Cognitive impairment in patients with bipolar disorder alone versus those with bipolar disorder comorbid with borderline personality disorder

BACKGROUND Bipolar disorder(BD)is a severe mental illness.BD often coexists with borderline personality disorders,making the condition more complex.AIM To explore the differences in cognitive impairment between patients with BD and those with BD comorbid with borderline personality disorder.METHODS Eighty patients with BD and comorbid borderline personality disorder and 80 patients with BD alone were included in groups A and B,respectively,and 80 healthy volunteers were included as controls.Cognitive function in each group was evaluated using the Chinese version of the repeatable battery for the assess-ment of neuropsychological status(RBANS),the Stroop color-word test,and the Wechsler intelligence scale-revised(WAIS-RC).RESULTS The indices of the RBANS,Stroop color-word test,and WAIS-RC in groups A and B were significantly lower than those of the control group(P<0.05).Group A had significantly longer Stroop color-word test times for single-character,single-color,double-character,and double-color,lower scores of immediate memory,visual breadth,verbal function dimensions and total score of the RBANS,as well as lower scores of verbal IQ,performance IQ,and overall IQ of the WAIS-RC compared with group B(P<0.05).Compared to group B,group A exhibited significantly longer single-character time,single-color time,double-character time,and double-color time in the Stroop color-word test(P<0.05).CONCLUSION The cognitive function of patients with BD complicated with borderline personality disorder is lower than that of patients with BD.

Correlations between five-pattern personality scores from traditional Chinese medicine and autonomic nervous response indicators in healthy female college students

Objective:To explore the correlations between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students,to provide a foundation for further exploration of the modern physiological basis of these personality types.Methods:Subjects were asked to fill in 'The Five-Pattern Personality Inventory' (revised edition 2008).Taiyang,Shaoyang,yin-yang balance,Taiyin,and Shaoyin personalities were scored.The galvanic skin response and heart rate,and the low frequency (LF),high frequency (HF),and LF/HF ratio of heart rate variability were collected using a 16-channel physiological recorder (BIOPAC MP150).Relationship between the five-pattern personality scores and autonomic nervous response indicators was analyzed using bivariate correlation.Results:The five-pattern personality scores of the subjects were compared with national averages.The Taiyang and Shaoyang personality scores of the subjects were significantly lower than the overall national average,the national female average,and the national female average in the 18-29-year-old age group (all P <.05).The Taiyang personality score was negatively correlated with both the LF and the HF (P =.009 and P =.001,respectively),and the yin-yang balance personality score was significantly negatively correlated with the galvanic skin response (P =.026).Conclusion:There is a relationship between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students.The higher the Taiyang personality score,the lower the sympathetic and vagus nerve excitability;the higher the yinyang balance personality score,the lower the sympathetic nerve excitability.

Neurofeedback Treatment of College Students' Test on Anxiety, Depression, Personality, and Mood

Biofeedback is used to treat the mental diseases of college students, such as test anxiety, depression, personality, and mood. Anxiety of the colleague students was first tested by test anxiety scale （TAS） and then treated by biofeedback. After getting the biofeedback treatment, the students＇ TAS scores, blood volume pulse, and skin conductance were decreased, especially, their TAS scores dropped markedly. Meanwhile, the level of EEG （61 rhythm/a rhythm） and peripheral temperature increased observably. Then, neurofeedbaek （β1 rhythm/α rhythm） was applied to treat students＇ depression, personality, and mood. As a result, these three kinds of symptoms got alleviated. And their therapeutic effects based on neurofeedback were more stable, durative and less reerudescent.

Personality Test

Here’s something that you mayfind interesting ...psychological profile.Have pen or pencil and paper ready.This is a real test given by the HumanRelations Dept. at many of the majorcorporations today. It helps them getbetter insight concerning their employ-ees and prospective employees.Ready? Be Honest! Begin!

Sub-Grouping Healthy Subjects’ Sensitivity to Pain and Its Relationship to Personality Traits: Results of a Cluster Analysis

Objective: Individual differences in the sensitivity to pain and the factors that may contribute to these differences are well studied. Nevertheless, there is no single test that can reliably classify subjects as being sensitive or insensitive to pain. Methods: In the present study, hierarchical clustering and K-means cluster analysis was used to identify subgroups among 191 healthy subjects (105 females, 86 males) according to their sensitivity to pain. Group determination was based on the subjects’ response to experimental noxious stimuli of heat (pain intensity), cold (cold pain threshold, tolerance, and intensity), and conditioned pain modulation (CPM, tested by co-administering repeated short painful heat stimuli and a conditioning tonic cold pain stimulation). In addition, in order to determine if the subjects in these subgroups differed on personality traits scores on Cloninger’s Tridimensional Personality Questionnaire (TPQ, outcome measure) for the three dimensions of personality: Novelty Seeking (NS);Harm Avoidance (HA);and Reward Dependence (RD) were calculated. Results: Based on pain scores, subjects were grouped as low pain (57%) with a low level of sensitivity in pain parameters, or high pain (43%) cluster members. The high pain had significant higher scores of HA (p = 0.05) and RD (p = 0.05) than the low pain group. Conclusions: This method of sub-grouping may be useful for identifying the mechanisms underlying individual variability in the sensitivity to pain and may point to groups at risk for experiencing high levels of clinical pain.

Personalized Learning Path Recommendations for Software Testing Courses Based on Knowledge Graphs

Software testing courses are characterized by strong practicality,comprehensiveness,and diversity.Due to the differences among students and the needs to design personalized solutions for their specific requirements,the design of the existing software testing courses fails to meet the demands for personalized learning.Knowledge graphs,with their rich semantics and good visualization effects,have a wide range of applications in the field of education.In response to the current problem of software testing courses which fails to meet the needs for personalized learning,this paper offers a learning path recommendation based on knowledge graphs to provide personalized learning paths for students.

Effects of personalized oral hygiene management on oral health status of pregnant women

BACKGROUND The Cariostat caries activity test(CAT)was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral health status of pregnant women.AIM To investigate whether personalized oral hygiene management enhances the oral health status of pregnant women.METHODS A total of 114 pregnant women who were examined at Dalian Women’s and Children’s Medical Center were divided into four groups:High-risk experimental group(n=29;CAT score≥2;received personalized oral hygiene management training),low-risk experimental group(n=29;CAT score≤1;received oral health education),high-risk control group(n=28;CAT score≥2),and low-risk control group(n=28;CAT score≤1).No hygiene intervention was provided to control groups.CAT scores at different times were compared using independent samples t-test and least significant difference t-test.RESULTS No significant difference in baseline CAT scores was observed between the experimental and control groups,either in the high-risk or low-risk groups.CAT scores were reduced significantly after 3(1.74±0.47 vs 2.50±0.38,P<0.0001)and 6 months(0.53±0.50 vs 2.45±0.42,P<0.0001)of personalized oral hygiene management intervention but not after oral health education alone(0.43±0.39 vs 0.46±0.33,P>0.05 and 0.45±0.36 vs 0.57±0.32,P>0.05,respectively).Within groups,the decrease in CAT scores was significant(2.43±0.44 vs 1.74±0.47 vs 0.53±0.50,P<0.0001)for only the high-risk experimental group.CONCLUSION Personalized oral hygiene management is effective in improving the oral health of pregnant women and can improve pregnancy outcomes and the oral health of the general population.

Ney man-Person准则的神经网络实现新算法(英文)

假设检验中Neyman_Person准则是一种基于似然比的信号分类、检测、识别方法 .神经网络是实现这种判定准则的优选方案 ,但是传统的最小平方学习算法 ,如BP算法等 ,往往不能取得全局最优解 .本文针对一种非最小平方学习算法 ,提出了一种概率分配原则 ,并给出了一种Neyman_Person准则的神经网络实现新算法 .文中对新算法在假设检验中的应用进行了仿真验证 ,结果表明新算法具有更小的误差 ,更加适用于Neyman_Person准则 .

Personalized chemotherapy in clear cell adenocarcinoma of the urethra:A case report

BACKGROUND Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor prognosis.Clear cell carcinoma of the urethra represents less than 0.02%of all malignancies in women.Adenocarcinomas account for 10%of female urethral carcinomas,of which 40%are the clear cell variant.Determining the presence or absence of certain mutations through genetic testing may predict whether a patient with cancer may benefit from a particular chemotherapy regimen.CASE SUMMARY A 40-year-old woman presented with a 3-year history of slow urinary flow and a 3-mo history of urinary urgency and frequency as well as gross hematuria.An abdominal and pelvic computed tomography scan demonstrated enlarged lymph nodes in the abdomen and pelvis.A biopsy of a left inguinal lymph node microscopically confirmed a metastatic adenocarcinoma of the urethra.Specialized genetic testing determined personalized chemotherapy.She was treated successfully with a non-platinum-based chemotherapy consisting of paclitaxel and bevacizumab.Following 3 cycles of paclitaxel and bevacizumab,she attained significant clinical improvement,and response by FDG-Positron emission tomography(PET)imaging showed a definite improvement in size and metabolic activity.She achieved complete response after 6 cycles of therapy by PET scan.The patient concluded 11 cycles of paclitaxel and bevacizumab,and a subsequent PET scan confirmed progression of metastatic disease.The patient was then treated with two cycles of doxorubicin after which a PET scan revealed a mixed response to the treatment.CONCLUSION We report the first case of a patient with metastatic clear cell adenocarcinoma of the urethra who underwent personalized chemotherapy after testing for cancer gene alterations.Our unique case represents the safe and effective use of nonplatinum-based chemotherapy in clear cell adenocarcinoma of the urethra.

Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis

Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis.

Self-worth and psychological adjustment of obese children:An analysis through the Draw-A-Person

AIM To investigate psychopathological correlates of child obesity via the Draw-A-Person test(DAP).METHODS The participants were 50 children with a mean age of 9.74 years.Body mass index(BMI) was used as a measure of body fat.Children were divided into normal(n = 17),overweight(n = 14) and obese(n = 19).Two qualitative methods of scoring the DAP based on an integrative approach were used to assess self-concept(ESW) and overall level of children's adjustment(EAC).A procedure for judging interpretative skills of clinicians was implemented before they evaluated children's drawings.RESULTS As predicted by our hypothesis,BMI was negatively correlated with ESW,r(50) =-0.29,P < 0.05,but not with EAC,r(50) =-0.08,P = ns.To evaluate the effect of gender,Pearson correlations were re-computedregrouping the sample accordingly:BMI and EAC reached a significant negative correlation in female subjects,r(24) =-0.36,P < 0.05,and a positive correlation in male subjects,r(26) = 0.37,P = < 0.05;negative correlation between BMI and ESW became stronger in females,r(24) =-0.51,P < 0.01 but not in males,whose correlation disappeared resulting not-significant,r(26) =-0.06,P = ns.No effect of age was found.Results indicate that obesity has a negative correlation exclusively on overall adjustment and self-concept in female children.CONCLUSION It was concluded that there is a negative bias toward females that reveals how the stigma of obesity is widespread in Western society.

The Dark Reflection of Sadism within the Brilliance of the Narcissistic Persona

This double blind randomized clinical trial with 84 participants, revealed that mental patients diagnosed with narcissism, and narcissistic celebrities mirror each other’s paranoid, obsessive and histrionic symptomatology, grandiosity, manipulative charm, and inner emptiness. Elite narcissists manifested insidious sadism in the absence of depressive affect, while the narcissistic patients were differentiated by their depressive and masochistic symptomatology. Elite narcissists demonstrated advanced empathic skills, contradicting past literature. However, their empathic advantage appeared void of compassion, merely employed as a self-serving tactic to exploit, intimidate and subordinate. Both experimental narcissistic groups evidenced more prevalent psychopathology, yet, higher achievement, efficacy and ambition than their reciprocal control groups, confirming the narcissists’ finesse in concealing psychopathology under the brilliance of their pseudosuperiority. The main danger is the affinity between masochism and sadism, bonding low and high functioning narcissistic counterparts to endlessly feed from each-others’ pathology, forming dysfunctional interpersonal relationships, cults or disintegrating societies. This sadomasochistic dependency also reflects several countries’ authoritarian trends, where narcissistic constituents’ unyielding loyalty elevates idolized leaders to power, preluding the establishment of toxic tyrannical governments.

Six-Minute Walk Test in Patients with Rheumatoid Arthritis

Background: The 6-minute walk test (6TC) was initially used as an instrument for assessing physical and cardiorespiratory capacity, but is currently being used to monitor treatments, and compare physical interventions and prognostic evaluation. Although already recognized as a research method in several specialties, 6TC has not been used in rheumatology. Patients with rheumatoid arthritis (RA) may have impaired functional capacity as well as increased cardiovascular mortality. An adequate functional evaluation of these patients is necessary and the 6TC may be useful in this sense. Objective: The aim of this study was to perform the 6-minute walk test in RA patients and to compare the performance with a control group. Method: A cross-sectional study was carried out in which the sample consisted of 85 women, 46 patients with rheumatoid arthritis and 39 healthy controls. A descriptive analysis of the data was performed. One-Way ANOVA methodology was used to compare the patient and control groups followed by the graphic analysis. Results: The distance walked on the 6TC by RA patients was on average 522.2 meters. In the distance control group found in the 6TC was on average 628.8 meters, the difference being statistically significant. Conclusion: In this study the distance covered in 6TC by women with RA was lower than that of healthy women of the same age.

子宫内膜种植窗检测结合个体化胚胎移植对反复种植失败患者的临床应用分析

目的:探讨子宫内膜种植窗检测(ERT)结合个体化胚胎移植(ET)改善反复种植失败患者的妊娠结局有效性。方法:回顾性分析2019年3月至2022年8月于中山大学附属第六医院生殖医学中心诊断为反复种植失败患者的临床资料,行ERT的428例作为ERT组,运用SPSS 26.0软件的倾向性评分匹配分析选择不行ERT的396例为对照组。比较两组的临床特征和妊娠结局,并比较子宫内膜种植窗(WOI)正常、延迟1 d、延迟2 d患者个体化ET后的妊娠结局。结果:ERT组临床妊娠率(47.73%vs.12.79%)和活产率(38.97%vs.9.76%)显著高于对照组,差异有统计学意义(P<0.05);并且ERT组的不孕因素中子宫内膜异位症(EMT)和多囊卵巢综合征(PCOS)因素占比较对照组高(P<0.05)。428例行ERT患者中发现有316例(73.83%)为WOI正常,有112例(26.17%)为WOI移位。WOI正常、WOI延迟1 d和WOI延迟2 d患者妊娠结局间差异无统计学意义(P>0.05)。结论:ERT技术结合个体化移植方案可以改善反复种植失败患者助孕结局,尤其是WOI移位患者,ERT技术具有应用前景和临床应用价值。

基于网络爬虫的智能推送就业系统研究与设计

文章提出一种基于网络爬虫的智能推送就业系统,旨在帮助用户更加高效地获取和筛选符合自己需求的就业信息。该系统通过自动化的网络爬取和数据处理技术,能够从各类招聘网站和企业官方网站中获取就业信息,并根据用户的个人需求和偏好进行智能推送。研究结果表明,系统的各个模块运行正常,响应快,有效提高了用户的就业信息获取效率。

面向序列诊断的强化计算机自适应测验方法

计算机自适应测验旨在根据学生历史表现为学生选择合适的题目,快速有效地测量学生的真实能力.然而在智能教育场景下,现有自适应测验策略仍存在目标复杂和知识稀疏等问题.为此,文中构建用于智能场景的可精准测评学生知识能力的面向序列诊断的强化计算机自适应测验方法,包括基于序列诊断的学生模拟器和学生画像模型,并针对真实场景中自适应测验的目标复杂性,设计薄弱点准确率、预测表现耦合、自适应测验时长、测验异常率和测验的难度结构这5个评价指标.进一步地,提出基于强化学习的计算机自适应测验选题策略,利用双通道自注意力学习及矛盾学习模块缓解知识稀疏的问题.真实数据上的实验表明,文中选题策略不仅可高效测量学生真实能力,还可优化学生的作答体验,同时选择的题目也具有一定的可解释性,从而为智能教育场景下的计算机自适应测验提供一个可行方案.

基于GM计数管个人剂量仪的设计与初步测试

针对辐射防护工作人员个人辐射剂量监测需求,设计了一种基于GM计数管的个人剂量仪。使用Altium Designer软件,设计了低压电路、高压电路、声光报警电路以及RTC时钟电路等,并完成样机的设计和研制。在X/γ射线辐射场中对研制的样机进行重复性、相对固有误差和能量响应的初步测量,测量结果为后续进一步优化该剂量仪提供了参考,以最终满足JJG 1009-2016技术规范的要求。该剂量仪具备瞬时剂量、累积剂量和脉冲计数显示以及报警阈值设置、声光振动报警等功能,在设计特点上突出便携式、低功耗和续航久的特点。

基于肌力分级法构建个性化周围性面神经炎治疗模式

目的:观察基于肌力分级法构建个性化治疗模式对周围性面神经炎运动功能的治疗效果。方法:选取周围性面神经炎患者90例,采用随机数字表法分为2组各45例。2组均接受相同的对症治疗和物理疗法。对照组接受面操训练,观察组接受基于肌力分级法的个性化康复治疗。分别于治疗前和治疗后第1、2、3、4周采用House-Brackmann面神经分级标准(H-B分级量表)和Sunnybrook评分量表评估治疗效果。治疗4周后评价2组的治愈率,6个月随访时评价2组的联带运动发生率。结果:与治疗前比较,2组均从第3周开始H-B分级量表评分明显下降(P<0.01);与对照组比较,观察组第3周和第4周的H-B分级量表评分明显下降(P<0.05);2组均从第2周开始Sunnybrook面神经评定量表评分明显升高(P<0.01);与对照组比较,观察组第3周和第4周的Sunnybrook面神经评定量表评分明显升高(P<0.05);治疗4周后,观察组治愈率明显高于对照组(60.0%、26.7%,χ^(2)=10.181,P=0.003);6个月后随访观察组的联带运动发生率显著低于对照组(4.4%、17.8%,χ^(2)=4.050,P=0.044)。结论:基于肌力分级法构建的个性化治疗模式可以精准描述面部肌肉损伤情况,制定精确的治疗方案,提高治愈率,降低联带运动发生率,值得在临床中广泛应用与推广。

HIV阳性患者个体化网络程序的可用性评价

目的评价人类免疫缺陷病毒(human immunodeficiency virus,HIV)阳性患者症状网络个体化程序的可用性。方法于2023年12月-2024年2月选取上海市公共卫生临床中心艾滋病(acquired immunodeficiency syndrome,AIDS)自愿咨询门诊就诊的HIV感染者、中心个案管理师等为研究对象。并基于“以用户为中心的理念”,对HIV患者个体化网络程序依次进行简捷形成性可用性评价、全面形成性可用性评价以及总结性可用性评价,收集量性及质性数据。结果研究共纳入22位研究对象,完成了三阶段的可用性评价,对所收集的质性资料编码归类后,形成了4个主题,对于评价过程中发现的部分问题及时进行了修正。结论该程序的功能基本符合设计者的要求,满足用户期望,不存在明显的可用性问题。为后续程序改进、个性化患者症状管理方案设计及临床推广打下基础。

Non-small cell lung cancer organoids:Advances and challenges in current applications

Lung cancer is emerging as a common malignancy worldwide,with non-small cell lung cancer(NSCLC)accounting for approximately 85%of all cases.Two-dimensional(2D)in vitro cell line cultures and animal models are currently used to study NSCLC.However,2D cell cultures fail to replicate the medication response and neoplastic heterogeneity of parental tumors.Animal models are expensive and require lengthy modeling cycles.The generation of in vitro three-dimensional(3D)tissue cultures called organoids,which exhibit multicellular,anatomical,and functional properties of real organs,is now achievable owing to advancements in stem cell culturing.The genetic,proteomic,morphological,and pharmacological characteristics of tumors are largely preserved in tumor organoids grown in vitro.The design and physiology of human organs can be precisely reconstructed in tumor organoids,opening new possibilities for complementing the use of animal models and studying human diseases.This review summarizes the development of NSCLC organoids and their applications in basic research,drug testing,immunotherapy,and individualized treatments.