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Saccades of video head impulse test in Meniere's disease and Vestibular Migraine: What can we learn from? 被引量:2
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作者 Yi Du Xingjian Liu +4 位作者 Lili Ren Yu Wang Fei Ji Weiwei Guo Ziming Wu 《Journal of Otology》 CSCD 2023年第2期79-84,共6页
Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This stud... Background:Saccades are often observed on video head impulse tests(vHIT)in patients with Meniere's Disease(MD)and Vestibular Migraine(VM).However,their saccadic features are not fully described.Objective:This study aims to identify the saccades characteristics of MD and VM.Methods:75 VM patients and 103 definite unilateral MD patients were enrolled in this study.First raw saccades were exported and analyzed.The VM patients were divided into left and right based on their ears,while the MD patients were separated into affected and unaffected subgroups based on their audiograms and symptoms.Results:The MD patients have more saccades on the affected side(85%vs.69%),and saccade velocity is more consistent than the contralateral side(shown by the coefficient of variation).The saccades occurrence rates on both sides are similar in VM(77%vs.76%),as are other saccadic parameters.The MD patients have more significant inter-aural differences than the VM patients,manifested in higher velocity(p-value 0.000),earlier arriving(p-value 0.010),and more time-domain gathered(p-value 0.003)on the affected side.Conclusions:Bilateral saccades are commonly observed in MD and VM.In contrast to MD,saccades on VM are subtle,scattered,and late-arrived.Furthermore,the MD patients showed inconsistent saccadic distribution with more velocity-uniform saccades on the affected side. 展开更多
关键词 Meniere's disease vestibular migraine SACCADES Video head impulse test Differential diagnosis
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Non-Traditional Management of Vestibular Migraine (Review)
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作者 Rafeek Mohammed Abdel Kader Alfarghal Mohamed +2 位作者 Mohamed Makhlof Rasha Ahmed Abdelmenaam Mohammed A. Gomaa 《International Journal of Otolaryngology and Head & Neck Surgery》 2023年第5期331-340,共10页
Objectives: Vestibular migraine is one of the most common causes of episodic vertigo in adults and even in children. Traditional;management may have a side effect on the long run. So the aim of this review is to expla... Objectives: Vestibular migraine is one of the most common causes of episodic vertigo in adults and even in children. Traditional;management may have a side effect on the long run. So the aim of this review is to explain the other non-medical lines of management for patients with migraine. Methods: English articles from Medline and Cochrane library were searched and reviewed. Results: Evidence indicates that non-traditional management has a prophylactic and therapeutic effect on migraine patients with all its steps. Conclusion: Due to the possible side effects of pharmacological drugs and drug addictions, the use of non-traditional management alone or in combination with normal cures have been proposed. However, further constructive studies are required. 展开更多
关键词 vestibular migraine Blue Light OBESITY STRESS
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Analysis of video head impulse test saccades data in patients with vestibular migraine or probable vestibular migraine 被引量:1
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作者 Yi Du Xingjian Liu +2 位作者 Lili Ren Yu Wang Ziming Wu 《Journal of Otology》 CSCD 2022年第4期197-202,共6页
Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their uti... Objective:Saccades accompanied by normal gain in video head impulse tests(vHIT)are often observed in patients with vestibular migraine(VM).However,they are not considered as an independent indicator,reducing their utility in diagnosing VM.To better understand clinical features of VM,it is necessary to understand raw saccades data.Methods:Fourteen patients with confirmed VM,45 patients with probable VM(p-VM)and 14 agematched healthy volunteers were included in this study.Clinical findings related to spontaneous nystagmus(SN),positional nystagmus(PN),head-shaking nystagmus(HSN),caloric test and vHIT were recorded.Raw saccades data were exported and numbered by their sequences,and their features analyzed.Results:VM patients showed no SN,PN or HSN,and less than half of them showed unilateral weakness(UW)on caloric test.The first saccades from lateral semicircular canal stimulation were the most predominant for both left and right sides.Neither velocity nor time parameters were significantly different when compared between the two sides.Most VM patients(86%)exhibited small saccades,around 35%of the head peak velocity,with a latency of 200e400 ms.Characteristics of saccades were similar in patients with p-VM.Only four normal subjects showed saccades,all unilateral and seemingly random.Conclusions:Small saccades involving bilateral semicircular canals with a scattered distribution pattern are common in patients with VM and p-VM. 展开更多
关键词 vestibular migraine Probable vestibular migraine Video head impulse test SACCADE Data analysis
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The Value of Subjective Visual Vertical in Diagnosis of Vestibular Migraine 被引量:3
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作者 Fei LI Jin XU +6 位作者 Gen-ru LI Rui GAO Chen-yong SHANG E TIAN Wei-jia KONG Jian-hua ZHUANG Su-lin ZHANG 《Current Medical Science》 2021年第4期654-660,共7页
Objective To study the value of the subjective visual vertical(SVV)in the diagnosis of vestibular migraine(VM).Methods This study recruited 128 VM patients and 64 age-matched normal subjects.We detected the SVV during... Objective To study the value of the subjective visual vertical(SVV)in the diagnosis of vestibular migraine(VM).Methods This study recruited 128 VM patients and 64 age-matched normal subjects.We detected the SVV during the interval between attacks in both groups,in sitting upright,and the head tilted at 45°to the left or right.We then examined the correlation between the SVV results with the vestibular evoked myogenic potential(VEMP)and canal paresis(CP).Results It was found there was a significant difference in SVV at the upright position between VM patients and normal controls(P=0.006)and no significant difference was found at the tilts of 45°to the left or right between the two groups.The SVV results at the upright position were significantly correlated with cervical VEMP(P=0.042)whereas not significantly correlated with CP and VEMP.There existed no significant difference in the conformity to the Müller effect(M effect)between the two groups.ROC analysis exhibited that the sensitivity,specificity of SVVs at the upright were 67.200%and 62.500%respectively.The diagnostic value of SVV at the upright position was significantly higher than that at tilts of 45°to the left and right(P=0.006).Nonetheless the diagnostic accuracy was relatively low.Conclusion Abnormality in SVV possibly stems from the lasting functional disorder of cerebellar or high-level cortical centers in VM patients or is linked to the vestibular compensation.The SVV is of low diagnostic value for VM and the value of SVV in VM warrants further study. 展开更多
关键词 vestibular migraine subjective visual vertical diagnostic value evaluation
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Changes of calcitonin gene-related peptide and other serological indicators in vestibular migraine patients
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作者 Xinyi Liu Yonghui Pan +2 位作者 Jingjing Wang Lei Zhang Junli Zhang 《Frigid Zone Medicine》 2021年第2期111-118,共8页
Objective:It aims to evaluate the diagnostic ability of CGRP and other blood indicators in vestibular migraine(VM)patients,and to explain the potential pathological effects of these biomarkers.The hypothesis of VM bei... Objective:It aims to evaluate the diagnostic ability of CGRP and other blood indicators in vestibular migraine(VM)patients,and to explain the potential pathological effects of these biomarkers.The hypothesis of VM being a variant of migraine was examined.Methods:A total of 32 VM patients,35 migraine patients,and 30 healthy control subjects(HC)were selected for this cross-sectional study.Detailed statistics on demographic data,clinical manifestations,calcitonin gene-related peptide(CGRP)and common clinical laboratory indicators were measured within 24 hours from the onset of the conditions.Receptor operating characteristic(ROC)curve and area under the curve(AUC)were analyzed for biomarkers.The risk factors of VM and migraine were determined through univariate and multivariate analyses.Results:Compared with HC,serum CGRP levels(p(VM)=0.012,p(Migraine)=0.028)increased and Mg^(2+)levels(p(VM)<0.001,p(Migraine)<0.001)deceased in VM patients and migraine patients.In multiple logistic regression,VM was correlated with CGRP[odds ratio(OR)=1.07;95%confidence interval(CI),1.02-1.12;P=0.01]and Mg^(2+)[odds ratio(OR)=0.03;95%CI,0.07-0.15;P<0.001].Migraine was correlated with CGRP[odds ratio(OR)=1.07;95%CI,1.02-1.12;P=0.01]and Mg^(2+)[odd ratio(OR=0.01;95%CI,0-0.02;P<0.001)].Mg^(2+)discriminated good differentiation between VM and migraine groups,with AUC of 0.649(95%CI,0.518 to 0.780).The optimal threshold for Mg^(2+)to diagnose VM was 0.805.Conclusions:This study demonstrated that CGRP and Mg^(2+)may be promising laboratory indicators to discriminate HC from VM/migraine,while Mg^(2+)may be uded as a discriminator between VM and migraine. 展开更多
关键词 calcitonin gene-related peptide vestibular migraine magnesium Ion trigeminovascular system
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Vestibular migraine in low-and lower-middle-income countries:A scoping review
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作者 Eric K.Kim Amina Seguya +4 位作者 May Htoo Thaw Peggy Tahir Eric J.Formeister Christopher J.Waterworth Ali F.Jaffer 《Journal of Otology》 CAS CSCD 2023年第3期173-184,共12页
Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively treat.The prevalence,appropriate diagnostic workup,and therapies for VM in low-and... Background:Vestibular migraine(VM)is a common cause of dizziness that is underrecognized,underdiagnosed,and challenging to effectively treat.The prevalence,appropriate diagnostic workup,and therapies for VM in low-and lower-middle-income countries(LLMICs)remain understudied.The objective of this scoping review is to evaluate the current state of VM research in LLMICs.Methods:PubMed,Embase,and Web of Science databases were searched to execute a scoping review of VM.Keywords“vestibular diseases”and“vertigo”were used in combination with terms referring to LLMICs as defined by the World Bank.Title and abstract screening,full-text review,and data collection were conducted by two authors independently.Results:Twenty-six studies were included in the scoping review.Most studies were cross-sectional(57.7%)or case studies/series(23.1%)and were conducted in urban settings only(92.3%).Geographic distribution of studies was skewed,with 65.4%of articles originating from India.The prevalence of VM among clinic patients ranged from 0.3%to 33.3%.VM most frequently presented as headache,nausea and vomiting,and photophobia.Radiographic imaging,audiometry,and electronystagmography/videonystagmography were the three most commonly utilized diagnostic modalities in the dizziness workup.The most studied pharmacotherapies included calcium channel blockers,followed by beta-blockers and antiepileptics.Case studies and series discussed less common VM pharmacotherapies,such as ayurvedic medicine.Conclusions:There is a need for more VM research in LLMICs,including innovative diagnostic approaches and therapies that can improve VM care globally.Equitable partnerships between LLMIC and highincome country researchers must expand vestibular research capacity and productivity in LLMICs. 展开更多
关键词 vestibular migraine migraine GLOBAL OTOLARYNGOLOGY Scoping review
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Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine 被引量:3
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作者 Mark A. Miller Benjamin T. Crane 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2016年第3期-,共6页
Objective:To measure the static visual vertical and the effect of visual rotation on the perception of visual vertical in migraine and vestibular migraine subjects. By so doing, we may better understand the vestibular... Objective:To measure the static visual vertical and the effect of visual rotation on the perception of visual vertical in migraine and vestibular migraine subjects. By so doing, we may better understand the vestibular contribution to the pathophysiology of migraine, as well as the capacity for visual compensation. Methods:The perception of visual vertical in the presence of static and dynamic visual cues was prospectively studied in 10 subjects with migraine, 6 subjects with vestibular migraines, and 10 controls. Subjects used a dial to rotate a fluorescent green line to the vertical position. Static visual vertical (SVV) was measured with a black background, as well as with a static random-dot visual pattern. This pattern was then rotated at various velocities to measure dy-namic visual vertical (DVV). Results: Migraine subjects had greater deviation from true vertical than controls in SVV (P<0.05). The DVV in migraine subjects was greater than controls when rotated in the coun-terclockwise at ?5?/s (P<0.01), ?20?/s (P<0.01), and ?80?/s (P<0.01), but not when the line was rotated clockwise. Vestibular migraine subjects did not deviate significantly from con-trols in SVV (P<0.37, P<0.22), but did show greater deviation in the DVV tasks at ?80 and ?20?/s (P<0.05, P<0.03). Migraine and vestibular migraine subjects demonstrated a wider range of vertical deviance when compared to controls (P<0.02). Conclusions:This study demonstrates a significant deviation of the perceived static as well as dynamic visual vertical in migraine subjects. Moving stimuli may have a greater influence on migraine and vestibular migraine subjects, which suggests an underlying sensory integration disorder. 展开更多
关键词 vestibular VISUAL VERTICAL migraine
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中医辨证治疗前庭性偏头痛的多中心前瞻性队列研究 被引量:3
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作者 刘寅 艾春玲 +4 位作者 李秀玲 王彦红 刘艳华 项颗 孙莉 《西部中医药》 2024年第2期149-152,共4页
目的:评价中医辨证治疗前庭性偏头痛的临床疗效,探讨中医辨证用药规律。方法:采用前瞻性队列研究方法,选取前庭性偏头痛患者197例,根据是否采用中医辨证治疗为暴露因素,分为中药组与西药组,分别为123例与74例。观察两组治疗第4、8、12... 目的:评价中医辨证治疗前庭性偏头痛的临床疗效,探讨中医辨证用药规律。方法:采用前瞻性队列研究方法,选取前庭性偏头痛患者197例,根据是否采用中医辨证治疗为暴露因素,分为中药组与西药组,分别为123例与74例。观察两组治疗第4、8、12周的眩晕复发率及相关结局指标。结果:治疗第4、8、12周,眩晕复发率中药组依次为14.9%、18.4%、29.7%,西药组依次为12.3%、32.8%、55.6%,其中第8、12周两组比较差异有统计学意义(P<0.05);治疗后第4周,眩晕残障量表评分(dizziness handicap inventory,DHI)、VAS评分改善情况西药组优于中药组,但差异无统计学意义(P>0.05),第8、12周DHI、VAS评分改善情况中药组均优于西药组(P<0.05);共收集门诊处方273首,涉及中药76味,使用频率前十位的中药依次为天麻、法半夏、柴胡、茯神、远志、茯苓、酸枣仁、煅龙骨、珍珠母、黄芩。结论:中医辨证治疗前庭性偏头痛在改善眩晕症状,控制眩晕复发方面优势明显,但起效速度方面不及西药治疗。临床用药以疏肝解郁、重镇安神为主,安神之法应贯穿治疗始终。 展开更多
关键词 前庭性偏头痛 中医辨证治疗 用药规律 队列研究
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黄春华从痰饮论治前庭性偏头痛经验介绍
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作者 陈昕 吴清忠 +4 位作者 肖俊锋 饶凯华 许雪梅 饶旺福 黄春华 《江西中医药大学学报》 2024年第1期20-22,共3页
黄春华于多年的临床实践中,认识到前庭性偏头痛多由脾阳受损、痰饮停于中焦所致,故当以健脾利水、温阳化饮为基本治则。总结黄春华治疗前庭性偏头痛的经验。并附验案1则以飨同道。
关键词 痰饮 前庭性偏头痛 临证经验
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前庭性偏头痛患者认知功能测评及眼震视图分析
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作者 王莉莉 陆灵美 《徐州医科大学学报》 CAS 2024年第8期581-585,共5页
目的测评前庭性偏头痛(VM)患者认知功能水平,分析、探讨眼震视图(VNG)在VM患者认知功能中的评估价值。方法选择2022年3月—2023年6月在启东市人民医院诊疗的60例VM患者为研究对象(VM组),同期纳入无眩晕、偏头痛或其他神经系统疾病的60... 目的测评前庭性偏头痛(VM)患者认知功能水平,分析、探讨眼震视图(VNG)在VM患者认知功能中的评估价值。方法选择2022年3月—2023年6月在启东市人民医院诊疗的60例VM患者为研究对象(VM组),同期纳入无眩晕、偏头痛或其他神经系统疾病的60例正常者作为对照(NC组)。采用简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)来评估VM组和NC组的总体认知水平,并使用重复性神经心理状态评定量表(RBANS)进行神经心理及多领域认知功能的全面测评,利用VNG观察VM患者眼动特征。结果与NC组相比,VM组患者轻度认知障碍(MCI)的发生率明显增加,MoCA评分显著降低,差异具有统计学意义(P<0.01);在即刻记忆、视觉广度、语言功能、注意力、延时记忆、处理速度和执行功能多个认知域均存在明显受损,差异具有统计学意义(P<0.05);与NC组相比,VM组患者MMSE评分偏低,但差异无统计学意义(P>0.05)。从VNG结果分析,VM组患者扫视试验、平稳跟踪试验、视动试验、位置性眼震的发生率均高于NC组,差异具有统计学意义(P<0.05);而自发性眼震、凝视试验的发生率与NC组相比差异无统计学意义(P>0.05)。结论VM患者认知功能损害较明显,体现在记忆力、语言能力、视觉广度、注意力、处理速度及执行功能等方面;分析VNG特征,发现前庭系统对VM患者的认知功能有显著影响。 展开更多
关键词 前庭性偏头痛 认知功能 眼震视图 简易精神状态评价量表 蒙特利尔认知评估量表 重复性神经心理状态评定量表 轻度认知障碍
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前庭性偏头痛相关视觉性眩晕发病机制的研究进展 被引量:3
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作者 牛玉格 张道培 张怀亮 《听力学及言语疾病杂志》 CAS CSCD 北大核心 2024年第1期85-89,共5页
前庭性偏头痛(vestibular migraine,VM)是临床常见的眩晕与偏头痛共存的前庭疾病,视觉诱发的眩晕是VM的典型前庭症状之一。VM相关视觉性眩晕的临床表现多样,受焦虑状态、晕动病、年龄等因素影响。解剖生理方面的联系、凝视不稳定、视觉... 前庭性偏头痛(vestibular migraine,VM)是临床常见的眩晕与偏头痛共存的前庭疾病,视觉诱发的眩晕是VM的典型前庭症状之一。VM相关视觉性眩晕的临床表现多样,受焦虑状态、晕动病、年龄等因素影响。解剖生理方面的联系、凝视不稳定、视觉前庭整合缺陷、感觉重塑受损、前庭中枢通路敏化、5-羟色胺和谷氨酸-谷氨酰胺循环等神经递质等多个机制可能导致了VM相关视觉性眩晕的发生。 展开更多
关键词 前庭性偏头痛 视觉 眩晕
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针刺激痛点联合盐酸氟桂利嗪治疗偏头痛的临床研究
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作者 张若滔 郭静 +7 位作者 王雪飞 温雅丽 王握瑜 刘璐 赵洛鹏 王麟鹏 李彬 徐晓白 《现代中西医结合杂志》 CAS 2024年第14期1930-1934,共5页
目的观察针刺激痛点联合盐酸氟桂利嗪治疗偏头痛患者的疗效及对炎症相关指标、血管活性物质的影响。方法选择2017年1月—2022年1月首都医科大学附属北京中医医院诊治的80例偏头痛患者为研究对象,根据随机数字表法按1:1比例将患者分为观... 目的观察针刺激痛点联合盐酸氟桂利嗪治疗偏头痛患者的疗效及对炎症相关指标、血管活性物质的影响。方法选择2017年1月—2022年1月首都医科大学附属北京中医医院诊治的80例偏头痛患者为研究对象,根据随机数字表法按1:1比例将患者分为观察组、对照组,每组40例。对照组予以假针刺+口服盐酸氟桂利嗪治疗,观察组予以激痛点针刺+口服盐酸氟桂利嗪治疗,针刺隔天治疗1次,2组均治疗4周。比较2组治疗后头痛情况,临床疗效,血清炎症相关指标[环氧化酶-2(COX-2)、降钙素基因相关肽(CGRP)、前列腺素E 2(PGE_(2))]及血管活性物质[血管性血友病因子(vWF)、内皮素-1(ET-1)、一氧化氮(NO)]水平、脑血流速度及不良反应发生情况。结果治疗后,观察组偏头痛发生次数、头痛发作总时间、疼痛程度VAS评分均明显低于对照组(P均<0.05);观察组总有效率明显高于对照组[92.5%(37/40)比75.0%(30/40),P<0.05];观察组血清COX-2、CGRP、PGE_(2)、vWF、ET-1水平均明显低于治疗前及对照组(P均<0.05),NO水平均明显高于治疗前及对照组(P均<0.05);观察组大脑前动脉、大脑中动脉、大脑后动脉、椎动脉、基底动脉的血流速度均明显慢于治疗前及对照组(P均<0.05)。治疗期间2组不良反应发生率比较差异无统计学意义(P>0.05)。结论针刺激痛点联合盐酸氟桂利嗪治疗偏头痛疗效显著,可有效缓解患者的疼痛症状,降低炎症相关指标水平,改善血管内皮功能和脑血流动力学,且治疗安全。 展开更多
关键词 偏头痛 激痛点 针刺疗法 盐酸氟桂利嗪 血管活性物质 脑血流动力学
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耳声发射在早期梅尼埃病和前庭性偏头痛鉴别诊断中的价值初探
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作者 孙政涛 刘博 张祎 《中国耳鼻咽喉头颈外科》 CSCD 2024年第8期497-500,共4页
目的分析梅尼埃病和前庭性偏头痛的畸变产物耳声发射(DPOAE)特征,探讨DPOAE在二者鉴别诊断中的参考价值。方法纳入在北京同仁医院确诊并连续入组的单侧梅尼埃病患者35例,年龄(41.86±10.77)岁,男21例,女14例;前庭性偏头痛患者32例,... 目的分析梅尼埃病和前庭性偏头痛的畸变产物耳声发射(DPOAE)特征,探讨DPOAE在二者鉴别诊断中的参考价值。方法纳入在北京同仁医院确诊并连续入组的单侧梅尼埃病患者35例,年龄(41.86±10.77)岁,男21例,女14例;前庭性偏头痛患者32例,年龄(39.97±8.99)岁,男7例,女25例,分析两组纯音听阈和DPOAE的反应幅值及信噪比,并对两组患者中平均听阈正常者进一步对比分析。结果(1)纳入的全部患者中,梅尼埃病组DPOAE在0.7~8 kHz范围内的反应幅值及信噪比均低于前庭性偏头痛组(P均<0.05);(2)平均听阈正常者中,梅尼埃病组在1 kHz处较前庭性偏头痛组的DPOAE信噪比低(Z=-2.495,P=0.013)。结论DPOAE可评估梅尼埃病及前庭性偏头痛患者的耳蜗功能并辅助早期疾病的鉴别诊断。 展开更多
关键词 偏头痛 梅尼埃病 诊断 畸变产物耳声发射 前庭性偏头痛
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Flunarizine inhibits sensory neuron excitability by blocking voltage-gated Na+ and Ca2+ currents in trigeminal ganglion neurons 被引量:7
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作者 YE Qing WANG Qiang +4 位作者 YAN Lan-yun WU Wen-hui LIU Sha XIAO Hang WAN Qi 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第17期2649-2655,共7页
Background Although flunarizine has been widely used for migraine prophylaxis with clear success, the mechanisms of its actions in migraine prophylaxis are not completely understood. The aim of this study was to inves... Background Although flunarizine has been widely used for migraine prophylaxis with clear success, the mechanisms of its actions in migraine prophylaxis are not completely understood. The aim of this study was to investigate the effects of flunarizine on tetrodotoxin-resistant Na+ channels and high-voltage activated Ca2+ channels of acutely isolated mouse trigeminal ganglion neurons. Methods Sodium currents and calcium currents in trigeminal ganglion neurons were monitored using whole-cell patch-clamp recordings. Paired Student's t test was used as appropriate to evaluate the statistical significance of differences between two group means. Results Both tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were blocked by flunarizine in a concentration-dependent manner with the concentration producing half-maximal current block values of 2.89 μmol/L and 2.73 μmol/L, respectively. The steady-state inactivation curves of tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were shifted towards more hyperpolarizing potentials after exposure to flunarizine. Furthermore, the actions of flunarizine in blocking tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were use-dependent, with effects enhanced at higher rates of channel activation. Conclusion Blockades of these currents might help explain the peripheral mechanism underlying the preventive effect of flunarizine on migraine attacks. 展开更多
关键词 flunarizine migraine tetrodotoxin-resistant sodium currents high-voltage activated calcium currents trigeminal ganglion neurons
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小针刀联合氟桂利嗪治疗前庭性偏头痛临床研究
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作者 李歌 张晓明 李敬伟 《安徽医药》 CAS 2024年第10期1947-1951,共5页
目的探究小针刀联合氟桂利嗪治疗前庭性偏头痛临床疗效。方法研究对象选取2020年10月至2022年10月南京同仁医院收治的90例前庭性偏头痛病人,按就诊顺序抽签随机分为三组,分别为对照组(30例,氟桂利嗪治疗)、小针刀组(30例,小针刀治疗)、... 目的探究小针刀联合氟桂利嗪治疗前庭性偏头痛临床疗效。方法研究对象选取2020年10月至2022年10月南京同仁医院收治的90例前庭性偏头痛病人,按就诊顺序抽签随机分为三组,分别为对照组(30例,氟桂利嗪治疗)、小针刀组(30例,小针刀治疗)、联合组[30例,小针刀(每周进行1次针刀治疗)联合氟桂利嗪治疗]。比较三组病人治疗效果、眩晕残障量表(DHI)评分、视觉模拟评分法(VAS)评分和不良反应发生情况。结果与对照组(56.67%)、小针刀组(66.67%)相比,联合组(90.00%)总改善率显著提高。同一时间点两组DHI评分比较差异有统计学意义,随治疗时间增加而减少(P<0.05);两组DHI评分组间与时点有交互效应(P<0.05),治疗2、3 d后,联合组、小针刀组和对照组DHI评分较治疗前降低(P<0.05),与对照组、小针刀组相比,联合组治疗2、3 d后DHI评分显著降低(P<0.05)。同一时间点两组VAS评分比较差异有统计学意义,随治疗时间增加而减少(P<0.05);两组VAS评分组间与时点有交互效应(P<0.05),治疗2、3 d后,联合组[(2.01±0.65)分、(1.15±0.35)分]、小针刀组[(2.43±0.71)分、(1.45±0.46)分]和对照组[(3.11±0.77)分、(2.05±0.51)分]VAS评分较治疗前[(5.72±1.25)分、(5.69±1.23)分、(5.65±1.21)分]降低(P<0.05),与对照组、小针刀组相比,联合组治疗2、3 d后VAS评分显著降低(P<0.05)。三组不良反应发生率比较,差异有统计学意义(P<0.05)。联合组不良反应发生率(13.33%,4/30)高于小针刀组(0.00%,0/30),低于对照组(30.00%,9/30)。治疗后,联合组(0.82±0.17)次/月、小针刀组(1.55±0.41)次/月和对照组(1.66±0.55)次/月,头痛发作频率较治疗前[(4.35±1.03)次/月、(4.55±1.17)次/月、(4.75±1.23)次/月]降低,与对照组、小针刀组相比,联合组治疗后头痛发作频率显著降低(P<0.05)。结论小针刀联合氟桂利嗪治疗前庭性偏头痛效果显著,可减轻病人头痛及眩晕程度,并且快速、安全、可靠。 展开更多
关键词 偏头痛 小针刀 疗效 氟桂利嗪 内耳前庭
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针刺联合中药治疗偏头痛疗效与安全性的Meta分析 被引量:2
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作者 张瑞环 杨耀峰 +2 位作者 王晓斌 惠文静 陈钧 《广州中医药大学学报》 CAS 2024年第2期520-530,共11页
【目的】采用Meta分析评价针刺联合中药治疗偏头痛的临床疗效及安全性。【方法】检索中国知网期刊全文数据库(CNKI)、万方学术期刊全文数据库(Wanfang)、维普中文科技期刊数据库(VIP)、中国生物医学数据库(CBM)、美国生物医学信息检索系... 【目的】采用Meta分析评价针刺联合中药治疗偏头痛的临床疗效及安全性。【方法】检索中国知网期刊全文数据库(CNKI)、万方学术期刊全文数据库(Wanfang)、维普中文科技期刊数据库(VIP)、中国生物医学数据库(CBM)、美国生物医学信息检索系统(PubMed)、国际循证医学图书馆(Cochrane Library)等各大数据库中有关针刺联合中药治疗偏头痛的随机对照研究。对照组患者采用西比灵药物治疗,试验组采用针刺联合中药治疗。应用Review Manager 5.3软件对纳入文献进行Meta分析。【结果】共纳入符合要求的随机对照研究26项。Meta分析结果显示:针刺联合中药的痊愈率[OR=2.33,95%CI(1.91,2.84),P<0.00001]、总有效率[OR=4.55,95%CI(3.44,6.01),P<0.00001]均高于西比灵药物组;针刺联合中药的不良反应[OR=0.29,95%CI(0.10,0.91),P=0.03]低于西比灵药物组;针刺联合中药的疼痛视觉模拟量表(VAS)评分[MD=-1.53,95%CI(-2.24,-0.83),P<0.0001]、头痛发作频次[MD=-1.51,95%CI(-1.92,-1.11),P<0.00001]、头痛持续时间[MD=-2.16,95%CI(-3.51,-0.81),P=0.002]、头痛积分[MD=-3.03,95%CI(-4.69,-1.38),P=0.0003]均低于西比灵药物组。GRADE证据评级示:痊愈率、总有效率为中级;不良反应、VAS评分、头痛发作频次均为低级;头痛持续时间、头痛积分为极低级。【结论】针刺联合中药治疗偏头痛相较于单纯西比灵治疗的临床疗效更为确切,且更加安全。 展开更多
关键词 针刺 中药 西比灵 偏头痛 META分析 系统评价
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川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗偏头痛疗效及对脑血流动力学和血清神经递质的影响
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作者 啜阿丹 王丽彦 林禹舜 《辽宁中医杂志》 CAS 北大核心 2024年第9期119-122,共4页
目的探讨川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗偏头痛的疗效和安全性。方法偏头痛患者86例随机分为对照组43例与试验组43例。对照组予以盐酸氟桂利嗪胶囊治疗,试验组予以川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗,两组均连续治疗4周... 目的探讨川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗偏头痛的疗效和安全性。方法偏头痛患者86例随机分为对照组43例与试验组43例。对照组予以盐酸氟桂利嗪胶囊治疗,试验组予以川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗,两组均连续治疗4周。观察两组疗效和不良反应,于治疗前和治疗后对患者进行偏头痛中医证候积分、视觉模拟量表(visual analogue scale,VAS)评分和特异性偏头痛生活质量量表(migraine quality of life scale,MSQ)评分,进行脑血流速度[大脑前动脉(anterior cerebral artery,ACA)、大脑后动脉(posterior cerebral artery,PCA)、大脑中动脉(middle cerebral artery,MCA)]和血清神经递质[5-羟色胺(5-hydroxytryptamine,5-HT)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、β-内啡肽(β-endorphin,β-EP)]的测定。结果试验组显愈率显著高于对照组(P<0.05),两组总有效率差异无统计学意义(P>0.05)。治疗后,试验组中医证候积分和VAS评分显著低于对照组(P<0.05),MSQ评分显著高于对照组(P<0.05)。治疗后,试验组ACA、PCA、MCA水平和血清CGBP水平均显著低于对照组(P<0.05),5-HT、β-EP水平显著高于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论川芎定痛饮加减联合盐酸氟桂利嗪胶囊治疗偏头痛患者能够更有效缓解患者偏头痛症状,提高疗效,其作用机制可能与调节脑血流速度和血清神经递质表达有关。 展开更多
关键词 偏头痛 川芎定痛饮 盐酸氟桂利嗪胶囊 脑血流动力学 神经递质
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前庭性偏头痛患者大脑皮质厚度异常研究
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作者 乔超 刘衍希 +2 位作者 阎文静 刘学军 王海萍 《精准医学杂志》 2024年第2期163-166,共4页
目的分析前庭性偏头痛(vestibular migraine,VM)患者大脑皮质厚度改变区域,为VM发病机制的研究提供理论依据。方法选择2021年6月—2022年12月于我院神经内科就诊的VM患者27例(设为VM组),同期招募28例健康志愿者作为对照组。所有受试者... 目的分析前庭性偏头痛(vestibular migraine,VM)患者大脑皮质厚度改变区域,为VM发病机制的研究提供理论依据。方法选择2021年6月—2022年12月于我院神经内科就诊的VM患者27例(设为VM组),同期招募28例健康志愿者作为对照组。所有受试者进行全脑磁共振(MR)扫描,采用基于表面形态学分析(SBM)方法分析并比较两组受试者MR图像中大脑皮质厚度;对VM组患者皮质厚度异常脑区与其病程、头痛发作频率、头晕发作频率、头痛视觉模拟评分(VAS)分值等参数进行Spearman相关性分析。结果与对照组相比,VM组患者左侧顶下小叶皮质厚度明显下降(P_(vertex)<0.01,P_(cluster)<0.05),但左侧顶下小叶皮质厚度与VM病程、头痛发作频率、头晕发作频率、头痛VAS分值均无相关性(P>0.05)。结论前庭性偏头痛患者大脑皮质厚度异常区域位于左侧顶下小叶,左侧顶下小叶可能参与了VM发生的病理生理过程。 展开更多
关键词 偏头痛 前庭疾病 脑皮质厚度 磁共振成像
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慢性前庭性偏头痛临床初识
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作者 刘俊宏 王理想 +3 位作者 马艳敏 王伟涛 张道培 张怀亮 《中华耳科学杂志》 CSCD 北大核心 2024年第1期44-48,共5页
本文主要阐述了慢性前庭性偏头痛(CVM)的基本概念。在前庭性偏头痛(VM)和慢性偏头痛相关知识的基础上,结合团队临床诊疗过程中所积累的经验,对CVM的基本特征、诱发因素、发病机制及相关疾病鉴别进行讨论。本文也尝试提出了CVM的临床分... 本文主要阐述了慢性前庭性偏头痛(CVM)的基本概念。在前庭性偏头痛(VM)和慢性偏头痛相关知识的基础上,结合团队临床诊疗过程中所积累的经验,对CVM的基本特征、诱发因素、发病机制及相关疾病鉴别进行讨论。本文也尝试提出了CVM的临床分期与诊断标准,旨在提高对CVM的认识,规范诊疗,降低误诊率,进一步丰富发展VM的内涵。 展开更多
关键词 慢性前庭性偏头痛 临床分期 诊断标准 慢性偏头痛
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前庭性偏头痛的自然-人文-环境胁迫因素研究进展
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作者 王理想 王伟涛 +1 位作者 张道培 张怀亮 《中华耳科学杂志》 CSCD 北大核心 2024年第2期267-270,共4页
前庭性偏头痛(vestibular migraine,VM)是一种以前庭症状为主,临床常见的反复发作性眩晕类疾病。自然环境和社会人文环境的变化常能胁迫VM的发作。环境胁迫诱发VM的机制可能与脑肠轴、神经环路、神经解剖以及感觉整合异常等多方面有关... 前庭性偏头痛(vestibular migraine,VM)是一种以前庭症状为主,临床常见的反复发作性眩晕类疾病。自然环境和社会人文环境的变化常能胁迫VM的发作。环境胁迫诱发VM的机制可能与脑肠轴、神经环路、神经解剖以及感觉整合异常等多方面有关。环境胁迫因素诱发VM发病机制的揭示,对VM的防治具有重要的临床意义。 展开更多
关键词 前庭性偏头痛 偏头痛 环境胁迫 环境因素诱发疾病 脑肠轴
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