The “National Institutes of Health” genetically heterogeneous (NIH-HS) rat stock was created in the 1980s through an eight-way cross of as much as possible separate inbred rat strains (i.e. the MR/N, WN/N, WKY/N, M5...The “National Institutes of Health” genetically heterogeneous (NIH-HS) rat stock was created in the 1980s through an eight-way cross of as much as possible separate inbred rat strains (i.e. the MR/N, WN/N, WKY/N, M520/N, F344/N, ACI/N, BN/SsN and BUF/N strains) which were readily available at that time. Hansen and Spuhler [1] developed a more naturalistic, genetically heterogeneous rat stock with the aim of optimizing the distribution of genotypic frequencies and recombination and under the hypothesis that the NIH-HS stock could yield a broad-range distribution of responses (broader than commonly used laboratory rat strains) to experimental conditions, and thus serve as a base population for selection studies. Along the last decade, in a series of studies we have phenotypically characterized the NIH-HS rat stock (a colony exists at our laboratory since 2004) for their anxiety/fearfulness profiles (using a battery of both unconditioned and conditioned tests/tasks), as well as regarding their stress-induced hormonal responses, coping style under inescapable stress and spatial learning ability. We have also compared the phenotypic profiles of NIH-HS rats with those of the low anxious RHA-I and the high anxious RLA-I rat strains. The NIH-HS rat stock is, as a population, a rather anxious type of rat, with predominantly reactive/passive coping style in unlearned and learned anxiety/fear tests, and elevated stress hormone responses (as well as enhanced “depressive” symptoms in the forced swimming test). Genetic studies currently under way have thus far revealed that the genetically heterogeneous NIH-HS rat stock constitutes a unique tool for fine mapping of QTL (for multiple behavioural and biological complex traits) to megabase resolution levels, thus enabling candidate gene identification. We give some examples of this in the present paper, while also highlighting that microarray gene expression studies reveal that HPA-axis- and prolactin-related genes (among others) in the amygdala appear to be related with (or associated to) the coping style and anxiety/fearfulness responses of NIH-HS rats.展开更多
BACKGROUND Hematological tumors are common malignant tumors,with high morbidity and mortality rates.Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health bec...BACKGROUND Hematological tumors are common malignant tumors,with high morbidity and mortality rates.Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease,rapid progression,high recurrence rates,complex treatment methods,and treatment costs.AIM To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological malignancies.METHODS A cross-sectional analysis of 100 patients with hematological malignancies,treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023,was conducted.Patients were assessed using a general data survey,a simplified scale for the fear of progression(FoP)of disease,a resilience scale,and the Pittsburgh Sleep Quality Index.Statistical analysis was conducted to determine the relationship between various patient characteristics and FoP,resilience,and sleep quality.Spearman’s correlation analysis was used to examine the correlations between mental resilience,FoP,and sleep quality.RESULTS The total FoP score mean value in patients with hematological malignancies was 38.09±5.16;the total resilience score mean value was 40.73±7.04;and the Pittsburgh Sleep Quality Index score mean value was 10.72±1.90.FoP,resilience,and sleep quality of the patients were associated with family per capita monthly income and patient education level(P<0.05).Spearman correlation analysis revealed that FoP was negatively correlated with resilience and sleep quality scores(r=-0.560,-0.537,P<0.01),respectively,and resilience was significantly associated with sleep quality scores(r=0.688,P<0.01).Mediation analysis showed that the mediating effect of resilience between FoP and sleep quality in patients with hematological malignancies was-0.100 and accounted for 50.51%of the total effect.This indicated that FoP directly and indirectly affected sleep quality through the mesomeric effect of resilience.CONCLUSION Resilience is an intermediary variable between FoP and sleep quality in patients with hematological malignancies.Medical staff should evaluate and follow-up FoP and resilience to implement measures to improve sleep quality.展开更多
Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen...Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen their disc herniation and cause further pain and injury. LDH conditions impact the individuals’ quality of life, to explore the relationship between lumbar curve, muscle strength, fear of movement and functional disability among patients with LDH. Methods: An electronic search was conducted on PubMed, Medline, Science Direct, Springerlink, Google Scholar and a hand search from reference lists was reviewed. Publications were included in human studies, patients 25 - 85 years of age, original studies and published in English language journals from January 2002 to December 2023. Result: In total, 64 articles were researched through the online search engines, and 9 papers were found through manual searches of reference lists. As a result, a total of 11 articles were included for the purpose of this review. The comprehensive analysis revealed the presence of eight cross-sectional studies, two retrospective studies and one experimental study. A minimum of 25 participants and a maximum of 360 participants were included. Ten studies included both genders, only one studies included healthy adults and patients with LDH but these studies didn’t mention gender. Results showed that the factors influencing LDH can be categorized into non-modifiable factors, such as gender, age, height or others. Modifiable factors included increased BMI, DM, smoking, alcohol, employment status, lifestyle and health problems or psychology. Conclusion: Females with greater VASC may be at risk of LDH. The lumbar extensor muscles indicated a localized disc herniation or nerve root pathology in patients with LDH. The fear of movement may lead to psychological consequences and reduce functional disability among patients with LDH.展开更多
Objective This study aimed to evaluate the effects of a mindfulness-based psychosomatic intervention on depression,anxiety,fear of childbirth(FOC),and life satisfaction of pregnant women in China.Methods Women experie...Objective This study aimed to evaluate the effects of a mindfulness-based psychosomatic intervention on depression,anxiety,fear of childbirth(FOC),and life satisfaction of pregnant women in China.Methods Women experiencing first-time pregnancy(n=104)were randomly allocated to the intervention group or a parallel active control group.We collected data at baseline(T0),postintervention(T1),3 days after delivery(T2),and 42 days after delivery(T3).The participants completed questionnaires for the assessment of the levels of depression,anxiety,FOC,life satisfaction,and mindfulness.Differences between the two groups and changes within the same group were analyzed at four time points using repeated-measures analysis of variance.Results Compared with the active control group,the intervention group reported lower depression levels at T2(P=0.038)and T3(P=0.013);reduced anxiety at T1(P=0.001)and T2(P=0.003);reduced FOC at T1(P<0.001)and T2(P=0.04);increased life satisfaction at T1(P<0.001)and T3(P=0.015);and increased mindfulness at T1(P=0.01)and T2(P=0.006).Conclusion The mindfulness-based psychosomatic intervention effectively increased life satisfaction and reduced perinatal depression,anxiety,and FOC.展开更多
Religion is one of the social entities that has had a significant impact on the pandemic.The study’s goals are to investigate the relationship between well-being and fear of COVID-19,as well as to test whether religi...Religion is one of the social entities that has had a significant impact on the pandemic.The study’s goals are to investigate the relationship between well-being and fear of COVID-19,as well as to test whether religious beliefs mediate the effect of wellbeing on fear of COVID-19.The sample comprised of 433 participants in Vietnam.Independent Sample t-Test,One-way ANOVA,mediation analysis were used to analyze the data.In the levels of well-being,individuals who engage in religious services daily have higher levels than those hardly and never attend,and people from the age of 18 to 30 have higher levels than individuals from 31 to above 60 years.In addition,people aged from 51 to above 60 have higher levels of religious beliefs than people aged from 18 to 50.Females experience more fear of COVID-19 compared to males.The latter illustrates that religious beliefs mediate the effect of well-being on fear of COVID-19.Social workers and clinicians must prioritize older adults and people with chronic diseases for early mental interventions,and they should be aware of the role of religion in psychological treatment integration.展开更多
AIM:To investigate the current situation and influencing factors of fear of falling in glaucoma patients in western China.METHODS:In this cross-sectional study,glaucoma patients treated in the Ophthalmology Department...AIM:To investigate the current situation and influencing factors of fear of falling in glaucoma patients in western China.METHODS:In this cross-sectional study,glaucoma patients treated in the Ophthalmology Department of West China Hospital of Sichuan University were conducted to investigate the demographic data,visual acuity,visual field,activities of daily living,risk of falling,fear of falling and psychological states.Generalized linear model was used for multivariate analysis with fear of falling as dependent variable and other factors as independent variables.RESULTS:The mean score of the Chinese version modified Fall Efficacy Scale(MFES)was 7.52±2.09 points.Univariate analysis and multivariate analysis showed that the history of falls within one year,visual acuity,visual field,risk of falling,activities of daily living and psychological states had statistically difference on fear of falling(P<0.05).CONCLUSION:Glaucoma patients in west China have relatively high risk of fear of falling.History of falling within 1y,severe visual function impairment,high risk of falling,incapable of independence of daily living,and abnormal psychological state are risk factors of fear of falling among glaucoma patients.展开更多
This study aimed to examine the relationship between COVID-19 vaccine refusal and religiosity and fear of death among Muslims living in Turkey. This cross-sectional study was conducted online with 1046 adults aged 18 ...This study aimed to examine the relationship between COVID-19 vaccine refusal and religiosity and fear of death among Muslims living in Turkey. This cross-sectional study was conducted online with 1046 adults aged 18 and older. The Ok-Religious Attitude Scale (Islam) (ORASI) (8 items) and Thorson-Powell Death Anxiety Scale (TPDAS) (20 items) were used as data collection instruments. The data were analyzed using the Pearson chi-square test, Student’s t-test, and binary logistic regression. A p-value of 0.05). In binary logistic regression analysis, vaccine rejection was 7.19 times higher among single people, 50.55 times higher among workers and tradesmen, and 3.36 times higher among people who did not have COVID-19. As religiosity increased, the risk of vaccine refusal decreased 1.037-fold.展开更多
This article addresses the predictability of Bitcoin’s price by examining relationships between Bitcoin and financial and emotional variables such as the Fear and Greed Index(FGI),the American Interest Rate(FED),and ...This article addresses the predictability of Bitcoin’s price by examining relationships between Bitcoin and financial and emotional variables such as the Fear and Greed Index(FGI),the American Interest Rate(FED),and the Stock Market Index(NASDAQ).Through the use of statistical techniques such as the Johansen Cointegration Test and Granger Causality,as well as forecasting models,the study reveals that,despite the notorious volatility of the cryptocurrency market,it is possible to identify consistent behavioral patterns that can be successfully used to predict Bitcoin returns.The approach that combines VAR models and neural networks stands out as an effective tool to assist investors and analysts in making informed decisions in an ever-changing market environment.展开更多
Considered a great example of investigative fiction,Mia per sempre[Mine Forever]which denounces violence against women,encourages them to speak out,seek assistance,and refuse to flee in terror,has been hailed as outst...Considered a great example of investigative fiction,Mia per sempre[Mine Forever]which denounces violence against women,encourages them to speak out,seek assistance,and refuse to flee in terror,has been hailed as outstanding work to denounce violence against women.The book is a study of women’s unusual relationships,which are marked by intense love,envious friendships,and unbreakable ties that result in mental instability,irrational behavior,or uncontrollable behavior.Tani’s work has also received recognition for including the knowledgeable perspectives of various specialists who offer a deeper and priceless understanding of these catastrophes occurring individuals’home.This study examines those instances of fear-sharing in relation to women’s independence and ability to move on or start new lives.The main question is how and why Tani’s employs fear.Who are the women or circumstances that cause fear?This paper considers the theoretical discourse on fear developed by scholars of the emotions such as,among others,Jaimal Yogis and Olsson and Phelps in order to examine the circumstances and outcomes of fear fashioned by Tani in her representation of Italian men’s criminal reaction to women’s autonomy.展开更多
Objective:This study aims to identify the relationship between the intolerance of uncertainty and the fear of COVID-19 in patients awaiting kidney transplantation during the COVID-19 pandemic.Methods:This descriptive ...Objective:This study aims to identify the relationship between the intolerance of uncertainty and the fear of COVID-19 in patients awaiting kidney transplantation during the COVID-19 pandemic.Methods:This descriptive and cross-sectional study was performed with the participation of 355 individuals.The data were collected with a patient information form,the intolerance of uncertainty scale–short form(IUS),and the fear of COVID-19 scale(FCV-19S).Results:The mean IUS–short form score of the participants was 53.03±5.11,and their mean FCV-19S score was 30.62±4.10.A statistically highly significant positive relationship was identified between the FCV-19S and IUS scores of the participants(r:0.850;P<0.001).Conclusion:As the patients’intolerance of uncertainty increased,their fears of COVID-19 also increased.For patients awaiting kidney transplantation during the COVID-19 pandemic,which is full of challenges,to cope with fear and uncertainty,it is recommended that patients are provided with care with a multidisciplinary team approach.展开更多
The authors study people’s worries about becoming victimized by events and conditions often blamed on“those up there”.Excessive worries are bad for people’s performance because they lead to risk avoidance and lowe...The authors study people’s worries about becoming victimized by events and conditions often blamed on“those up there”.Excessive worries are bad for people’s performance because they lead to risk avoidance and lower self-confidence.In two representative surveys conducted in Germany,it is found that victimization concerns are positively correlated with people’s gender,previous victimization,their estimated likelihood of being victimized,their fear of crime,their crime-avoidance behavior,their striving for tradition and security,and their negative attitudes toward crimes.Negative correlations are found for people’s education,their striving for universalism,and their social capital.When considering all predictors combined,people’s expected likelihood to become victimized is found to be the optimal predictor of victimization concerns.It is recommended that management concentrates on setting realistic levels of such risk estimates to avoid negative effects on people’s performance.展开更多
In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, wh...In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, which have caused her failure in the fulfillment of her view of freedom.展开更多
Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential neph...Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential nephrotoxicity.Nevertheless,recent studies have shown that these two inhalation anesthetics are similar in hepatorenal toxicity,cost,and long-term anesthetic effect.Moreover,sevoflurane possibly has less cognitive impact on young mice.In this study,C57BL/6 mice aged 8–10 weeks were exposed to 1.2%isoflurane or 2.4%sevoflurane for 6 hours.Cognitive function and memory were examined in young mice using the novel object recognition,contextual fear conditioning,and cued-fear extinction tests.Western blot assay was performed to detect expression levels of D1 dopamine receptor,catechol-O-methyltransferase,phospho-glycogen synthase kinase-3β,and total glycogen synthase kinase-3βin the hippocampus.Our results show that impaired performance was not detected in mice exposed to sevoflurane during the novel object recognition test.Contextual memory impairment in the fear conditioning test was shorter in the sevoflurane group than the isoflurane group.Long-term sevoflurane exposure did not affect memory consolidation,while isoflurane led to memory consolidation and reduced retention.Downregulation of hippocampal D1 dopamine receptors and phosphorylated glycogen synthase kinase-3β/total glycogen synthase kinase-3βand upregulation of catechol-O-methyltransferase may be associated with differing memory performance after exposure to isoflurane or sevoflurane.These results confirm that sevoflurane has less effect on cognitive impairment than isoflurane,which may be related to expression of D1 dopamine receptors and catechol-O-methyltransferase and phosphorylation of glycogen synthase kinase-3βin the hippocampus.This study was approved by the Institutional Animal Care and Use Committee,Nanjing University,China on November 20,2017(approval No.20171102).展开更多
Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to b...Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments.In this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model.We established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest disturbance.We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function.Our results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation.However,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory deficits.Additionally,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms.Overall,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm.All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November20,2017.展开更多
Humans and animals are in regular and at times close contact in modern intensive farming systems.The quality of human-animal interactions can have a profound impact on the productivity and welfare of farm animals.Inte...Humans and animals are in regular and at times close contact in modern intensive farming systems.The quality of human-animal interactions can have a profound impact on the productivity and welfare of farm animals.Interactions by humans may be neutral,positive or negative in nature.Regular pleasant contact with humans may result in desirable alterations in the physiology,behaviour,health and productivity of farm animals.On the contrary,animals that were subjected to aversive human contact were highly fearful of humans and their growth and reproductive performance could be compromised.Farm animals are particularly sensitive to human stimulation that occurs early in life,while many systems of the animals are still developing.This may have long-lasting impact and could possibly modify their genetic potential.The question as to how human contact can have a positive impact on responses to stressors,and productivity is not well understood.Recent work in our laboratory suggested that pleasant human contact may alter ability to tolerate various stressors through enhanced heat shock protein(hsp) 70 expression.The induction of hsp is often associated with increased tolerance to environmental stressors and disease resistance in animals.The attitude and consequent behaviour of stockpeople affect the animals' fear of human which eventually influence animals' productivity and welfare.Other than attitude and behaviour,technical skills,knowledge,job motivation,commitment and job satisfaction are prerequisites for high job performance.展开更多
BACKGROUND Elderly patients tend to have poor self-efficacy and poor confidence in postoperative rehabilitation for hip fractures,and are prone to negative emotions,which affect treatment compliance.AIM To evaluate th...BACKGROUND Elderly patients tend to have poor self-efficacy and poor confidence in postoperative rehabilitation for hip fractures,and are prone to negative emotions,which affect treatment compliance.AIM To evaluate the effects of evidence-based intervention on postoperative fear,compliance,and self-efficacy in elderly patients with hip fractures.METHODS A total of 120 patients with hip fracture surgically treated from June 2018 to June 2020 at the orthopedic department of our hospital were selected and divided into intervention and routine groups(n=60 each)according to different nursing methods.The basic rehabilitation methods of the two groups were consistent,but patients in the intervention group received evidence-based nursing interventions at the same time.Differences between groups in the scores of motion phobia,pain fear,rehabilitation training compliance,self-efficacy,nursing satisfaction,and hip joint function were compared before and after the intervention.RESULTS Before the intervention,there were no statistically significant differences in motion phobia and pain fear scores between the groups(all P>0.05).However,motion phobia scores at 1 wk after intervention initiation(P<0.05),and pain fear scores at 1 wk and 2 wk after intervention initiation(all P<0.05),were significantly lower in the intervention group than in the routine group.On the first day of intervention,there was no significant difference in rehabilitation treatment compliance between the groups(P>0.05);however,at 2 wk after intervention initiation,rehabilitation compliance was significantly better in the intervention group than in the routine group(P<0.05).Before the intervention,there were no statistically significant differences in the scores for the two self-efficacy dimensions(overcoming difficulties and rehabilitation exercise self-efficacy)and the total self-efficacy score between the groups(all P>0.05).After 2 wk of intervention,the scores for these two dimensions of self-efficacy and the total self-efficacy score were significantly higher in the intervention group than in the routine group(all P<0.05).At 3 and 6 mo after surgery,hip function as evaluated by the Harris hip score,was significantly better in the intervention group than in the routine group(P<0.05).Additionally,overall nursing satisfaction was significantly higher in the intervention group than in the routine group(P<0.05).CONCLUSION Evidence-based nursing intervention can alleviate fear of postoperative rehabilitation in elderly patients who underwent hip fracture surgery,and improve rehabilitation treatment compliance and patient self-efficacy,which promote hip function recovery.展开更多
基金grants for the MICINN (PSI2009-10532) “Fundació La Maratò TV3” (ref. 092630/31) 2009SGR-0051 and the European pro- ject/consortium “EURATRANS” (grant agreement HEALTH-F4- 2010-241504)
文摘The “National Institutes of Health” genetically heterogeneous (NIH-HS) rat stock was created in the 1980s through an eight-way cross of as much as possible separate inbred rat strains (i.e. the MR/N, WN/N, WKY/N, M520/N, F344/N, ACI/N, BN/SsN and BUF/N strains) which were readily available at that time. Hansen and Spuhler [1] developed a more naturalistic, genetically heterogeneous rat stock with the aim of optimizing the distribution of genotypic frequencies and recombination and under the hypothesis that the NIH-HS stock could yield a broad-range distribution of responses (broader than commonly used laboratory rat strains) to experimental conditions, and thus serve as a base population for selection studies. Along the last decade, in a series of studies we have phenotypically characterized the NIH-HS rat stock (a colony exists at our laboratory since 2004) for their anxiety/fearfulness profiles (using a battery of both unconditioned and conditioned tests/tasks), as well as regarding their stress-induced hormonal responses, coping style under inescapable stress and spatial learning ability. We have also compared the phenotypic profiles of NIH-HS rats with those of the low anxious RHA-I and the high anxious RLA-I rat strains. The NIH-HS rat stock is, as a population, a rather anxious type of rat, with predominantly reactive/passive coping style in unlearned and learned anxiety/fear tests, and elevated stress hormone responses (as well as enhanced “depressive” symptoms in the forced swimming test). Genetic studies currently under way have thus far revealed that the genetically heterogeneous NIH-HS rat stock constitutes a unique tool for fine mapping of QTL (for multiple behavioural and biological complex traits) to megabase resolution levels, thus enabling candidate gene identification. We give some examples of this in the present paper, while also highlighting that microarray gene expression studies reveal that HPA-axis- and prolactin-related genes (among others) in the amygdala appear to be related with (or associated to) the coping style and anxiety/fearfulness responses of NIH-HS rats.
文摘BACKGROUND Hematological tumors are common malignant tumors,with high morbidity and mortality rates.Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease,rapid progression,high recurrence rates,complex treatment methods,and treatment costs.AIM To explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological malignancies.METHODS A cross-sectional analysis of 100 patients with hematological malignancies,treated in the First Affiliated Hospital of Jinzhou Medical University between August 2022 and August 2023,was conducted.Patients were assessed using a general data survey,a simplified scale for the fear of progression(FoP)of disease,a resilience scale,and the Pittsburgh Sleep Quality Index.Statistical analysis was conducted to determine the relationship between various patient characteristics and FoP,resilience,and sleep quality.Spearman’s correlation analysis was used to examine the correlations between mental resilience,FoP,and sleep quality.RESULTS The total FoP score mean value in patients with hematological malignancies was 38.09±5.16;the total resilience score mean value was 40.73±7.04;and the Pittsburgh Sleep Quality Index score mean value was 10.72±1.90.FoP,resilience,and sleep quality of the patients were associated with family per capita monthly income and patient education level(P<0.05).Spearman correlation analysis revealed that FoP was negatively correlated with resilience and sleep quality scores(r=-0.560,-0.537,P<0.01),respectively,and resilience was significantly associated with sleep quality scores(r=0.688,P<0.01).Mediation analysis showed that the mediating effect of resilience between FoP and sleep quality in patients with hematological malignancies was-0.100 and accounted for 50.51%of the total effect.This indicated that FoP directly and indirectly affected sleep quality through the mesomeric effect of resilience.CONCLUSION Resilience is an intermediary variable between FoP and sleep quality in patients with hematological malignancies.Medical staff should evaluate and follow-up FoP and resilience to implement measures to improve sleep quality.
文摘Introduction: Lumbar disc herniation (LDH) refers to the rupture of the fibrous annulus of the intervertebral discs. Lumbar curvature may lead to the occurrence of lumbar disc degeneration. Fear of movement may worsen their disc herniation and cause further pain and injury. LDH conditions impact the individuals’ quality of life, to explore the relationship between lumbar curve, muscle strength, fear of movement and functional disability among patients with LDH. Methods: An electronic search was conducted on PubMed, Medline, Science Direct, Springerlink, Google Scholar and a hand search from reference lists was reviewed. Publications were included in human studies, patients 25 - 85 years of age, original studies and published in English language journals from January 2002 to December 2023. Result: In total, 64 articles were researched through the online search engines, and 9 papers were found through manual searches of reference lists. As a result, a total of 11 articles were included for the purpose of this review. The comprehensive analysis revealed the presence of eight cross-sectional studies, two retrospective studies and one experimental study. A minimum of 25 participants and a maximum of 360 participants were included. Ten studies included both genders, only one studies included healthy adults and patients with LDH but these studies didn’t mention gender. Results showed that the factors influencing LDH can be categorized into non-modifiable factors, such as gender, age, height or others. Modifiable factors included increased BMI, DM, smoking, alcohol, employment status, lifestyle and health problems or psychology. Conclusion: Females with greater VASC may be at risk of LDH. The lumbar extensor muscles indicated a localized disc herniation or nerve root pathology in patients with LDH. The fear of movement may lead to psychological consequences and reduce functional disability among patients with LDH.
基金supported by the National Center for Women and Children’s Health of the Chinese Center for Disease Control and Prevention。
文摘Objective This study aimed to evaluate the effects of a mindfulness-based psychosomatic intervention on depression,anxiety,fear of childbirth(FOC),and life satisfaction of pregnant women in China.Methods Women experiencing first-time pregnancy(n=104)were randomly allocated to the intervention group or a parallel active control group.We collected data at baseline(T0),postintervention(T1),3 days after delivery(T2),and 42 days after delivery(T3).The participants completed questionnaires for the assessment of the levels of depression,anxiety,FOC,life satisfaction,and mindfulness.Differences between the two groups and changes within the same group were analyzed at four time points using repeated-measures analysis of variance.Results Compared with the active control group,the intervention group reported lower depression levels at T2(P=0.038)and T3(P=0.013);reduced anxiety at T1(P=0.001)and T2(P=0.003);reduced FOC at T1(P<0.001)and T2(P=0.04);increased life satisfaction at T1(P<0.001)and T3(P=0.015);and increased mindfulness at T1(P=0.01)and T2(P=0.006).Conclusion The mindfulness-based psychosomatic intervention effectively increased life satisfaction and reduced perinatal depression,anxiety,and FOC.
文摘Religion is one of the social entities that has had a significant impact on the pandemic.The study’s goals are to investigate the relationship between well-being and fear of COVID-19,as well as to test whether religious beliefs mediate the effect of wellbeing on fear of COVID-19.The sample comprised of 433 participants in Vietnam.Independent Sample t-Test,One-way ANOVA,mediation analysis were used to analyze the data.In the levels of well-being,individuals who engage in religious services daily have higher levels than those hardly and never attend,and people from the age of 18 to 30 have higher levels than individuals from 31 to above 60 years.In addition,people aged from 51 to above 60 have higher levels of religious beliefs than people aged from 18 to 50.Females experience more fear of COVID-19 compared to males.The latter illustrates that religious beliefs mediate the effect of well-being on fear of COVID-19.Social workers and clinicians must prioritize older adults and people with chronic diseases for early mental interventions,and they should be aware of the role of religion in psychological treatment integration.
文摘AIM:To investigate the current situation and influencing factors of fear of falling in glaucoma patients in western China.METHODS:In this cross-sectional study,glaucoma patients treated in the Ophthalmology Department of West China Hospital of Sichuan University were conducted to investigate the demographic data,visual acuity,visual field,activities of daily living,risk of falling,fear of falling and psychological states.Generalized linear model was used for multivariate analysis with fear of falling as dependent variable and other factors as independent variables.RESULTS:The mean score of the Chinese version modified Fall Efficacy Scale(MFES)was 7.52±2.09 points.Univariate analysis and multivariate analysis showed that the history of falls within one year,visual acuity,visual field,risk of falling,activities of daily living and psychological states had statistically difference on fear of falling(P<0.05).CONCLUSION:Glaucoma patients in west China have relatively high risk of fear of falling.History of falling within 1y,severe visual function impairment,high risk of falling,incapable of independence of daily living,and abnormal psychological state are risk factors of fear of falling among glaucoma patients.
文摘This study aimed to examine the relationship between COVID-19 vaccine refusal and religiosity and fear of death among Muslims living in Turkey. This cross-sectional study was conducted online with 1046 adults aged 18 and older. The Ok-Religious Attitude Scale (Islam) (ORASI) (8 items) and Thorson-Powell Death Anxiety Scale (TPDAS) (20 items) were used as data collection instruments. The data were analyzed using the Pearson chi-square test, Student’s t-test, and binary logistic regression. A p-value of 0.05). In binary logistic regression analysis, vaccine rejection was 7.19 times higher among single people, 50.55 times higher among workers and tradesmen, and 3.36 times higher among people who did not have COVID-19. As religiosity increased, the risk of vaccine refusal decreased 1.037-fold.
文摘This article addresses the predictability of Bitcoin’s price by examining relationships between Bitcoin and financial and emotional variables such as the Fear and Greed Index(FGI),the American Interest Rate(FED),and the Stock Market Index(NASDAQ).Through the use of statistical techniques such as the Johansen Cointegration Test and Granger Causality,as well as forecasting models,the study reveals that,despite the notorious volatility of the cryptocurrency market,it is possible to identify consistent behavioral patterns that can be successfully used to predict Bitcoin returns.The approach that combines VAR models and neural networks stands out as an effective tool to assist investors and analysts in making informed decisions in an ever-changing market environment.
文摘Considered a great example of investigative fiction,Mia per sempre[Mine Forever]which denounces violence against women,encourages them to speak out,seek assistance,and refuse to flee in terror,has been hailed as outstanding work to denounce violence against women.The book is a study of women’s unusual relationships,which are marked by intense love,envious friendships,and unbreakable ties that result in mental instability,irrational behavior,or uncontrollable behavior.Tani’s work has also received recognition for including the knowledgeable perspectives of various specialists who offer a deeper and priceless understanding of these catastrophes occurring individuals’home.This study examines those instances of fear-sharing in relation to women’s independence and ability to move on or start new lives.The main question is how and why Tani’s employs fear.Who are the women or circumstances that cause fear?This paper considers the theoretical discourse on fear developed by scholars of the emotions such as,among others,Jaimal Yogis and Olsson and Phelps in order to examine the circumstances and outcomes of fear fashioned by Tani in her representation of Italian men’s criminal reaction to women’s autonomy.
文摘Objective:This study aims to identify the relationship between the intolerance of uncertainty and the fear of COVID-19 in patients awaiting kidney transplantation during the COVID-19 pandemic.Methods:This descriptive and cross-sectional study was performed with the participation of 355 individuals.The data were collected with a patient information form,the intolerance of uncertainty scale–short form(IUS),and the fear of COVID-19 scale(FCV-19S).Results:The mean IUS–short form score of the participants was 53.03±5.11,and their mean FCV-19S score was 30.62±4.10.A statistically highly significant positive relationship was identified between the FCV-19S and IUS scores of the participants(r:0.850;P<0.001).Conclusion:As the patients’intolerance of uncertainty increased,their fears of COVID-19 also increased.For patients awaiting kidney transplantation during the COVID-19 pandemic,which is full of challenges,to cope with fear and uncertainty,it is recommended that patients are provided with care with a multidisciplinary team approach.
文摘The authors study people’s worries about becoming victimized by events and conditions often blamed on“those up there”.Excessive worries are bad for people’s performance because they lead to risk avoidance and lower self-confidence.In two representative surveys conducted in Germany,it is found that victimization concerns are positively correlated with people’s gender,previous victimization,their estimated likelihood of being victimized,their fear of crime,their crime-avoidance behavior,their striving for tradition and security,and their negative attitudes toward crimes.Negative correlations are found for people’s education,their striving for universalism,and their social capital.When considering all predictors combined,people’s expected likelihood to become victimized is found to be the optimal predictor of victimization concerns.It is recommended that management concentrates on setting realistic levels of such risk estimates to avoid negative effects on people’s performance.
文摘In The Portrait of a Lady, Isabel Archer values her liberty higher than a sense of security that might be guaranteed by possessing great fortune. But there are some paradoxes in Isabel Archer's view of freedom, which have caused her failure in the fulfillment of her view of freedom.
基金supported by the National Natural Science Foundation of China,No.81730033(to XPG),No.81701371(to TJX)
文摘Isoflurane and sevoflurane are both inhalation anesthetics,but in clinical application,sevoflurane has been considered to be less suitable for long-term anesthesia because of its catabolic compounds and potential nephrotoxicity.Nevertheless,recent studies have shown that these two inhalation anesthetics are similar in hepatorenal toxicity,cost,and long-term anesthetic effect.Moreover,sevoflurane possibly has less cognitive impact on young mice.In this study,C57BL/6 mice aged 8–10 weeks were exposed to 1.2%isoflurane or 2.4%sevoflurane for 6 hours.Cognitive function and memory were examined in young mice using the novel object recognition,contextual fear conditioning,and cued-fear extinction tests.Western blot assay was performed to detect expression levels of D1 dopamine receptor,catechol-O-methyltransferase,phospho-glycogen synthase kinase-3β,and total glycogen synthase kinase-3βin the hippocampus.Our results show that impaired performance was not detected in mice exposed to sevoflurane during the novel object recognition test.Contextual memory impairment in the fear conditioning test was shorter in the sevoflurane group than the isoflurane group.Long-term sevoflurane exposure did not affect memory consolidation,while isoflurane led to memory consolidation and reduced retention.Downregulation of hippocampal D1 dopamine receptors and phosphorylated glycogen synthase kinase-3β/total glycogen synthase kinase-3βand upregulation of catechol-O-methyltransferase may be associated with differing memory performance after exposure to isoflurane or sevoflurane.These results confirm that sevoflurane has less effect on cognitive impairment than isoflurane,which may be related to expression of D1 dopamine receptors and catechol-O-methyltransferase and phosphorylation of glycogen synthase kinase-3βin the hippocampus.This study was approved by the Institutional Animal Care and Use Committee,Nanjing University,China on November 20,2017(approval No.20171102).
基金supported by the National Natural Science Foundation of China,No.81730033(to XPG),No.81701371(to TJX),No.81801380(to XZ)the Natural Science Foundation of Jiangsu Province of China,No.BK20170654(to TJX),No.BK20170129(to XZ)the Key Talent’s 13th Five-Year Plan for Strengthening Health of Jiangsu Province of China,No.ZDRCA2016069(to XPG)
文摘Sleep-wake rhythm disturbances,which are characterized by abnormal sleep timing or duration,are associated with cognitive dysfunction.Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating sleep patterns and improving cognitive behavior in abnormal sleep-wake pattern experiments.In this study,we examined whether light and sound interventions could reduce sleep-wake pattern disturbances and memory deficits in a sleep rhythm disturbance model.We established a model of sleep rhythm disturbance in C57 BL/6 J mice via a sleep deprivation method involving manual cage tapping,cage jostling,and nest disturbance.We used a Mini Mitter radio transmitter device to monitor motor activity in the mice and fear conditioning tests to assess cognitive function.Our results indicated that an intervention in which the mice were exposed to blue light(40-Hz flickering frequency)for 1 hour during their subjective daytime significantly improved the 24-hour-acrophase shift and reduced the degree of memory deficit induced by sleep deprivation.However,interventions in which the mice were exposed to a 40-Hz blue light at offset time or subjective night time points,as well as 2 Hz-blue light at 3 intervention time points(subjective day time,subjective night time,and offset time points),had no positive effects on circadian rhythm shift or memory deficits.Additionally,a 2000-Hz sound intervention during subjective day time attenuated the24-hour-acrophase shift and memory decline,while 440-Hz and 4000-Hz sounds had no effect on circadian rhythms.Overall,these results demonstrate that photoacoustic treatment effectively corrected abnormal sleep-wake patterns and cognitive dysfunction associated with sleep-deprivation-induced disturbances in sleep-wake rhythm.All animal experiments were approved by the Experimental Animal Ethics Committee of Drum Tower Hospital Affiliated to the Medical College of Nanjing University,China(approval No.20171102)on November20,2017.
文摘Humans and animals are in regular and at times close contact in modern intensive farming systems.The quality of human-animal interactions can have a profound impact on the productivity and welfare of farm animals.Interactions by humans may be neutral,positive or negative in nature.Regular pleasant contact with humans may result in desirable alterations in the physiology,behaviour,health and productivity of farm animals.On the contrary,animals that were subjected to aversive human contact were highly fearful of humans and their growth and reproductive performance could be compromised.Farm animals are particularly sensitive to human stimulation that occurs early in life,while many systems of the animals are still developing.This may have long-lasting impact and could possibly modify their genetic potential.The question as to how human contact can have a positive impact on responses to stressors,and productivity is not well understood.Recent work in our laboratory suggested that pleasant human contact may alter ability to tolerate various stressors through enhanced heat shock protein(hsp) 70 expression.The induction of hsp is often associated with increased tolerance to environmental stressors and disease resistance in animals.The attitude and consequent behaviour of stockpeople affect the animals' fear of human which eventually influence animals' productivity and welfare.Other than attitude and behaviour,technical skills,knowledge,job motivation,commitment and job satisfaction are prerequisites for high job performance.
文摘BACKGROUND Elderly patients tend to have poor self-efficacy and poor confidence in postoperative rehabilitation for hip fractures,and are prone to negative emotions,which affect treatment compliance.AIM To evaluate the effects of evidence-based intervention on postoperative fear,compliance,and self-efficacy in elderly patients with hip fractures.METHODS A total of 120 patients with hip fracture surgically treated from June 2018 to June 2020 at the orthopedic department of our hospital were selected and divided into intervention and routine groups(n=60 each)according to different nursing methods.The basic rehabilitation methods of the two groups were consistent,but patients in the intervention group received evidence-based nursing interventions at the same time.Differences between groups in the scores of motion phobia,pain fear,rehabilitation training compliance,self-efficacy,nursing satisfaction,and hip joint function were compared before and after the intervention.RESULTS Before the intervention,there were no statistically significant differences in motion phobia and pain fear scores between the groups(all P>0.05).However,motion phobia scores at 1 wk after intervention initiation(P<0.05),and pain fear scores at 1 wk and 2 wk after intervention initiation(all P<0.05),were significantly lower in the intervention group than in the routine group.On the first day of intervention,there was no significant difference in rehabilitation treatment compliance between the groups(P>0.05);however,at 2 wk after intervention initiation,rehabilitation compliance was significantly better in the intervention group than in the routine group(P<0.05).Before the intervention,there were no statistically significant differences in the scores for the two self-efficacy dimensions(overcoming difficulties and rehabilitation exercise self-efficacy)and the total self-efficacy score between the groups(all P>0.05).After 2 wk of intervention,the scores for these two dimensions of self-efficacy and the total self-efficacy score were significantly higher in the intervention group than in the routine group(all P<0.05).At 3 and 6 mo after surgery,hip function as evaluated by the Harris hip score,was significantly better in the intervention group than in the routine group(P<0.05).Additionally,overall nursing satisfaction was significantly higher in the intervention group than in the routine group(P<0.05).CONCLUSION Evidence-based nursing intervention can alleviate fear of postoperative rehabilitation in elderly patients who underwent hip fracture surgery,and improve rehabilitation treatment compliance and patient self-efficacy,which promote hip function recovery.