<div style="text-align:justify;"> Based on the detailed interpretation of high-accuracy 3D seismic data, the characteristics of regional unconformities, fracture systems, sedimentary filling and paleo-...<div style="text-align:justify;"> Based on the detailed interpretation of high-accuracy 3D seismic data, the characteristics of regional unconformities, fracture systems, sedimentary filling and paleo-stress field in Zhu 1 depression were comprehensively analyzed. The results showed that 2nd episode of Zhu-Qiong movement was an important tectonic transformation that occurred during rifting, basin structure patterns above and below the regional angular unconformity caused by 2nd episode had distinct differences. The orientations of those basin-controlling faults changed from NE, NEE to EW, NWW, which indicated that the paleo-stress field veered from NNW extension clockwise to sub-NS extension and basin structures patterns transformed from NE, NEE strong rifting to sub-EW, NWW weak rifting. The depocenter showed seesaw-like migration from S to N. And the sedimentary systems transformed from semi-deep-deep lacustrine facies to braided river delta facies developed in shore-shallow lacustrine. Combined with its tectonic recombination of periphery plates that period, the mechanism of above tectonic transformation had direct correspondence to the readjustment of the Indian plate and the Pacific plate. The southward subduction of the pro-to-south China Sea is the direct cause of this tectonic transformation. </div>展开更多
Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to s...Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to steroids （CLIPPERS） have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of infammation.展开更多
BACKGROUND Subgrouping patients with major depressive disorder is a promising solution for the issue of heterogeneity.However,the link between available subtypes and distinct pathological mechanisms is weak and yields...BACKGROUND Subgrouping patients with major depressive disorder is a promising solution for the issue of heterogeneity.However,the link between available subtypes and distinct pathological mechanisms is weak and yields disappointing results in clinical application.AIM To develop a novel approach for classification of patients with time-dependent prescription patterns at first onset in real-world settings.METHODS Drug-naive patients experiencing their first major depressive episode(n=105)participated in this study.Psychotropic agents prescribed in the first 24 mo following disease onset were recorded monthly and categorized as antidepressants,augmentation agents,and hypnosedatives.Monthly cumulative doses of agents in each category were converted into relevant equivalents.Four parameters were used to summarize the time-dependent prescription patterns for each psychotropic load:Stability,amount,frequency,and the time trend of monthly prescriptions.A K-means cluster analysis was used to derive subgroups of participants based on these input parameters of psychotropic agents across 24 mo.Clinical validity of the resulting data-driven clusters was compared using relevant severity indicators.RESULTS Four distinct clusters were derived from K-means analysis,which matches experts’consent:"Short-term antidepressants use","long-term antidepressants use","long-term antidepressants and sedatives use",and"long-term antidepressants,sedatives,and augmentation use".At the first 2 years of disease course,the four clusters differed on the number of antidepressants used at adequate dosage and duration,frequency of outpatient service use,and number of psychiatric admissions.After the first 2 years following disease onset,depression severity was differed in the four subgroups.CONCLUSION Our findings suggested a new approach to optimize the subgrouping of patients with major depressive disorder,which may assist future etiological and treatment response studies.展开更多
Objective:to explore brain-derived neu-rotrophic factor(BDNF)and matrix metalloproteinase-9(MMP9)messenger in peripheral blood lymphocytes of patients with depressive episodes before and after anti-depressant treatmen...Objective:to explore brain-derived neu-rotrophic factor(BDNF)and matrix metalloproteinase-9(MMP9)messenger in peripheral blood lymphocytes of patients with depressive episodes before and after anti-depressant treatment changes in RNA(mRNA)expres-sion levels.Methods:fifteen patients hospitalized with depression in the Afiliated Mental Hospital of Kunming Medical University from December 2021 to June 2022 were collected as research objects.After 4 weeks of anti-depressant treatment,BDNF mRNA and MMP9 mRNA in patients with depression were detected before and af-ter treatment,and statistically analyzed.Results:after 4 weeks of antidepressant treatment,there was no signif-icant difference in BDNF mRNA expression level after treatment compared with before treatment(P>0.05).The mRNA level of MMP9 was higher than that before treatment,and the difference was statistically significant(P<0.05).Conclusion:antidepressant therapy increases the expression of MMP9 mRNA,increasing the conver-sion of BDNF precursor(proBDNF)to mature for BDNF(mBDNF)to relieve depressive symptoms,and the total content of BDNF did not change significantly.展开更多
This paper investigates the origin and migration characteristics of petroleum in the northeastern part of the Baiyun Depression,Pearl River Mouth Basin(PRMB).The discovered petroleum in the study area is mainly locate...This paper investigates the origin and migration characteristics of petroleum in the northeastern part of the Baiyun Depression,Pearl River Mouth Basin(PRMB).The discovered petroleum in the study area is mainly located in the Lower Zhujiang Member(N_(1)z^(2))and mainly originated from the Enping Formation source rocks in the eastern sag.Active faults(vertical migration)and N_(1)z^(2)sandstones(lateral migration)acted as the petroleum migration systems.The fault activities in the Dongsha event controlled the episodic petroleum migration.Fractures in the fault zones provided effective conduits,and overpressure was the driving force.The vertical migration could not cross the fault zones laterally.The petroleum injection areas in the carrier beds were the contact zones of petroleum-migration faults and carrier beds.The lateral migration was steady-state migration,and buoyancy was the driving force.The migration pathways in the carrier beds were controlled by the structural morphology.Secondary petroleum migration in the study area could be divided into two parts:vertical migration along the fractures in the fault zones and lateral migration through preferential petroleum migration pathways(PPMPs)in the carrier beds.The petroleum migration behaviors,including migrating direction,driving force,and migration pattern,in the faults and sandstone carrier beds were quite different.This study provides a typical example for comprehending secondary migration processes and has great importance for determining future exploration targets in the deep-water area of the PRMB.展开更多
目的初步探索无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对中青年抑郁发作患者认知功能的影响及其性别差异。方法纳入首都医科大学附属北京安定医院住院的中青年抑郁发作患者,完成6次MECT,分别在基线、第3次MECT后、第...目的初步探索无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对中青年抑郁发作患者认知功能的影响及其性别差异。方法纳入首都医科大学附属北京安定医院住院的中青年抑郁发作患者,完成6次MECT,分别在基线、第3次MECT后、第6次MECT后采用17项汉密尔顿抑郁量表(17-item Hamilton depression scale,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、重复成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)对抑郁、焦虑症状和认知功能进行评分,分别在青年组和中年组中比较性别差异。结果纳入抑郁发作患者共122例,其中青年组83例、中年组39例。两组中,基线HAMD及HAMA评分、MECT后HAMD减分率均无性别差异(P>0.05)。重复测量方差分析显示,青年组中,RBANS总分、视觉广度因子分、注意因子分的时点效应具有统计学意义(P<0.05),治疗后较基线时提高,性别分组效应和交互效应无统计学意义(P>0.05)。中年组中,RBANS总分、视觉广度因子分的时点-性别分组交互效应具有统计学意义(P<0.05),女性患者RBANS总分、视觉广度因子分、注意因子分在第6次MECT后较基线时提高(P<0.05),时点效应和性别分组效应无统计学意义(P>0.05)。结论中青年抑郁患者MECT后认知功能整体有所改善,中年患者认知功能变化存在性别差异,需依据患者性别、年龄特征优化MECT方案,以减轻认知功能不良影响。展开更多
目的基于逆境和精神病理维度模型(dimensional model of adversity and psychopathology,DMAP)探索重性抑郁发作患者的威胁型和剥夺型儿童期创伤与功能失调性态度的关联。方法收集970例重性抑郁发作患者资料,根据简版儿童期创伤问卷(chi...目的基于逆境和精神病理维度模型(dimensional model of adversity and psychopathology,DMAP)探索重性抑郁发作患者的威胁型和剥夺型儿童期创伤与功能失调性态度的关联。方法收集970例重性抑郁发作患者资料,根据简版儿童期创伤问卷(childhood trauma questionnaire,CTQ-SF)评分将患者分为无创伤组(426例)、仅威胁组(86例)、仅剥夺组(210例)、混合组(248例),采用功能失调性态度量表(dysfunctional attitudes scale,DAS)评估患者的认知歪曲情况,DAS得分大于所有受试者得分的上四分位数定义为高认知歪曲。采用多因素logistic回归分析探究患者威胁型和剥夺型创伤与功能失调性态度的关联。结果无创伤组、仅威胁组、仅剥夺组、混合组整体高认知歪曲者比例存在统计学差异(19.25%vs.30.23%vs.20.00%vs.35.89%,P<0.001),且各维度高认知歪曲比例均存在统计学差异(P≤0.001)。多因素logistic回归分析显示,威胁型创伤与整体高认知歪曲呈正关联(OR=2.031,P<0.001),且威胁型创伤与DAS中脆弱性(OR=1.709,P<0.001)、吸引与排斥(OR=2.088,P<0.001)、完美化(OR=2.321,P<0.001)、强制性(OR=1.765,P=0.001)、寻求赞许(OR=1.837,P<0.001)、依赖性(OR=1.554,P=0.006)、自主性态度(OR=1.864,P<0.001)等7个维度高认知歪曲呈正关联,剥夺型创伤仅与认知哲学维度高认知歪曲呈正关联(OR=1.495,P=0.015)。结论重性抑郁发作患者的儿童期创伤与功能失调性态度紧密相关,威胁型创伤与整体及除认知哲学外的维度高认知歪曲正相关,而剥夺型创伤仅与认知哲学维度高认知歪曲正相关。展开更多
文摘<div style="text-align:justify;"> Based on the detailed interpretation of high-accuracy 3D seismic data, the characteristics of regional unconformities, fracture systems, sedimentary filling and paleo-stress field in Zhu 1 depression were comprehensively analyzed. The results showed that 2nd episode of Zhu-Qiong movement was an important tectonic transformation that occurred during rifting, basin structure patterns above and below the regional angular unconformity caused by 2nd episode had distinct differences. The orientations of those basin-controlling faults changed from NE, NEE to EW, NWW, which indicated that the paleo-stress field veered from NNW extension clockwise to sub-NS extension and basin structures patterns transformed from NE, NEE strong rifting to sub-EW, NWW weak rifting. The depocenter showed seesaw-like migration from S to N. And the sedimentary systems transformed from semi-deep-deep lacustrine facies to braided river delta facies developed in shore-shallow lacustrine. Combined with its tectonic recombination of periphery plates that period, the mechanism of above tectonic transformation had direct correspondence to the readjustment of the Indian plate and the Pacific plate. The southward subduction of the pro-to-south China Sea is the direct cause of this tectonic transformation. </div>
文摘Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic infammation with pontine perivascular enhancement responsive to steroids （CLIPPERS） have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of infammation.
基金Supported by the Ministry of Science and Technology,Taiwan,No.MOST 107-2314-B-002-219,No.MOST 108-2314-B-002-110-MY2the National Taiwan University Hospital,No.UN110-021.
文摘BACKGROUND Subgrouping patients with major depressive disorder is a promising solution for the issue of heterogeneity.However,the link between available subtypes and distinct pathological mechanisms is weak and yields disappointing results in clinical application.AIM To develop a novel approach for classification of patients with time-dependent prescription patterns at first onset in real-world settings.METHODS Drug-naive patients experiencing their first major depressive episode(n=105)participated in this study.Psychotropic agents prescribed in the first 24 mo following disease onset were recorded monthly and categorized as antidepressants,augmentation agents,and hypnosedatives.Monthly cumulative doses of agents in each category were converted into relevant equivalents.Four parameters were used to summarize the time-dependent prescription patterns for each psychotropic load:Stability,amount,frequency,and the time trend of monthly prescriptions.A K-means cluster analysis was used to derive subgroups of participants based on these input parameters of psychotropic agents across 24 mo.Clinical validity of the resulting data-driven clusters was compared using relevant severity indicators.RESULTS Four distinct clusters were derived from K-means analysis,which matches experts’consent:"Short-term antidepressants use","long-term antidepressants use","long-term antidepressants and sedatives use",and"long-term antidepressants,sedatives,and augmentation use".At the first 2 years of disease course,the four clusters differed on the number of antidepressants used at adequate dosage and duration,frequency of outpatient service use,and number of psychiatric admissions.After the first 2 years following disease onset,depression severity was differed in the four subgroups.CONCLUSION Our findings suggested a new approach to optimize the subgrouping of patients with major depressive disorder,which may assist future etiological and treatment response studies.
基金Yunnan Provincial Department of Science and Tech-nology Project(202001AY070001-280)Kunming Med-ical University 2022 Graduate Student Innovation Fund(2022S106).
文摘Objective:to explore brain-derived neu-rotrophic factor(BDNF)and matrix metalloproteinase-9(MMP9)messenger in peripheral blood lymphocytes of patients with depressive episodes before and after anti-depressant treatment changes in RNA(mRNA)expres-sion levels.Methods:fifteen patients hospitalized with depression in the Afiliated Mental Hospital of Kunming Medical University from December 2021 to June 2022 were collected as research objects.After 4 weeks of anti-depressant treatment,BDNF mRNA and MMP9 mRNA in patients with depression were detected before and af-ter treatment,and statistically analyzed.Results:after 4 weeks of antidepressant treatment,there was no signif-icant difference in BDNF mRNA expression level after treatment compared with before treatment(P>0.05).The mRNA level of MMP9 was higher than that before treatment,and the difference was statistically significant(P<0.05).Conclusion:antidepressant therapy increases the expression of MMP9 mRNA,increasing the conver-sion of BDNF precursor(proBDNF)to mature for BDNF(mBDNF)to relieve depressive symptoms,and the total content of BDNF did not change significantly.
基金supported by the National Science and Technology Major Projects of China(Grant No:2016ZX05026-007)。
文摘This paper investigates the origin and migration characteristics of petroleum in the northeastern part of the Baiyun Depression,Pearl River Mouth Basin(PRMB).The discovered petroleum in the study area is mainly located in the Lower Zhujiang Member(N_(1)z^(2))and mainly originated from the Enping Formation source rocks in the eastern sag.Active faults(vertical migration)and N_(1)z^(2)sandstones(lateral migration)acted as the petroleum migration systems.The fault activities in the Dongsha event controlled the episodic petroleum migration.Fractures in the fault zones provided effective conduits,and overpressure was the driving force.The vertical migration could not cross the fault zones laterally.The petroleum injection areas in the carrier beds were the contact zones of petroleum-migration faults and carrier beds.The lateral migration was steady-state migration,and buoyancy was the driving force.The migration pathways in the carrier beds were controlled by the structural morphology.Secondary petroleum migration in the study area could be divided into two parts:vertical migration along the fractures in the fault zones and lateral migration through preferential petroleum migration pathways(PPMPs)in the carrier beds.The petroleum migration behaviors,including migrating direction,driving force,and migration pattern,in the faults and sandstone carrier beds were quite different.This study provides a typical example for comprehending secondary migration processes and has great importance for determining future exploration targets in the deep-water area of the PRMB.
文摘目的初步探索无抽搐电休克治疗(modified electroconvulsive therapy,MECT)对中青年抑郁发作患者认知功能的影响及其性别差异。方法纳入首都医科大学附属北京安定医院住院的中青年抑郁发作患者,完成6次MECT,分别在基线、第3次MECT后、第6次MECT后采用17项汉密尔顿抑郁量表(17-item Hamilton depression scale,HAMD-17)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、重复成套神经心理状态测验(repeatable battery for the assessment of neuropsychological status,RBANS)对抑郁、焦虑症状和认知功能进行评分,分别在青年组和中年组中比较性别差异。结果纳入抑郁发作患者共122例,其中青年组83例、中年组39例。两组中,基线HAMD及HAMA评分、MECT后HAMD减分率均无性别差异(P>0.05)。重复测量方差分析显示,青年组中,RBANS总分、视觉广度因子分、注意因子分的时点效应具有统计学意义(P<0.05),治疗后较基线时提高,性别分组效应和交互效应无统计学意义(P>0.05)。中年组中,RBANS总分、视觉广度因子分的时点-性别分组交互效应具有统计学意义(P<0.05),女性患者RBANS总分、视觉广度因子分、注意因子分在第6次MECT后较基线时提高(P<0.05),时点效应和性别分组效应无统计学意义(P>0.05)。结论中青年抑郁患者MECT后认知功能整体有所改善,中年患者认知功能变化存在性别差异,需依据患者性别、年龄特征优化MECT方案,以减轻认知功能不良影响。
文摘目的基于逆境和精神病理维度模型(dimensional model of adversity and psychopathology,DMAP)探索重性抑郁发作患者的威胁型和剥夺型儿童期创伤与功能失调性态度的关联。方法收集970例重性抑郁发作患者资料,根据简版儿童期创伤问卷(childhood trauma questionnaire,CTQ-SF)评分将患者分为无创伤组(426例)、仅威胁组(86例)、仅剥夺组(210例)、混合组(248例),采用功能失调性态度量表(dysfunctional attitudes scale,DAS)评估患者的认知歪曲情况,DAS得分大于所有受试者得分的上四分位数定义为高认知歪曲。采用多因素logistic回归分析探究患者威胁型和剥夺型创伤与功能失调性态度的关联。结果无创伤组、仅威胁组、仅剥夺组、混合组整体高认知歪曲者比例存在统计学差异(19.25%vs.30.23%vs.20.00%vs.35.89%,P<0.001),且各维度高认知歪曲比例均存在统计学差异(P≤0.001)。多因素logistic回归分析显示,威胁型创伤与整体高认知歪曲呈正关联(OR=2.031,P<0.001),且威胁型创伤与DAS中脆弱性(OR=1.709,P<0.001)、吸引与排斥(OR=2.088,P<0.001)、完美化(OR=2.321,P<0.001)、强制性(OR=1.765,P=0.001)、寻求赞许(OR=1.837,P<0.001)、依赖性(OR=1.554,P=0.006)、自主性态度(OR=1.864,P<0.001)等7个维度高认知歪曲呈正关联,剥夺型创伤仅与认知哲学维度高认知歪曲呈正关联(OR=1.495,P=0.015)。结论重性抑郁发作患者的儿童期创伤与功能失调性态度紧密相关,威胁型创伤与整体及除认知哲学外的维度高认知歪曲正相关,而剥夺型创伤仅与认知哲学维度高认知歪曲正相关。
