It is generally accepted that the history of the expansion of the universe can be exactly described by the concordance model, which makes specific predictions about the shape of the Hubble diagram. The redshift-magnit...It is generally accepted that the history of the expansion of the universe can be exactly described by the concordance model, which makes specific predictions about the shape of the Hubble diagram. The redshift-magnitude Hubble diagram in the redshift range z = 0.0104 - 1 seems to confirm this expectation, and it is believed that this conformity is also valid in the high redshift range. However, this belief is not undisputed. Recent work in the high redshift range of up to z = 8.1 has shown that the shape of the Hubble diagram deviates considerably from the predictions made by the Lambda cold dark matter model. These analyses, however, were based on mixed SN1a and gamma ray burst data, and some astronomers argue that this may have biased the results. In this paper, 109 cosmology-independent, calibrated gamma ray burst z/μdata points are used to calculate the Hubble diagram in the range z = 0.034 to z = 8.1. The outcome of this analysis confirms prior results: contrary to expectations, the shape of the Hubble diagram turns out to be exponential, and this is difficult to explain within the framework of the standard model. The cosmological implications of this unexpected result are discussed.展开更多
Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing a...Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing and hydrometallurgical process of concentrate have been greatly developed. The construction of E pH diagrams has turned to multi component systems. However, there are some limits in plotting such diagrams. There is only one diagram for one multi component system, which can not reflect the truth of the aqueous reaction. In the paper, a new computation method is proposed to construct E pH diagrams. Component activity term is used to determine the boundary of stable areas. For the multi component systems, different atom ratios of elements have been taken into account. M S H 2O system is chosen to study since it is of importance in metallurgical solution. Compared with conventional methods, the algorithm is simple and conforms to real conditions.展开更多
Deposition of aggregated protein is associated with many human diseases. The mechanism by which protein aggregate species cause cellular death remains unclear. A profile revealing protein aggregation products under a ...Deposition of aggregated protein is associated with many human diseases. The mechanism by which protein aggregate species cause cellular death remains unclear. A profile revealing protein aggregation products under a diverse set of conditions allows the search of novel aggregate products and potential pathogens. To achieve this end, an isothermal transformation diagram (ITD) of lysozyme aggregation was constructed. AFM, TEM, and Thioflavin T binding assays were used to analyze the aggregate species synthesized under a broad range of pH values, protein concentrations, and incubation times. Four states were found: 1) soluble protein species;2) insoluble amyloid fibers;3) insoluble amorphous aggregates;and 4) protein hydrogels. The hydrogel-a rises from aggregated amyloid fibers. This work is part of an effort to construct an array of ITDs reporting aggregation properties of many disease relevant proteins, including amyloid beta, tau, α-synuclein, and others involved in protein aggregation diseases. In addition, we propose hydrogel cyto toxicity as a potential novel mechanism in the pathogenesis of amyloid diseases.展开更多
文摘It is generally accepted that the history of the expansion of the universe can be exactly described by the concordance model, which makes specific predictions about the shape of the Hubble diagram. The redshift-magnitude Hubble diagram in the redshift range z = 0.0104 - 1 seems to confirm this expectation, and it is believed that this conformity is also valid in the high redshift range. However, this belief is not undisputed. Recent work in the high redshift range of up to z = 8.1 has shown that the shape of the Hubble diagram deviates considerably from the predictions made by the Lambda cold dark matter model. These analyses, however, were based on mixed SN1a and gamma ray burst data, and some astronomers argue that this may have biased the results. In this paper, 109 cosmology-independent, calibrated gamma ray burst z/μdata points are used to calculate the Hubble diagram in the range z = 0.034 to z = 8.1. The outcome of this analysis confirms prior results: contrary to expectations, the shape of the Hubble diagram turns out to be exponential, and this is difficult to explain within the framework of the standard model. The cosmological implications of this unexpected result are discussed.
文摘Aqueous E pH Diagram is an essential tool for analyzing hydrometallurgical and corrosion processes. Due to the requirements for environmental protection and energy saving in recent years, waste water processing and hydrometallurgical process of concentrate have been greatly developed. The construction of E pH diagrams has turned to multi component systems. However, there are some limits in plotting such diagrams. There is only one diagram for one multi component system, which can not reflect the truth of the aqueous reaction. In the paper, a new computation method is proposed to construct E pH diagrams. Component activity term is used to determine the boundary of stable areas. For the multi component systems, different atom ratios of elements have been taken into account. M S H 2O system is chosen to study since it is of importance in metallurgical solution. Compared with conventional methods, the algorithm is simple and conforms to real conditions.
文摘Deposition of aggregated protein is associated with many human diseases. The mechanism by which protein aggregate species cause cellular death remains unclear. A profile revealing protein aggregation products under a diverse set of conditions allows the search of novel aggregate products and potential pathogens. To achieve this end, an isothermal transformation diagram (ITD) of lysozyme aggregation was constructed. AFM, TEM, and Thioflavin T binding assays were used to analyze the aggregate species synthesized under a broad range of pH values, protein concentrations, and incubation times. Four states were found: 1) soluble protein species;2) insoluble amyloid fibers;3) insoluble amorphous aggregates;and 4) protein hydrogels. The hydrogel-a rises from aggregated amyloid fibers. This work is part of an effort to construct an array of ITDs reporting aggregation properties of many disease relevant proteins, including amyloid beta, tau, α-synuclein, and others involved in protein aggregation diseases. In addition, we propose hydrogel cyto toxicity as a potential novel mechanism in the pathogenesis of amyloid diseases.
