After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promisi...After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients who exhibit better bimanual performance demonstrate more efficient cortical activation.Therefore,incorporating bilateral arm training in post-stroke rehabilitation is important for better outcomes.The combination of functional near-infrared spectroscopy with functional motor paradigms is valuable for assessing skills and developing targeted interventions in stroke rehabilitation.展开更多
Video-based action recognition is becoming a vital tool in clinical research and neuroscientific study for disorder detection and prediction.However,action recognition currently used in non-human primate(NHP)research ...Video-based action recognition is becoming a vital tool in clinical research and neuroscientific study for disorder detection and prediction.However,action recognition currently used in non-human primate(NHP)research relies heavily on intense manual labor and lacks standardized assessment.In this work,we established two standard benchmark datasets of NHPs in the laboratory:Monkeyin Lab(Mi L),which includes 13 categories of actions and postures,and MiL2D,which includes sequences of two-dimensional(2D)skeleton features.Furthermore,based on recent methodological advances in deep learning and skeleton visualization,we introduced the Monkey Monitor Kit(Mon Kit)toolbox for automatic action recognition,posture estimation,and identification of fine motor activity in monkeys.Using the datasets and Mon Kit,we evaluated the daily behaviors of wild-type cynomolgus monkeys within their home cages and experimental environments and compared these observations with the behaviors exhibited by cynomolgus monkeys possessing mutations in the MECP2 gene as a disease model of Rett syndrome(RTT).Mon Kit was used to assess motor function,stereotyped behaviors,and depressive phenotypes,with the outcomes compared with human manual detection.Mon Kit established consistent criteria for identifying behavior in NHPs with high accuracy and efficiency,thus providing a novel and comprehensive tool for assessing phenotypic behavior in monkeys.展开更多
BACKGROUND： In clinical practice, the degree of cognitive competence damage correlates to fine motor function deficits in children with psychomotor development retardation. Clear correlations between the two can help...BACKGROUND： In clinical practice, the degree of cognitive competence damage correlates to fine motor function deficits in children with psychomotor development retardation. Clear correlations between the two can help to develop and perform corresponding functional training for children with mental retardation （MR）. OBJECTIVE： This study was designed to evaluate and analyze the correlation of fine motor function to cognitive competence in MR children using the Peabody Developmental Motor Scale-Fine Motor （PDMS-FM） and Symbolic Play Test. DESIGN： Scale evaluation and correlation analysis. SETTING： Children＇s Rehabilitation Center ＆ Huajing District Hospital, Children＇s Hospital Affiliated to Fudan University. PARTICIPANTS： A total of 42 MR children, 28 males and 14 females, aged 14-69 months, were admitted to the Rehabilitation Center, Children＇s Hospital, Fudan University between June 2003 and April 2006, and were recruited for this study. All children corresponded to MR diagnosis criteria determined by Chinese Neurology and Psychiatry Society in 1989. Written informed consent for participating in the evaluation and for evaluated content was obtained from each child＇s guardian. METHODS： Subsequent to admission and prior to treatment, fine motor function of each MR child was evaluated using PDMS-FM （Chinese version）. The scale captured 98 items that formed the grasping （Gr） and visual-motor integration （Vi） subtests. Cognitive competence was evaluated using the Symbolic Play Test （Chinese version）, which captured four 6-item specific contents. The original score of each subtest was used to evaluate results for statistical analysis. Higher scores from the two evaluations indicated stronger abilities. Pearson correlation analysis was applied for analyzing data correlation. MAIN OUTCOME MEASURES： Fine motor function was evaluated using PDMS-FM. Cognitive competence was measured using the Symbolic Play Test. Correlations between results from the two evaluations were analyzed. RESULTS： All 42 MR children were included in the final analysis. Correlation analysis results demonstrated significant positive correlations of original scores existed between Gr and Vi subtests in the PDMS-FM （r = 0.761, P 〈 0.01）, and between Vi and Gr subtests in PDMS-FM and Symbolic Play Test （r = 0.663, 0.450, P 〈 0.01）. CONCLUSION： Fine motor function closely correlates to cognitive competence in MR children. This indicates fine motor function training should be developed in combination with cognitive competence training.展开更多
This study aimed to explore the performance of the perceptual-visuomotor skills and the production of handwriting in children with Learning Disabilities.A total of 56 children participated,being a convenience sample,o...This study aimed to explore the performance of the perceptual-visuomotor skills and the production of handwriting in children with Learning Disabilities.A total of 56 children participated,being a convenience sample,of both sexes,average age of eight years old,from 3rd to 5th grade level of Elementary School.The children were divided into the following groups:GI(28 children diagnosed with Learning Disabilities);GII(28 children with good academic performance,paired with GI in relation to chronological age and sex).They were evaluated individually in dysgraphic scale,visual perception development test,and fine motor evaluation.Data analysis was performed.There was a significant difference between GI and GII for the subtests of eye-hand coordination,copying,visual closure,fine motor precision,and fine manual control tests.They had difference between the groups for handwriting performance in descending and/or ascending subtests,irregularity of dimension,poor forms,and total score of Dysgraphia Scale.The results presented in this study indicate that children with Learning Disabilities can manifest significant visomotor impairment and deficit in legibility and handwriting quality,causing failures in the elaboration of sensorimotor plans that,added to the intrinsic deficit of long-term memory,result in persistent academic difficulties.展开更多
Teaching writing is an essential component of Chinese education in primary schools and an important foundation for students’reading,writing,and core literacy development.However,due to various reasons,children in the...Teaching writing is an essential component of Chinese education in primary schools and an important foundation for students’reading,writing,and core literacy development.However,due to various reasons,children in the lower grades always face multiple difficulties in the learning task of writing.Based on this educational status quo,this article puts forward strategic suggestions for improving writing skills in the lower grades of primary school.Teachers should analyze students and attend to each student individually,optimize teaching methods,and implement hierarchical teaching.They should also strengthen the training of students’fine motor skills to solidify the physiological foundation for writing.Emphasis should be placed on cultivating the core quality of aesthetic creation.Employing multiple process evaluations can inspire children’s long-term interest in learning.展开更多
目的:探究注意缺陷多动障碍(attention deficit and hyperactivity disorder,ADHD)男童的动作发展特点,为开拓ADHD儿童的非药物治疗手段提供理论依据。方法:从北京市某三甲医院招募19名ADHD男童,从北京市某公立小学1~4年级学生中筛查出A...目的:探究注意缺陷多动障碍(attention deficit and hyperactivity disorder,ADHD)男童的动作发展特点,为开拓ADHD儿童的非药物治疗手段提供理论依据。方法:从北京市某三甲医院招募19名ADHD男童,从北京市某公立小学1~4年级学生中筛查出ADHD男童61名,排除因主、客观因素不能完成全部测试者,最终入组65名ADHD男童,其中6~8岁41人,9~10岁24人,注意缺陷型ADHD(ADHDPI)48人,混合型ADHD(ADHD-C)17人,募集年龄相差不超过半岁的正常发育男童65名为正常对照。采用儿童粗大动作发展测试量表第三版(TGMD-3)、儿童动作协调能力标准评估工具第二版(MABC-2)分别评估儿童的粗大动作和精细动作发展水平,采用独立样本t检验比较ADHD男童与正常男童各项指标的组间差异,使用单因素方差分析比较各亚型之间及与正常对照的组间差异,显著性水平为P<0.05。结果:(1)整体分析显示:ADHD组TGMD-3总分和手部精细动作得分均显著低于正常组(P<0.01);(2)不同年龄段分析显示:6~8岁ADHD组的TGMD-3和手部精细动作得分均低于6~8岁正常组(P<0.001),9~10岁ADHD组仅手部精细动作得分低于同年龄正常组(P<0.05);(3)不同亚型分析显示:ADHD-C组的TGMD-3总分和手部精细动作得分均低于正常组(P<0.05),ADHD-PI组仅手部精细动作得分低于正常组(P<0.05),ADHD-PI组和ADHD-C组无显著差异。结论:6~10岁ADHD男童的粗大和精细动作发展均显著落后于同龄儿童,精细动作发展落后在低年龄和高年龄段ADHD男童中持续存在,混合型较注意缺陷型ADHD男童动作发展落后的范围更广。展开更多
基金supported by the National Key R&D Program of China,No.2020YFC2004202(to DX).
文摘After stroke,even high-functioning individuals may experience compromised bimanual coordination and fine motor dexterity,leading to reduced functional independence.Bilateral arm training has been proposed as a promising intervention to address these deficits.However,the neural basis of the impairment of functional fine motor skills and their relationship to bimanual coordination performance in stroke patients remains unclear,limiting the development of more targeted interventions.To address this gap,our study employed functional near-infrared spectroscopy to investigate cortical responses in patients after stroke as they perform functional tasks that engage fine motor control and coordination.Twenty-four high-functioning patients with ischemic stroke(7 women,17 men;mean age 64.75±10.84 years)participated in this cross-sectional observational study and completed four subtasks from the Purdue Pegboard Test,which measures unimanual and bimanual finger and hand dexterity.We found significant bilateral activation of the sensorimotor cortices during all Purdue Pegboard Test subtasks,with bimanual tasks inducing higher cortical activation than the assembly subtask.Importantly,patients with better bimanual coordination exhibited lower cortical activation during the other three Purdue Pegboard Test subtasks.Notably,the observed neural response patterns varied depending on the specific subtask.In the unaffected hand task,the differences were primarily observed in the ipsilesional hemisphere.In contrast,the bilateral sensorimotor cortices and the contralesional hemisphere played a more prominent role in the bimanual task and assembly task,respectively.While significant correlations were found between cortical activation and unimanual tasks,no significant correlations were observed with bimanual tasks.This study provides insights into the neural basis of bimanual coordination and fine motor skills in high-functioning patients after stroke,highlighting task-dependent neural responses.The findings also suggest that patients who exhibit better bimanual performance demonstrate more efficient cortical activation.Therefore,incorporating bilateral arm training in post-stroke rehabilitation is important for better outcomes.The combination of functional near-infrared spectroscopy with functional motor paradigms is valuable for assessing skills and developing targeted interventions in stroke rehabilitation.
基金supported by the National Key R&D Program of China (2021ZD0202805,2019YFA0709504,2021ZD0200900)National Defense Science and Technology Innovation Special Zone Spark Project (20-163-00-TS-009-152-01)+4 种基金National Natural Science Foundation of China (31900719,U20A20227,82125008)Innovative Research Team of High-level Local Universities in Shanghai,Science and Technology Committee Rising-Star Program (19QA1401400)111 Project (B18015)Shanghai Municipal Science and Technology Major Project (2018SHZDZX01)Shanghai Center for Brain Science and Brain-Inspired Technology。
文摘Video-based action recognition is becoming a vital tool in clinical research and neuroscientific study for disorder detection and prediction.However,action recognition currently used in non-human primate(NHP)research relies heavily on intense manual labor and lacks standardized assessment.In this work,we established two standard benchmark datasets of NHPs in the laboratory:Monkeyin Lab(Mi L),which includes 13 categories of actions and postures,and MiL2D,which includes sequences of two-dimensional(2D)skeleton features.Furthermore,based on recent methodological advances in deep learning and skeleton visualization,we introduced the Monkey Monitor Kit(Mon Kit)toolbox for automatic action recognition,posture estimation,and identification of fine motor activity in monkeys.Using the datasets and Mon Kit,we evaluated the daily behaviors of wild-type cynomolgus monkeys within their home cages and experimental environments and compared these observations with the behaviors exhibited by cynomolgus monkeys possessing mutations in the MECP2 gene as a disease model of Rett syndrome(RTT).Mon Kit was used to assess motor function,stereotyped behaviors,and depressive phenotypes,with the outcomes compared with human manual detection.Mon Kit established consistent criteria for identifying behavior in NHPs with high accuracy and efficiency,thus providing a novel and comprehensive tool for assessing phenotypic behavior in monkeys.
文摘BACKGROUND： In clinical practice, the degree of cognitive competence damage correlates to fine motor function deficits in children with psychomotor development retardation. Clear correlations between the two can help to develop and perform corresponding functional training for children with mental retardation （MR）. OBJECTIVE： This study was designed to evaluate and analyze the correlation of fine motor function to cognitive competence in MR children using the Peabody Developmental Motor Scale-Fine Motor （PDMS-FM） and Symbolic Play Test. DESIGN： Scale evaluation and correlation analysis. SETTING： Children＇s Rehabilitation Center ＆ Huajing District Hospital, Children＇s Hospital Affiliated to Fudan University. PARTICIPANTS： A total of 42 MR children, 28 males and 14 females, aged 14-69 months, were admitted to the Rehabilitation Center, Children＇s Hospital, Fudan University between June 2003 and April 2006, and were recruited for this study. All children corresponded to MR diagnosis criteria determined by Chinese Neurology and Psychiatry Society in 1989. Written informed consent for participating in the evaluation and for evaluated content was obtained from each child＇s guardian. METHODS： Subsequent to admission and prior to treatment, fine motor function of each MR child was evaluated using PDMS-FM （Chinese version）. The scale captured 98 items that formed the grasping （Gr） and visual-motor integration （Vi） subtests. Cognitive competence was evaluated using the Symbolic Play Test （Chinese version）, which captured four 6-item specific contents. The original score of each subtest was used to evaluate results for statistical analysis. Higher scores from the two evaluations indicated stronger abilities. Pearson correlation analysis was applied for analyzing data correlation. MAIN OUTCOME MEASURES： Fine motor function was evaluated using PDMS-FM. Cognitive competence was measured using the Symbolic Play Test. Correlations between results from the two evaluations were analyzed. RESULTS： All 42 MR children were included in the final analysis. Correlation analysis results demonstrated significant positive correlations of original scores existed between Gr and Vi subtests in the PDMS-FM （r = 0.761, P 〈 0.01）, and between Vi and Gr subtests in PDMS-FM and Symbolic Play Test （r = 0.663, 0.450, P 〈 0.01）. CONCLUSION： Fine motor function closely correlates to cognitive competence in MR children. This indicates fine motor function training should be developed in combination with cognitive competence training.
文摘This study aimed to explore the performance of the perceptual-visuomotor skills and the production of handwriting in children with Learning Disabilities.A total of 56 children participated,being a convenience sample,of both sexes,average age of eight years old,from 3rd to 5th grade level of Elementary School.The children were divided into the following groups:GI(28 children diagnosed with Learning Disabilities);GII(28 children with good academic performance,paired with GI in relation to chronological age and sex).They were evaluated individually in dysgraphic scale,visual perception development test,and fine motor evaluation.Data analysis was performed.There was a significant difference between GI and GII for the subtests of eye-hand coordination,copying,visual closure,fine motor precision,and fine manual control tests.They had difference between the groups for handwriting performance in descending and/or ascending subtests,irregularity of dimension,poor forms,and total score of Dysgraphia Scale.The results presented in this study indicate that children with Learning Disabilities can manifest significant visomotor impairment and deficit in legibility and handwriting quality,causing failures in the elaboration of sensorimotor plans that,added to the intrinsic deficit of long-term memory,result in persistent academic difficulties.
文摘Teaching writing is an essential component of Chinese education in primary schools and an important foundation for students’reading,writing,and core literacy development.However,due to various reasons,children in the lower grades always face multiple difficulties in the learning task of writing.Based on this educational status quo,this article puts forward strategic suggestions for improving writing skills in the lower grades of primary school.Teachers should analyze students and attend to each student individually,optimize teaching methods,and implement hierarchical teaching.They should also strengthen the training of students’fine motor skills to solidify the physiological foundation for writing.Emphasis should be placed on cultivating the core quality of aesthetic creation.Employing multiple process evaluations can inspire children’s long-term interest in learning.
文摘目的:探究注意缺陷多动障碍(attention deficit and hyperactivity disorder,ADHD)男童的动作发展特点,为开拓ADHD儿童的非药物治疗手段提供理论依据。方法:从北京市某三甲医院招募19名ADHD男童,从北京市某公立小学1~4年级学生中筛查出ADHD男童61名,排除因主、客观因素不能完成全部测试者,最终入组65名ADHD男童,其中6~8岁41人,9~10岁24人,注意缺陷型ADHD(ADHDPI)48人,混合型ADHD(ADHD-C)17人,募集年龄相差不超过半岁的正常发育男童65名为正常对照。采用儿童粗大动作发展测试量表第三版(TGMD-3)、儿童动作协调能力标准评估工具第二版(MABC-2)分别评估儿童的粗大动作和精细动作发展水平,采用独立样本t检验比较ADHD男童与正常男童各项指标的组间差异,使用单因素方差分析比较各亚型之间及与正常对照的组间差异,显著性水平为P<0.05。结果:(1)整体分析显示:ADHD组TGMD-3总分和手部精细动作得分均显著低于正常组(P<0.01);(2)不同年龄段分析显示:6~8岁ADHD组的TGMD-3和手部精细动作得分均低于6~8岁正常组(P<0.001),9~10岁ADHD组仅手部精细动作得分低于同年龄正常组(P<0.05);(3)不同亚型分析显示:ADHD-C组的TGMD-3总分和手部精细动作得分均低于正常组(P<0.05),ADHD-PI组仅手部精细动作得分低于正常组(P<0.05),ADHD-PI组和ADHD-C组无显著差异。结论:6~10岁ADHD男童的粗大和精细动作发展均显著落后于同龄儿童,精细动作发展落后在低年龄和高年龄段ADHD男童中持续存在,混合型较注意缺陷型ADHD男童动作发展落后的范围更广。
