Objection： To evaluate the impact of fertility-preserving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors. Methods： Retrospective analysis of 39 patients w...Objection： To evaluate the impact of fertility-preserving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors. Methods： Retrospective analysis of 39 patients with ovarian malignant germ cell tumors, 23 patients with malignant epithelial tumors and 4 patients with sexual cord mesenchymal tumors receiving conservative treatments. Results： Two patients lost follow-up （we do not statistics them）. Fifty-nine among 64 patients were alive up to now （92.19%）. The overall survival rate for ovarian epithelial malignancies, malignant germ cell tumors and sexual cord mesenchymal tumors were 95.45%, 89.47% and 100% respectively. Fifteen patients received second operation and recurrence was found in 6 patients. Among the 59 surviving patients, 53 patients have normal menstruation. Thirteen patients among 20 patients who want to pregnant have 15 pregnancies and 9 successful deliveries. Conclusion： The management of fertility-preserving surgery on patients with ovarian malignant germ cell tumors, whatever the FIGO staging is, is a safe option. For patients with ovarian epithelial carcinomas, fertility-preserving surgery only confined to low-stage （stage Ⅰ）, low-grade （G1）, and patients who want keep fertility function seriously. Cisplatinum-based combination chemotherapy is necessary. Standardized chemotherapy has no affection on fertility function.展开更多
For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with ...For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with regular assessment of treatment efficacy can achieve a promising outcome.After complete remission patients are suggested with assisted reproductive technology or maintenance therapy depending on their immediate pregnancy plan.Hysterectomy is recommended for patients who have finished reproduction while re-treatment for recurrent cases should be carefully informed.展开更多
文摘Objection： To evaluate the impact of fertility-preserving surgery and adjuvant chemotherapy on survival and fertility of young patients with ovarian malignant tumors. Methods： Retrospective analysis of 39 patients with ovarian malignant germ cell tumors, 23 patients with malignant epithelial tumors and 4 patients with sexual cord mesenchymal tumors receiving conservative treatments. Results： Two patients lost follow-up （we do not statistics them）. Fifty-nine among 64 patients were alive up to now （92.19%）. The overall survival rate for ovarian epithelial malignancies, malignant germ cell tumors and sexual cord mesenchymal tumors were 95.45%, 89.47% and 100% respectively. Fifteen patients received second operation and recurrence was found in 6 patients. Among the 59 surviving patients, 53 patients have normal menstruation. Thirteen patients among 20 patients who want to pregnant have 15 pregnancies and 9 successful deliveries. Conclusion： The management of fertility-preserving surgery on patients with ovarian malignant germ cell tumors, whatever the FIGO staging is, is a safe option. For patients with ovarian epithelial carcinomas, fertility-preserving surgery only confined to low-stage （stage Ⅰ）, low-grade （G1）, and patients who want keep fertility function seriously. Cisplatinum-based combination chemotherapy is necessary. Standardized chemotherapy has no affection on fertility function.
基金supported by the National Key R&D Program of China(No.2019YFC1005200 and 2019YFC1005204)National Key Technology R&D Program(No.2015BAI13B06).
文摘For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with regular assessment of treatment efficacy can achieve a promising outcome.After complete remission patients are suggested with assisted reproductive technology or maintenance therapy depending on their immediate pregnancy plan.Hysterectomy is recommended for patients who have finished reproduction while re-treatment for recurrent cases should be carefully informed.
