The relation of flow-mediated vasodilatation and diastolic function in uncomplicated Type 2 diabetic patients

Objectives: To evaluate the association of diastolic function of the left ventricle with flowme-diated dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type 2 diabetic patients were examined by pulse and tissue Doppler echocardiography and FMD of brachial artery. The patients were divided into 2 groups according to the size of the left ventricular relaxation parameter—E’. Results: The average age of the patients was 61 ± 6 years. FMD was 5.0 ± 1.8% in 41 patients with E’ from 3 to 7.4 cm/s (mean 6 cm/s) comparing to 5.1 ± 1.9% (p = 0.96) in 41 patients with E’ from 7.5 to 10.9 cm/s (mean 8.9 cm/s). E/E’ was 11.2 ± 2.3 in the group with lower E’ and 9.1 ± 1.6 in the group with higher E’ (p 0.001). Linear negative correlation was found between E/E’ and FMD for the patients with E’ from 3 to 7.4 cm/s (R2 = 0.131;p = 0.025) but not for the group of patients with the higher E’. The significant association between FMD and E/E’ was confirmed by multivariate analysis ((Rc)2 = 0.233;p 0.05). Conclusion: FMD has no impact on the left ventricular relaxation. However FMD is negatively associated with E/E’ in Type 2 diabetic patients who have low E’ as a sign of an impaired early relaxation.

The effect of aerobic training on endothelium-dependent vasodilatation in patients with coronary artery disease who were revascularized and young men

Aim: The aim of this study was to determine the effect of training on endothelium-dependent vasodilatation in patients with coronary artery disease (CAD) after revascularization and healthy young men. Background: Impaired endothelial function has been observed in patients with CAD and those with CAD risk factors. Studies have shown that exercise can enhance endothelial function. Methods: This experimental cross-sectional study was conducted on patients with CAD (3 months after CABG and PCI) and students of medical school in 2011. Endothelium dependent dilation of the brachial artery was determined by using high-resolution vascular ultrasonography through flow-mediated vasodilatation (FMD) after induction of ischemia, and the data were analyzed using SPSS, dependent t-test and ANCOVA. Findings: The findings showed that at baseline, FMD was reduced in revascularized patients, when compared with healthy young men, after 8 weeks, and exercise training significantly improved FMD in patients underwent training group [from 4.31 ± 1.45 (SD)% to 6.15 ± 0.773 (SD)%, p p ed unchanged, and even after aerobic training, it did not significantly modify the brachial artery diameter in these groups. Conclusion: Our study demonstrates that endothelial dysfunction persisting in CAD patients after revascularization and aerobic training can improve endothelial function in different vascular beds in CAD patients and healthy young men. This may contribute to the benefit of regular exercise in preventing and restricting cardiovascular disease.

检测肱动脉血流介导的血管舒张功能在预测妊娠期高血压疾病中的价值

目的：探讨肱动脉血流介导的血管舒张功能在预测妊娠期高血压疾病中的价值。方法：我们选取81名孕周小于18周的孕妇作为研究对象，在妊娠期间监测两次肱动脉血流介导的血管舒张功能（FMD），比较妊娠高血压疾病组（高血压组珈正常纽FMD。结果：正常组FMD1平均值为（20．9±12．70）%，高血压组FMD1平均值为（6．7±3．2）％，差异有显著性（P〈0．01），正常组FMD2平均值为（25±11）%，高血压组FMD2平均值为（6±4．3）％，差异也有显著性（P〈0．01）。测量FMD1时高血压组平均孕龄为（19．65±1．42凋，测量FMD2时高血压组孕妇平均孕龄为（29．7±1．24）%]，测量FMD1与罹患妊娠期高血压疾病的平均时间间隔为（13．8±2．9）%，测量FMD2和罹患妊娠期高血压疾病的平均时间间隔为（3．8±3．2），协。结论：孕1821周检测FMD是在早期预测妊娠高血压疾病中有一定价值。

匹伐他汀钙对高胆固醇血症患者动脉粥样硬化的影响（英文）

目的：观察匹伐他汀钙对高胆固醇血症患者外周血管的影响。创新点：首次在国内发现匹伐他汀钙能够改善高胆固醇血症患者肱动脉和颈动脉血管内皮功能而且延缓其动脉粥样硬化发展，并首次证实改善内皮功能是匹伐他汀钙延缓其动脉粥样硬化发展的重要原因。方法：按照入选排除标准，选取本院高胆固醇血症患者（HC），完成超声心动图检查的40例。根据剂量不同，分为两个剂量组：1 mg剂量组20例（男性5例，女性15例，平均年龄（55.20±8.35）岁），2 mg剂量组20例（男性9例，女性11例，平均年龄（57.56±6.09）岁）。访视结束后完成超声心动图检查的HC组36例，两个剂量组分别有2人失访。治疗后1 mg剂量组18例（男性3例，女性15例，平均年龄（56.00±7.85）岁），2 mg剂量组18例（男性7例，女性11例，平均年龄（57.79±6.46）岁）。选择本院同期体检中心30例正常人作为对照（年龄和性别均与病例组匹配，男性14例，女性16例，平均年龄（54.94±6.90）岁）。所有研究对象，均经隔夜禁食12～14小时，次日清晨抽取空腹肘静脉血，测定临床生化指标。采用Sequia 512彩色多普勒超声诊断仪，应用高分辩率外周血管超声技术，检测HC治疗前后肱动脉血流介导性舒张功能（FMD）、颈动脉结构和功能。 结论：经匹伐他汀钙治疗8周后，高胆固醇血症患者血管功能明显改善，表现为 FMD升高，僵硬度减小；颈动脉僵硬度和内中膜厚度（IMT）延缓进展与其内皮功能改善密切相关。