim was to establish a set of soilless cultivation and management method of facility strawberry cultivation in the south of China.[Method] In the research,strawberry species,substrate formulae,cultivation modes and nutri ent solutions were selected and optimized.[Result] Three-dimensional strawberry cultivation was much suitable for Frandy,Hongbao and Gumei No.1; substrate with coconut shred-mushroom residue-peat soil ratio at 2∶2∶1 was the optimal; the treatment C3,containing Ca（NO3）2·4H2O,KNO3,（NH4）2HPO4,MgSO4·7H2O,and NH4NO3 at 280,303,62,246 and 80 mg/L,promoted strawberry growth,and the cultivated strawberry was large and thick in leaves,thick in stem,dark green in leaf color,with best fruit yield and quality.Among three cultivation modes,the density,space use ratio and yield in the treatment with PVC pipes in A-shape were all higher and the strawberry was easier and more convenient for picking.[Conclusion] The research provides references for soilless cultivation of strawberry in the south of China.

Facility location model for a remanufacturing logistics network

First a remanufactming logistics network is con- structed, in which the structure of both the forward logistics and the reverse logistics are of two levels and all the logistics facilities are capacitated. Both the remanufactming products and the new products can be used to meet the demands of customers. Moreover, it is assumed that homogeneous facilities can be designed together into integrated ones, based on which a mixed integer nonlinear programming （MINLP） facility location model of the remanufacturing logistics network with six types of facilities to be sited is built. Then an algorithm based on enumeration for the model is given. The feasible combinations of binary variables are searched by enumeration, and the remaining sub-problems are solved by the LP solver. Finally, the validities of the model and the algorithm are illustrated by means of an example. The result of the sensitivity analysis of parameters indicates that the integration of homogeneous facilities may influence the optimal solution of the problem to a certain degree.

DESIGN OF NEW TEST FACILITY FOR MICRO-TURBO-MACHINERY

Micro-turbine engine has no enough space for measuring impeller characteristics,so the design and the construction of a new test facility of micro-turbo-machinery are presented for micro-centrifugal compressors and radial turbines.The facility is used for the full speed compressor test and the long duration hot turbine test.To rapidly adjust the testing condition,all regulations of the operating state are automatically completed by the control system.The facility is also used for testing the impeller performance with a series of diameter from 55 mm to 180 mm as a result of the modular design.A thermal protection system is designed to avoid the heat distortion caused by the high turbine inlet temperature over 1 100 K and provide a proper experimental environment for the electronic components.A photoelectric torque transducer with the accuracy of 1% is designed to measure the torque of rigid shaft at a high speed of 125 000 r/min.The designing techniques for micro-turbo-machineries are verified by the impeller testing of the facility.

Collaborative planning approach for anti-bioterrorism emergency facility location based on aerodynamics

To smooth the correlation process from bio-virus diffusion to emergency relief response,the Gaussian plume model is used to describe the diffusion of dangerous sources,where the bio-virus concentration at any given point in affected areas can be calculated.And the toxic load rule is introduced to define the borderline of the dangerous area at different levels.Combined with this,different emergency levels of different demand points in dangerous areas are confirmed using fuzzy clustering,which allows demand points at the same emergency level to cluster in a group.Some effective emergency relief centers are chosen from the candidate hospitals which are located in different emergency level affected areas by set covering.Bioterrorism experiments which were conducted in Nanjing,Jiangsu province are simulated,and the results indicate that the novel method can be used efficiently by decision makers during an actual anti-bioterrorism relief.

An Algorithm for Solving Generalized Single Row Facility Layout Problem

Layout design problem is to determine a suitable arrangement for the departments so that the total costs associated with the flow among departments become least. Single Row Facility Layout Problem, SRFLP, is one of the layout problems that have many practical applications. This problem and its specific scenarios are often used to model many of the raised issues in the field of facility location. SRFLP is an arrangement of n departments with a specified length in a straight line so that the sum of the weighted distances between the pairs of departments is minimized. This problem is NP-hard. In this paper, first, a lower bound for a special case of SRFLP is presented. Then, a general case of SRFLP is presented in which some new and real assumptions are added to generate more practical model. Then a lower bound, as well as an algorithm, is proposed for solving the model. Experimental results on some instances in literature show the efficiency of our algorithm.

The protein complex crystallography beamline(BL19U1)at the Shanghai Synchrotron Radiation Facility

The protein complex crystallographic beamline BL19U1 at the Shanghai Synchrotron Radiation Facility is one of the five beamlines dedicated to protein sciences operated by National Facility for Protein Science(Shanghai,China).The beamline,which features a small-gap invacuum undulator,has been officially open to users since March 2015.This beamline delivers X-ray in the energy range 7–15 keV.With its high flux,low divergence beam and a large active area detector,BL19U1 is designed for proteins with large molecular weight and large crystallographic unit cell dimensions.Good performance and stable operation of the beamline have allowed the number of Protein Data Bank(PDB)depositions and the number of articles published based on data collected at this beamline to increase steadily.To date,over 300 research groups have collected data at the beamline.More than 600 PDB entries have been deposited at the PDB(www.pdb.org).More than 300 papers have been published that include data collected at the beamline,including 21 research articles published in the top-level journals Cell,Nature,and Science.

Production of light nuclei and hypernuclei at High Intensity Accelerator Facility energy region

Heavy-ion collisions are powerful tools for studying hypernuclear physics.We develop a dynamical coalescence model coupled with an ART model(version1.0) to study the production rates of light nuclear clusters and hypernuclei in heavy-ion reactions,for instance,the deuteron(d),triton(t),helium(~3He),and hypertriton(_A^3H)in minimum bias(0-80%centrality)~6Li+^(12)C reactions at beam energy of 3.5A GeV.The penalty factor for light clusters is extracted from the yields,and the distributions of 0 angle of particles,which provide direct suggesetions about the location of particle detectors in the near future facility-High Intensity heavy-ion Accelerator Facility(HIAF) are investigated.Our calculation demonstrates that HIAF is suitable for studying hypernuclear physics.

A Hybrid MCDM Approach Based on ANP and TOPSIS for Facility Layout Selection

Facility layout selection is a multi-criteria decision making (MCDM) problem,since it has a strategic impact on the efficiency of manufacturing system.In view of the interdependency among selection criteria,analytic network process (ANP) is proposed to analyze the structure of the facility layout selection problem and determine the weights for each criterion.A network structure is constructed that shows all elements and clusters and their interactions.Limit priorities are also calculated which help decision maker evaluate the relative importance among criterion in the alternative selection process.Moreover,a hybrid MCDM approach that employs ANP and technique for order preference by similarity to an ideal solution (TOPSIS)method to rank the optimal facility layout alternatives.Finally,an application of a new aeronautic component assembly workshop facility layout selection is conducted.To further illustrate the advantage of the proposed approach,the difference between ANP-TOPSIS and AHP-TOPSIS methods are compared and discussed.Results have demonstrated the effectiveness and feasibility of the proposed method.

Design of wide-range energy material beamline at the Shanghai Synchrotron Radiation Facility

We report the design of a wide-range energy material beamline(E-line) with multiple experimental techniques at the Shanghai Synchrotron Radiation Facility.The undulators consisted of an elliptically polarizing undulator and in-vacuum undulator that generate the soft and hard X-rays, respectively. The beamline covered a wide energy range from 130 to 18 ke V with both a high photon flux([ 10^(12) phs/s with exit silt 30 lm in soft X-ray and [ 5 9 10^(12) phs/s in hard X-ray within 0.1%BW bandwidth) and promising resolving power(maximum E/DE [ 15,000 in soft X-ray with exit silt 30 lm and [6000 in hard X-ray). Moreover, the beam spots from the soft and hard X-rays were focused to the same sample position with a high overlap ratio, so that the surfaces, interfaces, and bulk properties were characterized in situ by changing the probing depth.

Tuning control system of a third harmonic superconducting cavity in the Shanghai Synchrotron Radiation Facility

Beam lifetime is dominated by Touschek scattering at the Shanghai Synchrotron Radiation Facility(SSRF).Touschek loss rate is affected by probability for scattering beyond the RF acceptance and the volume charge density of the bench.In the phaseⅡupgrade of the SSRF,a third harmonic superconducting cavity will be used to enhance the Touschek lifetime by lengthening the bunches.The Touschek lifetime improvement factor is affected by the voltage of a harmonic cavity.To stabilize the cavity voltage,a tuning control system was designed to control it.The design of the tuning control system was based on the SSRF third-generation low-level RF control system.Some hardware and specialized algorithms were redesigned to fit the harmonic cavity control.The design of the tuning control system is complete,and the control system has been tested.The test result shows that the fluctuation of amplitude is<±0.34%within 1.5 h,which satisfies the stability requirement.

Electromagnetic Pulses Generated From Laser Target Interactions at Shenguang Ⅱ Laser Facility

Significant electromagnetic pulses （EMP） can be generated by the intensive laser irradiating solid targets in inertial confinement fusion （ICF）. To evaluate the EMP intensity and distribution in and outside the laser chamber, we designed and fabricated a discone antenna with ultra-wide bands of over 10 GHz. The return loss （Sn parameter） of this antenna was below -10 dB and could even achieve under -30 dB at 3.1 GHz. The EMP intensity in this study at 80 cm and 40 cm away from the target chamber center （TCC） reached 400 kV/m and 2000 kV/m. The current results are expected to offer preliminary information to study physics regarding laser plasma interactions and will also lay experimental foundation for EMI shielding design to protect various diagnostics.