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利用CRISPR/Cas9技术构建FARS2基因定点突变的大鼠模型 被引量:1
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作者 李晨浩 车凤玉 +4 位作者 王国霞 杨行 李辉 张勇 杨颖 《神经解剖学杂志》 CAS CSCD 北大核心 2018年第6期737-741,共5页
目的:利用CRISPR/Cas9技术构建FARS2基因特定位点突变的大鼠模型。方法:根据FARS2基因序列,设计FARS2基因特异性的单链向导RNA(sgRNA)引物序列并克隆入pU57-T7-GDNA载体。利用T7RNA聚合酶体外转录sgRNA和Cas9mRNA。将体外转录的sgRNA/Ca... 目的:利用CRISPR/Cas9技术构建FARS2基因特定位点突变的大鼠模型。方法:根据FARS2基因序列,设计FARS2基因特异性的单链向导RNA(sgRNA)引物序列并克隆入pU57-T7-GDNA载体。利用T7RNA聚合酶体外转录sgRNA和Cas9mRNA。将体外转录的sgRNA/Cas9mRNA显微注射入SD大鼠受精卵,通过PCR和基因测序对FARS2基因特定位点突变进行检测和鉴定。繁育FARS2基因敲除大鼠并分析后代突变情况。结果:基因测序证实成功构建表达sgRNA载体,成功将sgRNA和Cas9mRNA直接注射入大鼠受精卵。基因测序鉴定获得5只F0代初建鼠。DNA测序结果证实5号大鼠(ID#5)发生了gac>tac突变,该突变并可遗传至子代大鼠。结论:利用CRISPR/Cas9技术成功制备FARS2基因定点突变的大鼠模型,为进一步研究FARS2的功能奠定了基础。 展开更多
关键词 CRISPR/Cas9 fars2 sgRNA 遗传性痉挛性截瘫 基因敲除大鼠
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Sedimentary Environments and Correlative Sequence Stratigraphy of Upper Cretaceous—Paleogene Succession in Shiraz Area, Fars, SW IRAN 被引量:2
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作者 Mirzaee Mahmoodabadi Reza 《Open Journal of Geology》 2014年第1期1-17,共17页
Sequence stratigraphic evidences have been used in this research to investigate the stratigraphic correlation of cretaceous paleogene succession in Shiraz area, Fars, SW Iran. For this purpose, 4 stratigraphic section... Sequence stratigraphic evidences have been used in this research to investigate the stratigraphic correlation of cretaceous paleogene succession in Shiraz area, Fars, SW Iran. For this purpose, 4 stratigraphic sections have been chosen and provided. According to petrographic study and field evidences, 4 depositional sequences were identified including the Tarbur, Sachun and Jahrum formations in the east and the Gurpi, Pabadeh and Asmari formations in the west of study area. After identifying the boundaries and systems tract facies, it has been found that the mentioned formations have been deposited among the continuous/discontinuous boundaries in an equivalent manner. In this case, the purple shale (between the Gurpi and Pabdeh formations) could be considered equivalent to the upper part of the Sachun formation. From the point of Paleogeography, the plat-form sedimentary environment covered almost the whole area during the Oligo-Miocene age, so that the Asmari formation would have been deposited, which is marked by sharp contact as disconformity on Jahrum formation in the east of the basin and with continuous contact (C.C) on the Pabdeh formation in the west and southwest. 展开更多
关键词 Iran fars SHIRAZ Sedimentary Environment Sequence STRATIGRAPHY Cretaceous-Tertiary Boundary
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Does prospective permutation scan statistics work well with cutaneous leishmaniais as a high-frequency or malaria as a low-frequency infection in Fars province, Iran?
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作者 Abbas Rezaianzadeh Marjan Zare +3 位作者 Hamidreza Tabatabaee Mohsen Ali-Akbarpour Hossain Faramarzi Mostafa Ebrahimi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2018年第10期478-484,共7页
Objective: To determine whether permutation scan statistics was more efficient in finding prospective spatial-temporal outbreaks for cutaneous leishmaniasis(CL) or for malaria in Fars province, Iran in 2016. Methods: ... Objective: To determine whether permutation scan statistics was more efficient in finding prospective spatial-temporal outbreaks for cutaneous leishmaniasis(CL) or for malaria in Fars province, Iran in 2016. Methods: Using time-series data including 29 177 CL cases recorded during 2010-2015 and 357 malaria cases recorded during 2010-2015, CL and malaria cases were predicted in 2016. Predicted cases were used to verify if they followed uniform distribution over time and space using space-time analysis. To testify the uniformity of distributions, permutation scan statistics was applied prospectively to detect statistically significant and non-significant outbreaks. Finally, the findings were compared to determine whether permutation scan statistics worked better for CL or for malaria in the area. Prospective permutation scan modeling was performed using SatScan software. Results: A total of 5 359 CL and 23 malaria cases were predicted in 2016 using time-series models. Applied timeseries models were well-fitted regarding auto correlation function, partial auto correlation function sample/model, and residual analysis criteria(Pv was set to 0.1). The results indicated two significant prospective spatial-temporal outbreaks for CL(P<0.5) including Most Likely Clusters, and one non-significant outbreak for malaria(P>0.5) in the area. Conclusions: Both CL and malaria follow a space-time trend in the area, but prospective permutation scan modeling works better for detecting CL spatial-temporal outbreaks. It is not far away from expectation since clusters are defined as accumulation of cases in specified times and places. Although this method seems to work better with finding the outbreaks of a high-frequency disease; i.e., CL, it is able to find non-significant outbreaks. This is clinically important for both high-and low-frequency infections; i.e., CL and malaria. 展开更多
关键词 CUTANEOUS leishmaniais MALARIA PROSPECTIVE PERMUTATION scan statistics fars PROVINCE Iran
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Determining endemic values of cutaneous leishmaniasis in Iranian Fars province by retrospectively detected clusters and receiver operating characteristic curve analysis
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作者 Marjan Zare Abbas Rezaianzadeh +3 位作者 Hamidreza Tabatabaee Hossain Faramarzi Mohsen Aliakbarpour Mostafa Ebrahimi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2019年第9期359-364,共6页
Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and... Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and the endemic values of cutaneous leishmaniasis were determined by retrospective clusters derived from spatiotemporal permutation modeling on a time-series design. The accuracy of the values was assessed using receiver operating characteristic(ROC) curve. SPSS version 22, Arc GIS, and ITSM 2002 software tools were used for analysis. Results: Nine statistically significant retrospective clusters(P<0.05) resulted in finding seven significant and accurate endemic values(P<0.1). These valid endemic scores were generalized to the other 18 cities based on 6 different climates in the province. Conclusions: Retrospectively detected clusters with the help of ROC curve analysis could help determine cutaneous leishmaniasis endemic values which are essential for future prediction and prevention policies in the area. 展开更多
关键词 Cutaneous LEISHMANIASIS Retrospective CLUSTERS Receiver operating characteristic curve ENDEMIC VALUES fars PROVINCE
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Application of Statistical Methods to Biomarkers for Geochemical Evaluation and Genetic Type Determination of Gas Condensates in the Persian Gulf and Coastal Fars,Southern Iran
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作者 Mohammad Javad SEIDY Mohammad Hossein SABERI 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第4期1246-1256,共11页
In a comprehensive geochemical study,the genetic relationships among 14 samples of gas condensates from the Persian Gulf were investigated for the purpose of evaluating the respective source rocks in terms of both age... In a comprehensive geochemical study,the genetic relationships among 14 samples of gas condensates from the Persian Gulf were investigated for the purpose of evaluating the respective source rocks in terms of both age and sedimentary paleoenvironment.Chemometric analysis was used for categorization and determination of a certitude range to determine the genetic type of the condensate families in the studied basin.The samples were collected from Late Permian-Triassic reservoirs(Dalan and Kangan formations)located in 6 gasfields(gas condensate)hosting some of Iran’s most important gas/gas condensate reserves.Obtained by gas chromatography-mass spectrometry(GC-MS),a total of 16 biomarker parameters(10 maturity-related parameters and 6 sedimentary environment-related parameters)were used to evaluate the samples in terms of thermal maturity(and hence their positions in the maturity chart),the sedimentary environment of the source rock and the lithology.Application of Hierarchical Clustering Analysis(HCA)and Principal Component Analysis(PCA)to the collected data led to the categorization of the samples into three main genetic groups,Ⅰ-Ⅲ.GroupsⅠandⅢwere found to be located in the east and the west of the Persian Gulf,respectively,while GroupⅡwas developed between the two other groups. 展开更多
关键词 gas condensate satistical methods genetic linkage thermal maturation Persian Gulf Coastal fars
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Evaluation of Hydrocarbon Potential in the Jahrom Area, Interior Fars, Zagros
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作者 Mehdi Hosseinpour Zahra Maleki Mohsen Aleali 《Open Journal of Geology》 2017年第3期429-442,共14页
The study area is located in the Fars area (Interior Fars sub-basin). This area, which is part of the Zagros fold-thrust belt, is located in Zagros simple folded sub zone. It is known as one of the most important regi... The study area is located in the Fars area (Interior Fars sub-basin). This area, which is part of the Zagros fold-thrust belt, is located in Zagros simple folded sub zone. It is known as one of the most important regions in the world Gas rich. In this area, anticlinal folds are a different orientation of such as the North Western-South Eastern, East-West and North Eastern-South Western. The Karbasi and Khaftar anticlines are case study anticlines in the interior Fars sub-basin (Fassa area). The anticlines in the Fars region, which are located in the Zagros fold-thrust belt, are valuable because they possess several hydrocarbons. The main aim of this paper is evaluation of hydrocarbon potential in the Jahrom area (Interior Fars) based on interpretation of the Isopach maps and well data. This paper presents part of the results of a regional study of the Coastal Fars area in the Zagros Simply folded belt, based on original fieldwork, satellite images, structural sections, geological maps and well data. In order to investigate of periods Nezamabad fault activity, Isopach maps of the study area has been prepared based on well drilling data and the thickness of the drilled formations. In this study utilizes the thickness of the drilled formations in the study area, for each sedimentary unit was carried out to prepare Isopach maps. The Isopach map prepared based on GIS software method and exploration well data. The Nezamabad fault has been lacked of activity at the deposition time of the Dalan, Kangan, Dashtak, Fahliyan, Gadvan, Dariyan, Kazhdomi, Sarvak, Gurpi and Pabdeh formations within the Khaftar and Karbasi anticline area. Accordingly, changes in basin floor, at the time of sedimentation these formations has not been affected by the Nezamabad fault. Probably the Nezamabad fault has been activated during deposition of the Surmeh, Hith, Laffan and Ilam formations and in this area paleo-basin has been controlled by this fault. In other words, it seems that, activity of the Nezamabad fault in this area have been limited to Jurassic and Cretaceous periods (Coniacian and Senomanian). This can means that in this periods time, the Nezamabad fault have been active sedimentation along with tectonic processes and activities affected on thickness of the Surmeh, Hith, Laffan and Ilam formations. Finally, it seems that the Nezamabad Fault activity has been affected on the source rock, reservoir rock and cap rock and then controlled distributing of hydrocarbon System of the study area in the Khaftar and Karbasi as anticlinal oil traps. 展开更多
关键词 HYDROCARBON POTENTIAL Jahrom Area Nezamabad FAULT INTERIOR fars ZAGROS
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指纹自动识别系统(FARS)简介
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作者 阎振宇 《刑事技术》 1990年第5期49-,共1页
指纹自动识别系统(FARS)是公安部重点指令性课题,由公安部第二研究所承担并完成。FARS为自动与半自动(MFRS)相结合的系统,采用公安部第二研究所独创的指纹'特征图'识别方法。'特征图'以指纹细节特征作为原始数据,系统... 指纹自动识别系统(FARS)是公安部重点指令性课题,由公安部第二研究所承担并完成。FARS为自动与半自动(MFRS)相结合的系统,采用公安部第二研究所独创的指纹'特征图'识别方法。'特征图'以指纹细节特征作为原始数据,系统通过摄像。 展开更多
关键词 fars 指纹细节特征 特征图 识别方法 图像处理 特征点 侦察破案 证据作用 模块化结构设计 自动抽取
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基于全基因组水平的花生FAR1转录因子家族分析
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作者 赵小波 李春娟 +6 位作者 孙全喜 王奇 牟艺菲 王娟 苑翠玲 姜常松 单世华 《花生学报》 北大核心 2024年第2期1-9,共9页
FAR1是一类起源于转座子酶的转录因子,在光敏色素A(phyA)信号通路的启动中起到非常重要的作用。基于全基因组水平对其家族分析,可为深入研究FAR1基因在花生生长发育、逆境胁迫响应中的分子调控机理提供依据。本研究在花生基因组中共鉴定... FAR1是一类起源于转座子酶的转录因子,在光敏色素A(phyA)信号通路的启动中起到非常重要的作用。基于全基因组水平对其家族分析,可为深入研究FAR1基因在花生生长发育、逆境胁迫响应中的分子调控机理提供依据。本研究在花生基因组中共鉴定出60个FAR1基因,该转录因子家族成员分成3个亚组,Ⅰ、Ⅱ、Ⅲ亚组中分别包含了21、20和19个花生FAR1蛋白。65%直系同源基因的Ka/Ks值小于0.5,这些基因结构稳定、较为保守,经历了较强的负选择作用。转录组数据分析发现,大部分FAR1基因在花生叶片中表达。本研究结果有助于了解花生FAR1基因家族的进化与功能,为下一步深入研究该基因家族的功能提供依据。 展开更多
关键词 花生 FAR1转录因子 生物信息学
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一例FARS2基因变异所致联合氧化磷酸化缺陷14型患儿的遗传学分析
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作者 马健 张洪伟 +4 位作者 律玉强 高敏 王东 盖中涛 刘毅 《中华医学遗传学杂志》 CAS CSCD 2022年第12期1393-1397,共5页
目的:探讨一例表现为无诱因惊厥发作、生长发育迟缓、血乳酸值升高的2月龄患儿的遗传学病因。方法:应用二代测序技术对患儿进行全外显子组和线粒体环基因测序,用Sanger测序对候选致病变异进行验证,依据美国医学遗传学及基因组学学会相... 目的:探讨一例表现为无诱因惊厥发作、生长发育迟缓、血乳酸值升高的2月龄患儿的遗传学病因。方法:应用二代测序技术对患儿进行全外显子组和线粒体环基因测序,用Sanger测序对候选致病变异进行验证,依据美国医学遗传学及基因组学学会相关指南进行致病性分析。检索PubMed、万方数据库和中国知网数据库中FARS2变异所致的联合氧化磷酸化缺乏症14型(COXPD14)的病例报道,总结其临床特征及基因变异谱。结果:全外显子组测序提示患儿携带FARS2基因c.925G>A(p.G309S)和c.405C>A(p.H135Q)复合杂合变异;Sanger测序证实这两个变异分别遗传自母亲和父亲。其中c.925G>A为HGMD数据库已收录的致病变异,c.405C>A预测为疑似致病变异。检索文献另发现30例COXPD14患者,其FARS2变异类型包括错义变异、剪接变异、读码框内碱基缺失和编码区微缺失。结论:COXPD14临床表现以发育迟缓(96%)、癫痫发作(97%)和乳酸升高(96%)最为经典。FARS2基因c.925G>A(p.G309S)和c.405C>A(p.H135Q)复合杂合变异是本例患儿的发病原因。 展开更多
关键词 联合氧化磷酸化缺乏症14型 fars2基因 全外显子组测序
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FAR模型下国产电影字幕人机英译对比研究——以《流浪地球2》的字幕翻译为例
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作者 冯瑞贞 李若凡 《海外英语》 2024年第16期4-9,共6页
国产电影字幕的翻译对讲好中国故事,弘扬中国文化,增强民族凝聚力和文化自信起着十分重要的作用。作为一部在海外获得口碑与票房“双丰收”的科幻大片,《流浪地球2》为文化产业及国家形象“走出去”提供了借鉴和参考。本研究以瑞典学者J... 国产电影字幕的翻译对讲好中国故事,弘扬中国文化,增强民族凝聚力和文化自信起着十分重要的作用。作为一部在海外获得口碑与票房“双丰收”的科幻大片,《流浪地球2》为文化产业及国家形象“走出去”提供了借鉴和参考。本研究以瑞典学者Jan Pederson提出的FAR字幕翻译质量评估模型为研究框架,比较国产电影《流浪地球2》中字幕英译的三个不同版本:人工翻译、神经网络机器翻译和生成式AI翻译,分析不同版本的翻译质量及其局限性,对比不同翻译方法对电影情节架构、人物角色塑造产生的影响和效果;探究不同翻译方式对于文化差异、语言习惯等因素的适应性。基于实际应用需求,提出相应的优化策略和建议,为汉译英字幕翻译实践和研究以及FAR模型的实际操作提供参考,为提升国产电影字幕翻译的质量和效率提供借鉴,从而推动国产电影字幕翻译多元化,促进国产电影在国际市场上进一步推广和传播。 展开更多
关键词 FAR模型 人机翻译 电影字幕翻译 《流浪地球2》
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运用FARS模型对语篇修辞结构的实证分析
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作者 尤丽萍 《雪莲》 2015年第6X期119-121,共3页
本文简要介绍"语篇关系结构分析框架理论"(the Framework for the Analysis of the Relational Structure of Texts,FARS)的7种修辞结构关系类型,并运用该模型对2段语篇进行分析。比较了两段语篇修辞关系运用的特点,发现语篇... 本文简要介绍"语篇关系结构分析框架理论"(the Framework for the Analysis of the Relational Structure of Texts,FARS)的7种修辞结构关系类型,并运用该模型对2段语篇进行分析。比较了两段语篇修辞关系运用的特点,发现语篇一修辞手法运用灵活多样;而语篇二中部分修辞关系重复出现,过度使用某些直观形式标记。 展开更多
关键词 fars模型 修辞结构 关系
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Background removal from global auroral images:Data-driven dayglow modeling 被引量:1
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作者 A.Ohma M.Madelaire +4 位作者 K.M.Laundal J.P.Reistad S.M.Hatch S.Gasparini S.J.Walker 《Earth and Planetary Physics》 EI CSCD 2024年第1期247-257,共11页
Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but... Global images of auroras obtained by cameras on spacecraft are a key tool for studying the near-Earth environment.However,the cameras are sensitive not only to auroral emissions produced by precipitating particles,but also to dayglow emissions produced by photoelectrons induced by sunlight.Nightglow emissions and scattered sunlight can contribute to the background signal.To fully utilize such images in space science,background contamination must be removed to isolate the auroral signal.Here we outline a data-driven approach to modeling the background intensity in multiple images by formulating linear inverse problems based on B-splines and spherical harmonics.The approach is robust,flexible,and iteratively deselects outliers,such as auroral emissions.The final model is smooth across the terminator and accounts for slow temporal variations and large-scale asymmetries in the dayglow.We demonstrate the model by using the three far ultraviolet cameras on the Imager for Magnetopause-to-Aurora Global Exploration(IMAGE)mission.The method can be applied to historical missions and is relevant for upcoming missions,such as the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission. 展开更多
关键词 AURORA dayglow modeling global auroral images far ultraviolet images dayglow removal
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FAR3d程序对EAST上阿尔芬不稳定性识别过程中的应用
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作者 王曦辉 黄娟 +5 位作者 赵海林 JVarela 付静 孙延旭 史唱 王书松 《原子能科学技术》 EI CSCD 北大核心 2024年第1期14-22,共9页
为更好理解EAST实验中的等离子体不稳定性现象,文章从实验和模拟两个角度,对EAST中高βN放电区间的阿尔芬不稳定性现象进行了分析。在实验上,本文使用高频磁探针和电子回旋辐射诊断对不稳定性的频率、位置、环向模数进行判断。在模拟上... 为更好理解EAST实验中的等离子体不稳定性现象,文章从实验和模拟两个角度,对EAST中高βN放电区间的阿尔芬不稳定性现象进行了分析。在实验上,本文使用高频磁探针和电子回旋辐射诊断对不稳定性的频率、位置、环向模数进行判断。在模拟上首次应用了FAR3d程序,识别了在ρ=0.45、频率为87 kHz的主导模式TAE(toroidicity-induced Alfven eigenmode),以及ρ=0.55、频率为62 kHz的次主导模式EPM(energetic particle mode),环向模数均为2,与实验中的测量结果对比在误差范围内基本一致,自洽地识别了不稳定性的类型并且得到了位置与频率信息。在此基础上,对有限拉莫轨道(finite Larmor radius, FLR)效应进行评估。模拟结果显示,在EAST高βN放电区间,FLR效应对识别低环向模数n的不稳定性模式的影响较小。在该放电的模式的识别过程中可关闭FLR以加速计算。FAR3d程序高效的计算能力和精准的模拟结果,可为后续EAST的实验提供指导。 展开更多
关键词 FAR3d 阿尔芬本征模 EAST 快离子
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术前外周血SII、NLR、PLR、FAR、MLR及CA125在卵巢透明细胞癌诊断中的临床价值分析
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作者 张雯丽 宋文静 +2 位作者 贺艺璇 王丽杉 陈爱平 《临床医学进展》 2024年第2期4650-4655,共6页
目的:探讨术前外周血系统性免疫炎症指数(SII)、中性粒细胞–淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、纤维蛋白原–白蛋白比值(FAR)、单核细胞–淋巴细胞比值(MLR)及血清糖类抗原125(CA125)在卵巢良性肿瘤及卵巢透明细胞癌(OCCC... 目的:探讨术前外周血系统性免疫炎症指数(SII)、中性粒细胞–淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、纤维蛋白原–白蛋白比值(FAR)、单核细胞–淋巴细胞比值(MLR)及血清糖类抗原125(CA125)在卵巢良性肿瘤及卵巢透明细胞癌(OCCC)中的差异,分析其诊断价值。方法:选取青岛大学附属医院2014年1月~2023年9月收治的114例卵巢透明细胞癌(卵巢透明细胞癌组)和119例卵巢良性肿瘤(卵巢良性肿瘤组)患者的临床资料进行回顾性分析。检测术前外周血中SII、NLR、PLR、FAR、MLR及CA125水平,对每组病例所对应的SII、NLR、PLR、FAR、MLR及CA125进行对比分析,运用受试者工作特征(ROC)曲线分析SII、NLR、PLR、FAR、MLR及CA125在卵巢透明细胞癌中诊断价值。结果:OCCC组术前外周血SII、NLR、PLR、MLR及CA125水平高于卵巢良性肿瘤组,FAR水平低于卵巢良性肿瘤组,差异有统计学意义。SII、NLR、PLR、FAR、MLR及CA125的ROC曲线下面积(AUC)分别为0.729、0.720、0.708、0.869、0.719、0.696。结论:术前外周血SII、NLR、PLR、FAR、MLR可作为辅助临床评估与诊断OCCC的指标。 展开更多
关键词 卵巢透明细胞癌 SII NLR PLR FAR MLR及CA125
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纤维蛋白原与白蛋白比值在妇科恶性肿瘤中的研究进展
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作者 傅俊杰 金玉杰 彭存旭 《中文科技期刊数据库(引文版)医药卫生》 2024年第3期0008-0012,共5页
妇科恶性肿瘤的发病率高,病因复杂,复发率也较高,对患者的身体和心理均造成严重影响。如何及时准确的评估疾病的预后,给予针对性的干预措施显得尤为重要。近年来,许多研究均表明炎症、营养状况与癌症的预后有关。纤维蛋白原与白蛋白比值... 妇科恶性肿瘤的发病率高,病因复杂,复发率也较高,对患者的身体和心理均造成严重影响。如何及时准确的评估疾病的预后,给予针对性的干预措施显得尤为重要。近年来,许多研究均表明炎症、营养状况与癌症的预后有关。纤维蛋白原与白蛋白比值( fibrinogen to albumin ratio,FAR)较单一指标能更好的反映患者的炎症和营养状态,被用于多种疾病的预后评估。FAR是新发现的一种炎症指标,检测便利,成本低廉,可以为临床预后判断提供更多的参考。本文就FAR在妇科恶性肿瘤领域的研究进展予以综述。 展开更多
关键词 纤维蛋白原 白蛋白 FAR 妇科恶行肿瘤
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Far and Near Optimization:A New Simple and Effective Metaphor-LessOptimization Algorithm for Solving Engineering Applications
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作者 Tareq Hamadneh Khalid Kaabneh +3 位作者 Omar Alssayed Kei Eguchi Zeinab Monrazeri Mohammad Dehghani 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第11期1725-1808,共84页
In this article,a novel metaheuristic technique named Far and Near Optimization(FNO)is introduced,offeringversatile applications across various scientific domains for optimization tasks.The core concept behind FNO lie... In this article,a novel metaheuristic technique named Far and Near Optimization(FNO)is introduced,offeringversatile applications across various scientific domains for optimization tasks.The core concept behind FNO lies inintegrating global and local search methodologies to update the algorithm population within the problem-solvingspace based on moving each member to the farthest and nearest member to itself.The paper delineates the theoryof FNO,presenting a mathematical model in two phases:(i)exploration based on the simulation of the movementof a population member towards the farthest member from itself and(ii)exploitation based on simulating themovement of a population member towards the nearest member from itself.FNO’s efficacy in tackling optimizationchallenges is assessed through its handling of the CEC 2017 test suite across problem dimensions of 10,30,50,and 100,as well as to address CEC 2020.The optimization results underscore FNO’s adeptness in exploration,exploitation,and maintaining a balance between them throughout the search process to yield viable solutions.Comparative analysis against twelve established metaheuristic algorithms reveals FNO’s superior performance.Simulation findings indicate FNO’s outperformance of competitor algorithms,securing the top rank as the mosteffective optimizer across a majority of benchmark functions.Moreover,the outcomes derived by employing FNOon twenty-two constrained optimization challenges from the CEC 2011 test suite,alongside four engineering designdilemmas,showcase the effectiveness of the suggested method in tackling real-world scenarios. 展开更多
关键词 OPTIMIZATION stochastic method FAR NEAR metaheuristic algorithm exploration EXPLOITATION
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A nonlinear wake model of a wind turbine considering the yaw wake steering
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作者 Yunzhou LI Zhiteng GAO +2 位作者 Shoutu LI Suiping QI Xiaoyu TANG 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第3期715-727,共13页
Duo to fluctuations in atmospheric turbulence and yaw control strategies,wind turbines are often in a yaw state.To predict the far wake velocity field of wind turbines quickly and accurately,a wake velocity model was ... Duo to fluctuations in atmospheric turbulence and yaw control strategies,wind turbines are often in a yaw state.To predict the far wake velocity field of wind turbines quickly and accurately,a wake velocity model was derived based on the method of momentum conservation considering the wake steering of the wind turbine under yaw conditions.To consider the shear effect of the vertical incoming wind direction,a two-dimensional Gaussian distribution function was introduced to model the velocity loss at different axial positions in the far wake region based on the assumption of nonlinear wake expansion.This work also developed a“prediction-correction”method to solve the wake velocity field,and the accuracy of the model results was verified in wake experiments on the Garrad Hassan wind turbine.Moreover,a 33-kW two-blade horizontal axis wind turbine was simulated using this method,and the results were compared with the classical wake model under the same parameters and the computational fluid dynamics(CFD)simulation results.The results show that the nonlinear wake model well reflected the influence of incoming flow shear and yaw wake steering in the wake velocity field.Finally,computation of the wake flow for the Horns Rev offshore wind farm with 80 wind turbines showed an error within 8%compared to the experimental values.The established wake model is less computationally intensive than other methods,has a faster calculation speed,and can be used for engineering calculations of the wake velocity in the far wakefield of wind turbines. 展开更多
关键词 far wake wake model wake steering wind shear wind farm
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基于PNI-SII-FAR的局部晚期结肠癌复发风险预测模型的构建和验证
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作者 崔俊杰 庄梦婷 +3 位作者 李帅 李雨秋 崔永征 宋军 《齐齐哈尔医学院学报》 2024年第12期1120-1126,共7页
目的旨在探讨预后营养指数(PNI),系统免疫炎症指数(SII)及纤维蛋白原与白蛋白比值(FAR)对局部晚期结肠癌患者术后化疗后复发的影响,以及建立和验证预后预测模型。方法回顾性分析2016年10月—2020年9月就诊于本院的162例局部晚期结肠癌... 目的旨在探讨预后营养指数(PNI),系统免疫炎症指数(SII)及纤维蛋白原与白蛋白比值(FAR)对局部晚期结肠癌患者术后化疗后复发的影响,以及建立和验证预后预测模型。方法回顾性分析2016年10月—2020年9月就诊于本院的162例局部晚期结肠癌患者的相关数据。根据7︰3比例,将全部样本随机划分为训练组(114例)和测试组(48例)两组。在训练组内实施单因素及多因素的回归分析,筛选出3年内复发的独立危险因素,然后创建列线图预测模型,最后在训练组和测试组中使用校准曲线和临床决策曲线验证模型的预测能力。结果在162例患者中,有67例通过组织学或影像学检查证实3年内复发,复发比例为41.35%。单因素和多因素分析的结果表明,预后营养指数(PNI)≤48.6、全身免疫炎症指数(SII)>418.459、纤维蛋白原与白蛋白比值(FAR)>0.091、以及低分化和N分期为局部晚期结肠癌患者术后化疗后3年内复发的独立危险因素(P<0.05)。根据上述风险因素构建列线图预测模型,校准曲线显示预测结果与实际情况表现出良好的一致性,临床决策曲线分析结果显示该预测模型临床应用价值较高。结论PNI、SII和FAR是局部晚期结肠癌术后化疗后3年内复发的重要预测因素。基于PNI-SII-FAR构建的列线图预测模型,有助于临床医生综合评估患者预后并制定个体化诊疗方案。 展开更多
关键词 PNI SII FAR 局部晚期结肠癌 复发预测模型
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Clinical and Evolutive Aspects of Severe Acute Malnutrition in Children Aged 0 - 59 Months at Maroua Regional Hospital in Cameroon’s Far North Region
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作者 Palma Haoua Abouame Selangai Hélène Kamo +7 位作者 Sime Tchouamo Arielle Annick Fernando Kemta Lepka Daniel Nemsi Sadjo Salihou Aminou Haman Soureya Yolande Feudjo Ulrich Dama Félicitée Nguefack 《Open Journal of Pediatrics》 2024年第4期700-711,共12页
Introduction: Severe acute malnutrition remains one of the most important causes of under-five mortality. In Cameroon, the northern regions have the highest prevalence, with 1.4% in the Far North in 2021. These childr... Introduction: Severe acute malnutrition remains one of the most important causes of under-five mortality. In Cameroon, the northern regions have the highest prevalence, with 1.4% in the Far North in 2021. These children are managed at the Internal therapeutic and Nutrional Centre, one of which is located at Maroua Regional Hospital, the third level referral Hospital. We therefore proposed to carry out a study on the clinical and evolutive aspects of these children. Materials and Methods: it was a descriptive, cross-sectional study from January 2020 to December 2022, at the ITNC (CNTI) of Maroua Regional Hospital. The sample size was obtained from the Lorentz formula. Patient records were used for data collection. We excluded all incomplete records and patients with less than 24 hours of admission. Results: Out of the 873 patients we recruited, the prevalence of severe malnutrition was estimated at 18 %. The average age was 14 months, with a male predominance. The main reasons for consultation were fever (42%) and diarrhoea (35%). Marasmus was the predominant clinical form. The major medical complications were sepsis (32.9%) and malaria (16.8%). HIV prevalence was 2.5% and tuberculosis was 4.9%. Most patients had haemoglobin levels between 7 and 10g/dl. 79.3% were cured and 6.5% died. The main causes of death were sepsis and malaria. Conclusion: Severe acute malnutrition remains a major problem in the Far North region. Several joint actions are needed to break this cycle. 展开更多
关键词 Severe Acute Malnutrition Children Far North Cameroon
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Analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents: A case study of Fars Province, Iran
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作者 Saeed Lotfi Ali Reza Honarvar Saeid Gholamzadeh 《Chinese Journal of Traumatology》 CAS CSCD 2019年第4期233-239,共7页
Purpose: An analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents in Fars Province of Iran to prevent and reduce traffic accidents in the futu... Purpose: An analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents in Fars Province of Iran to prevent and reduce traffic accidents in the future. Methods: This cross-sectional study was conducted to integrate all the pervious researches performed on mortality rate of road traffic accidents in Fars Province from March 21,2013 to March 20,2017. In order to reveal the relationships between the factors affecting mortality rates of road traffic accidents, the data regarding road traffic accidents extracted from resources such as Legal Medicine Organization, Traffic Police, Accident & Emergency Department, as well as Department of Roads and Urban Development of Fars Province, then cleaned and the applicable attributes embedded in the data all aggregated for further analysis. It should be noted that the data not related to Fars Province were deleted, the data analyzed, converted and the aggregation between various attributes identified. The aggregation between these different attributes as well as the FP-growth algorithm and two indexes of support and confidence calculated and interesting and effective rules extracted. In the end, several accident-p「ovoking factors, the degree of consecutive and interdepende nee of each one in road accide nts identified and in traduced. The statistical analysis was conducted by using Rapid Miner software. Results: Of the 6216 people dead due to road traffic accidents, 4865 (79.02%) were male and 1292 (20.98%) were female, 59 of them have no clear gender. The largest portion of people died of road traffic accidents belonged to married and self-employed men who collided with motorcycles in autumn. Moreover, young individuals (aged 19-40 years) w让h secondary educational level who died of accidents in summer at 12:00 a.m. and then 5:00 p.m. in outer city main roads of Kazerun-Shiraz, then Darab- Shiraz, Fasa-Darab and in within-city main streets had the highest mortality rates. Among women, the middle-aged group (aged 41-65 years) followed by young-aged group (aged 19-40 years) with elementary educational level and then illiterate accounted for the highest mortality rate of road traffic accidents. The automobiles involved in accidents included Pride, Peugeot 405, Peykan pickup, Sama nd, Peugeot Pars, other vehicles and motorcycles. Conclusion: The high mortality rate of illiterate and low-literate in various age groups indicates that educational level plays a crucial role as a factor in road accidents, requiring related organizations such as Traffic Police and Ministry of Education to take necessary measures and policies. 展开更多
关键词 ROAD TRAFFIC accidents MORTALITY Vehicle fars PROVINCE Iran
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