Objective:Aim of present study is to scientifically,verify the antidiabetic activity/potency of Vernonia amygdalina in human diabetes.Methods:A search was made at Nnewi,South - East Nigeria for known diabetes who use ...Objective:Aim of present study is to scientifically,verify the antidiabetic activity/potency of Vernonia amygdalina in human diabetes.Methods:A search was made at Nnewi,South - East Nigeria for known diabetes who use Vernonia amygdalina either as their sole or supplementary antidiabetic.A total of ten volunteers comprising, eight females and two males were recruited.They were all of age range of 36-50 and average weight of 78 kg and suffering from non - insulin form of diabetes.The purpose of the study was explained to them and their consent obtained.They were asked not to take any other antidiabetic outside Vernonia amygdalina throughout the four weeks study period.There was however,no form of restrictions to their choice of diet or life style. They were requested to abstain from any drugs a week prior to commencement of study.Their prescriber’s dosage range was followed and minimum daily dose of 210 mL(approximately 220 mg of dry extract) was administered in Week-1,followed by daily dose of 420 mL(440 mg) in Week-2.In Week-3 they received 630 mL (660 mg) daily dose and in Week-4,they received daily dose of 840 mL(880 mg).Their fasting blood sugar were estimated pre-crude drug administration and on weekly basis for the four week study period.Their weekly weights were measured to check for possible weight gain or loss.Results were subjected to statistical analysis and Students T-Test was used to calculate P-value.P-value≤0.05 were considered significant.Results:It was observed that all the volunteers in the study group were taking Vernonia amygdalina only as supplementary. Two volunteers dropped out of the study at the end of Week-3 leaving us with 8 in Week-4.There was no significant bodyweight change within the four week study.The starting mean fasting blood sugar which was 133.3 mg/dL(7.41 mmol/L) rose to 136.6 mg/dL(7.59 mmol/L) in Week-1,to 149.5 mg/dL(8.31 mmol/L) in Week-2 and to 166.5 mg/dL(9.30 mmol/L) in Week-3.Week-4 had us left with 8 volunteers with a mean of 190.6 mg/dL(10.59 mmol/L).There was significant differences in increase in sugar levels between the pre-crade extract administration and treatment period with Vernonia amygdalina(P≤0.05 for Week-1,Ps?0.02 for Week-2,P^0.01 for Week-3 and PssO.001 for Week-4).Conclusion:Claims of antidiabetic efficacy of Vernonia amygdalina in human diabetes are scientifically non verifiable based on our work hence these claims are false.We also feel bold to state that we could not demonstrate any antidiabetic activity of Vernonia amygdalina in human subjects.We recommend that NAFDAC and all relevant agencies must sit up and control all forms advertorial on Medicinal plants until such are well studied and proven.展开更多
A d,I mixture (R-R and S-S) can be resolved into the d and the I enantiomers. while the mesoisomer (R-S, identical with S-R) cannot be physically separated. This fact has occasionally been 'extrapolated' to di...A d,I mixture (R-R and S-S) can be resolved into the d and the I enantiomers. while the mesoisomer (R-S, identical with S-R) cannot be physically separated. This fact has occasionally been 'extrapolated' to differentiate d,l and meso isomers with a chiral shift reagent where the meso isomer is presumed not to show any signal 'doubling' during the (usually) downfield shift. This assumption hasbeen shown to be incorrect by the behavior of a meso molecule which does give signal 'doubling'.展开更多
科学技术的发展使得利用电子资料库自主学习英语词汇成为可能。文章以经典外文范本Love is a Fallacy中的词汇为分析对象,从网络语料库BNC(British National Corpus)中提取所有包含关键词或结构的语句,对检索结果进行结构对比和词语分...科学技术的发展使得利用电子资料库自主学习英语词汇成为可能。文章以经典外文范本Love is a Fallacy中的词汇为分析对象,从网络语料库BNC(British National Corpus)中提取所有包含关键词或结构的语句,对检索结果进行结构对比和词语分析。从词频统计、词义掌握、辨析同义、词语搭配四个方面论证这一基于语料库自主学习过程的可行性和实用性。展开更多
Strong nationalism has now become a buzzword in Western press or academiccomments on China and also an important argument for the“China threat”. SomeWestern scholars assert that rising Chinese nationalism will lead ...Strong nationalism has now become a buzzword in Western press or academiccomments on China and also an important argument for the“China threat”. SomeWestern scholars assert that rising Chinese nationalism will lead to external expan-sion and hegemonism. Not a few Western scholars have challenged this展开更多
Love Is a Fallacy is a great work of Max Shulman, one of the America's most famous humorists. Literary pragmatics,an interdiscipline between literature and pragmatics, is concerned with the examples in which pragm...Love Is a Fallacy is a great work of Max Shulman, one of the America's most famous humorists. Literary pragmatics,an interdiscipline between literature and pragmatics, is concerned with the examples in which pragmatics is combined with linguistic and literary methods. Speech Act Theory, initiated by John Austin and developed by Paul Grice, has been employed in literary pragmatics. This paper aims to explore the characterization of the three roles in Love Is a Fallacy in the light of literary pragmatics. By delving into the realization of speech act and the flouting of the maxims of Cooperative Principle, the establishment process of characters can be better demonstrated.展开更多
We start with a description of the statistical inferential framework and the duality between observed data and the true state of nature that underlies it. We demonstrate here that the usual testing of dueling hypothes...We start with a description of the statistical inferential framework and the duality between observed data and the true state of nature that underlies it. We demonstrate here that the usual testing of dueling hypotheses and the acceptance of one and the rejection of the other is a framework which can often be faulty when such inferences are applied to individual subjects. This follows from noting that the statistical inferential framework is predominantly based on conclusions drawn for aggregates and noting that what is true in the aggregate frequently does not hold for individuals, an ecological fallacy. Such a fallacy is usually seen as problematic when each data record represents aggregate statistics for counties or districts and not data for individuals. Here we demonstrate strong ecological fallacies even when using subject data. Inverted simulations, of trials rightly sized to detect meaningful differences, yielding a statistically significant p-value of 0.000001 （1 in a million） and associated with clinically meaningful differences between a hypothetical new therapy and a standard therapy, had a proportion of instances of subjects with standard therapy effect better than new therapy effects close to 30%. A ―winner take all‖ choice between two hypotheses may not be supported by statistically significant differences based on stochastic data. We also argue the incorrectness across many individuals of other summaries such as correlations, density estimates, standard deviations and predictions based on machine learning models. Despite artifacts we support the use of prospective clinical trials and careful unbiased model building as necessary first steps. In health care, high touch personalized care based on patient level data will remain relevant even as we adopt more high tech data-intensive personalized therapeutic strategies based on aggregates.展开更多
Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articl...Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articles, we have demonstrated that Special Relativity is based on optical experiments and observations that have been incorrectly explained by the theory of a non-existent ether. Our findings show that all known experiments can be explained using classical concepts of space and time, thereby refuting the theory of relativity. This article also addresses the fallacy of the widely accepted etheric Doppler effects and its significant role in the history of science.展开更多
文摘Objective:Aim of present study is to scientifically,verify the antidiabetic activity/potency of Vernonia amygdalina in human diabetes.Methods:A search was made at Nnewi,South - East Nigeria for known diabetes who use Vernonia amygdalina either as their sole or supplementary antidiabetic.A total of ten volunteers comprising, eight females and two males were recruited.They were all of age range of 36-50 and average weight of 78 kg and suffering from non - insulin form of diabetes.The purpose of the study was explained to them and their consent obtained.They were asked not to take any other antidiabetic outside Vernonia amygdalina throughout the four weeks study period.There was however,no form of restrictions to their choice of diet or life style. They were requested to abstain from any drugs a week prior to commencement of study.Their prescriber’s dosage range was followed and minimum daily dose of 210 mL(approximately 220 mg of dry extract) was administered in Week-1,followed by daily dose of 420 mL(440 mg) in Week-2.In Week-3 they received 630 mL (660 mg) daily dose and in Week-4,they received daily dose of 840 mL(880 mg).Their fasting blood sugar were estimated pre-crude drug administration and on weekly basis for the four week study period.Their weekly weights were measured to check for possible weight gain or loss.Results were subjected to statistical analysis and Students T-Test was used to calculate P-value.P-value≤0.05 were considered significant.Results:It was observed that all the volunteers in the study group were taking Vernonia amygdalina only as supplementary. Two volunteers dropped out of the study at the end of Week-3 leaving us with 8 in Week-4.There was no significant bodyweight change within the four week study.The starting mean fasting blood sugar which was 133.3 mg/dL(7.41 mmol/L) rose to 136.6 mg/dL(7.59 mmol/L) in Week-1,to 149.5 mg/dL(8.31 mmol/L) in Week-2 and to 166.5 mg/dL(9.30 mmol/L) in Week-3.Week-4 had us left with 8 volunteers with a mean of 190.6 mg/dL(10.59 mmol/L).There was significant differences in increase in sugar levels between the pre-crade extract administration and treatment period with Vernonia amygdalina(P≤0.05 for Week-1,Ps?0.02 for Week-2,P^0.01 for Week-3 and PssO.001 for Week-4).Conclusion:Claims of antidiabetic efficacy of Vernonia amygdalina in human diabetes are scientifically non verifiable based on our work hence these claims are false.We also feel bold to state that we could not demonstrate any antidiabetic activity of Vernonia amygdalina in human subjects.We recommend that NAFDAC and all relevant agencies must sit up and control all forms advertorial on Medicinal plants until such are well studied and proven.
文摘A d,I mixture (R-R and S-S) can be resolved into the d and the I enantiomers. while the mesoisomer (R-S, identical with S-R) cannot be physically separated. This fact has occasionally been 'extrapolated' to differentiate d,l and meso isomers with a chiral shift reagent where the meso isomer is presumed not to show any signal 'doubling' during the (usually) downfield shift. This assumption hasbeen shown to be incorrect by the behavior of a meso molecule which does give signal 'doubling'.
文摘科学技术的发展使得利用电子资料库自主学习英语词汇成为可能。文章以经典外文范本Love is a Fallacy中的词汇为分析对象,从网络语料库BNC(British National Corpus)中提取所有包含关键词或结构的语句,对检索结果进行结构对比和词语分析。从词频统计、词义掌握、辨析同义、词语搭配四个方面论证这一基于语料库自主学习过程的可行性和实用性。
文摘Strong nationalism has now become a buzzword in Western press or academiccomments on China and also an important argument for the“China threat”. SomeWestern scholars assert that rising Chinese nationalism will lead to external expan-sion and hegemonism. Not a few Western scholars have challenged this
文摘Love Is a Fallacy is a great work of Max Shulman, one of the America's most famous humorists. Literary pragmatics,an interdiscipline between literature and pragmatics, is concerned with the examples in which pragmatics is combined with linguistic and literary methods. Speech Act Theory, initiated by John Austin and developed by Paul Grice, has been employed in literary pragmatics. This paper aims to explore the characterization of the three roles in Love Is a Fallacy in the light of literary pragmatics. By delving into the realization of speech act and the flouting of the maxims of Cooperative Principle, the establishment process of characters can be better demonstrated.
文摘We start with a description of the statistical inferential framework and the duality between observed data and the true state of nature that underlies it. We demonstrate here that the usual testing of dueling hypotheses and the acceptance of one and the rejection of the other is a framework which can often be faulty when such inferences are applied to individual subjects. This follows from noting that the statistical inferential framework is predominantly based on conclusions drawn for aggregates and noting that what is true in the aggregate frequently does not hold for individuals, an ecological fallacy. Such a fallacy is usually seen as problematic when each data record represents aggregate statistics for counties or districts and not data for individuals. Here we demonstrate strong ecological fallacies even when using subject data. Inverted simulations, of trials rightly sized to detect meaningful differences, yielding a statistically significant p-value of 0.000001 （1 in a million） and associated with clinically meaningful differences between a hypothetical new therapy and a standard therapy, had a proportion of instances of subjects with standard therapy effect better than new therapy effects close to 30%. A ―winner take all‖ choice between two hypotheses may not be supported by statistically significant differences based on stochastic data. We also argue the incorrectness across many individuals of other summaries such as correlations, density estimates, standard deviations and predictions based on machine learning models. Despite artifacts we support the use of prospective clinical trials and careful unbiased model building as necessary first steps. In health care, high touch personalized care based on patient level data will remain relevant even as we adopt more high tech data-intensive personalized therapeutic strategies based on aggregates.
文摘Instead of relying on the erroneous principles of Special Relativity, this paper proposes a new theory based on the emission of photons by a source and their re-emission by a transparent medium. Through over 60 articles, we have demonstrated that Special Relativity is based on optical experiments and observations that have been incorrectly explained by the theory of a non-existent ether. Our findings show that all known experiments can be explained using classical concepts of space and time, thereby refuting the theory of relativity. This article also addresses the fallacy of the widely accepted etheric Doppler effects and its significant role in the history of science.
