Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper li...Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.展开更多
目的研究对小鼠不同频率的重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)的抗抑郁作用,并探讨重复经颅磁刺激的安全性。方法昆明种小鼠分为高频组、低频组、模型组及对照组。高频组和和低频组分别接受连续5天的...目的研究对小鼠不同频率的重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)的抗抑郁作用,并探讨重复经颅磁刺激的安全性。方法昆明种小鼠分为高频组、低频组、模型组及对照组。高频组和和低频组分别接受连续5天的高频重复经颅磁刺激(10Hz)和低频重复经颅磁刺激(2Hz)处理,模型组与对照组不接受rTMS处理。以开场实验研究rTMS的安全性,以强迫游泳实验研究不同频率rTMS对小鼠抗抑郁样作用,同时通过海马肾上腺素受体对其机制进行探讨。结果研究发现在开场实验中,高频组、低频组和对照组小鼠的行为指标,包括:穿越格数,直立数,理毛数和排泄数差异均无显著性。在强迫游泳实验中,与模型组相比,低频组的潜伏期延长,悬浮时间缩短,同时不同频率的重复经颅磁刺激对小鼠海马肾上腺素受体的表达产生不同的影响。结论不同频率的重复经颅磁刺激的抗抑郁样作用不同,低频重复经颅磁刺激具有一定的抗抑郁样作用。而高频和低频的重复经颅磁刺激均具有安全性。展开更多
文摘Low-frequency repetitive transcranial magnetic stimulation（LF-r TMS） to the contralesional hemisphere and intensive occupational therapy（i OT） have been shown to contribute to a significant improvement in upper limb hemiparesis in patients with chronic stroke. However, the effect of the combined intervention program of LF-r TMS and i OT on cognitive function is unknown. We retrospectively investigated whether the combined treatment influence patient＇s Trail-Making Test part B（TMT-B） performance, which is a group of easy and inexpensive neuropsychological tests that evaluate several cognitive functions. Twenty-five patients received 11 sessions of LF-r TMS to the contralesional hemisphere and 2 sessions of i OT per day over 15 successive days. Patients with right- and left-sided hemiparesis demonstrated significant improvements in upper limb motor function following the combined intervention program. Only patients with right-sided hemiparesis exhibited improved TMT-B performance following the combined intervention program, and there was a significant negative correlation between Fugl-Meyer Assessment scale total score change and TMT-B performance. The results indicate the possibility that LF-r TMS to the contralesional hemisphere combined with i OT improves the upper limb motor function and cognitive function of patients with right-sided hemiparesis. However, further studies are necessary to elucidate the mechanism of improved cognitive function.
文摘目的研究对小鼠不同频率的重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)的抗抑郁作用,并探讨重复经颅磁刺激的安全性。方法昆明种小鼠分为高频组、低频组、模型组及对照组。高频组和和低频组分别接受连续5天的高频重复经颅磁刺激(10Hz)和低频重复经颅磁刺激(2Hz)处理,模型组与对照组不接受rTMS处理。以开场实验研究rTMS的安全性,以强迫游泳实验研究不同频率rTMS对小鼠抗抑郁样作用,同时通过海马肾上腺素受体对其机制进行探讨。结果研究发现在开场实验中,高频组、低频组和对照组小鼠的行为指标,包括:穿越格数,直立数,理毛数和排泄数差异均无显著性。在强迫游泳实验中,与模型组相比,低频组的潜伏期延长,悬浮时间缩短,同时不同频率的重复经颅磁刺激对小鼠海马肾上腺素受体的表达产生不同的影响。结论不同频率的重复经颅磁刺激的抗抑郁样作用不同,低频重复经颅磁刺激具有一定的抗抑郁样作用。而高频和低频的重复经颅磁刺激均具有安全性。
