The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of Metronidazole (MTZ) contained in the ...The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of Metronidazole (MTZ) contained in the reference substance (SR) and in a pharmaceutical specialty Flagyl<sup>®</sup> 250 mg tablet (FLG). The method developed was linear and accurate in accordance with USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent with the concentration present in the proprietary medicines (250 mg). The study of the influence of physicochemical parameters on the MTZ content in SR and FLG showed that MTZ contents are unstable in the presence of Ethanol at 96˚, KOH at 0.1N and bile salts but also when the temperature is higher than 25˚C. However, they remain stable in the presence of light and H<sub>2</sub>O<sub>2</sub> and undergo degradation in an acidic environment.展开更多
目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(...目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。展开更多
Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver abscess.It is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily...Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver abscess.It is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the cecum.It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris.People of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone levels.ALA is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for drainage.While majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial infection.Based on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment decisions.Recent research has revealed the role of venous thrombosis-related ischemia in the severity of ALA.Recent years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited accuracy.Metronidazole has been the drug of choice for ALA patients for many years.However,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic medications.Although the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust conclusions.Percutaneous drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of mortality.With regard to all of the aforementioned issues,this article intends to present an updated review of ALA.展开更多
文摘The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of Metronidazole (MTZ) contained in the reference substance (SR) and in a pharmaceutical specialty Flagyl<sup>®</sup> 250 mg tablet (FLG). The method developed was linear and accurate in accordance with USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent with the concentration present in the proprietary medicines (250 mg). The study of the influence of physicochemical parameters on the MTZ content in SR and FLG showed that MTZ contents are unstable in the presence of Ethanol at 96˚, KOH at 0.1N and bile salts but also when the temperature is higher than 25˚C. However, they remain stable in the presence of light and H<sub>2</sub>O<sub>2</sub> and undergo degradation in an acidic environment.
文摘目的:探讨硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮的美学效果及疗效和安全性。方法:选取2020年12月-2022年12月湖南省中医药研究院附属医院收治的84例玫瑰痤疮患者,按随机数表法分为观察组(硫酸羟氯喹联合甲硝唑凝胶治疗,n=42)和对照组(甲硝唑凝胶治疗,n=42)。比较两组患者的治疗效果、不良反应,比较两组患者治疗前后的临床症状评分、痤疮特异性生活质量量表(Acne-specific quality of life scale,Acne-QOL)评分及白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumo rnecrosis factor-α,TNF-α)水平。结果:观察组总有效率为95.24%,显著高于对照组的80.95%(P<0.05);治疗后两组各项临床症状评分显著低于治疗前,观察组低于对照组(P<0.05);治疗后两组Acne-QOL各项评分显著高于治疗前,观察组高于对照组(P<0.05);治疗后两组IL-6、CRP、TNF-α显著低于治疗前,观察组低于对照组(P<0.05);观察组和对照组的不良反应总发生率分别为9.52%、7.14%,差异无统计学意义(P>0.05)。结论:硫酸羟氯喹联合甲硝唑凝胶治疗玫瑰痤疮安全有效,可有效改善患者的临床症状,提高患者的面部美学效果及生活质量。
文摘Amebic liver abscess(ALA)is still a common problem in the tropical world,where it affects over three-quarters of patients with liver abscess.It is caused by an anaerobic protozoan Entamoeba hystolytica,which primarily colonises the cecum.It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris.People of the male gender,during their reproductive years,are most prone to ALA,and this appears to be due to a poorly mounted immune response linked to serum testosterone levels.ALA is more common in the right lobe of the liver,is strongly associated with alcohol consumption,and can heal without the need for drainage.While majority of ALA patients have an uncomplicated course,a number of complications have been described,including rupture into abdomino-thoracic structures,biliary fistula,vascular thrombosis,bilio-vascular compression,and secondary bacterial infection.Based on clinico-radiological findings,a classification system for ALA has emerged recently,which can assist clinicians in making treatment decisions.Recent research has revealed the role of venous thrombosis-related ischemia in the severity of ALA.Recent years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited accuracy.Metronidazole has been the drug of choice for ALA patients for many years.However,concerns over the resistance and adverse effects necessitate the creation of new,safe,and potent antiamebic medications.Although the indication of the drainage of uncomplicated ALA has become more clear,high-quality randomised trials are still necessary for robust conclusions.Percutaneous drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis,for whom surgery represents a significant risk of mortality.With regard to all of the aforementioned issues,this article intends to present an updated review of ALA.
