As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluoresce...As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good sensitivity.The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in vivo.In this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery.展开更多
A colorimetric and fluorescent sensor for trace water in methanol has been designed and characterized, which is a kind of aluminium-Schiff base coordination complex derived from diaminomaleonitrile. The fluorescence p...A colorimetric and fluorescent sensor for trace water in methanol has been designed and characterized, which is a kind of aluminium-Schiff base coordination complex derived from diaminomaleonitrile. The fluorescence properties of this complex have been studied based on excited state intramolecular proton transfer （ESIPT） and intramolecular charge transfer （ICT） mechanism. The fluorescent emission of AI-L complex can be quenched by 0.1% water and distinguished by naked eyes. The detection limitation is 0.01% recognized by fluorescence spectra.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(21708034,21877100,81903574)Fundamental Research Funds for the Provincial Universities of Zhejiang(RF-B2019003).
文摘As a powerful tool to advance drug discovery,molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels.When compared with other detection methods,fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’transport,with multi-color capacity,high specificity and good sensitivity.The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution,both in vitro and in vivo.In this short review,we discuss recent developments of small molecule-based fluorophore-drug conjugates,including non-cleavable and cleavable ones,that are capable of visualizing drug delivery.
文摘A colorimetric and fluorescent sensor for trace water in methanol has been designed and characterized, which is a kind of aluminium-Schiff base coordination complex derived from diaminomaleonitrile. The fluorescence properties of this complex have been studied based on excited state intramolecular proton transfer （ESIPT） and intramolecular charge transfer （ICT） mechanism. The fluorescent emission of AI-L complex can be quenched by 0.1% water and distinguished by naked eyes. The detection limitation is 0.01% recognized by fluorescence spectra.
