OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control ...OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.展开更多
目的优化肺痿颗粒中黄芪甲苷的超临界CO_2萃取最佳工艺。方法以黄芪甲苷的含量为指标,选取粉碎粒度、萃取时间、夹带剂浓度和夹带剂流速为影响因素,采用L_9(3~4)正交试验法,优化提取工艺。结果处方最佳提取工艺为粉碎粒度40目、提取时间...目的优化肺痿颗粒中黄芪甲苷的超临界CO_2萃取最佳工艺。方法以黄芪甲苷的含量为指标,选取粉碎粒度、萃取时间、夹带剂浓度和夹带剂流速为影响因素,采用L_9(3~4)正交试验法,优化提取工艺。结果处方最佳提取工艺为粉碎粒度40目、提取时间1.5 h、夹带剂浓度95%乙醇和夹带剂流速10 m L·min^(-1)进行超临界萃取。结论该优选工艺有效成分提取率高,条件可行,为肺痿颗粒工艺的优化提供科学依据。展开更多
基金Supported by the Special Scientific Research for Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of China:Effects of Feiwei Granules in the treatment of IPF(No.200807046)
文摘OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.
文摘目的优化肺痿颗粒中黄芪甲苷的超临界CO_2萃取最佳工艺。方法以黄芪甲苷的含量为指标,选取粉碎粒度、萃取时间、夹带剂浓度和夹带剂流速为影响因素,采用L_9(3~4)正交试验法,优化提取工艺。结果处方最佳提取工艺为粉碎粒度40目、提取时间1.5 h、夹带剂浓度95%乙醇和夹带剂流速10 m L·min^(-1)进行超临界萃取。结论该优选工艺有效成分提取率高,条件可行,为肺痿颗粒工艺的优化提供科学依据。
