BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we ai...BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we aimed to determine a new method for long-term retention of the ventilation tube.AIM To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.METHODS A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube placement.The patients were randomly divided into two groups:Control group and treatment group.Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm removed.Only conventional ventilation tubes were placed in this study.Outcome measures were tube position and patency.Tube retention time and any complications were documented.RESULTS Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study.The tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.展开更多
目的基于卵巢子宫内膜异位囊肿(OE)和卵巢输卵管积脓或积水(OP/OH)间囊液成分的差异,探讨单源双能CT综合分析对OE和OP/OH的鉴别诊断价值。资料与方法回顾性分析2011年7月—2017年4月于大连医科大学附属第一医院放射科应用单源双能CT行...目的基于卵巢子宫内膜异位囊肿(OE)和卵巢输卵管积脓或积水(OP/OH)间囊液成分的差异,探讨单源双能CT综合分析对OE和OP/OH的鉴别诊断价值。资料与方法回顾性分析2011年7月—2017年4月于大连医科大学附属第一医院放射科应用单源双能CT行宝石能谱成像(GSI)扫描,并经手术病理证实的20例OE患者及13例OP/OH患者。分别测量各病变最大囊腔囊液不同单能量(40~140 ke V)的CT值、有效原子序数、钙(水)浓度、脂(水)浓度、血(水)浓度,并计算能谱曲线斜率(K值)。比较各能谱参数的差异,使用受试者工作特性(ROC)曲线评估存在差异的参数对OE的诊断价值。结果 OE组40~60 ke V单能量CT值、K值均高于OP/OH组,差异有统计学意义(P<0.05)。两病变囊液70~140 ke V单能量CT值、有效原子序数、钙(水)浓度、脂(水)浓度、血(水)浓度值差异均无统计学意义(P>0.05)。40~60 ke V单能量CT值、K值诊断OE的AUC值分别为0.717(95%CI 0.581~0.902)、0.707(95%CI 0.556~0.884)、0.701(95%CI 0.555~0.885)、0.703(95%CI 0.541~0.889)。其中40 ke V单能量下CT值的诊断效能最高,当阈值为43.74 HU时,诊断OE的敏感度为54.5%,特异度为94.1%。结论 40~60 ke V单能量CT值、K值对OE和OP/OH的鉴别诊断具有重要的辅助信息。单源双能CT能谱综合分析平台为OE和OP/OH的鉴别诊断提供了重要信息。展开更多
基金Supported by Shanghai Leadership Talent Training Plan,No. 2017062the Key Project of Shanghai Jiao Tong University Medicine Science and Engineering Interdisciplinary Foundation,No. YG2016ZD02+3 种基金Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support,No.20152233Multi-Center Clinical Research Plan of Medical College of Shanghai Jiao Tong University,No. DLY201823the Clinical Research Plan of Shanghai Shen Kang Hospital Development Center,No. 16CR4022A and No.16CR3041ANational Natural Science Foundation of China,No.81974142.
文摘BACKGROUND Although long-term retention of a ventilation tube is required in many ear diseases,spontaneous removal of conventional ventilation tube is observed in patients within 3 to 12 mo.To address this issue,we aimed to determine a new method for long-term retention of the ventilation tube.AIM To explore the value of removing the biofilm for long-term retention of tympanostomy ventilation tubes.METHODS A case-control study design was used to evaluate the safety and effectiveness of long-term tube retention by directly removing the biofilm(via surgical exfoliation)in patients who underwent myringotomy with ventilation tube placement.The patients were randomly divided into two groups:Control group and treatment group.Patients in the treatment group underwent regular biofilm exfoliation surgery in the clinic,whereas those in the control group did not have their biofilm removed.Only conventional ventilation tubes were placed in this study.Outcome measures were tube position and patency.Tube retention time and any complications were documented.RESULTS Eight patients with biofilm removal and eight patients without biofilm removal as a control group were enrolled in the study.The tympanostomy tube retention time was significantly longer in the treatment group(43.5±26.4 mo)than in the control group(9.5±6.9 mo)(P=0.003).More tympanostomy tubes were found to be patent and in correct position in the treatment group during the follow-up intervals than in the control group(P=0.01).CONCLUSION Despite the use of short-term ventilation tubes,direct biofilm removal can be a well-tolerated and effective treatment for long-term tube retention of tympanostomy ventilation tubes in patients who underwent myringotomy.
文摘目的基于卵巢子宫内膜异位囊肿(OE)和卵巢输卵管积脓或积水(OP/OH)间囊液成分的差异,探讨单源双能CT综合分析对OE和OP/OH的鉴别诊断价值。资料与方法回顾性分析2011年7月—2017年4月于大连医科大学附属第一医院放射科应用单源双能CT行宝石能谱成像(GSI)扫描,并经手术病理证实的20例OE患者及13例OP/OH患者。分别测量各病变最大囊腔囊液不同单能量(40~140 ke V)的CT值、有效原子序数、钙(水)浓度、脂(水)浓度、血(水)浓度,并计算能谱曲线斜率(K值)。比较各能谱参数的差异,使用受试者工作特性(ROC)曲线评估存在差异的参数对OE的诊断价值。结果 OE组40~60 ke V单能量CT值、K值均高于OP/OH组,差异有统计学意义(P<0.05)。两病变囊液70~140 ke V单能量CT值、有效原子序数、钙(水)浓度、脂(水)浓度、血(水)浓度值差异均无统计学意义(P>0.05)。40~60 ke V单能量CT值、K值诊断OE的AUC值分别为0.717(95%CI 0.581~0.902)、0.707(95%CI 0.556~0.884)、0.701(95%CI 0.555~0.885)、0.703(95%CI 0.541~0.889)。其中40 ke V单能量下CT值的诊断效能最高,当阈值为43.74 HU时,诊断OE的敏感度为54.5%,特异度为94.1%。结论 40~60 ke V单能量CT值、K值对OE和OP/OH的鉴别诊断具有重要的辅助信息。单源双能CT能谱综合分析平台为OE和OP/OH的鉴别诊断提供了重要信息。
