Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy

The RAS-RAF-MEK-ERK signaling pathway(MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antitumor strategy.Dozens of potent non-ATP-competitive allosteric MEK1/2 inhibitors have been developed that have produced substantial improvement in clinical outcomes over the past decade.However, the efficacy of these agents is limited, and response rates are variable in a wide range of tumors that harbor RAS and RAF mutations due to the development of resistance, which is derived mainly from the persistence of MAPK signaling and increased activation of the mutual feedback networks.Both intrinsic and acquired resistance to MEK inhibitors necessitates the synergistic targeting of both pathways to restore the therapeutic effects of a single agent.In this review, the significant role of the MAPK pathway in carcinogenesis and its therapeutic potential are comprehensively examined with a focus on MEK inhibitors.Then, the activation of feedback networks accompanying MEK inhibition is briefly reviewed.Combination strategies that involve the simultaneous inhibition of the original and resistance pathways are highlighted and elaborately described on the basis of the latest research progress.Finally, the obstacles to the development of MEK-related combination systems are discussed in order to lay the groundwork for their clinical application as frontline treatments for individual patients with MAPK-hyperactivated malignancies.

Research on Narrowband Line Spectrum Noise Control Method Based on Nearest Neighbor Filter and BP Neural Network Feedback Mechanism

Thefilter-x least mean square(FxLMS)algorithm is widely used in active noise control(ANC)systems.However,because the algorithm is a feedback control algorithm based on the minimization of the error signal variance to update thefilter coefficients,it has a certain delay,usually has a slow convergence speed,and the system response time is long and easily affected by the learning rate leading to the lack of system stability,which often fails to achieve the desired control effect in practice.In this paper,we propose an active control algorithm with near-est-neighbor trap structure and neural network feedback mechanism to reduce the coefficient update time of the FxLMS algorithm and use the neural network feedback mechanism to realize the parameter update,which is called NNR-BPFxLMS algorithm.In the paper,the schematic diagram of the feedback control is given,and the performance of the algorithm is analyzed.Under various noise conditions,it is shown by simulation and experiment that the NNR-BPFxLMS algorithm has the following three advantages:in terms of performance,it has higher noise reduction under the same number of sampling points,i.e.,it has faster convergence speed,and by computer simulation and sound pipe experiment,for simple ideal line spectrum noise,compared with the convergence speed of NNR-BPFxLMS is improved by more than 95%compared with FxLMS algorithm,and the convergence speed of real noise is also improved by more than 70%.In terms of stability,NNR-BPFxLMS is insensitive to step size changes.In terms of tracking performance,its algorithm responds quickly to sudden changes in the noise spectrum and can cope with the complex control requirements of sudden changes in the noise spectrum.

Quantum feedback networks and control:A brief survey

The purpose of this paper is to provide a brief review of some recent developments in quantum feedback networks and control.A quantum feedback network (QFN) is an interconnected system consisting of open quantum systems linked by free fields and/or direct physical couplings.Basic network constructs,including series connections as well as feedback loops,are discussed.The quantum feedback network theory provides a natural framework for analysis and design.Basic properties such as dissipation,stability,passivity and gain of open quantum systems are discussed.Control system design is also discussed,primarily in the context of open linear quantum stochastic systems.The issue of physical realizability is discussed,and explicit criteria for stability,positive real lemma,and bounded real lemma are presented.Finally for linear quantum systems,coherent H∞ and LQG control are described.

Feedback LSTM Network Based on Attention for Image Description Generator

Images are complex multimedia data which contain rich semantic information.Most of current image description generator algorithms only generate plain description,with the lack of distinction between primary and secondary object,leading to insufficient high-level semantic and accuracy under public evaluation criteria.The major issue is the lack of effective network on high-level semantic sentences generation,which contains detailed description for motion and state of the principal object.To address the issue,this paper proposes the Attention-based Feedback Long Short-Term Memory Network(AFLN).Based on existing codec framework,there are two independent sub tasks in our method:attention-based feedback LSTM network during decoding and the Convolutional Block Attention Module(CBAM)in the coding phase.First,we propose an attentionbased network to feedback the features corresponding to the generated word from the previous LSTM decoding unit.We implement feedback guidance through the related field mapping algorithm,which quantifies the correlation between previous word and latter word,so that the main object can be tracked with highlighted detailed description.Second,we exploit the attention idea and apply a lightweight and general module called CBAM after the last layer of VGG 16 pretraining network,which can enhance the expression of image coding features by combining channel and spatial dimension attention maps with negligible overheads.Extensive experiments on COCO dataset validate the superiority of our network over the state-of-the-art algorithms.Both scores and actual effects are proved.The BLEU 4 score increases from 0.291 to 0.301 while the CIDEr score rising from 0.912 to 0.952.

Cascading failures in congested complex networks with feedback

In this article, we investigate cascading failures in complex networks by introducing a feedback. To characterize the effect of the feedback, we define a procedure that involves a self-organization of trip distribution during the process of cascading failures. For this purpose, user equilibrium with variable demand is used as an alternative way to determine the traffic flow pattern throughout the network. Under the attack, cost function dynamics are introduced to discuss edge overload in complex networks, where each edge is assigned a finite capacity （controlled by parameter α）. We find that scale-free networks without considering the effect of the feedback are expected to be very sensitive to α as compared with random networks, while this situation is largely improved after introducing the feedback.

Adaptive output feedback control for nonlinear time-delay systems using neural network

This paper extends the adaptive neural network （NN） control approaches to a class of unknown output feedback nonlinear time-delay systems. An adaptive output feedback NN tracking controller is designed by backstepping technique. NNs are used to approximate unknown functions dependent on time delay, Delay-dependent filters are introduced for state estimation. The domination method is used to deal with the smooth time-delay basis functions. The adaptive bounding technique is employed to estimate the upper bound of the NN approximation errors. Based on Lyapunov- Krasovskii functional, the semi-global uniform ultimate boundedness of all the signals in the closed-loop system is proved, The feasibility is investigated by two illustrative simulation examples.

Adaptive Output-feedback Regulation for Nonlinear Delayed Systems Using Neural Network

A novel adaptive neural network （NN） output-feedback regulation algorithm for a class of nonlinear time-varying timedelay systems is proposed. Both the designed observer and controller are independent of time delay. Different from the existing results, where the upper bounding functions of time-delay terms are assumed to be known, we only use an NN to compensate for all unknown upper bounding functions without that assumption. The proposed design method is proved to be able to guarantee semi-global uniform ultimate boundedness of all the signals in the closed system, and the system output is proved to converge to a small neighborhood of the origin. The simulation results verify the effectiveness of the control scheme.

Adaptive output-feedback control for MIMO nonlinear systems with time-varying delays using neural networks

An adaptive neural network output-feedback regulation approach is proposed for a class of multi-input-multi-output nonlinear time-varying delayed systems.Both the designed observer and controller are free from time delays.Different from the existing results,this paper need not the assumption that the upper bounding functions of time-delay terms are known,and only a neural network is employed to compensate for all the upper bounding functions of time-delay terms,so the designed controller procedure is more simplified.In addition,the resulting closed-loop system is proved to be semi-globally ultimately uniformly bounded,and the output regulation error converges to a small residual set around the origin.Two simulation examples are provided to verify the effectiveness of control scheme.

Backstepping sliding mode control for uncertain strict-feedback nonlinear systems using neural-network-based adaptive gain scheduling

A neural-network-based adaptive gain scheduling backstepping sliding mode control（NNAGS-BSMC） approach for a class of uncertain strict-feedback nonlinear system is proposed.First, the control problem of uncertain strict-feedback nonlinear systems is formulated. Second, the detailed design of NNAGSBSMC is described. The sliding mode control（SMC） law is designed to track a referenced output via backstepping technique.To decrease chattering result from SMC, a radial basis function neural network（RBFNN） is employed to construct the NNAGSBSMC to facilitate adaptive gain scheduling, in which the gains are scheduled adaptively via neural network（NN）, with sliding surface and its differential as NN inputs and the gains as NN outputs. Finally, the verification example is given to show the effectiveness and robustness of the proposed approach. Contrasting simulation results indicate that the NNAGS-BSMC decreases the chattering effectively and has better control performance against the BSMC.

Adaptive Neural Network-Based Control for a Class of Nonlinear Pure-Feedback Systems With Time-Varying Full State Constraints

In this paper, an adaptive neural network(NN)control approach is proposed for nonlinear pure-feedback systems with time-varying full state constraints. The pure-feedback systems of this paper are assumed to possess nonlinear function uncertainties. By using the mean value theorem, pure-feedback systems can be transformed into strict feedback forms. For the newly generated systems, NNs are employed to approximate unknown items. Based on the adaptive control scheme and backstepping algorithm, an intelligent controller is designed. At the same time, time-varying Barrier Lyapunov functions(BLFs)with error variables are adopted to avoid violating full state constraints in every step of the backstepping design. All closedloop signals are uniformly ultimately bounded and the output tracking error converges to the neighborhood of zero, which can be verified by using the Lyapunov stability theorem. Two simulation examples reveal the performance of the adaptive NN control approach.

Neural Network Based Adaptive Tracking Control for a Class of Pure Feedback Nonlinear Systems With Input Saturation

In this paper, an adaptive neural networks(NNs)tracking controller is proposed for a class of single-input/singleoutput(SISO) non-affine pure-feedback non-linear systems with input saturation. In the proposed approach, the original input saturated nonlinear system is augmented by a low pass filter.Then, new system states are introduced to implement states transformation of the augmented model. The resulting new model in affine Brunovsky form permits direct and simpler controller design by avoiding back-stepping technique and its complexity growing as done in existing methods in the literature.In controller design of the proposed approach, a state observer,based on the strictly positive real(SPR) theory, is introduced and designed to estimate the new system states, and only two neural networks are used to approximate the uncertain nonlinearities and compensate for the saturation nonlinearity of actuator. The proposed approach can not only provide a simple and effective way for construction of the controller in adaptive neural networks control of non-affine systems with input saturation, but also guarantee the tracking performance and the boundedness of all the signals in the closed-loop system. The stability of the control system is investigated by using the Lyapunov theory. Simulation examples are presented to show the effectiveness of the proposed controller.

A Trust Management Scheme Based on Behavior Feedback for Opportunistic Networks

In the harsh environment where n ode density is sparse, the slow-moving nodes cannot effectively utilize the encountering opportunities to realize the self-organized identity authentications, and do not have the chance to join the network routing. However, considering m ost of the communications in opportunistic networks are caused by forwarding operations, there is no need to establish the complete mutual authentications for each conversation. Accordingly, a novel trust management scheme is presented based on the information of behavior feedback, in order to complement the insufficiency of identity authentications. By utilizing the certificate chains based on social attributes, the mobile nodes build the local certificate graphs gradually to realize the web of "Identity Trust" relationship. Meanwhile, the successors generate Verified Feedback Packets for each positive behavior, and consequently the "Behavior Trust" relationship is formed for slow-moving nodes. Simulation result shows that, by implementing our trust scheme, the d elivery probability and trust reconstruction ratio can be effectively improved when there are large numbers of compromised nodes, and it means that our trust management scheme can efficiently explore and filter the trust nodes for secure forwarding in opportunistic networks.

ON THE STABILITY OF CELLULAR NEURAL NETWORKS WITH FEEDBACK MODE

Cellular Neural Networks (CNN) with feedback mode and M×N cells are equivalent to a network which possesses 2M×N cells, a neighborhood with mirror-like structure, space-variant templates and without feedback as well as without input templates. The stability of the CNN with feedback mode and transformations with the neighborhood of mirror-like structure are discussed.

Output Feedback Control of Networked Systems

This paper considers the problem of control of networked systems via output feedback. The controller consists of two parts: a state observer that estimates plant state from the output when it is available via the communication network, and a model of the plant that is used to generate a control signal when the plant output is not available from the network. Necessary and sufficient conditions for the exponential stability of the closed loop system are derived in terms of the networked dwell time and the system parameters. The results suggest simple procedures for designing the output feedback controller proposed. Numerical simulations show the feasibility and efficiency of the proposed methods.

Output-feedback adaptive stochastic nonlinear stabilization using neural networks

For the first time, an adaptive backstepping neural network control approach is extended to a class of stochastic non- linear output-feedback systems. Different from the existing results, the nonlinear terms are assumed to be completely unknown and only a neural network is employed to compensate for all unknown nonlinear functions so that the controller design is more simplified. Based on stochastic LaSalle theorem, the resulted closed-loop system is proved to be globally asymptotically stable in probability. The simulation results further verify the effectiveness of the control scheme.

Decision feedback equalizer based on non-singleton fuzzy regular neural networks

A new equalization method is proposed in this paper for severely nonlinear distorted channels. The structure of decision feedback is adopted for the non-singleton fuzzy regular neural network that is trained by gradient-descent algorithm. The model shows a much better performance on anti-jamming and nonlinear classification, and simulation is carried out to compare this method with other nonlinear channel equalization methods. The results show the method has the least bit error rate （BER）.

Controlling disease spread on networks with feedback mechanism

Many real-world networks have the ability to adapt themselves in response to the state of their nodes. This paper studies controlling disease spread on network with feedback mechanism, where the susceptible nodes are able to avoid contact with the infected ones by cutting their connections with probability when the density of infected nodes reaches a certain value in the network. Such feedback mechanism considers the networks＇ own adaptivity and the cost of immunization. The dynamical equations about immunization with feedback mechanism ave solved and theoretical predictions are in agreement with the results of large scale simulations. It shows that when the lethality a increases, the prevalence decreases more greatly with the same immunization g. That is, with the same cost, a better controlling result can be obtained. This approach offers an effective and practical policy to control disease spread, and also may be relevant to other similar networks.

Adaptive Backstepping Output Feedback Control for SISO Nonlinear System Using Fuzzy Neural Networks

In this paper, a new fuzzy-neural adaptive control approach is developed for a class of single-input and single-output （SISO） nonlinear systems with unmeasured states. Using fuzzy neural networks to approximate the unknown nonlinear functions, a fuzzy- neural adaptive observer is introduced for state estimation as well as system identification. Under the framework of the backstepping design, fuzzy-neural adaptive output feedback control is constructed recursively. It is proven that the proposed fuzzy adaptive control approach guarantees the global boundedness property for all the signals, driving the tracking error to a small neighbordhood of the origin. Simulation example is included to illustrate the effectiveness of the proposed approach.

Design and Implementation of an Adaptive Feedback Queue Algorithm over Open Flow Networks

The concurrent presence of different types of traffic in multimedia applications might aggravate a burden on the underlying data network, which is bound to affect the transmission quality of the specified traffic. Recently, several proposals for fulfilling the quality of service(QoS) guarantees have been presented. However, they can only support coarse-grained QoS with no guarantee of throughput, jitter, delay or loss rate for different applications. To address these more challenging problems, an adaptive scheduling algorithm for Parallel data Processing with Multiple Feedback(PPMF) queues based on software defined networks(SDN) is proposed in this paper, which can guarantee the quality of service of high priority traffic in multimedia applications. PPMF combines the queue bandwidth feedback mechanism to realise the automatic adjustment of the queue bandwidth according to the priority of the packet and network conditions, which can effectively solve the problem of network congestion that has been experienced by some queues for a long time. Experimental results show PPMF significantly outperforms other existing scheduling approaches in achieving 35--80% improvement on average time delay by adjusting the bandwidth adaptively, thus ensuring the transmission quality of the specified traffic and avoiding effectively network congestion.

Control of Halo-Chaos in Beam Transport Network via Neural Network Adaptation with Time-Delayed Feedback

在横梁运输网络(隧道) 的光圈混乱控制的题目为高水流的质子横梁 since1990' 的许多重要应用程序成为了一个关键担心的问题。在这篇论文，磁场适应控制基于神经网络，推迟 withtime 的反馈为与周期的集中的隧道在横梁运输网络压制横梁光圈混乱被建议。高水流的质子横梁的信封半径被控制由合适选择控制结构和神经网络的参数到达匹配的横梁半径，调整延期时间和神经网络的控制系数。