Objective:The present study was carried out to investigate the phytochemical constituents,in vitro antioxidant potential and anthelmintic activities of Flacourtia sepiaria Roxb leaves.Methods:The dried powdered leaves...Objective:The present study was carried out to investigate the phytochemical constituents,in vitro antioxidant potential and anthelmintic activities of Flacourtia sepiaria Roxb leaves.Methods:The dried powdered leaves of Flacourtia sepiaria were extracted using petroleum ether,chloroform,ethyl acetate and methanol by a soxhlet extractor and preliminary phytochemical screening was performed using standard protocols.All the extract was evaluated for their potential antioxidant activities using test such as DPPH,superoxide anion radical,hydroxyl radical,nitric oxide radical scavenging abilities,ferrous chelating ability and total phenolic and flavanoid content.Anthelmintic activity of extract was screened in adult Indian earthworm model.Results:Preliminary screening revealed the presence of bioactive compounds especially phenolics,tannins and terpenoids in all extracts.The phenolic and flavanoid content was highest in methanolic extract and lowest in petroleum ether extract.The paralytic(9.4610.212)and death time(31.43±1.148)of methanolic extract was found to be significant(P<0.05)when compared with paralytic(7.33±0.206)and death lime(18.60±0.229)of standard piperazine citrate at 100 mg/mL concentration.Conclusions:The results of the present study indicate that the leaf extracts of Flacourtia sepiaria exhibited strong antioxidant activity and possess significant anthelmintic activity and thus it is a good source of antioxidant and anthelmintic constituents.展开更多
1 Results Natural products,and especially those extracted from higher plants,have for many years served as new leads for new pharmaceuticals.We here report on the multi-step synthesis of 1-O-steryl 6-O-acyl glucosides...1 Results Natural products,and especially those extracted from higher plants,have for many years served as new leads for new pharmaceuticals.We here report on the multi-step synthesis of 1-O-steryl 6-O-acyl glucosides,synthetic analogues which are structurally related to the mixture of natural products (1) extracted from the plant Flacourtia indica[1],that may be used medicinally for their anti-tumor activities.See Fig.1.展开更多
基金supported by University Grants Commission,India(Grant No.41-738/20)
文摘Objective:The present study was carried out to investigate the phytochemical constituents,in vitro antioxidant potential and anthelmintic activities of Flacourtia sepiaria Roxb leaves.Methods:The dried powdered leaves of Flacourtia sepiaria were extracted using petroleum ether,chloroform,ethyl acetate and methanol by a soxhlet extractor and preliminary phytochemical screening was performed using standard protocols.All the extract was evaluated for their potential antioxidant activities using test such as DPPH,superoxide anion radical,hydroxyl radical,nitric oxide radical scavenging abilities,ferrous chelating ability and total phenolic and flavanoid content.Anthelmintic activity of extract was screened in adult Indian earthworm model.Results:Preliminary screening revealed the presence of bioactive compounds especially phenolics,tannins and terpenoids in all extracts.The phenolic and flavanoid content was highest in methanolic extract and lowest in petroleum ether extract.The paralytic(9.4610.212)and death time(31.43±1.148)of methanolic extract was found to be significant(P<0.05)when compared with paralytic(7.33±0.206)and death lime(18.60±0.229)of standard piperazine citrate at 100 mg/mL concentration.Conclusions:The results of the present study indicate that the leaf extracts of Flacourtia sepiaria exhibited strong antioxidant activity and possess significant anthelmintic activity and thus it is a good source of antioxidant and anthelmintic constituents.
文摘1 Results Natural products,and especially those extracted from higher plants,have for many years served as new leads for new pharmaceuticals.We here report on the multi-step synthesis of 1-O-steryl 6-O-acyl glucosides,synthetic analogues which are structurally related to the mixture of natural products (1) extracted from the plant Flacourtia indica[1],that may be used medicinally for their anti-tumor activities.See Fig.1.
