Aim To prepare and characterize ferromagnetic fluids for hyperthermia of tumor. Methods Ferromagnetic fluids （FFs） of magnetite （Fe3O4） was prepared in the presence of polyethylene glycol （PEG-6000） by chemical ...Aim To prepare and characterize ferromagnetic fluids for hyperthermia of tumor. Methods Ferromagnetic fluids （FFs） of magnetite （Fe3O4） was prepared in the presence of polyethylene glycol （PEG-6000） by chemical precipitation method. The iron content of the FFs was determined by spectrophotometric method using o-phenanthroline. The FFs/PEG-6000 was characterized by transmission electron microscopy （TEM）, X-ray diffraction （XRD）, infrared spectrometry （IR）, and vibrating sample magnetometer （VSM）. Heating effects of the FFs was measured in an alternating magnetic field in vitro. The hyperthermia of FFs in a rabbit was performed. Results The FFs/PEG-6000 was proved to be composed of Fe3O4 by XRD and IR. TEM showed that the ferromagnetic particles appeared to be almost spherical and dispersed well The average particle size was 13.3 ± 3.8 nm by XRD. The saturation magnetization and residual magnetization of the FFs were 23.39 A/m （1.556 emu/g） and 0.56 A/m （0.02604 emu/g）, respectively. The coercive force was 12 Oe. The specific absorption rate （SAR） of FFs was 69 ± 10W/g [Fe]. After direct injection of FFs to hepatic VX2 carcinoma of a rabbit, the temperature in the core of the tumor was between 41 - 46 ℃ in an alternating magnetic field. Conclusion FFs/PEG-6000 was expected to be useful in hyperthermia of tumor.展开更多
文摘Aim To prepare and characterize ferromagnetic fluids for hyperthermia of tumor. Methods Ferromagnetic fluids （FFs） of magnetite （Fe3O4） was prepared in the presence of polyethylene glycol （PEG-6000） by chemical precipitation method. The iron content of the FFs was determined by spectrophotometric method using o-phenanthroline. The FFs/PEG-6000 was characterized by transmission electron microscopy （TEM）, X-ray diffraction （XRD）, infrared spectrometry （IR）, and vibrating sample magnetometer （VSM）. Heating effects of the FFs was measured in an alternating magnetic field in vitro. The hyperthermia of FFs in a rabbit was performed. Results The FFs/PEG-6000 was proved to be composed of Fe3O4 by XRD and IR. TEM showed that the ferromagnetic particles appeared to be almost spherical and dispersed well The average particle size was 13.3 ± 3.8 nm by XRD. The saturation magnetization and residual magnetization of the FFs were 23.39 A/m （1.556 emu/g） and 0.56 A/m （0.02604 emu/g）, respectively. The coercive force was 12 Oe. The specific absorption rate （SAR） of FFs was 69 ± 10W/g [Fe]. After direct injection of FFs to hepatic VX2 carcinoma of a rabbit, the temperature in the core of the tumor was between 41 - 46 ℃ in an alternating magnetic field. Conclusion FFs/PEG-6000 was expected to be useful in hyperthermia of tumor.
