Objective:To collect comprehensive information about the features of favic patients in Ahvaz (Capital of Khouzestan,Iran) and analyze the extent of the differences with their corresponding in other regions.Methods:A t...Objective:To collect comprehensive information about the features of favic patients in Ahvaz (Capital of Khouzestan,Iran) and analyze the extent of the differences with their corresponding in other regions.Methods:A total of 103 patients with acute hemolysis admitted to pediatric division of Abouzar Hospital located in the city of Ahvaz,Iran during 21st of June 2008 to 20th of June 2009 were analyzed retrospectively.Results:95.14% of the patients had favism while 4.86% of them underwent hemolysis due to other reasons.These patients were male(68.93%) and female children(31.06%) admitted mostly during the spring season.The three main symptoms were urine discoloration,jaundice and vomiting.At the admission time,the main hematologic findings were as follows:G6PD sufficient status(45.63%),G6PD deficient status(54.36%) and hemoglobin concentration:2.5-11.8(mean±SD:6.45±2.12) g/dL.Conclusions:In conclusion,Ahvaz was determined as a black zone for favism in which the disease can be considered a life threatening health problem.Moreover,slight differences were observed in the three main symptoms compared with favic patients in other regions.展开更多
目的系统综述葡萄糖-6-磷酸脱氢酶(glucose-6-phoshate dehydrogenase,G6PD)缺乏症的禁忌中药研究现状。方法通过中国知网、维普、万方、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane Library等数据库系统检索国...目的系统综述葡萄糖-6-磷酸脱氢酶(glucose-6-phoshate dehydrogenase,G6PD)缺乏症的禁忌中药研究现状。方法通过中国知网、维普、万方、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane Library等数据库系统检索国内外有关G6PD缺乏症的禁忌中药研究,提取并整理相关证据进行分析。结果散沫花、热带铁苋菜等有导致G6PD缺乏症患者红细胞溶破的倾向,尤其是高浓度状态下,诱发溶血反应的风险更高;茶多酚在细胞实验中,可以使G6PD缺乏症患者红细胞的氧化状态发生改变;黄连和小檗碱存在争议,可能并不是G6PD缺乏症的禁忌用药;银杏叶提取物注射剂、葛根素注射剂、血栓通注射液、舒血宁注射液、薄荷喷粉和含薄荷醇的药膏等,则有可能致G6PD缺乏症患者发生溶血。各药物引起G6PD缺乏症患者溶血的机制包括氧化机制,免疫机制,及破坏红细胞膜结构与功能、改变红细胞渗透脆性等机制。结论相关研究结果具一定参考意义,但也存在实验严谨性欠佳、报道时效性欠佳、纳入数据量偏少、用药细节披露不完全、所获证据等级偏低等不少问题,未来可考虑采取更高级别的实验方法、扩大数据量和提高严谨性、研究浓度或剂量依赖关系、观察药物在长期应用时致红细胞损伤的累积效应、研究G6PD缺乏症禁忌中药的种属关系和致溶血的具体化学成分等,以更深入的研究为临床实践提供参考和指导。展开更多
文摘Objective:To collect comprehensive information about the features of favic patients in Ahvaz (Capital of Khouzestan,Iran) and analyze the extent of the differences with their corresponding in other regions.Methods:A total of 103 patients with acute hemolysis admitted to pediatric division of Abouzar Hospital located in the city of Ahvaz,Iran during 21st of June 2008 to 20th of June 2009 were analyzed retrospectively.Results:95.14% of the patients had favism while 4.86% of them underwent hemolysis due to other reasons.These patients were male(68.93%) and female children(31.06%) admitted mostly during the spring season.The three main symptoms were urine discoloration,jaundice and vomiting.At the admission time,the main hematologic findings were as follows:G6PD sufficient status(45.63%),G6PD deficient status(54.36%) and hemoglobin concentration:2.5-11.8(mean±SD:6.45±2.12) g/dL.Conclusions:In conclusion,Ahvaz was determined as a black zone for favism in which the disease can be considered a life threatening health problem.Moreover,slight differences were observed in the three main symptoms compared with favic patients in other regions.
文摘目的系统综述葡萄糖-6-磷酸脱氢酶(glucose-6-phoshate dehydrogenase,G6PD)缺乏症的禁忌中药研究现状。方法通过中国知网、维普、万方、中国生物医学文献数据库、PubMed、Web of Science、Embase、Cochrane Library等数据库系统检索国内外有关G6PD缺乏症的禁忌中药研究,提取并整理相关证据进行分析。结果散沫花、热带铁苋菜等有导致G6PD缺乏症患者红细胞溶破的倾向,尤其是高浓度状态下,诱发溶血反应的风险更高;茶多酚在细胞实验中,可以使G6PD缺乏症患者红细胞的氧化状态发生改变;黄连和小檗碱存在争议,可能并不是G6PD缺乏症的禁忌用药;银杏叶提取物注射剂、葛根素注射剂、血栓通注射液、舒血宁注射液、薄荷喷粉和含薄荷醇的药膏等,则有可能致G6PD缺乏症患者发生溶血。各药物引起G6PD缺乏症患者溶血的机制包括氧化机制,免疫机制,及破坏红细胞膜结构与功能、改变红细胞渗透脆性等机制。结论相关研究结果具一定参考意义,但也存在实验严谨性欠佳、报道时效性欠佳、纳入数据量偏少、用药细节披露不完全、所获证据等级偏低等不少问题,未来可考虑采取更高级别的实验方法、扩大数据量和提高严谨性、研究浓度或剂量依赖关系、观察药物在长期应用时致红细胞损伤的累积效应、研究G6PD缺乏症禁忌中药的种属关系和致溶血的具体化学成分等,以更深入的研究为临床实践提供参考和指导。
