BACKGROUND Dental focal infection-induced ventricular and spinal canal empyema is an extremely rare,severe,acute disease that is clinically associated with extremely high morbidity and mortality.Traditional cerebrospi...BACKGROUND Dental focal infection-induced ventricular and spinal canal empyema is an extremely rare,severe,acute disease that is clinically associated with extremely high morbidity and mortality.Traditional cerebrospinal fluid(CSF)bacterial culture is time-consuming,with a low positive rate,which frequently results in severe irreversible consequences.The next-generation sequencing technique is an emerging pathogenic microorganism detection method that can obtain results in a short time with high accuracy,thus providing great assistance in the clinical diagnosis and treatment of this disease.CASE SUMMARY This paper reports a rare case of dental focal infection-induced ventricular and spinal canal empyema.During the course of treatment at a local hospital,the patient had negative results from repeated CSF bacterial cultures and was empirically given vancomycin treatment.After transfer to our hospital,the nextgeneration sequencing technique was adopted to determine that the pathogenic microorganisms were multiple anaerobic infectious bacteria derived from the oral cavity.The antibiotic therapeutic scheme was adjusted in a timely manner,and the ventricular and spinal canal inflammation was also controlled.However,the antibiotics that had been applied at the local hospital were not able to cover all pathogenic microorganisms,which resulted in irreversible injury to the brain stem,finally leading to patient death.CONCLUSION Dental focal infection-induced ventricular and spinal canal empyema is an extremely rare,severe,acute disease with high morbidity and mortality.Any delay in diagnosis and treatment will result in irreversible consequences.The early application of the next-generation sequencing technique can obtain results in a short time and clarify a diagnosis.Appropriate antibiotic treatment combined with suitable surgical intervention is the key to managing this disease.展开更多
文摘BACKGROUND Dental focal infection-induced ventricular and spinal canal empyema is an extremely rare,severe,acute disease that is clinically associated with extremely high morbidity and mortality.Traditional cerebrospinal fluid(CSF)bacterial culture is time-consuming,with a low positive rate,which frequently results in severe irreversible consequences.The next-generation sequencing technique is an emerging pathogenic microorganism detection method that can obtain results in a short time with high accuracy,thus providing great assistance in the clinical diagnosis and treatment of this disease.CASE SUMMARY This paper reports a rare case of dental focal infection-induced ventricular and spinal canal empyema.During the course of treatment at a local hospital,the patient had negative results from repeated CSF bacterial cultures and was empirically given vancomycin treatment.After transfer to our hospital,the nextgeneration sequencing technique was adopted to determine that the pathogenic microorganisms were multiple anaerobic infectious bacteria derived from the oral cavity.The antibiotic therapeutic scheme was adjusted in a timely manner,and the ventricular and spinal canal inflammation was also controlled.However,the antibiotics that had been applied at the local hospital were not able to cover all pathogenic microorganisms,which resulted in irreversible injury to the brain stem,finally leading to patient death.CONCLUSION Dental focal infection-induced ventricular and spinal canal empyema is an extremely rare,severe,acute disease with high morbidity and mortality.Any delay in diagnosis and treatment will result in irreversible consequences.The early application of the next-generation sequencing technique can obtain results in a short time and clarify a diagnosis.Appropriate antibiotic treatment combined with suitable surgical intervention is the key to managing this disease.
