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In silico evaluation of kuwanon compounds as antiviral agents targeting H9N2 influenza virus
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作者 Ansari Vikhar Danish Ahmad Yasar Qazi +4 位作者 Subur Wadood Khan Mohd Mukhtar Khan Altamash Ansari Sarfaraz Khan Syed iftequar Ahmed 《Infectious Diseases Research》 2024年第4期42-53,共12页
Background:The threat of avian influenza a subtype avian influenza A(H9N2)virus remains a significant concern,necessitating the exploration of novel antiviral agents.This study employs network pharmacology and computa... Background:The threat of avian influenza a subtype avian influenza A(H9N2)virus remains a significant concern,necessitating the exploration of novel antiviral agents.This study employs network pharmacology and computational analysis to investigate the potential of kuwanons,a natural compounds against H9N2 influenza virus.Methods:Leveraging comprehensive databases and bioinformatics tools,we elucidate the molecular mechanisms underlying Kuwanons pharmacological effects against H9N2 influenza virus.Network pharmacology identifies H9N2 influenza virus targets and compounds through integrated protein-protein interaction and Kyoto Encyclopedia of Genes and Genomes analyses.Molecular docking studies were performed to assess the binding affinities and structural interactions of Kuwanon analogues with key targets,shedding light on their potential inhibitory effects on viral replication and entry.Results:Compound-target network analysis revealed complex interactions(120 nodes,163 edges),with significant interactions and an average node degree of 2.72.Kyoto Encyclopedia of Genes and Genomes analysis revealed pathways such as Influenza A,Cytokine-cytokine receptor interaction pathway in H9N2 influenza virus.Molecular docking studies revealed that the binding free energy for the docked ligands ranged between-5.2 and-9.4 kcal/mol for the human interferon-beta crystal structure(IFNB1,Protein Data Bank:1AU1)and-5.4 and-9.6 kcal/mol for Interleukin-6(IL-6,PDB:4CNI).Conclusion:Our findings suggest that kuwanon exhibits promising antiviral activity against H9N2 influenza virus by targeting specific viral proteins,highlighting its potential as a natural therapeutic agent in combating avian influenza infections. 展开更多
关键词 network pharmacology molecular docking kuwanons H9N2 influenza virus natural compounds
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Porous TiFe_(2) intermetallic compound fabricated via elemental powder reactive synthesis
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作者 Qian Zhao Zhenli He +3 位作者 Yuehui He Yue Qiu Zhonghe Wang Yao Jiang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第4期764-772,共9页
Porous intermetallics show potential in the field of filtration and separation as well as in the field of catalysis.Herein,porous Ti Fe2intermetallics were fabricated by the reactive synthesis of elemental powders.The... Porous intermetallics show potential in the field of filtration and separation as well as in the field of catalysis.Herein,porous Ti Fe2intermetallics were fabricated by the reactive synthesis of elemental powders.The phase transformation and pore formation of porous TiFe2intermetallics were investigated,and its corrosion behavior and hydrogen evolution reaction(HER)performance in alkali solution were studied.Porous TiFe2intermetallics with porosity in the range of 34.4%-56.4%were synthesized by the diffusion reaction of Ti and Fe elements,and the pore formation of porous TiFe2intermetallic compound is the result of a combination of the bridging effect and the Kirkendall effect.The porous TiFe2samples exhibit better corrosion resistance compared with porous 316L stainless steel,which is related to the formation of uniform nanosheets on the surface that hinder further corrosion,and porous TiFe2electrode shows the overpotential of 220.6 and 295.6 mV at 10 and 100 mA·cm-2,suggesting a good catalytic performance.The synthesized porous Fe-based intermetallic has a controllable pore structure as well as excellent corrosion resistance,showing its potential in the field of filtration and separation. 展开更多
关键词 TiFe2 intermetallic compound porous materials reactive synthesis corrosion behavior hydrogen evolution reaction
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FeS-FeS_2组合物的热分析动力学 被引量:1
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作者 阳富强 朱伟方 刘晓霞 《石油学报(石油加工)》 EI CAS CSCD 北大核心 2017年第6期1167-1175,共9页
为了揭示储油罐硫腐蚀产物的氧化自燃历程,在30~1000℃的温度区间,升温速率为10、15、20℃/min的实验条件下,采用同步热分析仪表征了储罐硫腐蚀产物主要成分FeS和FeS_2以及FeS-FeS_2组合物的氧化热解特性。对升温速率15℃/min下FeS和Fe... 为了揭示储油罐硫腐蚀产物的氧化自燃历程,在30~1000℃的温度区间,升温速率为10、15、20℃/min的实验条件下,采用同步热分析仪表征了储罐硫腐蚀产物主要成分FeS和FeS_2以及FeS-FeS_2组合物的氧化热解特性。对升温速率15℃/min下FeS和FeS_2的TG-DTG-DSC曲线及FeS-FeS_2组合物的TG-DTG曲线进行比较,进一步采用Flynn-Wall-Ozawa(FWO)和Kissinger 2种热分析动力学方法分别求解FeS-FeS_2组合物的表观活化能。结果表明,6种样品的着火温度主要分布在413.82~508.80℃之间;除FeS外,其他样品的TG曲线趋势相似,DTG曲线在500~650℃温度范围内普遍存在2个质量损失峰值。FeS-FeS_2组合物在氧化自燃过程中,FeS和FeS_2并非简单孤立地发生反应,而是FeS和FeS_2相互作用;组合物中FeS_2的质量分数为20%时,平均表观活化能达到最小,FWO法和Kissinger法计算的平均表观活化能分别为172.95和164.56kJ/mol,且其自燃倾向性最大。 展开更多
关键词 硫腐蚀产物 fes-fes2组合物 相互作用 表观活化能
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FeS-FeS_2组合物的吸附孔分形特征
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作者 阳富强 宋雨泽 朱伟方 《福州大学学报(自然科学版)》 CAS 北大核心 2019年第1期118-123,共6页
为揭示高硫矿山硫化矿石吸附孔隙分形特征,采集FeS-FeS_2组合物进行低温氮吸附实验,测量4种FeS-FeS_2组合物的比表面积、总孔容及平均孔径,揭示其孔隙特征.运用FHH模型计算得到4种FeS-FeS_2组合物的分形维数,并分析不同FeS-FeS_2组合物... 为揭示高硫矿山硫化矿石吸附孔隙分形特征,采集FeS-FeS_2组合物进行低温氮吸附实验,测量4种FeS-FeS_2组合物的比表面积、总孔容及平均孔径,揭示其孔隙特征.运用FHH模型计算得到4种FeS-FeS_2组合物的分形维数,并分析不同FeS-FeS_2组合物分形维数与孔隙参数、吸附能力的关系.研究表明,4种样品低温氮吸附-解析曲线虽在形态上略有差异,但均属于IV型; FeS-FeS_2组合物气体吸附主要集中在2~8 nm介孔上;随着FeS-FeS_2组合物中FeS质量分数增加,样品分形维数也会增大;分形维数增大,FeS-FeS_2组合物的比表面积和总孔容相应增大,平均孔径相应减小,孔隙结构越复杂,孔表面变得越粗糙;分形维数与FeS-FeS_2组合物的气体吸附能力呈现正相关性,即分形维数越大,吸附能力越强.因此,FeS-FeS_2组合物中FeS质量分数的增大引起分数维数增加,有助于FeS-FeS_2组合物表面吸附存储氧气,更易使硫化矿石发生氧化自燃. 展开更多
关键词 fes-fes2组合物 低温氮吸附 孔隙特征 分形维数 自燃
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基于广泛靶向代谢组学解析不同树龄及栽培条件的野酿2号腺枝毛葡萄类黄酮差异
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作者 谢林君 张劲 +7 位作者 周咏梅 韦荣福 庞丽婷 吴代东 李洪艳 刘金标 周思泓 成果 《南方农业学报》 CAS CSCD 北大核心 2024年第8期2262-2276,共15页
【目的】基于广泛靶向代谢组学分析不同树龄及栽培条件的野酿2号腺枝毛葡萄类黄酮差异代谢物情况,为提升葡萄及葡萄酒品质提供理论参考依据。【方法】以不同树龄及栽培条件(地域和架式)的野酿2号腺枝毛葡萄为试材,测定粒重、pH、可溶性... 【目的】基于广泛靶向代谢组学分析不同树龄及栽培条件的野酿2号腺枝毛葡萄类黄酮差异代谢物情况,为提升葡萄及葡萄酒品质提供理论参考依据。【方法】以不同树龄及栽培条件(地域和架式)的野酿2号腺枝毛葡萄为试材,测定粒重、pH、可溶性固形物、可滴定酸含量及亮度值(L^(*))、红—绿色度值(a^(*))、黄—蓝色度值(b^(*)),并利用超高效液相色谱—串联质谱仪对其成熟期葡萄果实进行广泛靶向代谢组学分析。【结果】不同树龄及栽培条件的野酿2号腺枝毛葡萄理化指标之间存在不同程度的差异,栽培地域对葡萄果实理化指标影响较大,栽种于相思湖葡萄示范基地的果实成熟度更好,但果粒较小、果皮颜色较浅;栽培架式及树龄对葡萄果实的粒重影响较小,对糖酸含量影响较大;同一地域采用篱架栽培的葡萄果实较棚架栽培成熟度更好,且树龄越大,果实成熟度越好。从不同树龄及栽培条件的成熟期葡萄果实中共鉴定出11类789种代谢物,其中黄酮类最多,为187种。12个样品中共存在271个差异代谢物,共聚为7个类群,黄酮类化合物在各亚类中占比最高,特别是第Ⅱ类群,占比高达59%,其次是第Ⅰ类群,占比为49%。利用差异代谢物能明确区分来自不同地域、架式和树龄的葡萄果实样品,其中地域样品间的差异最大,且黄酮类化合物是造成差异的最主要化合物。明阳双季葡萄示范基地栽培较相思湖葡萄示范基地栽培更利于杨梅素、槲皮素、表儿茶素及甲基花翠素等类黄酮化合物的积累,5年树龄较8年树龄更有利于促进山柰酚、儿茶素和花青素的积累,而棚架栽培较篱架栽培更利于黄烷-3-醇、花青素双糖苷和花葵素双糖苷的积累。可溶性固形物含量与黄酮醇中的槲皮素和杨梅素含量呈显著负相关,L^(*)和a^(*)均与杨梅素呈显著负相关。【结论】不同树龄及栽培条件的野酿2号腺枝毛葡萄果实类黄酮代谢物含量存在差异,其中地域影响最明显。 展开更多
关键词 腺枝毛葡萄 野酿2 广泛靶向代谢组学 树龄 栽培条件 差异代谢物 类黄酮化合物
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布地奈德/福莫特罗粉吸入剂联合复方甲氧那明治疗急性呼吸综合征冠状病毒-2感染亚急性咳嗽的临床疗效分析
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作者 倪孔守 费英明 +1 位作者 王汝团 矫捷 《福建医科大学学报》 2024年第4期263-265,共3页
目的回顾性分析信必可都保[布地奈德/福莫特罗粉吸入剂(Ⅰ)=320μg/9.0μg]联合阿斯美(复方甲氧那明)治疗急性呼吸综合征冠状病毒-2(SARS-COV-2)感染后亚急性咳嗽的临床疗效。方法收集2022年12月—2023年6月确诊的SARS-COV-2(Omicron BA... 目的回顾性分析信必可都保[布地奈德/福莫特罗粉吸入剂(Ⅰ)=320μg/9.0μg]联合阿斯美(复方甲氧那明)治疗急性呼吸综合征冠状病毒-2(SARS-COV-2)感染后亚急性咳嗽的临床疗效。方法收集2022年12月—2023年6月确诊的SARS-COV-2(Omicron BA.5.2、BF.7感染)亚急性咳嗽患者220例,分为观察组和对照组,每组各110例。观察组给予信必可都保吸入(1吸/次,2次/日),阿斯美口服(2粒/次,3次/日);对照组给予咳必清、酮替芬和孟鲁司特钠三联药物常规止咳、平喘对症治疗。采用咳嗽程度评分表(CET)观察并记录治疗后第3、5、7天咳嗽缓解情况,检测呼出气一氧化氮(FeNO),并进行疗效评价。结果治疗后第3、5、7天患者的CET评分、FeNO值均较前下降。观察组临床控制86例,显效11例,有效9例,无效4例,总有效率96%;对照组临床控制68例,显效17例,有效13例,无效12例,总有效率89%。2组的总有效率比较,差别有统计学意义(P<0.05)。结论信必可都保和阿斯美联合治疗SARS-COV-2(Omicron BA.5.2、BF.7感染)亚急性咳嗽,可明显改善患者的咳嗽症状。 展开更多
关键词 布地奈德/福莫特罗粉吸入剂 复方甲氧那明 联合治疗 急性呼吸综合征冠状病毒-2 咳嗽 咳嗽程度评分表
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Single-Phase Ternary Compounds with a Disordered Lattice and Liquid Metal Phase for High-Performance Li-Ion Battery Anodes 被引量:1
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作者 Yanhong Li Lei Zhang +8 位作者 Hung-Yu Yen Yucun Zhou Gun Jang Songliu Yuan Jeng-Han Wang Peixun Xiong Meilin Liu Ho Seok Park Wenwu Li 《Nano-Micro Letters》 SCIE EI CAS CSCD 2023年第5期36-50,共15页
Si is considered as the promising anode materials for lithium-ion batteries(LIBs)owing to their high capacities of 4200 mAh g-1and natural abundancy.However,severe electrode pulverization and poor electronic and Li-io... Si is considered as the promising anode materials for lithium-ion batteries(LIBs)owing to their high capacities of 4200 mAh g-1and natural abundancy.However,severe electrode pulverization and poor electronic and Li-ionic conductivities hinder their practical applications.To resolve the afore-mentioned problems,we first demonstrate a cation-mixed disordered lattice and unique Li storage mechanism of single-phase ternary GaSiP_(2)compound,where the liquid metallic Ga and highly reactive P are incorporated into Si through a ball milling method.As confirmed by experimental and theoretical analyses,the introduced Ga and P enables to achieve the stronger resistance against volume variation and metallic conductivity,respectively,while the cation-mixed lattice provides the faster Li-ionic diffusion capability than those of the parent GaP and Si phases.The resulting GaSiP_(2)electrodes delivered the high specific capacity of 1615 mAh g-1and high initial Coulombic efficiency of 91%,while the graphite-modified GaSiP_(2)(GaSiP_(2)@C)achieved 83%of capacity retention after 900 cycles and high-rate capacity of 800 at 10,000 mA g-1.Furthermore,the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)//Ga SiP_(2)@C full cells achieved the high specific capacity of 1049 mAh g-1after 100 cycles,paving a way for the rational design of high-performance LIB anode materials. 展开更多
关键词 Multinary compounds Liquid metal GaSiP_(2) Disordered lattice Li-ion batteries
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Effective anti-inflammatory phenolic compounds from dandelion:identification and mechanistic insights using UHPLC-ESI-MS/MS,fluorescence quenching and anisotropy,molecular docking and dynamics simulation 被引量:1
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作者 Hui Zou Tingting Ben +2 位作者 Ping Wu Geoffrey I.N.Waterhouse Yilun Chen 《Food Science and Human Wellness》 SCIE CSCD 2023年第6期2184-2194,共11页
This novel study identifi es the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins(toll-like receptor 4,TLR4;co-receptor myelo... This novel study identifi es the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins(toll-like receptor 4,TLR4;co-receptor myeloid differentiation protein-2,MD-2)using UHPLC-ESI-MS/MS,lipopolysaccharide(LPS)-stimulated THP-1 cell line,fluorescence quenching and anisotropy,molecular docking(single ligand and multi-ligand docking)and molecular dynamics simulation.A 50%aqueous methanol extract had a greater anti-inflammatory effect and higher chicoric acid content,compared with the 100%water and 100%methanol extracts.Chicoric acid,chlorogenic acid,methylophiopogonone A,caffeic acid,gallic acid monohydrate and 4’-O-demethylbroussonin A had relatively high binding energies and contents in all extracts.Chicoric acid competed with chlorogenic acid,4’-O-demethylbroussonin A and quercetin for MD-2.Among dandelion’s phenolics,chicoric acid most effectively hindered TLR4-MD-2 complex formation,with a quenching constant of 0.62×10^(6) L/mol for MD-2 or TLR4 at 320 K,and binding energies of-6.87 and-5.97 kcal/mol,respectively,for MD-2 and TLR4. 展开更多
关键词 Dandelion extracts Phenolic compounds binding affinity TLR4-MD-2 antagonist Anti-inflammatory agent
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枯草芽孢杆菌PW2挥发性产物对黄曲霉的抑制作用 被引量:1
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作者 张凯歌 魏琛 +4 位作者 余璐 杜明艳 李晓冉 林亲录 王青云 《食品与生物技术学报》 CAS CSCD 北大核心 2024年第5期122-129,共8页
为探寻安全、高效的黄曲霉新型抑制物,采用顶空固相微萃取-气质联用(HS-SPME-GC-MS)技术对枯草芽孢杆菌(Bacillus subtilis)PW2所产具有抗霉活性的挥发性有机化合物(volatile organic compounds,VOCs)进行了成分鉴定,并利用平板对扣法... 为探寻安全、高效的黄曲霉新型抑制物,采用顶空固相微萃取-气质联用(HS-SPME-GC-MS)技术对枯草芽孢杆菌(Bacillus subtilis)PW2所产具有抗霉活性的挥发性有机化合物(volatile organic compounds,VOCs)进行了成分鉴定,并利用平板对扣法从鉴定出的成分中筛选具有强抗霉活性的目标化合物,通过平板对扣法和96孔板梯度稀释法测定目标化合物对黄曲霉的最小抑菌体积分数(MIC),使用黄曲霉毒素B_(1)(aflatoxin B_(1),AFB_(1))ELISA检测试剂盒分析了目标化合物对黄曲霉产AFB_(1)的抑制作用,使用扫描电子显微镜(scanning electron microscope,SEM)观察受试黄曲霉孢子形态的变化和采用分光光度法测定受试黄曲霉细胞膜麦角甾醇相对含量,以探讨抗霉机理。结果显示,从PW2所产VOCs中共鉴定出41种组分,并从中筛选出异辛醇为目标化合物;平板对扣法和96孔板梯度稀释法测得异辛醇对黄曲霉的MIC分别为0.169μL/mL和6.25μL/mL;PDB培养基中异辛醇体积分数分别为3.13、6.25、12.50μL/mL时,均能有效抑制AFB_(1)的产生,且随异辛醇体积分数的升高,抑制效果增强;异辛醇处理可导致黄曲霉孢子表面凹陷和孢子破裂,并且影响细胞膜中麦角甾醇的相对含量,造成细胞膜受损。该研究可为开发以异辛醇为功能成分的黄曲霉抑制剂提供理论参考。 展开更多
关键词 枯草芽孢杆菌 挥发性有机化合物 异辛醇 黄曲霉
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复合混凝剂中Ca^(2+)对高溶解态磷坑塘水混凝效果的影响 被引量:1
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作者 程紫微 王涛 +5 位作者 郭忠 马龙 张俊 王玉飞 黄晨慧 徐慧 《环境保护科学》 CAS 2024年第1期87-95,147,共10页
文章以Ca^(2+)改性后的AlCl_(3)和PACl作为混凝剂进行混凝实验,通过出水浊度、余铝、总磷、絮体粒径及有机物组成等分析改性后混凝剂的作用机理,探讨混凝剂中存在的Ca^(2+)对高磷坑塘水混凝效果的影响机制。浊度去除方面,低投加量下Ca^(... 文章以Ca^(2+)改性后的AlCl_(3)和PACl作为混凝剂进行混凝实验,通过出水浊度、余铝、总磷、絮体粒径及有机物组成等分析改性后混凝剂的作用机理,探讨混凝剂中存在的Ca^(2+)对高磷坑塘水混凝效果的影响机制。浊度去除方面,低投加量下Ca^(2+)可明显降低出水浊度。当投加量为0.10 mmol/L时,PACl出水浊度下降了33.52 NTU,AlCl_(3)出水浊度下降了28.72 NTU。余铝去除方面,当AlCl_(3)作混凝剂时,Ca^(2+)可以通过增加混凝剂的电中和能力来降低出水余铝浓度。溶解态磷去除方面,Ca^(2+)与磷酸根反应或通过压缩双电层和吸附电中和作用来增加溶解态磷的去除率。当投加量为0.20 mmol/L时,Ca^(2+)浓度为0.9 mmol/L,PACl溶解态磷去除率较未改性前提高16.1%。絮体粒径方面,Ca^(2+)可以促进颗粒之间脱稳凝聚,增加絮体粒径和分形维数,AlCl_(3)在0.20 mmol/L投加量下絮体粒径增加79μm。并且Ca^(2+)的加入使AlCl_(3)生成的絮体抗剪切能力更强,但是絮体受到破坏后更不容易恢复,使PACl形成絮体强度因子和恢复因子变大。有机物去除方面,Ca^(2+)可以提高有机物的去除率。对于0.20 mmol/L投加量,Ca^(2+)为0.06 mmol/L投加量条件下AlCl_(3)改性后混凝剂荧光响应值由1100降至800。 展开更多
关键词 混凝 高磷 CA^(2+) 复合混凝剂
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复合改性纳米TiO_(2)催化降解五氯苯酚的试验研究 被引量:1
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作者 赵连波 张瑶瑶 +2 位作者 常丹 李梦耀 许小英 《工业用水与废水》 CAS 2024年第3期50-55,共6页
为了探究纳米C-Co/TiO_(2)催化剂降解五氯苯酚的动力学特性,采用溶胶-凝胶法,制备了C、Co双元素掺杂复合改性的纳米C-Co/TiO_(2)催化剂。利用XRD、SEM-EDS、UV-vis进行表征分析,结果表明:掺杂C、Co元素后,纳米C-Co/TiO_(2)晶型未发生改... 为了探究纳米C-Co/TiO_(2)催化剂降解五氯苯酚的动力学特性,采用溶胶-凝胶法,制备了C、Co双元素掺杂复合改性的纳米C-Co/TiO_(2)催化剂。利用XRD、SEM-EDS、UV-vis进行表征分析,结果表明:掺杂C、Co元素后,纳米C-Co/TiO_(2)晶型未发生改变,特征峰强度增强,晶体结晶性好,粒径约为12.08 nm;催化剂表面呈现球状堆积形貌,比表面积大,有利于反应物吸附脱附;与纯TiO_(2)相比,催化剂带隙能降低,对可见光的响应性增强。结合降解过程中产物的紫外吸收光谱,探究五氯苯酚的催化降解机理。根据试验检测结果,分析拟合初始浓度与降解速率的线性关系,得到光催化降解五氯苯酚的L-H模型动力学方程:r0=0.38491 0.0951C_(0)/1+0.0951C_(0)。 展开更多
关键词 复合改性纳米TiO_(2) 碳钴双掺杂 光催化降解 五氯苯酚 动力学方程
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中药通过影响肠道菌群治疗2型糖尿病的研究进展 被引量:1
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作者 曾珊 伍晓乐 +5 位作者 徐杨 李秭钰 唐焓嫣 雷诗懿 王渝凯 徐玉玲 《中国抗生素杂志》 CAS CSCD 北大核心 2024年第8期860-866,共7页
2型糖尿病(diabetes mellitus type 2, T2DM)作为一种慢性疾病,起病隐匿,三多一少是常见症状,目前发病机制尚不明确。若血糖控制欠佳,5~10年会诱发一系列其他疾病如语言障碍、血管病变、中风瘫痪等,严重损害患者健康,威胁生命。目前,通... 2型糖尿病(diabetes mellitus type 2, T2DM)作为一种慢性疾病,起病隐匿,三多一少是常见症状,目前发病机制尚不明确。若血糖控制欠佳,5~10年会诱发一系列其他疾病如语言障碍、血管病变、中风瘫痪等,严重损害患者健康,威胁生命。目前,通过调节肠道菌群对该病进行治疗干预成为最新研究方向。中药作为我国传统用药,能有效降低血糖,缓解T2DM所带来的心绞痛等并发症。已有研究表明中药、中药复方及活性成分能通过影响肠道菌群菌种类、数量、相对丰富度、代谢途径等调节糖尿病炎症或刺激胰岛细胞,以达到治疗或舒缓T2DM症状的目的。本文通过查阅文献对中药影响肠道菌群治疗、干预T2DM的相关研究进行综述,并提出在肠道菌群研究方面的一些不足之处,期望能为中药更全面地发挥其治疗作用提供参考。 展开更多
关键词 中药 中药复方 活性成分 肠道菌群 2型糖尿病
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斯里兰卡瓦拉沉香中2个新的5,6,7-三羟基-2-(2-苯乙基)-5,6,7,8-四氢色酮
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作者 陈乐瑶 盖翠娟 +5 位作者 蔡彩虹 王昊 李薇 戴好富 梅文莉 陈惠琴 《热带亚热带植物学报》 CAS CSCD 北大核心 2024年第4期549-554,共6页
为了解斯里兰卡来源瓦拉(Aquilaria walla)沉香中的化学成分,采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备高效液相色谱法从其乙醇提取物中分离得到2个2-(2-苯乙基)色酮类化合物,通过质谱、核磁共振等现代波谱学方法分别鉴定为(5R... 为了解斯里兰卡来源瓦拉(Aquilaria walla)沉香中的化学成分,采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱及半制备高效液相色谱法从其乙醇提取物中分离得到2个2-(2-苯乙基)色酮类化合物,通过质谱、核磁共振等现代波谱学方法分别鉴定为(5R,6S,7S)-5,6,7-三羟基-2-(2-苯乙基)-5,6,7,8-四氢色酮(1)和(5R,6S,7S)-5,6,7-三羟基-2-[2-(4-甲氧基)苯乙基]-5,6,7,8-四氢色酮(2),均为新化合物。化合物1和2对脂多糖诱导小鼠单核巨噬细胞RAW264.7产生NO无抑制作用,MTT法表明对5株人肿瘤细胞不具有体外生长抑制作用,200μg/m L的化合物2对酪氨酸酶具有弱抑制作用,抑制率为(21.67±1.67)%。 展开更多
关键词 瓦拉沉香 5 6 7-三羟基-2-(2-苯乙基)-四氢色酮 酪氨酸酶抑制 新化合物
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Lewis base-assisted Lewis acid-catalyzed selective alkene formation via alcohol dehydration and synthesis of 2-cinnamyl-1,3-dicarbonyl compounds from 2-aryl-3,4-dihydropyrans
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作者 刘昌会 潘彬 顾彦龙 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2016年第6期979-986,共8页
Acid-catalyzed dehydration of alcohols has been widely employed for the synthesis of alkenes. However, activated alcohols when employed as substrates in dehydration reactions are often pla-gued by the lack of alkene s... Acid-catalyzed dehydration of alcohols has been widely employed for the synthesis of alkenes. However, activated alcohols when employed as substrates in dehydration reactions are often pla-gued by the lack of alkene selectivity. In this work, the reaction system can be significantly improved through enhancing the performance of Lewis acid catalysts in the dehydration of activated alcohols by combining with a Lewis base. Observations of the reaction mechanism revealed that the Lewis base component might have changed the reaction rate order. Although both the principal and side reaction rates decreased, the effect was markedly more observed on the latter reaction. Therefore, the selectivity of the dehydration reaction was improved. On the basis of this observation, a new route to synthesize 2-cinnamyl-1,3-dicarbonyl compounds was developed by using 2-aryl-3,4- di-hydropyran as a starting substrate in the presence of a Lewis acid/Lewis base combined catalyst system. 展开更多
关键词 Synergistic catalysis Acid-base catalysis Dehydration of alcohol 2-Cinnamyl-1 3-dicarbonyl compound Homogeneous catalysis
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A mild,efficient and selective iodination of aromatic compounds using iodine and 1,4-bis(triphenylphosphonium)-2-butene peroxodisulfate 被引量:1
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作者 Rashid Badri Maryam Gorjizadeh 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第12期1439-1443,共5页
A simple and efficient method for the iodination of aromatic compounds has been achieved in the presence of iodine and 1,4- bis(triphenylphosphonium)-2-butene peroxodisulfate.
关键词 Iodoaromafic compounds Aromatic compounds IODINE 1 4-Bis(triphenylphosphonium)-2-butene peroxodisulfate
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中药复方基于细胞信号通路防治2型糖尿病的研究进展
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作者 彭川 冉思燕 +6 位作者 何苗 陈正涛 胡玉立 李梅 吴丽丽 秦灵灵 刘铜华 《世界科学技术-中医药现代化》 CSCD 北大核心 2024年第6期1497-1504,共8页
2型糖尿病作为一种慢性代谢性疾病,随着发病率的不断增加,给人类健康造成极大的威胁。越来越多的研究证实,糖尿病的发病机制与多种细胞信号通路的改变密切相关。虽然有大量研究报道中药复方通过调控细胞信号通路防治糖尿病,但对其调控... 2型糖尿病作为一种慢性代谢性疾病,随着发病率的不断增加,给人类健康造成极大的威胁。越来越多的研究证实,糖尿病的发病机制与多种细胞信号通路的改变密切相关。虽然有大量研究报道中药复方通过调控细胞信号通路防治糖尿病,但对其调控细胞信号通路的作用机制尚缺乏系统完善的综述。鉴于此,本文通过综合近几年国内外文献,对中药复方基于细胞信号通路防治2型糖尿病的研究进行归纳总结,发现主要与PI3K/AKT、AMPK、MAPK、NF-κB、Nrf2/ARE、PPAR、TGF-β等信号通路有关,此系列信号通路能够通过抑制胰岛细胞凋亡、保护胰岛β细胞功能、改善胰岛素抵抗、抑制肝脏糖异生、促进糖原合成、减轻炎症反应、抗氧化应激等来治疗2型糖尿病,同时分析当前研究存在的问题以及未来发展趋势,以期为中药复方防治糖尿病的药物开发与临床应用提供科学的理论基础。 展开更多
关键词 2型糖尿病 中药复方 细胞信号通路 研究进展
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Enhanced photodegradation of phenolic compounds by adding TiO_2 to soil in a rotary reactor 被引量:2
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作者 WANG Jing-xian CHEN Shuo QUAN Xie ZHAO Hui-min ZHAO Ya-zhi 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2006年第6期1107-1112,共6页
Photodegradation ofpentachlorophenol (PCP) and p-nitrophenol (PNP) in soil was carried out in a designed rotary reactor, which can provide the soil particles with continually uniform irradiation, and on a series o... Photodegradation ofpentachlorophenol (PCP) and p-nitrophenol (PNP) in soil was carried out in a designed rotary reactor, which can provide the soil particles with continually uniform irradiation, and on a series of thin soil layers. TiO2, as a kind of environmental friendly photocatalyst, was introduced to the soil to enhance the processes. Compared with that on the soil layers, photodegradation of PCP at initial concentration of 60 mg/kg was improved dramatically in the rotary reactor no matter whether TiO2 was added, with an increase of 3.0 times in the apparent first-order rate constants. The addition of 1 wt% TiO2 furthered the improvement by 1.4 times. Without addition of TiO2, PNP (initial concentration of 60 mg/kg) photodegradation rate in the rotary reactor was similar to that on the soil layers. When 1 wt% additional TiO2 was added, PNP photodegradation was enhanced obviously, and the enhancement in the rotary reactor was 2 times of that on the soil layers, which may be attributed to the higher frequency of the contact between PNP on soil particles and the photocatalyst. The effect of soil pH and initial concentrations of the target compounds on the photodegradation in the rotary reactor was investigated. The order of the degradation rate at different soil pH was relative to the aggregation of soil particles during mixing in the rotary reactor. Photodegradation of PCP and PNP at different initial concentrations showed that addition of TiO2 to enhance the photodegradation was more suitable for contaminated soil with higher concentration of PCP, while was effective for contaminated soil at each PNP concentration tested in our study. 展开更多
关键词 TiO2 PHOTODEGRADATION phenolic compounds soil remediation
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Hierarchical pore structure of activated carbon fabricated by CO_2/microwave for volatile organic compounds adsorption 被引量:18
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作者 Wenjuan Qiu Kang Dou +3 位作者 Ying Zhou Haifeng Huang Yinfei Chen Hanfeng Lu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第1期81-88,共8页
An activated carbon pore-expanding technique was achieved through innovative reactivation by CO_2/microwave.The original and modified activated carbons were characterized by nitrogen adsorption–desorption,scanning el... An activated carbon pore-expanding technique was achieved through innovative reactivation by CO_2/microwave.The original and modified activated carbons were characterized by nitrogen adsorption–desorption,scanning electron microscopy,transmission electron microcopy,and Fourier transform infrared spectroscopy.The mesopore volume increased from 0.122 cm^3·g^(-1) to 0.270 cm^3·g^(-1),and a hierarchical pore structure was formed.A gradual decrease in the phenolic hydroxyl and carboxyl groups on the surface of activated carbon enhanced the surface inertia of granular activated carbon(GAC).The toluene desorption rate of the modified sample increased by 8.81% compared with that of the original GAC.Adsorption isotherm fittings revealed that the Langmuir model was applicable for the original and modified activated carbons.The isosteric adsorption heat of toluene on the activated carbon decreased by approximately 50%,which endowed the modified sample with excellent stability in application.The modified samples showed an enhanced desorption performance of toluene,thereby opening a way to extend the cycle life and improve the economic performance of carbon adsorbent in practical engineering applications. 展开更多
关键词 Activated carbon CO2/microwave Pore regulation volatile organic compounds Desorption
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Structures and Properties of Two Pb^Ⅱ Compounds and Theoretical Study of 2,4-Oxybis(benzoic acid) 被引量:1
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作者 唐龙 付峰 +2 位作者 王记江 刘启瑞 曹佳 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2015年第10期1479-1486,共8页
Two Pb^Ⅱ coordination polymers [Pb(oba)(2,2′-bipy)]·1.5H2O(1) and [Pb(oba)(phen)](2)(H2oba = 2,4-oxybis(benzoic acid), 2,2′-bipy = 2,2′-bipyridine, phen = 1,10-phenanthroline) were synthesized... Two Pb^Ⅱ coordination polymers [Pb(oba)(2,2′-bipy)]·1.5H2O(1) and [Pb(oba)(phen)](2)(H2oba = 2,4-oxybis(benzoic acid), 2,2′-bipy = 2,2′-bipyridine, phen = 1,10-phenanthroline) were synthesized by hydrothermal reactions and characterized by single-crystal X-ray diffraction, thermogravimetric analyses, IR spectroscopy and elemental analysis. Structures of compounds 1 and 2 are similar. Compounds 1 and 2 show 1D wavy chains, which are further connected through aromatic π-π stacking interactions to expand into 2D wavelike networks. The crystal structure of 2,4-oxybis(benzoic acid) ligand(3) was obtained, and its full geometry optimization was carried out by using DFT methods at the B3LYP/6-31G(d) level. The calculated data show that the bond distances and bond angles were very close to the experimental data. The values of the frontier orbital energies indicate that this configuration is stable. Moreover, the solid-state fluorescence properties of 1-3 have also been investigated. 展开更多
关键词 Pb^Ⅱ compound 2 4-oxybis(benzoic acid) fluorescent properties theoretical study
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“蛋壳-膜”结构的NiCo_(2)S_(4)/rGO复合材料制备与电化学性能的研究
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作者 黄立志 陈娜丽 +3 位作者 谈本刚 黄晓雪 孙戈婷 冯辉霞 《应用化工》 CAS CSCD 北大核心 2024年第2期346-350,共5页
以氧化石墨烯(GO)为原料,MOFs材料ZIF-67为牺牲模板,制备了NiCo_(2)S_(4)/还原氧化石墨烯(rGO)复合材料,采用SEM、TEM、XRD、XPS和Raman测试技术对其结构进行了表征,研究了其电化学性能。结果表明,所制NiCo_(2)S_(4)/rGO复合材料具有“... 以氧化石墨烯(GO)为原料,MOFs材料ZIF-67为牺牲模板,制备了NiCo_(2)S_(4)/还原氧化石墨烯(rGO)复合材料,采用SEM、TEM、XRD、XPS和Raman测试技术对其结构进行了表征,研究了其电化学性能。结果表明,所制NiCo_(2)S_(4)/rGO复合材料具有“蛋壳-膜”结构,在1 A/g的电流密度下,比电容为1 350 F/g,电流密度增至20 A/g时比电容的保持率为46.93%,是纯NiCo_(2)S_(4)的1.28倍;3 000次循环后比电容保持率为99.4%,高于纯NiCo_(2)S_(4)活化后的。 展开更多
关键词 NiCo_(2)S_(4) 还原氧化石墨烯 复合材料 超级电容器
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