Waterborne acrylic emulsions modified with organic siloxanes and aziridine crosslinker were synthesized and applied as coating of controlled release fertilizer. The free films were characterized and the nutrient relea...Waterborne acrylic emulsions modified with organic siloxanes and aziridine crosslinker were synthesized and applied as coating of controlled release fertilizer. The free films were characterized and the nutrient release profiles of the coated fertilizers were determined. The results show that methyl silicone oil and methylsilanolate sodium could not improve water resistance performance and glass transition temperature Tgof coatings, while the firmness is enhanced. Aziridine crosslinker improves the water resistance performance, firmness and Tg. Incorporation of methyl silicone oil and aziridine crosslinker gives an excellent aqueous acrylic emulsion for coated controlled release fertilizer, with the 30-day cumulative nutrient release reduced to 16% and an estimated nutrient release duration over 190 days. Therefore, this waterborne coating is promising to meet the requirements for controlled release of nutrient and environmental protection.展开更多
Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole pro...Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole process of big and small tomatoes were studied,and their application effects were contrasted and analyzed,and application advantages and scopes of the two models were concluded.展开更多
In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results...In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results obtained were listed as follows:(1)The incidence rate of bacterial wilt ascended more quickly after July 10 th,the incidence of CK reached 78.30%on July 25 th.(2)The control effect of“youmeili 3 g+tetramycin 200 times liquid”reached 69.47%,significantly higher than other treatments.(3)The output value of“Youmeil 3 g+tetramycin 200 times liquid”served as 1635.66 yuan/667m^2,with the highest economic character in all treatments.In a word,integrated technology of medicine and fertilizer was a feasible approach to control tobacco bacterial wilt.展开更多
Introduced the technology and application of treating the gasification effluent offertilizer with the physical-chemistry and biochemistry united technology.The technology issimple and viable, and occupies less land.Wh...Introduced the technology and application of treating the gasification effluent offertilizer with the physical-chemistry and biochemistry united technology.The technology issimple and viable, and occupies less land.When the main equipment runs normally, thegasification effluent of fertilizer treated with the united technology reached the requirementby second-degree discharge standard of the'Discharge standard of water pollutants forsynthesize ammonia industry'.展开更多
This paper describes the field tests carried out to evaluate the new Vicon RS-EDW centrifugal fertilizer spreader, to be used in Precision Agriculture. The results of initial dynamic calibration tests showed a signifi...This paper describes the field tests carried out to evaluate the new Vicon RS-EDW centrifugal fertilizer spreader, to be used in Precision Agriculture. The results of initial dynamic calibration tests showed a significant and systematic difference between the application rates of the two discs (about 20%). This difference had to be corrected by the manufacturer that carried out the necessary changes to the electric actuators. The fertilizer spreader had good distribution homogeneity, considering different working velocities and different positions in the parcel. The pattern distribution curve for 18% super phosphate fertilizer led to an effective working width of 28 meters, with a coefficient of variation of 15%. The longitudinal test, under experimental working conditions led to a machine delay time of 6-7 seconds. The results show an actual fertilization application density between 74%-90% of that determined for each location. These results confirm that the spreader can be used to spread fertilizer differentially in the field.展开更多
[Objective] The aim was to research high-yielding cultivation and fertilization technology for Lvhan No.l, a new Chinese rice cultivar, in Angola. [Method] In rainy season of 2012, high-yielding cultivation and fertil...[Objective] The aim was to research high-yielding cultivation and fertilization technology for Lvhan No.l, a new Chinese rice cultivar, in Angola. [Method] In rainy season of 2012, high-yielding cultivation and fertilization technology of Lvhan No.l, a new cultivar of earlier ripe and drought resistant rice, was researched in CATETE farm of Luanda suburb with pot experiment method. [Result] In CATETE farm, Lvhan No.1 rice were directly sown in black clay and the rice can be significantly improved in plant height, grain weight of single plant, biological yield of single plant, ear length, total grain number per ear, number of filled grain per ear and thousand seed weight, as well as economic coefficient and ratio of grain to straw, if applied with base fertilizer made up of DAP (N:P2Os=14:43), or compound fertilizer of N, P and K (N:P2Os:K^O=15:15:15) and with Duannai fertilizer and ear-grain fertilizer made up of urea. If DAP is taken as base fertilizer, the optimal quantity is 300 kg/hm2. If compound fertilizer of N, P and K is taken as base fertilizer, the optimal quantity is 450 kg/hm2, but urea at 75 kg/hm2 should be applied as Duannai fertilizer and ear- grain fertilizer, respectively, on time. [Conclusion] The research provides technical ref- erences for planting of Chinese rice cultivars in Angola.展开更多
The technological change as an exogenous variable is introduced into the RCK model with endogenous fertility in this paper. It is proved that the model has at least a nonzero steady state and the nonzero steady state ...The technological change as an exogenous variable is introduced into the RCK model with endogenous fertility in this paper. It is proved that the model has at least a nonzero steady state and the nonzero steady state is unique when the parameters satisfies some conditions. By phrase protrait analysis, the unique nonzero steady state is saddle and the economy has a unique optimal growth path. The results obtained implies that the relationship between the technological change and population growth rate determinated by the economic structure and the parental ethies. For the economy in which the parents is selfish, promoting the technological change rate decreases the fertility at the steady state. On the other hand, for the economy in which the parents is less selfish, the fertility increases as the technological change rate increases.展开更多
Technology was developed for obtaining ecologically pure composites containing nitrogenous fertilizers of prolonged action and nitrogen-fixing microorganisms in order to increase productivity of cereal crops. As a res...Technology was developed for obtaining ecologically pure composites containing nitrogenous fertilizers of prolonged action and nitrogen-fixing microorganisms in order to increase productivity of cereal crops. As a result of application of this composite nitrogenous fertilizer hectare norm decreases by 40%-55%, while productivity increases by 15%-30%, compared to those of the control.展开更多
Climate change is increasingly affecting farm-level decisions on when to plant and which climate smart agriculture (CSA) options to use. This study was conducted to determine the profitability and farmer acceptability...Climate change is increasingly affecting farm-level decisions on when to plant and which climate smart agriculture (CSA) options to use. This study was conducted to determine the profitability and farmer acceptability of different CSA options for maize-bean production in drought-prone areas of Uganda. It was conducted on-farm in Rakai and Nakasongola districts during 2020 and 2021. Variables included: planting date (early vs late);varieties (common beans: NABE 4 and NAROBEAN 2, and maize: Longe 5 and Bazooka);intercropping versus pure stand;and fertiliser use (manure, Diammonium phosphate (DAP) or combination). The experimental design was split-split plot, replicated six times. Over two years, early planting caused 16% and up to 46% higher yields of maize and beans, respectively, than late planting, resulting in 14% - 28% and 18% - 43% higher Benefit/Cost (B/C) ratio for maize and beans, respectively. Intercropping reduced maize and beans yield by 16% - 25% and 52% - 57%, respectively. The B/C was highest for sole maize;intercropping was more profitable than sole beans. Fertilizer (DAP) was most profitable when Bazooka was early-planted as sole crop followed by intercrop. For late planted-crop, manure was better. These practices were more beneficial when applied simultaneously for both crops excluding bean variety. Farmers’ lessons stressed the importance of early planting and fertilizer use;however, majority indicated they were to adopt more than two of the practices tested.展开更多
Objective:To investigate the incidence of neonatal birth defects in assisted reproductive technology(ART)by in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).Methods:The clinical data of 4229 cases...Objective:To investigate the incidence of neonatal birth defects in assisted reproductive technology(ART)by in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).Methods:The clinical data of 4229 cases of singleton deliver by infertile patients under 35 years old who received IVF/ICSI-ET in our center were analyzed.According to different fertilization methods,they were divided into IVF group(2967 cases)and ICSI group(1262 cases).The general situation of birth,birth defects and the location of defects were compared between the two groups.Results:a total of 38 cases of neonatal birth defects were found,the incidence of birth defects was 0.89%,including 30 cases(1.01%)in IVF group and 8 cases(0.64%)in ICSI group.There was no significant difference in the incidence of birth defects between the two groups(P>0.05).There was also no significant difference in birth weight,gestational age and gender ratio between the two groups(P>0.05).Conclusion:Different fertilization methods in assisted reproductive technology do not increase the incidence of neonatal birth defects.展开更多
This paper summarizes the development process and research status of orchard fertilization technology,introduces many kinds of fertilization methods,such as soil testing and fertilizer recommendation method,and nutrit...This paper summarizes the development process and research status of orchard fertilization technology,introduces many kinds of fertilization methods,such as soil testing and fertilizer recommendation method,and nutrition diagnosis method,probes into the main problems existing in orchard fertilization,and puts forward some suggestions for solving them. The development of orchard fertilization technology in China is also projected.展开更多
The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF)and normal embryonic development.Widely adopted clinical approaches for sperm sample processing in...The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF)and normal embryonic development.Widely adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to sperm.Although a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming,none of these approaches have been fully validated by clinical-grade assessment criteria.In this study,a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is presented.Bioinspired by the temperature microenvironment in the fallopian tube during natural sperm selection,a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and fabricated.This study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45 human sperm samples.Results indicated that a temperature range of 35–36.5℃along the separation channel significantly improves human sperm motility rate((85.25±6.28)%vs.(60.72±1.37)%;P=0.0484),increases normal sperm morphology rate((16.42±1.43)%vs.(12.55±0.88)%;P<0.0001),and reduces DNA fragmentation((7.44±0.79)%vs.(10.36±0.72)%;P=0.0485)compared to the nonthermotaxis group.Sperm thermotaxis is species-specific,and selected mouse sperm displayed the highest motility in response to a temperature range of 36–37.5℃ along the separation channel.Furthermore,IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to blastocyst.This microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF success rate for patients with oligozoospermia and asthenozoospermia.展开更多
Reliable molecular biomarkers to predict fertility remain scarce.The current study investigated the potential of testis-specific circBOULE RNAs as biomarkers for male infertility and sperm quality.Using reverse transc...Reliable molecular biomarkers to predict fertility remain scarce.The current study investigated the potential of testis-specific circBOULE RNAs as biomarkers for male infertility and sperm quality.Using reverse transcription-PCR and real-time reverse transcription-PCR assays,we identified seven circular RNAs from the human BOULE gene in human sperm.We observed that the expression level of circEx3-6 was significantly reduced in asthenozoospermia,while the expression levels of both circEx2-6 and circEx2-7 were decreased in terato-zoospermia,compared with the controls.Furthermore,we demonstrated that the expression level of circEx2-6 was negatively correlated with the sperm DNA fragmentation index,and the expression level of circEx2-7 was correlated with both fertilization and cleavage rates in those treated with the assisted reproductive technologies.Further functional analyses in a transgenic fly model supported the roles of circBOULE RNAs in sperm development and human male fertility.Collectively,our findings support that sperm circBOULE RNAs may serve as diagnostic biomarkers for assessing sperm motility and DNA quality.Therefore,clinical application and significance of sperm circBOULE RNAs in the assisted reproductive technologies warrant further investigation.展开更多
In economics,opportunity cost means the maximum value of choosing one behavior over others in the situation where resources are limited(Parkin,2016).In the process of making reproductive decision,opportunity cost reve...In economics,opportunity cost means the maximum value of choosing one behavior over others in the situation where resources are limited(Parkin,2016).In the process of making reproductive decision,opportunity cost reveals the trade-off between time,resources,and economic benefits that individuals face when choosing to have children or not.During this process,the technological changes make the paths of career development diverse and rapidly changing,remarkably increasing the opportunity cost of childbirth and parenting.This leads to individuals more inclined to postpone or reduce childbirth when balancing their careers and families,thereby resulting in low fertility rates in developed economies.展开更多
In vitro fertilization(IVF)is one of the most used assisted reproductive technology(ART)techniques today.However,the success of IVF procedures heavily relies on maintaining a sterile environment in laboratories.This n...In vitro fertilization(IVF)is one of the most used assisted reproductive technology(ART)techniques today.However,the success of IVF procedures heavily relies on maintaining a sterile environment in laboratories.This narrative review examines the effects of microbiological contamination in IVF laboratories,exploring its sources,impacts on IVF outcomes,and preventive measures.We conducted a complete literature search using databases such as PubMed and Google Scholar,focusing on studies published within the last fifteen years.Our findings highlight that microbiological contamination can significantly impair embryo quality,reduce implantation and pregnancy rates,and increase the risk of miscarriage and infection.The review also discusses current best practices for contamination prevention and identifies areas for future research.This work emphasizes the critical importance of stringent sterility protocols in IVF laboratories and calls for continued vigilance and innovation in maintaining optimal conditions for assisted reproduction.展开更多
基金Supported by the National 12th Five-Year Science and Technology Supporting Program(2011BAD11B01)the Research & Development Projects Cooperation Project of Chinese Academy of Sciences(YDJDBNJ-2012-023)
文摘Waterborne acrylic emulsions modified with organic siloxanes and aziridine crosslinker were synthesized and applied as coating of controlled release fertilizer. The free films were characterized and the nutrient release profiles of the coated fertilizers were determined. The results show that methyl silicone oil and methylsilanolate sodium could not improve water resistance performance and glass transition temperature Tgof coatings, while the firmness is enhanced. Aziridine crosslinker improves the water resistance performance, firmness and Tg. Incorporation of methyl silicone oil and aziridine crosslinker gives an excellent aqueous acrylic emulsion for coated controlled release fertilizer, with the 30-day cumulative nutrient release reduced to 16% and an estimated nutrient release duration over 190 days. Therefore, this waterborne coating is promising to meet the requirements for controlled release of nutrient and environmental protection.
基金Supported by "Sannongliufang" Technology Collaboration Program in Zhejiang Province in 2014
文摘Integrated water and fertilizer technology has the advantages of saving water,fertilizer and labour,which is widely applied in tomato plantation. Integrated water and fertilizer technology in topdressing and whole process of big and small tomatoes were studied,and their application effects were contrasted and analyzed,and application advantages and scopes of the two models were concluded.
基金Supported by Science and Technology Project of Yunnan Tobacco Company(2015YN07,2017YN26)~~
文摘In order to validate the control effects of integrated technology of medicine and fertilizer on tobacco bacterial wilt,field experiments were conducted by using youmeili and tetracycline as the test agents.The results obtained were listed as follows:(1)The incidence rate of bacterial wilt ascended more quickly after July 10 th,the incidence of CK reached 78.30%on July 25 th.(2)The control effect of“youmeili 3 g+tetramycin 200 times liquid”reached 69.47%,significantly higher than other treatments.(3)The output value of“Youmeil 3 g+tetramycin 200 times liquid”served as 1635.66 yuan/667m^2,with the highest economic character in all treatments.In a word,integrated technology of medicine and fertilizer was a feasible approach to control tobacco bacterial wilt.
文摘Introduced the technology and application of treating the gasification effluent offertilizer with the physical-chemistry and biochemistry united technology.The technology issimple and viable, and occupies less land.When the main equipment runs normally, thegasification effluent of fertilizer treated with the united technology reached the requirementby second-degree discharge standard of the'Discharge standard of water pollutants forsynthesize ammonia industry'.
文摘This paper describes the field tests carried out to evaluate the new Vicon RS-EDW centrifugal fertilizer spreader, to be used in Precision Agriculture. The results of initial dynamic calibration tests showed a significant and systematic difference between the application rates of the two discs (about 20%). This difference had to be corrected by the manufacturer that carried out the necessary changes to the electric actuators. The fertilizer spreader had good distribution homogeneity, considering different working velocities and different positions in the parcel. The pattern distribution curve for 18% super phosphate fertilizer led to an effective working width of 28 meters, with a coefficient of variation of 15%. The longitudinal test, under experimental working conditions led to a machine delay time of 6-7 seconds. The results show an actual fertilization application density between 74%-90% of that determined for each location. These results confirm that the spreader can be used to spread fertilizer differentially in the field.
基金Supported by International Cooperation Program of Anhui Provincial Science&Technology Department(11030603031)~~
文摘[Objective] The aim was to research high-yielding cultivation and fertilization technology for Lvhan No.l, a new Chinese rice cultivar, in Angola. [Method] In rainy season of 2012, high-yielding cultivation and fertilization technology of Lvhan No.l, a new cultivar of earlier ripe and drought resistant rice, was researched in CATETE farm of Luanda suburb with pot experiment method. [Result] In CATETE farm, Lvhan No.1 rice were directly sown in black clay and the rice can be significantly improved in plant height, grain weight of single plant, biological yield of single plant, ear length, total grain number per ear, number of filled grain per ear and thousand seed weight, as well as economic coefficient and ratio of grain to straw, if applied with base fertilizer made up of DAP (N:P2Os=14:43), or compound fertilizer of N, P and K (N:P2Os:K^O=15:15:15) and with Duannai fertilizer and ear-grain fertilizer made up of urea. If DAP is taken as base fertilizer, the optimal quantity is 300 kg/hm2. If compound fertilizer of N, P and K is taken as base fertilizer, the optimal quantity is 450 kg/hm2, but urea at 75 kg/hm2 should be applied as Duannai fertilizer and ear- grain fertilizer, respectively, on time. [Conclusion] The research provides technical ref- erences for planting of Chinese rice cultivars in Angola.
基金Supported by the National Natural Science Foundation of China!(79970104)
文摘The technological change as an exogenous variable is introduced into the RCK model with endogenous fertility in this paper. It is proved that the model has at least a nonzero steady state and the nonzero steady state is unique when the parameters satisfies some conditions. By phrase protrait analysis, the unique nonzero steady state is saddle and the economy has a unique optimal growth path. The results obtained implies that the relationship between the technological change and population growth rate determinated by the economic structure and the parental ethies. For the economy in which the parents is selfish, promoting the technological change rate decreases the fertility at the steady state. On the other hand, for the economy in which the parents is less selfish, the fertility increases as the technological change rate increases.
文摘Technology was developed for obtaining ecologically pure composites containing nitrogenous fertilizers of prolonged action and nitrogen-fixing microorganisms in order to increase productivity of cereal crops. As a result of application of this composite nitrogenous fertilizer hectare norm decreases by 40%-55%, while productivity increases by 15%-30%, compared to those of the control.
文摘Climate change is increasingly affecting farm-level decisions on when to plant and which climate smart agriculture (CSA) options to use. This study was conducted to determine the profitability and farmer acceptability of different CSA options for maize-bean production in drought-prone areas of Uganda. It was conducted on-farm in Rakai and Nakasongola districts during 2020 and 2021. Variables included: planting date (early vs late);varieties (common beans: NABE 4 and NAROBEAN 2, and maize: Longe 5 and Bazooka);intercropping versus pure stand;and fertiliser use (manure, Diammonium phosphate (DAP) or combination). The experimental design was split-split plot, replicated six times. Over two years, early planting caused 16% and up to 46% higher yields of maize and beans, respectively, than late planting, resulting in 14% - 28% and 18% - 43% higher Benefit/Cost (B/C) ratio for maize and beans, respectively. Intercropping reduced maize and beans yield by 16% - 25% and 52% - 57%, respectively. The B/C was highest for sole maize;intercropping was more profitable than sole beans. Fertilizer (DAP) was most profitable when Bazooka was early-planted as sole crop followed by intercrop. For late planted-crop, manure was better. These practices were more beneficial when applied simultaneously for both crops excluding bean variety. Farmers’ lessons stressed the importance of early planting and fertilizer use;however, majority indicated they were to adopt more than two of the practices tested.
基金Major Science and Technology Project of Hainan Province(No.ZDKJ2017007)Key Research and Development Project of Hainan Provincial Science and Technology Department(No.ZDYF2019158)Scientific Research Project of Health and Family Planning Industry in Hainan Province(No.19A200124)。
文摘Objective:To investigate the incidence of neonatal birth defects in assisted reproductive technology(ART)by in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).Methods:The clinical data of 4229 cases of singleton deliver by infertile patients under 35 years old who received IVF/ICSI-ET in our center were analyzed.According to different fertilization methods,they were divided into IVF group(2967 cases)and ICSI group(1262 cases).The general situation of birth,birth defects and the location of defects were compared between the two groups.Results:a total of 38 cases of neonatal birth defects were found,the incidence of birth defects was 0.89%,including 30 cases(1.01%)in IVF group and 8 cases(0.64%)in ICSI group.There was no significant difference in the incidence of birth defects between the two groups(P>0.05).There was also no significant difference in birth weight,gestational age and gender ratio between the two groups(P>0.05).Conclusion:Different fertilization methods in assisted reproductive technology do not increase the incidence of neonatal birth defects.
基金Supported by Jiangxi Social Science Planning Project:Research on the Activation of Traditional Villages in Jiangxi Province from the Perspective of Cultural Conservation:A Case Study of Fuhe River Basin(Grant No.17BJ16).
文摘This paper summarizes the development process and research status of orchard fertilization technology,introduces many kinds of fertilization methods,such as soil testing and fertilizer recommendation method,and nutrition diagnosis method,probes into the main problems existing in orchard fertilization,and puts forward some suggestions for solving them. The development of orchard fertilization technology in China is also projected.
基金supported by the Key Research and Development Project of Hubei Province,China(No.2021BCA111)。
文摘The selection of the most motile and functionally competent sperm is an essential basis for in vitro fertilization(IVF)and normal embryonic development.Widely adopted clinical approaches for sperm sample processing intensely rely on centrifugation and wash steps that may induce mechanical damage and oxidative stress to sperm.Although a few microfluidic sperm sorting devices may avoid these adverse effects by exploiting intrinsic guidance mechanisms of sperm swimming,none of these approaches have been fully validated by clinical-grade assessment criteria.In this study,a microfluidic sperm sorting device that enables the selection of highly motile and functional sperm via their intrinsic thermotaxis is presented.Bioinspired by the temperature microenvironment in the fallopian tube during natural sperm selection,a microfluidic device with controllable temperature gradients along the sperm separation channel was designed and fabricated.This study investigated the optimal temperature conditions for human sperm selection and fully characterized thermotaxis-selected sperm with 45 human sperm samples.Results indicated that a temperature range of 35–36.5℃along the separation channel significantly improves human sperm motility rate((85.25±6.28)%vs.(60.72±1.37)%;P=0.0484),increases normal sperm morphology rate((16.42±1.43)%vs.(12.55±0.88)%;P<0.0001),and reduces DNA fragmentation((7.44±0.79)%vs.(10.36±0.72)%;P=0.0485)compared to the nonthermotaxis group.Sperm thermotaxis is species-specific,and selected mouse sperm displayed the highest motility in response to a temperature range of 36–37.5℃ along the separation channel.Furthermore,IVF experiments indicated that the selected sperm permitted an increased fertilization rate and improved embryonic development from zygote to blastocyst.This microfluidic thermotaxic selection approach will be translated into clinical practice to improve the IVF success rate for patients with oligozoospermia and asthenozoospermia.
基金supported by the National Natural Science Foundation of China(Grant Nos.31970792 and 31771652).
文摘Reliable molecular biomarkers to predict fertility remain scarce.The current study investigated the potential of testis-specific circBOULE RNAs as biomarkers for male infertility and sperm quality.Using reverse transcription-PCR and real-time reverse transcription-PCR assays,we identified seven circular RNAs from the human BOULE gene in human sperm.We observed that the expression level of circEx3-6 was significantly reduced in asthenozoospermia,while the expression levels of both circEx2-6 and circEx2-7 were decreased in terato-zoospermia,compared with the controls.Furthermore,we demonstrated that the expression level of circEx2-6 was negatively correlated with the sperm DNA fragmentation index,and the expression level of circEx2-7 was correlated with both fertilization and cleavage rates in those treated with the assisted reproductive technologies.Further functional analyses in a transgenic fly model supported the roles of circBOULE RNAs in sperm development and human male fertility.Collectively,our findings support that sperm circBOULE RNAs may serve as diagnostic biomarkers for assessing sperm motility and DNA quality.Therefore,clinical application and significance of sperm circBOULE RNAs in the assisted reproductive technologies warrant further investigation.
文摘In economics,opportunity cost means the maximum value of choosing one behavior over others in the situation where resources are limited(Parkin,2016).In the process of making reproductive decision,opportunity cost reveals the trade-off between time,resources,and economic benefits that individuals face when choosing to have children or not.During this process,the technological changes make the paths of career development diverse and rapidly changing,remarkably increasing the opportunity cost of childbirth and parenting.This leads to individuals more inclined to postpone or reduce childbirth when balancing their careers and families,thereby resulting in low fertility rates in developed economies.
文摘In vitro fertilization(IVF)is one of the most used assisted reproductive technology(ART)techniques today.However,the success of IVF procedures heavily relies on maintaining a sterile environment in laboratories.This narrative review examines the effects of microbiological contamination in IVF laboratories,exploring its sources,impacts on IVF outcomes,and preventive measures.We conducted a complete literature search using databases such as PubMed and Google Scholar,focusing on studies published within the last fifteen years.Our findings highlight that microbiological contamination can significantly impair embryo quality,reduce implantation and pregnancy rates,and increase the risk of miscarriage and infection.The review also discusses current best practices for contamination prevention and identifies areas for future research.This work emphasizes the critical importance of stringent sterility protocols in IVF laboratories and calls for continued vigilance and innovation in maintaining optimal conditions for assisted reproduction.