目的：探讨一种临床上实用的磁共振成像（MRI）检测手段来预测股骨头坏死（osteonecrosis of thefemoral head,ONFH）的塌陷。方法：选择37例ARCO分期为Ⅰ期和Ⅱ期的ONFH患者,在MRI的中部冠状位和矢状位图像上分别测量坏死角度,根据公...目的：探讨一种临床上实用的磁共振成像（MRI）检测手段来预测股骨头坏死（osteonecrosis of thefemoral head,ONFH）的塌陷。方法：选择37例ARCO分期为Ⅰ期和Ⅱ期的ONFH患者,在MRI的中部冠状位和矢状位图像上分别测量坏死角度,根据公式计算坏死范围指数,比较塌陷组和未塌陷组该指数的差异,并根据该指数对患者发生股骨头塌陷的危险程度进行分级。平均随访期为25个月。结果：塌陷组和未塌陷组的坏死范围指数分别为56.13±17.65和18.34±10.87,差异有统计学意义。随访中无一例股骨头发生塌陷的低危组,其股骨头坏死范围指数均小于30;股骨头均发生塌陷的高危组,其股骨头坏死范围指数均大于40;而中危组的坏死范围指数介于30~40,股骨头塌陷发生率为45%。结论：利用MRI测量和计算ONFH的坏死范围指数是预测ONFH患者是否发生股骨头塌陷的有效方法。展开更多
Background： Prevention of osteonecrosis （ON） has seldom been addressed. The purpose of this study was to evaluate the effect of resveratrol on preventing steroid-induced ON in rabbits. Methods： Seventy-two rabbits...Background： Prevention of osteonecrosis （ON） has seldom been addressed. The purpose of this study was to evaluate the effect of resveratrol on preventing steroid-induced ON in rabbits. Methods： Seventy-two rabbits were divided into four groups： （l） NEC （ON） group： thirty rabbits were treated with lipopolysaccharide （LPS） once, then with methylprednisolone （MPS） daily for 3 days; （2） PRE （prevention） group： thirty rabbits were given one dose of LPS, then MPS daily for 3 days, and resveratrol on day 0 and daily for 2 weeks： （3） RES （resveratrol） group： six rabbits were given resveratrol for 2 weeks but without LPS/MPS; （4） CON （control） group： six rabbits were given alcohol for 2 weeks but without LPS/MPS. Levels of plasma tissue-type plasminogen activator （t-PAL plasminogen activator inhibitor 1 （PAl-1）, thrombomodulin （TM）, vascular endothelial growth factor （VEGF）, maximum enhancement （ME） by magnetic resonance imaging, and ON incidence were evaluated. Results： The PRE group had a lower ON incidence than the NEC group, but with no significant differences at 2 weeks and 12 weeks. Tile RES and CON groups did not develop ON. TM and VEGF were significantly higher in the NEC group compared with the PRE group at weeks 1, 2, and 4 （TM： 1 week, P= 0.029; 2 weeks, P= 0.005; and 4 weeks, P = 0.047; VEGF： 1 week, P= 0.039; 2 weeks, P= 0.021; 4 weeks. P = 0.014） but the difference disappeared at 12 weeks. The levels of t-PA and PAl-I were not significantly different between the NEC and PRE groups. The TM, t-PA, PAl-l, and VEGF concentrations in the RES and CON groups did not change over time. Compared to the baseline, ME in the NEC group decreased significantly （P = 0.025） at week 1, increased significantly （P = 0.021） at week 2, and was decreased at week 12. The variance was insignificant in the PRE group. Conclusions： Resveratrol may improve blood supply to bone in a rabbit model of ON of the femoral head via anti-inflammatory effects to protect the vascular endothelium and reduce thrombosis.展开更多
文摘目的：探讨一种临床上实用的磁共振成像（MRI）检测手段来预测股骨头坏死（osteonecrosis of thefemoral head,ONFH）的塌陷。方法：选择37例ARCO分期为Ⅰ期和Ⅱ期的ONFH患者,在MRI的中部冠状位和矢状位图像上分别测量坏死角度,根据公式计算坏死范围指数,比较塌陷组和未塌陷组该指数的差异,并根据该指数对患者发生股骨头塌陷的危险程度进行分级。平均随访期为25个月。结果：塌陷组和未塌陷组的坏死范围指数分别为56.13±17.65和18.34±10.87,差异有统计学意义。随访中无一例股骨头发生塌陷的低危组,其股骨头坏死范围指数均小于30;股骨头均发生塌陷的高危组,其股骨头坏死范围指数均大于40;而中危组的坏死范围指数介于30~40,股骨头塌陷发生率为45%。结论：利用MRI测量和计算ONFH的坏死范围指数是预测ONFH患者是否发生股骨头塌陷的有效方法。
文摘Background： Prevention of osteonecrosis （ON） has seldom been addressed. The purpose of this study was to evaluate the effect of resveratrol on preventing steroid-induced ON in rabbits. Methods： Seventy-two rabbits were divided into four groups： （l） NEC （ON） group： thirty rabbits were treated with lipopolysaccharide （LPS） once, then with methylprednisolone （MPS） daily for 3 days; （2） PRE （prevention） group： thirty rabbits were given one dose of LPS, then MPS daily for 3 days, and resveratrol on day 0 and daily for 2 weeks： （3） RES （resveratrol） group： six rabbits were given resveratrol for 2 weeks but without LPS/MPS; （4） CON （control） group： six rabbits were given alcohol for 2 weeks but without LPS/MPS. Levels of plasma tissue-type plasminogen activator （t-PAL plasminogen activator inhibitor 1 （PAl-1）, thrombomodulin （TM）, vascular endothelial growth factor （VEGF）, maximum enhancement （ME） by magnetic resonance imaging, and ON incidence were evaluated. Results： The PRE group had a lower ON incidence than the NEC group, but with no significant differences at 2 weeks and 12 weeks. Tile RES and CON groups did not develop ON. TM and VEGF were significantly higher in the NEC group compared with the PRE group at weeks 1, 2, and 4 （TM： 1 week, P= 0.029; 2 weeks, P= 0.005; and 4 weeks, P = 0.047; VEGF： 1 week, P= 0.039; 2 weeks, P= 0.021; 4 weeks. P = 0.014） but the difference disappeared at 12 weeks. The levels of t-PA and PAl-I were not significantly different between the NEC and PRE groups. The TM, t-PA, PAl-l, and VEGF concentrations in the RES and CON groups did not change over time. Compared to the baseline, ME in the NEC group decreased significantly （P = 0.025） at week 1, increased significantly （P = 0.021） at week 2, and was decreased at week 12. The variance was insignificant in the PRE group. Conclusions： Resveratrol may improve blood supply to bone in a rabbit model of ON of the femoral head via anti-inflammatory effects to protect the vascular endothelium and reduce thrombosis.
