Purpose: The purpose of this study was to investigate the effects of obesity and aerobic exercise training on oxidant-antioxidant balance,neurotrophic factor levels, and blood-brain barrier(BBB) function.Methods: Ten ...Purpose: The purpose of this study was to investigate the effects of obesity and aerobic exercise training on oxidant-antioxidant balance,neurotrophic factor levels, and blood-brain barrier(BBB) function.Methods: Ten non-obese healthy men(body mass index < 25 kg/m2) and 10 obese men(body mass index ≥ 25 kg/m2) were included in the study.Both groups performed treadmill exercise for 40 min 3 times weekly for 8 weeks at 70% heart rate reserve. Blood samples were collected to examine oxidant-antioxidant balance(reactive oxygen species(ROS) and superoxide dismutase(SOD) activity levels), neurotrophic factors(brain-derived neurotrophic factor(BDNF), nerve growth factor, and glial cell line-derived neurotrophic factor levels), and BBB function(S100βand neuron-specific enolase(NSE) levels) before and after exercise training.Results: The obese group showed significantly greater changes than the non-obese group in serum ROS(-0.46 ± 0.31 mmol/L vs.-0.10 ±0.17 mmol/L,p=0.005),serum S100 p levels(-8.50 ± 5.92 ng/L vs.-0.78 ± 5.45 ng/L,p=0.007),and serum NSE levels(-0.89 ± 0.54 μg/L vs.-0.01 ± 0.74 μg/L,p= 0.007) after training. At baseline,the obese group showed significantly higher serum ROS and S100β levels and significantly lower serum SOD activity and BDNF levels than the non-obese group(p < 0.05). The obese group showed significantly lower serum ROS, S100β,and NSE levels and significantly higher serum SOD activity and BDNF levels after training compared with baseline(p < 0.05).Conclusion: These results suggest that obesity can reduce serum neurotrophic factor levels and can induce BBB dysfunction. On the other hand,aerobic exercise can improve an oxidant-antioxidant imbalance in obese subjects and limit BBB dysfunction.展开更多
Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obst...Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obstacles,cost-effective strategies must be developed,including exercise as a complement to hemodialysis therapy.Objective:To determine the effectiveness of exercise therapy on functional balance,physical performance,and quality of life among patients undergoing hemodialysis:a randomized controlled trial.Methods:This randomized controlled trial study was carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and had a medically stable condition who were randomly divided into training(n=32)exercise therapy and(n=31)control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests were used at the significant level of(P=0.05).Results:6 Minute-Walk Test(6MWT)(0.013),and in the Physical Activity Scale for the Elderly(PASE)(0.014),and Short Survey Form 36(SF-36)questionnaires and health-related quality of life(HRQOL)(0.001)had significant improvements in the training group in comparison to the control group from pre to post-test,also physical performance(0.001)was improving as compared with control group(0.89)at(P=0.05).Conclusion:Resistance exercise therapy interventions for eight weeks effectively improve the physical function and performance,activity levels,and health-related quality of life of patients with chronic kidney disease and undergoing regular hemodialysis compared with a control group.展开更多
Elderly is an age group that has a high risk of experiencing health problems. One risk that can be experienced by the elderly is the risk of falling. One of the risk factors for falling in the elderly is decreasing in...Elderly is an age group that has a high risk of experiencing health problems. One risk that can be experienced by the elderly is the risk of falling. One of the risk factors for falling in the elderly is decreasing in postural balance of the elderly. One of the non-pharmacological therapies developed to reduce the risk of falling in the elderly is to improve the ability of the elderly, especially in controlling postural balance. The purpose of this study was to determine the effectiveness of 12 balance exercises to improve postural balance in the elderly. This type of research is quasi experiments with static group comparison. The research data are obtained by researchers using observation sheet, then the data are tabulated. This study involved two research groups namely the control group (the group not given the intervention) and the treatment group (the group that was given the 12 balance exercise intervention). From the results of Paired samples, t-test with significance level α = 0.05 is obtained by the significance value (p) of 0.025. This study shows that the provision of 12 balance therapy exercise strategy is effective to improve postural balance in the elderly as a preventive effort from the risk of falling.展开更多
The purpose of this study was to evaluate the effect of pelvic exercise on standing balance in patients with incomplete cervical spinal cord injury for healthy rehabilitation. 11 patients (8 men and 3 women) with leve...The purpose of this study was to evaluate the effect of pelvic exercise on standing balance in patients with incomplete cervical spinal cord injury for healthy rehabilitation. 11 patients (8 men and 3 women) with levels of incomplete injury between cervical 3 and cervical 6 who were participated in a study measuring the standing balance using an interactive balance system (IBS) before and after pelvic exercise. The index of standing balance after pelvic exercise was significantly lower than before exercise in patients with incomplete cervical cord injury. The greatest improvements were observed in incomplete cervical spinal cord injury with neurologic levels of cervical 3 and 4 with Brown-Sequard syndrome. These results suggest that the pelvic exercise for rehabilitation significantly improved in part standing balance in patients with incomplete cervical spinal cord injury.展开更多
Objective: To systematically evaluate the effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients. Methods: The literature databases such as the Cochrane Library, EMbase, PubM...Objective: To systematically evaluate the effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients. Methods: The literature databases such as the Cochrane Library, EMbase, PubMed, Web of Science, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP) and Wan Fang database (Wan Fang) were retrieved. Randomized controlled trials (RCTs) regarding the effects of Pilates exercise on balance, walking and lower limbs motor function of stroke patients were retrieved. Data were collected and evaluated independently by two researchers. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 5 RCTs were included, including 182 subjects were chosen. The result showed that compared with the routine care group, Pilates exercise can effectively improve the balance of stroke patients when they have trained eight weeks [MD=4.71, 95%CI (2.14, 7.28), P=0.0003], shorten the time of the Timed Up and Go test (TUG)[MD=-1.63, 95%CI (-2.69,-0.56), P=0.003], increase the stride velocity [MD=3.83, 95%CI (1.43, 6.23), P=0.002]. However, the evidence did not support the effectiveness of Pilates exercise on increasing the score of Fugl-Meyer Assessment-Lower Extremity (FMA-LE) of stroke patients [MD=6.70, 95%CI (-3.46, 16.86), P=0.20]. Conclusion: The findings suggest that Pilates could improve the balance and walking speed of stroke patients. However, there still is the lack of the evidence in improving lower limb function. Due to the limitation of the quality of the included studies. highquality studies still should be conducted to investigate the effect of Pilates exercise in stroke patients.展开更多
Objective: To study the effects of balance exercise training on chronic nerve injury, GLP-1 and inflammatory mediator secretion in patients with senile dementia. Methods: Patients with senile dementia who were treated...Objective: To study the effects of balance exercise training on chronic nerve injury, GLP-1 and inflammatory mediator secretion in patients with senile dementia. Methods: Patients with senile dementia who were treated in the Fourth People's Hospital of Ya'an between February 2015 and January 2018 were chosen as the research subjects and randomly divided into two groups, the experimental group received balance exercise training and the control group received routine intervention. The levels of chronic nerve injury indexes, GLP-1 and inflammatory cytokines in serum as well as the expression of inflammatory signaling molecules in peripheral blood were determined before and after intervention. Results:Compared with those of same group before intervention, serum Hcy, Aβ1-42, Tau, IL-1β, IL-18, TNF-α and IFN-γ levels as well as peripheral blood NLRP3, Caspase-1 and DOCK2 expression intensity of both groups were decreasing whereas serum SOD, PON1 and GLP-1 levels as well as peripheral blood PKA and CREB expression intensity were increasing after intervention, and serum Hcy, Aβ1-42, Tau, IL-1β, IL-18, TNF-α and IFN-γ levels as well as peripheral blood NLRP3, Caspase-1 and DOCK2 expression intensity of experimental group after intervention were lower than those of control group whereas serum SOD, PON1 and GLP-1 levels as well as peripheral blood PKA and CREB expression intensity were higher than those of control group. Conclusion: Balance exercise training can reduce the chronic nerve injury and regulate the secretion of GLP-1 and inflammatory mediators in patients with senile dementia.展开更多
Objective To examine the effect of multisensory exercise on balance disorders.Methods PubMed,Scopus and Web of Science were searched to identify eligible studies published before January 1,2020.Eligible studies includ...Objective To examine the effect of multisensory exercise on balance disorders.Methods PubMed,Scopus and Web of Science were searched to identify eligible studies published before January 1,2020.Eligible studies included randomized control trials(RCTs),non-randomized studies,case-control studies,and cohort studies.The methodological quality of the included studies was evaluated using JBI Critical Appraisal Checklists for RCTs and for Quasi-Experimental Studies by two researchers independently.A narrative synthesis of intervention characteristics and health-related outcomes was performed.Results A total of 11 non-randomized studies and 9 RCTs were eligible,including 667 participants.The results supported our assumption that multisensory exercise improved balance in people with balance disorders.All of the 20 studies were believed to be of high or moderate quality.Conclusion Our study confirmed that multisensory exercise was effective in improving balance in people with balance disorders.Multisensory exercises could lower the risk of fall and enhance confidence level to improve the quality of life.Further research is needed to investigate the optimal strategy of multisensory exercises and explore the underlying neural and molecular mechanisms of balance improvement brought by multisensory exercises.展开更多
The purpose of the present study was to examine the effects of a 24-week Tai Chi exercise intervention on balance and other physical changes such as flexibility and reaction time(RT)among healthy older males.Methods:T...The purpose of the present study was to examine the effects of a 24-week Tai Chi exercise intervention on balance and other physical changes such as flexibility and reaction time(RT)among healthy older males.Methods:Thirty-eight male subjects aged 55-65 years without prior Tai Chi experience were recruited from a local community in Shanghai,China.A 60-min Tal Chi exercise session was performed three times a week for 24 weeks.Changes in RT,sit-and-reach flexibility and balance (static balance with eyes open and closed respectively)were measured before and after the Tal Chi intervention.Results:After the 24-week Tai Chi intervention,the choice RT(P < 0.05)decreased,and sit-and-reach flexibility improved (P < 0.01)over the pre-test(7.8 ±6.2 vs.7.1 ±3.0cm).Sway length,area,X-axis deviation amplitude and Y-axis deviation amplitude performance decreased significantly after the intervention with a double-foot stance with eyes open(P < 0.05).Sway length,area and average sway speed showed a statistically significant decrease after the intervention with the double-foot stance with eyes closed.In the single-footstance with eyes open condition,sway length and average swayspeed showed a statistically significant decrease(P<0.05).Conclusion:The 24-week Tai Chi exercise intervention had a positive influence on balance control in older males.Copyright(C)2012,Shanghai University of Sport.Production and hosting by Elsevier B.V.All rights reserved.展开更多
Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life o...Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not elucidated.The purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult individuals.Participants(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andflexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 weeks.Balance(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the intervention.Blood sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor levels.Significant improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the intervention.In addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained unchanged.This study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult individuals.In addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation status.The Ethics Research Committee of Centro Universitário Metodista-IPA,Brazil approved the current study on June 6,2019(approval No.3.376.078).展开更多
Background: This preliminary study examined the effects of an 8-week supervised reactive balance training program on reaction time (RT) and foot speed, static balance and balance confidence in healthy older adults ...Background: This preliminary study examined the effects of an 8-week supervised reactive balance training program on reaction time (RT) and foot speed, static balance and balance confidence in healthy older adults compared to an exercise control group. Methods: Twenty-five older adults were randomly assigned to a reactive balance training group (QuickBoard; n = 12; 71.0 ± 8.6 years) or a stationary cycling group (control; n = 13; 70.2 ± 6.0 years). Both groups were tested for foot RT foot speed, static balance, and balance confidence at baseline, 4-week, 8-week, and 4-week follow-up. Results: Results indicated significant improvements in QuickBoard foot RT and speed in both groups with greater improvements in the QuickBoard group. However, no group difference was found in static balance performance. Conclusion: Although the improvements in RT and foot speed may be beneficial for fall and trip prevention, the implications of the current findings for trio avoidance and oerformance of daily tasks are unclear.展开更多
Objective: The objective of this study was to verify the effects of two different training protocols based on Core Stability and Body Balance exercises in subjects with Parkinsons’s Disease. Methods: Eight elderly me...Objective: The objective of this study was to verify the effects of two different training protocols based on Core Stability and Body Balance exercises in subjects with Parkinsons’s Disease. Methods: Eight elderly men with PD (age of 73 ± 9 years, weight 69 ± 16 kg, height 164 ± 13 cm, 2 ± 1 of Disability Score according to Hoehn and Yahr scale). The disability score was evaluated using Hoehn and Yahr scale. This study was 12-month-long organized in 3 blocks of 4 months each. The sample was divided in two groups formed by 4 subjects each group. During the first four months, one group performed core stability exercises (CSG) while the other group exercised itself through a Balance Exercises Program (BG). After this first part of the study both protocols were stopped for the following 4 months. Finally, the group were reversed (counter balance design) for the last 4 months of physical activity. The two groups were measured twice, before (T0) and after the treatment (T1). Both treatments were designed in order to investigate the improvement in core muscles performance in order to grant a better balance control and to reduce the risk of falling. Results: statistically significant variations were found in the flight time of Sit-to-Stand (p < 0.05, +27%) and in the step length (p < 0.05, ?3%). In the CSG group, statistically significant variations were detected in Speed of Steps (p < 0.05, +5%), Step Cadence (p < 0.05, +3%), and Left Stride Duration (p < 0.05, ?3%) (Table 1). Conclusion: Both Body Balance and Core training can be considered two good physical exercise methods for people with PD. This study highlights the positive effects of this training protocol on legs strength improvements and on the balance control while walking.展开更多
This quasi-experimental study compared the results of a traditional model of physical therapy(PT)care to a PT wellness model known as GroupHab.The traditional model included discharge from PT with a home exercise prog...This quasi-experimental study compared the results of a traditional model of physical therapy(PT)care to a PT wellness model known as GroupHab.The traditional model included discharge from PT with a home exercise program(HEP)to be self-administered with or without the addition of a community-based exercise program.The wellness model included participation in a PT-designed and supervised group exercise program(GroupHab class)in an outpatient clinical setting following discharge from PT.Independent t-tests were used to compare the number of falls,exercise frequency,and exercise duration between the two groups.A repeated measures,analysis of variance(RM-ANOVA)compared changes in balance confidence scores both within and between groups,and a multivariate analysis of variance(MANOVA)analyzed group differences across multiple quality of life ratings using the SF-20.All data were analyzed at the 0.05 alpha level using SPSS 24 statistical software.Our results showed a significantly greater reduction in recurrent falls among the GroupHab wellness group compared to the HEP group(t=2.811,p=0.009).The resulting odds ratio for subsequent falls was 2.2 among HEP participants and 0.2 among GroupHab participants.Exercise adherence was also greater for those who participated in the GroupHab class.They documented greater exercise frequency(t=-3.253,p=0.002)and more exercise minutes(t=-7.188,p<0.001)than those who participated in the HEP.When comparing changes in the participants’balance confidence,we found an average increase of 5%among GroupHab participants compared to a 6%decrease among HEP participants(F=16.877,p<0.001,power=0.981).Although our multivariate analysis of the SF-20 scores revealed no significant difference overall(F=0.768,p=0.73),the univariate analyses showed significantly greater improvements among GroupHab participants in selected areas of physical function.These results suggest that at-risk older adults who are discharged into a functionally-based group exercise class are less likely to experience recurrent falls and are more likely to have more confidence in their balance than those who are discharged with a standard HEP and/or use of community-based exercise classes.展开更多
Background: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia(EAH) during prolonged exercise. The aim of this study was to determine the incidence of E...Background: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia(EAH) during prolonged exercise. The aim of this study was to determine the incidence of EAH within the broader context of fluid regulation among soldiers performing a 40-km route-march ingesting water ad libitum.Methods: Twenty-eight healthy male soldiers participated in this observational trial. Pre-and post-exercise body mass, blood and urine samples were collected. Blood samples were assessed for serum sodium([Na+]), glucose, creatinine, urea nitrogen(BUN), plasma osmolality, creatine kinase(CK), and plasma arginine vasopressin(AVP) concentrations. Plasma volume(PV) was calculated using hematocrit and hemoglobin. Urine samples were analyzed for osmolality and (Na+)Water intake was assessed by weighing bottles before, during and after the march. The mean relative humidity was 55.7%(21.9–94.3%) and the mean dry bulb temperature was 27.1°C(19.5°C-37.0°C) during the exercise.Results: Twenty-five soldiers(72±10 kg)(Mean±SD) completed the march in 09:11±00:43(hr:min). Participants consumed 736±259 ml/h of water and lost 2.8±0.9 kg(4.0%±1.4%, P<0.05) of body mass. Significant(pre-march vs. post-march;P<0.05) decreases in serum [Na+](141 mmol/L vs. 136 mmol/L), plasma osmolality(303 m Osmol/kg H2O vs. 298 m Osmol/kg H2O), and serum creatinine(111 μmol/L vs. 101 μmol/L) and urine [Na+](168 mmol/L vs. 142 mmol/L), as well as significant increases in plasma AVP(2 pg/ml vs. 11 pg/ml), plasma CK(1423 U/L vs. 3894 U/L) and urine osmolality(1035 m Osmol/kg H2O vs. 1097 m Osmol/kg H2O) were found. The soldier(72 kg) with the lowest postexercise sodium level completed the march in 08:38. He drank 800 ml/h, lost 2% body mass, and demonstrated(prepost) increases in plasma osmolality(294–314 m Osmol/kg H2O), BUN(20–30 mg/dl), AVP(2–16 pg/ml) and PV(41%). His urine osmolality decreased from 1114 m Osmol/kg H2O to 1110 m Osmol/kg H2O. No participants finished the route-march with a serum [Na+] indicating hypernatremia(range, 134–143 mmol/L).Conclusions: Ad libitum drinking resulted in 4% body mass loss with a 2 mmol/L serum [Na+] reduction in conjunction with high urine osmolality(>1000 m Osmol/kg H2O) and plasma AVP. No single hydration strategy likely prevents EAH, but hypernatremia(cellular dehydration) was not seen despite >2% body mass losses and high urine osmolality.展开更多
目的探讨健康操结合认知任务训练在帕金森合并轻度认知障碍(Parkinson's disease with mild cognitive impairment,PD-MCI)患者中的应用效果。方法选取南通市第四人民医院2021年9月—2023年3月收治的PD-MCI患者90例,依照随机分配原...目的探讨健康操结合认知任务训练在帕金森合并轻度认知障碍(Parkinson's disease with mild cognitive impairment,PD-MCI)患者中的应用效果。方法选取南通市第四人民医院2021年9月—2023年3月收治的PD-MCI患者90例,依照随机分配原则分为2组,各45例。对照组采取常规健康教育及常规训练,观察组在上述基础上采取健康操结合认知任务训练,为期6个月。对比2组干预前后认知功能[蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易精神状态检查量表(mini-mental state examination,MMSE)评分]、跌倒风险[修订版跌倒效能量表(modified fall efficacy scale,MFES)评分]、运动功能[帕金森综合评分量表3(unified Parkinson's disease rating scale-Ⅲ,UPDRS-Ⅲ)评分]、平衡能力[起立-行走测试(timed up and go test,TUG)]。结果干预后,观察组MoCA、MMSE评分分别为(23.81±2.30)分、(23.59±1.80)分,较干预前升高,且高于对照组的(20.13±2.55)分、(20.78±2.32)分(P<0.05)。干预后,2组MFES评分较干预前升高,观察组为(7.34±0.59)分,高于对照组的(6.42±0.77)分(P<0.05);2组UPDRS-Ⅲ评分较干预前下降,观察组为(16.52±2.21)分,低于对照组的(18.15±2.04)分(P<0.05)。干预后,2组单任务TUG、双任务TUG时间均较干预前缩短,观察组为(11.44±0.70)s、(18.39±1.44)s,短于对照组的(13.54±1.26)s、(21.26±1.53)s(P<0.05)。结论健康操结合认知任务训练在PD-MCI患者中应用效果良好,能改善患者认知功能和运动功能,提高平衡能力,降低跌倒风险。展开更多
基金supported by the Dong-A University research fund
文摘Purpose: The purpose of this study was to investigate the effects of obesity and aerobic exercise training on oxidant-antioxidant balance,neurotrophic factor levels, and blood-brain barrier(BBB) function.Methods: Ten non-obese healthy men(body mass index < 25 kg/m2) and 10 obese men(body mass index ≥ 25 kg/m2) were included in the study.Both groups performed treadmill exercise for 40 min 3 times weekly for 8 weeks at 70% heart rate reserve. Blood samples were collected to examine oxidant-antioxidant balance(reactive oxygen species(ROS) and superoxide dismutase(SOD) activity levels), neurotrophic factors(brain-derived neurotrophic factor(BDNF), nerve growth factor, and glial cell line-derived neurotrophic factor levels), and BBB function(S100βand neuron-specific enolase(NSE) levels) before and after exercise training.Results: The obese group showed significantly greater changes than the non-obese group in serum ROS(-0.46 ± 0.31 mmol/L vs.-0.10 ±0.17 mmol/L,p=0.005),serum S100 p levels(-8.50 ± 5.92 ng/L vs.-0.78 ± 5.45 ng/L,p=0.007),and serum NSE levels(-0.89 ± 0.54 μg/L vs.-0.01 ± 0.74 μg/L,p= 0.007) after training. At baseline,the obese group showed significantly higher serum ROS and S100β levels and significantly lower serum SOD activity and BDNF levels than the non-obese group(p < 0.05). The obese group showed significantly lower serum ROS, S100β,and NSE levels and significantly higher serum SOD activity and BDNF levels after training compared with baseline(p < 0.05).Conclusion: These results suggest that obesity can reduce serum neurotrophic factor levels and can induce BBB dysfunction. On the other hand,aerobic exercise can improve an oxidant-antioxidant imbalance in obese subjects and limit BBB dysfunction.
文摘Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obstacles,cost-effective strategies must be developed,including exercise as a complement to hemodialysis therapy.Objective:To determine the effectiveness of exercise therapy on functional balance,physical performance,and quality of life among patients undergoing hemodialysis:a randomized controlled trial.Methods:This randomized controlled trial study was carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and had a medically stable condition who were randomly divided into training(n=32)exercise therapy and(n=31)control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests were used at the significant level of(P=0.05).Results:6 Minute-Walk Test(6MWT)(0.013),and in the Physical Activity Scale for the Elderly(PASE)(0.014),and Short Survey Form 36(SF-36)questionnaires and health-related quality of life(HRQOL)(0.001)had significant improvements in the training group in comparison to the control group from pre to post-test,also physical performance(0.001)was improving as compared with control group(0.89)at(P=0.05).Conclusion:Resistance exercise therapy interventions for eight weeks effectively improve the physical function and performance,activity levels,and health-related quality of life of patients with chronic kidney disease and undergoing regular hemodialysis compared with a control group.
文摘Elderly is an age group that has a high risk of experiencing health problems. One risk that can be experienced by the elderly is the risk of falling. One of the risk factors for falling in the elderly is decreasing in postural balance of the elderly. One of the non-pharmacological therapies developed to reduce the risk of falling in the elderly is to improve the ability of the elderly, especially in controlling postural balance. The purpose of this study was to determine the effectiveness of 12 balance exercises to improve postural balance in the elderly. This type of research is quasi experiments with static group comparison. The research data are obtained by researchers using observation sheet, then the data are tabulated. This study involved two research groups namely the control group (the group not given the intervention) and the treatment group (the group that was given the 12 balance exercise intervention). From the results of Paired samples, t-test with significance level α = 0.05 is obtained by the significance value (p) of 0.025. This study shows that the provision of 12 balance therapy exercise strategy is effective to improve postural balance in the elderly as a preventive effort from the risk of falling.
文摘The purpose of this study was to evaluate the effect of pelvic exercise on standing balance in patients with incomplete cervical spinal cord injury for healthy rehabilitation. 11 patients (8 men and 3 women) with levels of incomplete injury between cervical 3 and cervical 6 who were participated in a study measuring the standing balance using an interactive balance system (IBS) before and after pelvic exercise. The index of standing balance after pelvic exercise was significantly lower than before exercise in patients with incomplete cervical cord injury. The greatest improvements were observed in incomplete cervical spinal cord injury with neurologic levels of cervical 3 and 4 with Brown-Sequard syndrome. These results suggest that the pelvic exercise for rehabilitation significantly improved in part standing balance in patients with incomplete cervical spinal cord injury.
文摘Objective: To systematically evaluate the effects of Pilates exercise on balance, walking and lower limbs motor function in stroke patients. Methods: The literature databases such as the Cochrane Library, EMbase, PubMed, Web of Science, Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), VIP Database for Chinese Technical Periodicals (VIP) and Wan Fang database (Wan Fang) were retrieved. Randomized controlled trials (RCTs) regarding the effects of Pilates exercise on balance, walking and lower limbs motor function of stroke patients were retrieved. Data were collected and evaluated independently by two researchers. Then, we adopted RevMan 5.3 software to perform a meta-analysis. Results: A total of 5 RCTs were included, including 182 subjects were chosen. The result showed that compared with the routine care group, Pilates exercise can effectively improve the balance of stroke patients when they have trained eight weeks [MD=4.71, 95%CI (2.14, 7.28), P=0.0003], shorten the time of the Timed Up and Go test (TUG)[MD=-1.63, 95%CI (-2.69,-0.56), P=0.003], increase the stride velocity [MD=3.83, 95%CI (1.43, 6.23), P=0.002]. However, the evidence did not support the effectiveness of Pilates exercise on increasing the score of Fugl-Meyer Assessment-Lower Extremity (FMA-LE) of stroke patients [MD=6.70, 95%CI (-3.46, 16.86), P=0.20]. Conclusion: The findings suggest that Pilates could improve the balance and walking speed of stroke patients. However, there still is the lack of the evidence in improving lower limb function. Due to the limitation of the quality of the included studies. highquality studies still should be conducted to investigate the effect of Pilates exercise in stroke patients.
文摘Objective: To study the effects of balance exercise training on chronic nerve injury, GLP-1 and inflammatory mediator secretion in patients with senile dementia. Methods: Patients with senile dementia who were treated in the Fourth People's Hospital of Ya'an between February 2015 and January 2018 were chosen as the research subjects and randomly divided into two groups, the experimental group received balance exercise training and the control group received routine intervention. The levels of chronic nerve injury indexes, GLP-1 and inflammatory cytokines in serum as well as the expression of inflammatory signaling molecules in peripheral blood were determined before and after intervention. Results:Compared with those of same group before intervention, serum Hcy, Aβ1-42, Tau, IL-1β, IL-18, TNF-α and IFN-γ levels as well as peripheral blood NLRP3, Caspase-1 and DOCK2 expression intensity of both groups were decreasing whereas serum SOD, PON1 and GLP-1 levels as well as peripheral blood PKA and CREB expression intensity were increasing after intervention, and serum Hcy, Aβ1-42, Tau, IL-1β, IL-18, TNF-α and IFN-γ levels as well as peripheral blood NLRP3, Caspase-1 and DOCK2 expression intensity of experimental group after intervention were lower than those of control group whereas serum SOD, PON1 and GLP-1 levels as well as peripheral blood PKA and CREB expression intensity were higher than those of control group. Conclusion: Balance exercise training can reduce the chronic nerve injury and regulate the secretion of GLP-1 and inflammatory mediators in patients with senile dementia.
基金supported by grants from the National Twelfth Five-Year Research Program of China(No.2012BAI12B02)the National Natural Science Foundation of China(No.81873701)the Two-hundred Talent Fund of Medical College of Shanghai Jiao Tong University(No.20191921).
文摘Objective To examine the effect of multisensory exercise on balance disorders.Methods PubMed,Scopus and Web of Science were searched to identify eligible studies published before January 1,2020.Eligible studies included randomized control trials(RCTs),non-randomized studies,case-control studies,and cohort studies.The methodological quality of the included studies was evaluated using JBI Critical Appraisal Checklists for RCTs and for Quasi-Experimental Studies by two researchers independently.A narrative synthesis of intervention characteristics and health-related outcomes was performed.Results A total of 11 non-randomized studies and 9 RCTs were eligible,including 667 participants.The results supported our assumption that multisensory exercise improved balance in people with balance disorders.All of the 20 studies were believed to be of high or moderate quality.Conclusion Our study confirmed that multisensory exercise was effective in improving balance in people with balance disorders.Multisensory exercises could lower the risk of fall and enhance confidence level to improve the quality of life.Further research is needed to investigate the optimal strategy of multisensory exercises and explore the underlying neural and molecular mechanisms of balance improvement brought by multisensory exercises.
基金supported by the Major Program of Shanghai Science Technical Committee,Shanghai(No. 08490512800)Shanghai Key Disciplinary Areas Ⅲof China(No.S30803)
文摘The purpose of the present study was to examine the effects of a 24-week Tai Chi exercise intervention on balance and other physical changes such as flexibility and reaction time(RT)among healthy older males.Methods:Thirty-eight male subjects aged 55-65 years without prior Tai Chi experience were recruited from a local community in Shanghai,China.A 60-min Tal Chi exercise session was performed three times a week for 24 weeks.Changes in RT,sit-and-reach flexibility and balance (static balance with eyes open and closed respectively)were measured before and after the Tal Chi intervention.Results:After the 24-week Tai Chi intervention,the choice RT(P < 0.05)decreased,and sit-and-reach flexibility improved (P < 0.01)over the pre-test(7.8 ±6.2 vs.7.1 ±3.0cm).Sway length,area,X-axis deviation amplitude and Y-axis deviation amplitude performance decreased significantly after the intervention with a double-foot stance with eyes open(P < 0.05).Sway length,area and average sway speed showed a statistically significant decrease after the intervention with the double-foot stance with eyes closed.In the single-footstance with eyes open condition,sway length and average swayspeed showed a statistically significant decrease(P<0.05).Conclusion:The 24-week Tai Chi exercise intervention had a positive influence on balance control in older males.Copyright(C)2012,Shanghai University of Sport.Production and hosting by Elsevier B.V.All rights reserved.
文摘Epigenetic changes have been shown to be associated with both aging process and aging-related diseases.There is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not elucidated.The purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult individuals.Participants(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andflexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 weeks.Balance(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the intervention.Blood sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor levels.Significant improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the intervention.In addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained unchanged.This study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult individuals.In addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation status.The Ethics Research Committee of Centro Universitário Metodista-IPA,Brazil approved the current study on June 6,2019(approval No.3.376.078).
文摘Background: This preliminary study examined the effects of an 8-week supervised reactive balance training program on reaction time (RT) and foot speed, static balance and balance confidence in healthy older adults compared to an exercise control group. Methods: Twenty-five older adults were randomly assigned to a reactive balance training group (QuickBoard; n = 12; 71.0 ± 8.6 years) or a stationary cycling group (control; n = 13; 70.2 ± 6.0 years). Both groups were tested for foot RT foot speed, static balance, and balance confidence at baseline, 4-week, 8-week, and 4-week follow-up. Results: Results indicated significant improvements in QuickBoard foot RT and speed in both groups with greater improvements in the QuickBoard group. However, no group difference was found in static balance performance. Conclusion: Although the improvements in RT and foot speed may be beneficial for fall and trip prevention, the implications of the current findings for trio avoidance and oerformance of daily tasks are unclear.
文摘Objective: The objective of this study was to verify the effects of two different training protocols based on Core Stability and Body Balance exercises in subjects with Parkinsons’s Disease. Methods: Eight elderly men with PD (age of 73 ± 9 years, weight 69 ± 16 kg, height 164 ± 13 cm, 2 ± 1 of Disability Score according to Hoehn and Yahr scale). The disability score was evaluated using Hoehn and Yahr scale. This study was 12-month-long organized in 3 blocks of 4 months each. The sample was divided in two groups formed by 4 subjects each group. During the first four months, one group performed core stability exercises (CSG) while the other group exercised itself through a Balance Exercises Program (BG). After this first part of the study both protocols were stopped for the following 4 months. Finally, the group were reversed (counter balance design) for the last 4 months of physical activity. The two groups were measured twice, before (T0) and after the treatment (T1). Both treatments were designed in order to investigate the improvement in core muscles performance in order to grant a better balance control and to reduce the risk of falling. Results: statistically significant variations were found in the flight time of Sit-to-Stand (p < 0.05, +27%) and in the step length (p < 0.05, ?3%). In the CSG group, statistically significant variations were detected in Speed of Steps (p < 0.05, +5%), Step Cadence (p < 0.05, +3%), and Left Stride Duration (p < 0.05, ?3%) (Table 1). Conclusion: Both Body Balance and Core training can be considered two good physical exercise methods for people with PD. This study highlights the positive effects of this training protocol on legs strength improvements and on the balance control while walking.
基金Charlotte Walter,DPT assisted in creation of the survey used in this study.
文摘This quasi-experimental study compared the results of a traditional model of physical therapy(PT)care to a PT wellness model known as GroupHab.The traditional model included discharge from PT with a home exercise program(HEP)to be self-administered with or without the addition of a community-based exercise program.The wellness model included participation in a PT-designed and supervised group exercise program(GroupHab class)in an outpatient clinical setting following discharge from PT.Independent t-tests were used to compare the number of falls,exercise frequency,and exercise duration between the two groups.A repeated measures,analysis of variance(RM-ANOVA)compared changes in balance confidence scores both within and between groups,and a multivariate analysis of variance(MANOVA)analyzed group differences across multiple quality of life ratings using the SF-20.All data were analyzed at the 0.05 alpha level using SPSS 24 statistical software.Our results showed a significantly greater reduction in recurrent falls among the GroupHab wellness group compared to the HEP group(t=2.811,p=0.009).The resulting odds ratio for subsequent falls was 2.2 among HEP participants and 0.2 among GroupHab participants.Exercise adherence was also greater for those who participated in the GroupHab class.They documented greater exercise frequency(t=-3.253,p=0.002)and more exercise minutes(t=-7.188,p<0.001)than those who participated in the HEP.When comparing changes in the participants’balance confidence,we found an average increase of 5%among GroupHab participants compared to a 6%decrease among HEP participants(F=16.877,p<0.001,power=0.981).Although our multivariate analysis of the SF-20 scores revealed no significant difference overall(F=0.768,p=0.73),the univariate analyses showed significantly greater improvements among GroupHab participants in selected areas of physical function.These results suggest that at-risk older adults who are discharged into a functionally-based group exercise class are less likely to experience recurrent falls and are more likely to have more confidence in their balance than those who are discharged with a standard HEP and/or use of community-based exercise classes.
基金funded by the Director Technology Development,Department of Defence,South Africa
文摘Background: It remains unclear if ad libitum water drinking, as a hydration strategy, prevents exercise-associated hyponatremia(EAH) during prolonged exercise. The aim of this study was to determine the incidence of EAH within the broader context of fluid regulation among soldiers performing a 40-km route-march ingesting water ad libitum.Methods: Twenty-eight healthy male soldiers participated in this observational trial. Pre-and post-exercise body mass, blood and urine samples were collected. Blood samples were assessed for serum sodium([Na+]), glucose, creatinine, urea nitrogen(BUN), plasma osmolality, creatine kinase(CK), and plasma arginine vasopressin(AVP) concentrations. Plasma volume(PV) was calculated using hematocrit and hemoglobin. Urine samples were analyzed for osmolality and (Na+)Water intake was assessed by weighing bottles before, during and after the march. The mean relative humidity was 55.7%(21.9–94.3%) and the mean dry bulb temperature was 27.1°C(19.5°C-37.0°C) during the exercise.Results: Twenty-five soldiers(72±10 kg)(Mean±SD) completed the march in 09:11±00:43(hr:min). Participants consumed 736±259 ml/h of water and lost 2.8±0.9 kg(4.0%±1.4%, P<0.05) of body mass. Significant(pre-march vs. post-march;P<0.05) decreases in serum [Na+](141 mmol/L vs. 136 mmol/L), plasma osmolality(303 m Osmol/kg H2O vs. 298 m Osmol/kg H2O), and serum creatinine(111 μmol/L vs. 101 μmol/L) and urine [Na+](168 mmol/L vs. 142 mmol/L), as well as significant increases in plasma AVP(2 pg/ml vs. 11 pg/ml), plasma CK(1423 U/L vs. 3894 U/L) and urine osmolality(1035 m Osmol/kg H2O vs. 1097 m Osmol/kg H2O) were found. The soldier(72 kg) with the lowest postexercise sodium level completed the march in 08:38. He drank 800 ml/h, lost 2% body mass, and demonstrated(prepost) increases in plasma osmolality(294–314 m Osmol/kg H2O), BUN(20–30 mg/dl), AVP(2–16 pg/ml) and PV(41%). His urine osmolality decreased from 1114 m Osmol/kg H2O to 1110 m Osmol/kg H2O. No participants finished the route-march with a serum [Na+] indicating hypernatremia(range, 134–143 mmol/L).Conclusions: Ad libitum drinking resulted in 4% body mass loss with a 2 mmol/L serum [Na+] reduction in conjunction with high urine osmolality(>1000 m Osmol/kg H2O) and plasma AVP. No single hydration strategy likely prevents EAH, but hypernatremia(cellular dehydration) was not seen despite >2% body mass losses and high urine osmolality.
文摘目的探讨健康操结合认知任务训练在帕金森合并轻度认知障碍(Parkinson's disease with mild cognitive impairment,PD-MCI)患者中的应用效果。方法选取南通市第四人民医院2021年9月—2023年3月收治的PD-MCI患者90例,依照随机分配原则分为2组,各45例。对照组采取常规健康教育及常规训练,观察组在上述基础上采取健康操结合认知任务训练,为期6个月。对比2组干预前后认知功能[蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)、简易精神状态检查量表(mini-mental state examination,MMSE)评分]、跌倒风险[修订版跌倒效能量表(modified fall efficacy scale,MFES)评分]、运动功能[帕金森综合评分量表3(unified Parkinson's disease rating scale-Ⅲ,UPDRS-Ⅲ)评分]、平衡能力[起立-行走测试(timed up and go test,TUG)]。结果干预后,观察组MoCA、MMSE评分分别为(23.81±2.30)分、(23.59±1.80)分,较干预前升高,且高于对照组的(20.13±2.55)分、(20.78±2.32)分(P<0.05)。干预后,2组MFES评分较干预前升高,观察组为(7.34±0.59)分,高于对照组的(6.42±0.77)分(P<0.05);2组UPDRS-Ⅲ评分较干预前下降,观察组为(16.52±2.21)分,低于对照组的(18.15±2.04)分(P<0.05)。干预后,2组单任务TUG、双任务TUG时间均较干预前缩短,观察组为(11.44±0.70)s、(18.39±1.44)s,短于对照组的(13.54±1.26)s、(21.26±1.53)s(P<0.05)。结论健康操结合认知任务训练在PD-MCI患者中应用效果良好,能改善患者认知功能和运动功能,提高平衡能力,降低跌倒风险。