Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium...Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal models.However,human trials are needed to validate these findings.Carbamazepine's repurposing holds promise for OA management,potentially revolutionizing treatment paradigms.Further research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life.展开更多
Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurement...Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurements. In this way, the development of CM has not been keeping pace with the advance in science and technology and the progress in orthodox medicine. In order to meet the requirements of modern science and technology, an evidence based approach must be adopted. Reassurance is needed to convince people for safety and efficacy of CM and give confidence to the evidence based demands ——“Tradition is confirmed by Modern Science” (1) .展开更多
The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in...The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.展开更多
Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise...Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.展开更多
Alzheimer's disease(AD):AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age(early state AD)(Agrawal et a...Alzheimer's disease(AD):AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age(early state AD)(Agrawal et al.,2017).展开更多
This paper presents the effects of surface finish and treatment on the high cycle fatigue behaviour of vibrating cylinder block of a new two-stroke free piston engine at complex variable amplitude loading conditions u...This paper presents the effects of surface finish and treatment on the high cycle fatigue behaviour of vibrating cylinder block of a new two-stroke free piston engine at complex variable amplitude loading conditions using frequency response approach. Finite element modelling and frequency response analysis was conducted using finite element analysis software Package MSC.PATRAN/MSC.NASTRAN and fatigue life prediction was carried out using MSC.FATIGUE software. Based on the finite element results, different frequency response approach was applied to predict the cylinder block fatigue life. Results for different load histories and material combinations are also discussed. Results indicated great effects for all surface finish and treatment. It is concluded that polished and cast surface finish conditions give the highest and lowest cylinder block lives, respectively; and that Nitrided treatment leads to longest cylinder block life. The results were used to draw contour plots of fatigue life and damage in the worst or most damaging case.展开更多
To the Editor:We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatme...To the Editor:We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatment of difficult liver colorectal metastases (CRM) and right-lung CRM, reporting their experience in a cohort of 11 patients.展开更多
Here, we present the clinical and radiological results of three neglected volar metacarpophalangeal dislocations in 2 patients, which were treated with open reductions 10 and 24 mo after the dislocations. There was a ...Here, we present the clinical and radiological results of three neglected volar metacarpophalangeal dislocations in 2 patients, which were treated with open reductions 10 and 24 mo after the dislocations. There was a mean of a 20°(range 10°-30°) limitation of extension and a 53.3°(range 30°-70°) limitation of flexion preoperatively. Postoperatively, there was no limitation of extension(at 8 and 12 mo) in any of the fingers. In terms of flexion, one finger had full function, one had a 10° and the last one had a 30° limitation of flexion. Two of the fingers presented anesthesia preoperatively, which improved to hypesthesia postoperatively. One finger had hypesthesia, which improved postoperatively. During surgery, a ruptured dorsal capsule was found to have interposed into the joint, making closed reduction impossible. Our experience with these two patients demonstrated that, even in neglected cases, open reduction using an isolated dorsal approach may result in satisfactory clinical andradiological outcomes.展开更多
BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality rate.This report describes the successful endovascular treatment(EVT)of two patients with severe PVT.CASE SU...BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality rate.This report describes the successful endovascular treatment(EVT)of two patients with severe PVT.CASE SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 d.The second patient was a 48-year-old man who presented with acute abdominal pain.Following contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric veins.Hybrid treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under laparotomy.The portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,respectively.CONCLUSION Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.展开更多
Objective:To review the related researches on the treatment of depression around the world and to summarize the advantages and disadvantages of antidepressants and psychotherapy,so that to find a more effective treatm...Objective:To review the related researches on the treatment of depression around the world and to summarize the advantages and disadvantages of antidepressants and psychotherapy,so that to find a more effective treatment plan for depression.Methods:The principles of several common pharmaceutical treatment combined with psychological approach were analyzed,cognitive behavioral therapy,interpersonal psychotherapy and socia1 support therapy included.Results:Some experimental results were illustrated and the advantages of Pharmaceutical treatment combined with psychological approach was revealed.Conclusion:Research indicates when pharmaceutical treatment is available,the combination of drugs and psychotherapy is more effective than sole pharmaceutical treatment.展开更多
Objective:To analyze the effect of two approaches of microsurgery in the treatment of pituitary tumor.Methods:The main body of this study was 69 patients with pituitary tumor who came to the hospital between December ...Objective:To analyze the effect of two approaches of microsurgery in the treatment of pituitary tumor.Methods:The main body of this study was 69 patients with pituitary tumor who came to the hospital between December 2016 and December 2019.Taking the coin method as the standard,group A underwent nasal-sphenoid sinus approach with 36 cases;group B underwent transcranial approach with 33 cases.The treatment effects were compared.Results:The total effective rate of group A was 94.44%,and that of group B was 72.73%;the therapeutic index of group A was better than that of group B;the complication rate of group A was 8.33%,and that of group B was 30.30%(P<0.05).After treatment,the tumor volume of both groups decreased,and group A was smaller than group B(P<0.05).Conclusion:Nasal-sphenoid sinus approach for patients with pituitary tumors can improve the treatment index,enhance the curative effect,reduce the size of the tumor,and have better safety.展开更多
This review mainly compares the major treatment approaches to child phonological disorder,namely,Core Vocabulary Approach for the treatment of inconsistent phonological disorder,Distinctive Features Approach and ABAB-...This review mainly compares the major treatment approaches to child phonological disorder,namely,Core Vocabulary Approach for the treatment of inconsistent phonological disorder,Distinctive Features Approach and ABAB-Withdrawal Approach for the treatment of consistent phonological disorder,and Eclectic Approach for real clinical treatment.Different approaches have different efficacy and the application of a certain treatment approach depends on the various conditions of the subjects.展开更多
The Author Reply:We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the livera...The Author Reply:We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the liverand lung both treated in a minimal access fashion. However, giventhe interest of the authors insight, it appears misleading when related to that discussed in our report which was clearly referred toother patients' profiles. Indeed, they described a case with a singleperipheral nodule in the right lung and a single liver metastasesin segment 5. This uncommon situation (less than 2% of patientsaccording to the LiverMetSurvey registry [2]), is obviouslya more than reasonable indication for a mini-invasive approach.However, our patients received surgery for complex oncological involvementof the liver: as described, this means large and/or multiplelesions, in contact or invading the hepatic veins at caval confluence.For such conditions we have introduced original surgicalapproaches [3,4]: in such conditions we would select a J-shapedthoracophrenolaparotomy for the liver per se [5]. This incision forsuch complex conditions other than allowing the liver clearance in a single operation rather than in staged approach [6], allows justin case the removal of lung nodules. Therefore, we thank again theauthors for their interest to our report, and furthermore we congratulatefor the original management of the shared clinical case.However, the condition recalled by the authors is related to a scenariooncologically and surgically at the opposite side of that discussedin our paper and for that somehow suggesting a comparisonis misleading.展开更多
Objective To summarize the clinical features of intracranial aneurysms of posterior cerebral artery (PCA) ,and the surgical approaches and operative skills to treat them . Methods The aneurysms arose from the P1 segme...Objective To summarize the clinical features of intracranial aneurysms of posterior cerebral artery (PCA) ,and the surgical approaches and operative skills to treat them . Methods The aneurysms arose from the P1 segment in 3 patients,the P2 segment in 5 patients and the P3 segment in 2 patients.展开更多
Objective To evaluate surgical strategy of decompression via posterior-anterior approach and anterior fixation in treatment fracture-dislocation of lower cervical spine with bilateral facet joints dislocation. Methods...Objective To evaluate surgical strategy of decompression via posterior-anterior approach and anterior fixation in treatment fracture-dislocation of lower cervical spine with bilateral facet joints dislocation. Methods This展开更多
Objective To investigate the clinical effects of surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach. Methods The data of 21 cases with serious lower lumbar burst fract...Objective To investigate the clinical effects of surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach. Methods The data of 21 cases with serious lower lumbar burst fracture were analyzed retrospectively.展开更多
Objective To investigate the feasibility and surgical effects of posterior articular process approach for the treatment of L1-L3 lumbar disc herniation.Methods A retrospective study,of17patients with upper lumbar inte...Objective To investigate the feasibility and surgical effects of posterior articular process approach for the treatment of L1-L3 lumbar disc herniation.Methods A retrospective study,of17patients with upper lumbar intervertebml disc展开更多
Objective To evaluate the feasibility,safety and efficacy of surgical treatment of the thoracic and thoracolumbar disc herniations through the posterior far lateral approach.Methods From April 2005 to June 2010,24 con...Objective To evaluate the feasibility,safety and efficacy of surgical treatment of the thoracic and thoracolumbar disc herniations through the posterior far lateral approach.Methods From April 2005 to June 2010,24 consecutive patients展开更多
Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indic...Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indicators before and after the intervention were measured(knowledge mastery,prevention and treatment compliance,personal behavior,self-care ability,management satisfaction,complication rate).Results:After analyzing pre-and post-intervention indicators,statistical significance was found(P<0.05).The intervention received a satisfaction rate of 80.00%,with a complication rate of 10.00%.Conclusion:Using a solution-focused approach for ankylosing spondylitis(AS)patients can enhance their understanding and attitude toward disease prevention and treatment,improve their behaviors and self-care ability,resulting in high satisfaction and reduced complications.展开更多
文摘Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal models.However,human trials are needed to validate these findings.Carbamazepine's repurposing holds promise for OA management,potentially revolutionizing treatment paradigms.Further research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life.
文摘Chinese medicine (CM) has been an experience based practice over the past three thousand years. The safety and efficacy of CM has been practised through experience, rather than nowadays’ modern scientific measurements. In this way, the development of CM has not been keeping pace with the advance in science and technology and the progress in orthodox medicine. In order to meet the requirements of modern science and technology, an evidence based approach must be adopted. Reassurance is needed to convince people for safety and efficacy of CM and give confidence to the evidence based demands ——“Tradition is confirmed by Modern Science” (1) .
基金Intervento cofinanziato dal Fondo di Sviluppo e Coesione 2007-2013–APQ Ricerca Regione Puglia“Programma regionale a sostegno della specializzazione intelligente e della sostenibilitàsociale ed ambientale-Future In Research”.Project ID:I2PCTF6
文摘The prevention and treatment of neurodegenerative diseases is the new challenge for pharmaceutical industry,but also for public institutions,physicians,patients,and their families.The spread of these pathologies is,in fact,a real social problem,especially in the Western Countries where the population age is increasing and chronic diseases are more and more common.
基金supported in part by the Israeli Ministry of Science,Technology and Space to UA(Grant number 3-12069)
文摘Hyperbaric oxygen therapy as a new treatment approach for Alzheimer’s disease(AD):Alongside the increase in life expectancy,the prevalence of age-related disorders,such as neurodegenerative diseases,is on the rise.For example,AD,the most common form of dementia in the elderly,accounts for 60–80%of all dementia cases.
文摘Alzheimer's disease(AD):AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age(early state AD)(Agrawal et al.,2017).
基金Project (No. 03-02-02-0056 PR0025/04-03) supported by Ministry of Science, Technology and Innovation, Malaysia
文摘This paper presents the effects of surface finish and treatment on the high cycle fatigue behaviour of vibrating cylinder block of a new two-stroke free piston engine at complex variable amplitude loading conditions using frequency response approach. Finite element modelling and frequency response analysis was conducted using finite element analysis software Package MSC.PATRAN/MSC.NASTRAN and fatigue life prediction was carried out using MSC.FATIGUE software. Based on the finite element results, different frequency response approach was applied to predict the cylinder block fatigue life. Results for different load histories and material combinations are also discussed. Results indicated great effects for all surface finish and treatment. It is concluded that polished and cast surface finish conditions give the highest and lowest cylinder block lives, respectively; and that Nitrided treatment leads to longest cylinder block life. The results were used to draw contour plots of fatigue life and damage in the worst or most damaging case.
文摘To the Editor:We read with tremendous interest the paper by Del Fabbroet al. [1]. In this thorough article, the authors meticulously underlinethe advantages of a modified j-shaped incision for the simultaneoustreatment of difficult liver colorectal metastases (CRM) and right-lung CRM, reporting their experience in a cohort of 11 patients.
文摘Here, we present the clinical and radiological results of three neglected volar metacarpophalangeal dislocations in 2 patients, which were treated with open reductions 10 and 24 mo after the dislocations. There was a mean of a 20°(range 10°-30°) limitation of extension and a 53.3°(range 30°-70°) limitation of flexion preoperatively. Postoperatively, there was no limitation of extension(at 8 and 12 mo) in any of the fingers. In terms of flexion, one finger had full function, one had a 10° and the last one had a 30° limitation of flexion. Two of the fingers presented anesthesia preoperatively, which improved to hypesthesia postoperatively. One finger had hypesthesia, which improved postoperatively. During surgery, a ruptured dorsal capsule was found to have interposed into the joint, making closed reduction impossible. Our experience with these two patients demonstrated that, even in neglected cases, open reduction using an isolated dorsal approach may result in satisfactory clinical andradiological outcomes.
文摘BACKGROUND Acute portal vein thrombosis(PVT)with bowel necrosis is a fatal condition with a 50%-75%mortality rate.This report describes the successful endovascular treatment(EVT)of two patients with severe PVT.CASE SUMMARY The first patient was a 22-year-old man who presented with abdominal pain lasting 3 d.The second patient was a 48-year-old man who presented with acute abdominal pain.Following contrast-enhanced computed tomography,both patients were diagnosed with massive PVT extending to the splenic and superior mesenteric veins.Hybrid treatment(simultaneous necrotic bowel resection and EVT)was performed in a hybrid operating room(OR).EVTs,including aspiration thrombectomy,catheter-directed thrombolysis(CDT),and continuous CDT,were performed via the ileocolic vein under laparotomy.The portal veins were patent 4 and 6 mo posttreatment in the 22-year-old and 48-year-old patients,respectively.CONCLUSION Hybrid necrotic bowel resection and transileocolic EVT performed in a hybrid OR is effective and safe.
文摘Objective:To review the related researches on the treatment of depression around the world and to summarize the advantages and disadvantages of antidepressants and psychotherapy,so that to find a more effective treatment plan for depression.Methods:The principles of several common pharmaceutical treatment combined with psychological approach were analyzed,cognitive behavioral therapy,interpersonal psychotherapy and socia1 support therapy included.Results:Some experimental results were illustrated and the advantages of Pharmaceutical treatment combined with psychological approach was revealed.Conclusion:Research indicates when pharmaceutical treatment is available,the combination of drugs and psychotherapy is more effective than sole pharmaceutical treatment.
文摘Objective:To analyze the effect of two approaches of microsurgery in the treatment of pituitary tumor.Methods:The main body of this study was 69 patients with pituitary tumor who came to the hospital between December 2016 and December 2019.Taking the coin method as the standard,group A underwent nasal-sphenoid sinus approach with 36 cases;group B underwent transcranial approach with 33 cases.The treatment effects were compared.Results:The total effective rate of group A was 94.44%,and that of group B was 72.73%;the therapeutic index of group A was better than that of group B;the complication rate of group A was 8.33%,and that of group B was 30.30%(P<0.05).After treatment,the tumor volume of both groups decreased,and group A was smaller than group B(P<0.05).Conclusion:Nasal-sphenoid sinus approach for patients with pituitary tumors can improve the treatment index,enhance the curative effect,reduce the size of the tumor,and have better safety.
文摘This review mainly compares the major treatment approaches to child phonological disorder,namely,Core Vocabulary Approach for the treatment of inconsistent phonological disorder,Distinctive Features Approach and ABAB-Withdrawal Approach for the treatment of consistent phonological disorder,and Eclectic Approach for real clinical treatment.Different approaches have different efficacy and the application of a certain treatment approach depends on the various conditions of the subjects.
文摘The Author Reply:We thank Dr. Sucameli et al. for the interest toward our article[1] and for the opportunity for further discussing on this issue,providing a case report of single metastastic fore sites in the liverand lung both treated in a minimal access fashion. However, giventhe interest of the authors insight, it appears misleading when related to that discussed in our report which was clearly referred toother patients' profiles. Indeed, they described a case with a singleperipheral nodule in the right lung and a single liver metastasesin segment 5. This uncommon situation (less than 2% of patientsaccording to the LiverMetSurvey registry [2]), is obviouslya more than reasonable indication for a mini-invasive approach.However, our patients received surgery for complex oncological involvementof the liver: as described, this means large and/or multiplelesions, in contact or invading the hepatic veins at caval confluence.For such conditions we have introduced original surgicalapproaches [3,4]: in such conditions we would select a J-shapedthoracophrenolaparotomy for the liver per se [5]. This incision forsuch complex conditions other than allowing the liver clearance in a single operation rather than in staged approach [6], allows justin case the removal of lung nodules. Therefore, we thank again theauthors for their interest to our report, and furthermore we congratulatefor the original management of the shared clinical case.However, the condition recalled by the authors is related to a scenariooncologically and surgically at the opposite side of that discussedin our paper and for that somehow suggesting a comparisonis misleading.
文摘Objective To summarize the clinical features of intracranial aneurysms of posterior cerebral artery (PCA) ,and the surgical approaches and operative skills to treat them . Methods The aneurysms arose from the P1 segment in 3 patients,the P2 segment in 5 patients and the P3 segment in 2 patients.
文摘Objective To evaluate surgical strategy of decompression via posterior-anterior approach and anterior fixation in treatment fracture-dislocation of lower cervical spine with bilateral facet joints dislocation. Methods This
文摘Objective To investigate the clinical effects of surgical treatment of lower lumbar fracture with mini-incision via retroperitoneal anterior approach. Methods The data of 21 cases with serious lower lumbar burst fracture were analyzed retrospectively.
文摘Objective To investigate the feasibility and surgical effects of posterior articular process approach for the treatment of L1-L3 lumbar disc herniation.Methods A retrospective study,of17patients with upper lumbar intervertebml disc
文摘Objective To evaluate the feasibility,safety and efficacy of surgical treatment of the thoracic and thoracolumbar disc herniations through the posterior far lateral approach.Methods From April 2005 to June 2010,24 consecutive patients
文摘Objective:To analyze the effect of solution-focused approach on advanced schistosomiasis(AS).Methods:10 cases of patients with AS that were treated with a solution-focused approach were included in our study.The indicators before and after the intervention were measured(knowledge mastery,prevention and treatment compliance,personal behavior,self-care ability,management satisfaction,complication rate).Results:After analyzing pre-and post-intervention indicators,statistical significance was found(P<0.05).The intervention received a satisfaction rate of 80.00%,with a complication rate of 10.00%.Conclusion:Using a solution-focused approach for ankylosing spondylitis(AS)patients can enhance their understanding and attitude toward disease prevention and treatment,improve their behaviors and self-care ability,resulting in high satisfaction and reduced complications.