BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use i...BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.展开更多
Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （grou...Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （group A） and a conventional acupoints group （group B） by a computer generated allocation list, 32 cases in each one. In the trial group, acupuncture was applied at xinshu （心俞 15）, Ganshu （刊俞 18）, Pishu （脾俞 BL 20） and Geshu （膈俞 BL 17）. In the control group, acupuncture was applied conventionally to Neiguan （内关 PC 6）, Shenmen （神门 HT 7）, Sanyinjiao （三阴交 SP 6）, Baihui （百会 GV 20） and Sishencong （四神聪 EX-HN 2）. Ten treatments made a session. The efficacy was analyzed statistically after 3 sessions of treatment. Results There were significant differences between the two groups in the relief of sleep disorders after the treatment （P〈0.O2）. The improvement in sleep efficiency was different significantly （P〈0.05）. The difference in sleep difficulty was significant in Chinese medicine （TCM） symptom score （P〈0.05）. Conclusion The clinical efficacy is achieved by either acupuncture at back-shu points or by acupuncture at conventional acupoints. The improvements of sleep efficiency and sleep disorder scores in PSO.I, and sleep difficulty in TCM as well as the long-term efficacy are superior in group A as compared with those in group B.展开更多
Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication ...Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication （10 cases）. For the group with electroacupuncture, Shenting （神庭 GV 24）, Baihui （百会 GV 20）, Pishu （脾俞 BL 20）, Weishu（胃俞 BL 21）, Dachangshu （大肠俞 BL 25）, Xiaochangshu （小肠俞BL 27） were selected for treatment; and for the group of medication, venlafaxine was given as usual. 30 days later, an open unidirectional qualitative response sequential method was taken to compare the therapeutic effects of two groups. Result The therapeutic effects from two 8 cases proved that the group of electroacupuncture was better than the group of medication. Conclusion For depression, scalp acupuncture accompanied by acupuncture on the Back-shu points has a better effect for depression, and is superior to medication.展开更多
Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In t...Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.展开更多
Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based...Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based on syndrome differentiation. The short-form General Health Survey （MOSSF GHS） and the Chalder Questionnaires for Fatigue were adopted for evaluating the therapeutic effects. Results： Of the 22 patients, 4 cases showed a marked effect, 11 got effect, 7 got failure, and the total effective rate was 68.2%. Conclusion： Puncturing Back-Shu points is effective in relieving the symptoms of chronic fatigue syndrome and enhancing the patients＇ health standard.展开更多
Objective： To observe the clinical efficacy on pricking bloodletting and cupping therapy combined with Chinese herbal mask in treating acne. Methods： Thirty-seven patients with ache were randomly divided into a tre...Objective： To observe the clinical efficacy on pricking bloodletting and cupping therapy combined with Chinese herbal mask in treating acne. Methods： Thirty-seven patients with ache were randomly divided into a treatment group （treated by pricking bloodletting and cupping therapy combined with Chinese herbal mask） and a control group （only by Chinese herbal mask）. The therapeutic efficacy was observed after 2-course treatment. Results： The total effective rate in the treatment group was 94.7% versus 61.1% in the control group. According to the statistical management, the total effective rate in the treatment group was significantly higher than that in the control group （P〈O.05）. Conclusion： Pricking bloodletting and cupping therapy combined with Chinese herbal mask therapy for acne is more effective than Chinese herbal mask treatment alone.展开更多
Objective： To evaluate the clinical efficacy of puncturing Back-Shu acupoints for insomnia. Methods： Sixty patients were randomly divided into two groups, 30 cases in each. Back-Shu acupoints acupuncture was employ...Objective： To evaluate the clinical efficacy of puncturing Back-Shu acupoints for insomnia. Methods： Sixty patients were randomly divided into two groups, 30 cases in each. Back-Shu acupoints acupuncture was employed in the treatment group, whereas conventional acupoints acupuncture was administered in the control group. And the efficacy was assessed by the efficiency rate of relief of sleep disorders and the global Pittsburgh Sleep Quality Index （PSOJ） score. Results： The total effective rate was 93.3% in the treatment group, versus 80.0% in the control group, showing that the two groups were significantly different （P〈0.01）. After treatment, the global PSO, I scores in the two groups decreased compared with those before treatment （P〈0.01）, and the global PSO, I scores of the two groups after treatment were also statistically different （P〈0.05）. Conclusion： Puncturing Back-Shu acupoints can effectively reduce the global PSQI score, improve the patient＇s quality of life, has a good effect on insomnia.展开更多
文摘BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.
基金Supported by National Natural Science Foundation:No.81173335
文摘Objective To observe the clinical therapeutic effect on insomnia treated with acupuncture at back-shu points. Methods Sixty-four cases of insomnia were selected and divided randomly into a back-shu points group （group A） and a conventional acupoints group （group B） by a computer generated allocation list, 32 cases in each one. In the trial group, acupuncture was applied at xinshu （心俞 15）, Ganshu （刊俞 18）, Pishu （脾俞 BL 20） and Geshu （膈俞 BL 17）. In the control group, acupuncture was applied conventionally to Neiguan （内关 PC 6）, Shenmen （神门 HT 7）, Sanyinjiao （三阴交 SP 6）, Baihui （百会 GV 20） and Sishencong （四神聪 EX-HN 2）. Ten treatments made a session. The efficacy was analyzed statistically after 3 sessions of treatment. Results There were significant differences between the two groups in the relief of sleep disorders after the treatment （P〈0.O2）. The improvement in sleep efficiency was different significantly （P〈0.05）. The difference in sleep difficulty was significant in Chinese medicine （TCM） symptom score （P〈0.05）. Conclusion The clinical efficacy is achieved by either acupuncture at back-shu points or by acupuncture at conventional acupoints. The improvements of sleep efficiency and sleep disorder scores in PSO.I, and sleep difficulty in TCM as well as the long-term efficacy are superior in group A as compared with those in group B.
文摘Objective To find therapeutic effect of acupuncture treating depression. Methods Eighteen cases of depression divided into two groups： one group treated with electroacupuncture （8 cases）, the other with medication （10 cases）. For the group with electroacupuncture, Shenting （神庭 GV 24）, Baihui （百会 GV 20）, Pishu （脾俞 BL 20）, Weishu（胃俞 BL 21）, Dachangshu （大肠俞 BL 25）, Xiaochangshu （小肠俞BL 27） were selected for treatment; and for the group of medication, venlafaxine was given as usual. 30 days later, an open unidirectional qualitative response sequential method was taken to compare the therapeutic effects of two groups. Result The therapeutic effects from two 8 cases proved that the group of electroacupuncture was better than the group of medication. Conclusion For depression, scalp acupuncture accompanied by acupuncture on the Back-shu points has a better effect for depression, and is superior to medication.
基金Supported by the subject of clinical research on treating chronic fatigue syndrome by acupuncture on the reaction point of back-shu points in Dongzhimen Hospital Beijing University of Chinese Medicine:2016-DZM111-JC006~~
文摘Objective: To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome(CFS).Methods: Sixty patients were randomized into treatment group and control group. In treatment group,the back-shu points of five zang organs were adopted for acupuncture. Shènshū(肾俞 BL23) was perpendicularly needled 15-30 mm in depth. The rest of the selected points were inserted obliquely 15-30 mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10 s for each acupoint. In control group, the acupoints were approximately 1.5-2 cm away outward from the back-shu points of five zang organs(about on the middle of the two sidelines of the bladder meridian of foottaiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled6-9 mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14(FS-14) and the Symptom Check-List 90(SCL-90) after treatment.Results: The total effective rate was 86.67% in the treatment group and 53.33% in the control group(P<0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment(all P<0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced(both P<0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group(P<0.01, P<0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment(P<0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment(P< 0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group(P< 0.01, P< 0.05).Conclusions: Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient’s somatic fatigue, mental fatigue and psychological status.
文摘Objective： To observe the clinical effect of puncturing Back-Shu points in treating chronic fatigue syndrome. Methods： Twenty-two subjects were recruited and treated by puncturing corresponding Back-Shu points based on syndrome differentiation. The short-form General Health Survey （MOSSF GHS） and the Chalder Questionnaires for Fatigue were adopted for evaluating the therapeutic effects. Results： Of the 22 patients, 4 cases showed a marked effect, 11 got effect, 7 got failure, and the total effective rate was 68.2%. Conclusion： Puncturing Back-Shu points is effective in relieving the symptoms of chronic fatigue syndrome and enhancing the patients＇ health standard.
文摘Objective： To observe the clinical efficacy on pricking bloodletting and cupping therapy combined with Chinese herbal mask in treating acne. Methods： Thirty-seven patients with ache were randomly divided into a treatment group （treated by pricking bloodletting and cupping therapy combined with Chinese herbal mask） and a control group （only by Chinese herbal mask）. The therapeutic efficacy was observed after 2-course treatment. Results： The total effective rate in the treatment group was 94.7% versus 61.1% in the control group. According to the statistical management, the total effective rate in the treatment group was significantly higher than that in the control group （P〈O.05）. Conclusion： Pricking bloodletting and cupping therapy combined with Chinese herbal mask therapy for acne is more effective than Chinese herbal mask treatment alone.
文摘Objective： To evaluate the clinical efficacy of puncturing Back-Shu acupoints for insomnia. Methods： Sixty patients were randomly divided into two groups, 30 cases in each. Back-Shu acupoints acupuncture was employed in the treatment group, whereas conventional acupoints acupuncture was administered in the control group. And the efficacy was assessed by the efficiency rate of relief of sleep disorders and the global Pittsburgh Sleep Quality Index （PSOJ） score. Results： The total effective rate was 93.3% in the treatment group, versus 80.0% in the control group, showing that the two groups were significantly different （P〈0.01）. After treatment, the global PSO, I scores in the two groups decreased compared with those before treatment （P〈0.01）, and the global PSO, I scores of the two groups after treatment were also statistically different （P〈0.05）. Conclusion： Puncturing Back-Shu acupoints can effectively reduce the global PSQI score, improve the patient＇s quality of life, has a good effect on insomnia.
