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Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity 被引量:19
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作者 Michael Hollis Kavitha Nair +3 位作者 Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas 《World Journal of Gastroenterology》 SCIE CAS 2015年第27期8284-8292,共9页
Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expre... Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC. 展开更多
关键词 COLORECTAL cancer microrna Expression Serum microrna fecal microrna Diagnostic PROGNOSTIC Therapeutic
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