Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography （CT） data of a volunteer＇s head. A finite- difference time-domain （FDTD） method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution （64-65 ℃） can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted （26.8-266.7 mm3） along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

Estimation of the stress levels in the focal region before and after the 2001 M=8.1 Western Kunlun Mountain Pass earth-quake

A method estimating the stress level in the focal region of an earthquake is proposed here. Taking the 2001 M=8.1 Western Kunlun Mountain Pass earthquake as an example, we estimate its stress level in the focal region before and after it by this method. The results show that the stress level in the focal region just prior to the initiation of this event is approximately 6.3-8 MPa, and about 5-6.7 MPa remained in the focal region after its occurrence. The stress in the focal region decreased by roughly twenty percent after this event.

Focal region field of a two dimensional Gregorian system coated with isotropic Chiral medium

Focal region field of a two dimensional Gregorian system coated with chiral medium is analyzed at high frequency. Maslov's method is used because the Geometrical Optics approximation fails at focal points. Maslov’s method combines the simplicity of ray theory and the generality of Fourier transform. Fields patterns are calculated numerically and the results are plotted. The effects of thickness of chiral layer, chirality parameter of the chiral medium and permittivity of the medium are analyzed. The problem of simple dielectric layer is discussed as a special case of this problem.

Applying artificial neural networks to achieve quantitative division of potential focal regions

There are put forward in this paper the principle of using artificial neural networks to determine the featureswhich reflect seismotectonics and seismicity of the potential focal regions and the method to divide quantitativelythe potential focal regions. The calculation of the actual data of North China area shows that it may fully reveal the relations between the potential focal regions and their controling characteristics by the method, of which the principle is concise and convenient to apply, the calculated results reasonable, the division in a meticulous way and the achievement practicable.

Regional stress field in Yunnan revealed by the focal mechanisms of moderate and small earthquakes

We determined focal mechanism solutions of 627 earthquakes of magnitude M ≥ 3.0 in Yunnan from January 2008 to May 2018 by using broadband waveforms recorded by 287 permanent and temporary regional stations. The results clearly revealed predominantly strike-slip faulting characteristics for earthquakes in Yunnan, with focal depths concentrated in the top 10 km of the crust. The earthquake mechanisms obtained were combined with the global centroid moment tensor solutions of 80 additional earthquakes from 1976 to 2016 to invert for the regional variations of stress field orientation by using a damped regional-scale stress inversion scheme.Results of the stress field inversion confirmed that the Yunnan region is under a strike–slip stress regime, with both maximum and minimum stress axes being nearly horizontal. The maximum compressional axes are primarily oriented in a northwest-southeast direction, and they experience a clockwise rotation from north to south, whereas the maximum extensional axes are oriented largely northeast-southwest. The maximum compressional axes are in line with the global positioning system–inferred horizontal velocity field and the southeastward escape of the Sichuan–Yunnan Rhombic Block, whereas the maximum extensional axes are consistent with anisotropy derived from SKS splitting. Against the strike–slip background, normal faulting stress regimes can be seen in the Tengchong volcanic area as well as in other areas with complex crisscrossing fault zones.

Determinations of directions of the mean stress field in Sichuan-Yunnan region from a number of focal mechanism solutions

Based on the spatial orientation and slip direction of the fault plane solutions, we present the expression of corresponding mechanical axis tensor in geographic coordinate system, and then put forward a method for calculating average mechanical axis tensor and its eigenvalues, which involves solving the corresponding eigenequation. The method for deducing mean stress field from T, B, and P axes parameters of a number of focal mechanism solutions has been verified by inverting data of mean stress fields in Fuyun region and in Tangshan region with fitting method of slip direction, and both results are consistent. To study regional average stress field, we need to choose a population of focal mechanism solutions of earthquakes in the massifs where there are significant tectonic structures. According to the focal mechanism solutions of 256 moderate-strong earthquakes occurred in 13 seismic zones of Sichuan-Yunnan region, the quantitative analysis results of stress tensor in each seismic zone have been given. The algorithm of such method is simple and convenient, which makes the method for analyzing tectonic stress field with large amount of focal mechanism solution data become quantified.

Variation of stress field in the source region around a strong shock：an example

An earthquake with magnitude 6.6 occurred on November 16,1983 in the Kaoiki,Hawii.The hierarchical clustering analyses were made by stages for the focal mechanism solutions of 74 earthquakes with M≥3.0 in this area from 1977 to 1985,it was found that each type of focal mechanism is roughly with invariable percentage,and that the strike-slip events including the mainshock,which did not appear in other stages,occurred in the stage around M=6.6 mainshock.The dominant types in the other stages were depressed in the period around the mainshock. This is a believable precursor phenomena.orientation of the principal axes of stress field was inversed by fitting slip vector based on the focal mechanisms in the different periods.The results show that the stress field around the main shock with M=6.6 was more stable,its maximum and minimum principal axes is nearly horizontal in EW and NS direction respectively,the middle one is nearly vertical.The middle principal axis of stress field in the other periods appeared to be horizontal and the corresponding seismic rupture horizontally slip with a small dip.The significant difference between the stress field of source region in the period around the strong shock and that in the other periods shows that the seismogeny and occurrence of the strong shock were controlled by the variation of stress field.The characteristic environment factors of Kaoiki region and its effects were discussed.

The Study on the Strong Ground Motion Attenuation Relationship in the Pishan Area,Xinjiang Uygur Autonomous Region

Small earthquake data from the Pishan MS6.5 aftershocks is collected by the Xinjiang Regional Digital Seismic Observation Network.Five parameters of the focal region are obtained by micro genetic inversion:stress dropΔσof 75.95 bars,quality factor parameters Q0of 186.33 andηof 0.26,geometric attenuation parameters R1of 72.18km and R2of 139.70km.We calculate the Fourier spectrum and combine it with the random phase spectrum to get the ground motion time history,and build the strong motion acceleration attenuation relationship.The strong ground motion acceleration attenuation of the Pishan area is thus obtained.Because of the insufficiency of strong ground motion records,we added the records from the Wuqia MS6.9 earthquake on October 5,2008,the Akto MS6.2 earthquake on October 6,2008,and the Lop MS6.0 earthquake on March 9,2012 to the data.The comparison of the calculation results and the empirical attenuation relationships with strong ground motion records reveal that the strong motion data of Pishan and Lop earthquakes is higher than the empirical attenuation relationships.The Wuqia MS6.9 earthquake strong motion data is consistent with Yu Yanxiangs(2013)short axis result,and lower than the present result.

A study on the focal parameters of Shidian M=5.9 earthquake sequences in 2001

On the basis of about 300 earthquake wave forms observed in the Shidian MS=5.9 sequences on April 12, 2001 recorded in Kunming Digital Seismic Network, the spectra of shear wave have been used to estimate the focal parameters of these earthquake sequences. The results show that within the magnitude range of 1.5~5.3, the seis-mic moments are 1010~1016 N?m, the corner frequencies are 0.2~0.8 Hz, radii of the focal rupture are 200~2 500 m and the stress drops are 0.1×105~20×105Pa. Through the statistical analyses of variation of corner frequency fc and stress drop ?σ with time, it is discovered that the average corner frequency of the foreshock sequences is obviously lower than that of the aftershock sequences. Contrarily, the average stress drops ?σ of the foreshock sequences are clearly higher than that of the aftershocks. It is considered that these variation characteristics of av-erage corner frequency and stress drops before and after the main shock have index significance to the precursory information before a strong earthquake. The higher stress drops for the foreshock sequences show that the higher shear stresses have been stored in the area of main shock. After the main shock, most of the stresses have been released, so the aftershock sequences show a rupture process of lower stresses.

The Focal Depth Analysis of the Inner Mongolia-Ningxia Border Area Earthquakes

We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat method, double difference location method,and deterministic method (PTD) for the determination of focal depth,and compared the results. The CAP moment tensor inversion method is used to determine the focal depths of the Alxa Left Banner M5. 8 and M4. 2 earthquakes. The final results of the focal depth by the deterministic method (PTD) and the double difference location method fit well with the tectonic characteristics of the Inner Mongolia-Ningxia border area,but those of the simplex method and the Hyposat method do not. The average depth of the Inner Mongolia-Ningxia border seismic tectonic zone is 13. 32 ± 8 km.

盖州青石岭震群断层面参数的确定及构造应力场特征研究

根据之前学者的双差定位结果,使用Fit_Fault软件包计算盖州青石岭震群发震断层面走向为114.30°,倾角74.67°。收集2001年至2011年辽宁地区的震源机制解资料,采用全局网格搜索算法,反演该地区的构造应力场,其主压应力轴为NEE向,主张应力轴为NNW向,整体呈现拉张的应力状态。并据此确定出青石岭震群发震断层的滑动角是35.49°,为左旋走滑性质。模拟在辽宁地区构造应力体系下各种产状的断层面上可产生的相对剪应力和相对正应力分布情况,发现该震群发震断层面上的相对剪应力和相对正应力分别为0.513和0.576。分析认为盖州青石岭震群是一处地质薄弱带,背景构造应力场在其最近一期的活动中未起主导作用。

TFAP2A对肾小球硬化相关基因ADCK4转录调控机制的研究

目的探索细胞中TFAP2A对局灶节段性肾小球硬化(FSGS)相关基因含aarF结构域的激酶4(ADCK4)的转录调控机制及TFAP2A与ADCK4是否存在特定的结合区域。方法生物信息学分析肾小球硬化基因火山图,ADCK4及TFAP2A表达水平的关系。JASPAR数据库预测ADCK4基因转录起始位点-464 bp/+206 bp区域包含TFAP2A转录因子结合位点;TFAP2A siRNA浓度分别为5、10、15µmol/L,TFAP2A过表达质粒质量浓度分别为50、100、300µg/L,通过双萤光素酶报告基因实验验证TFAP2A对ADCK4基因启动子水平的调控作用。TFAP2A siRNA及TFAP2A过表达质粒转染细胞,实时荧光定量PCR检测TFAP2A、ADCK4 mRNA表达,蛋白免疫印迹实验检测TFAP2A、ADCK4蛋白表达。染色质免疫沉淀试验验证TFAP2A与ADCK4启动子的特定区域结合。结果生物信息学分析显示FSGS肾组织中RNA-Seq RNA表达上调的基因273个,表达下调的基因219个;ADCK4与TFAP2A表达水平呈正相关(P<0.01)。双萤光素酶报告基因实验证明TFAP2A siRNA浓度为10、15µmol/L的ADCK4启动子相对萤光素酶活性增强,TFAP2A过表达质粒质量浓度为100、300µg/L的ADCK4启动子萤光素酶活性降低(P<0.05)。与对照组相比,实验组ADCK4 mRNA和蛋白表达水平升高;过表达实验中,与对照组比较,实验组ADCK4 mRNA和蛋白表达水平降低(P<0.05)。染色质免疫沉淀试验发现TFAP2A能与ADCK4启动子的特定区域结合。结论转录因子TFAP2A负向调控ADCK4基因表达,增加了调控足细胞重要基因的转录因子成员。

1995年苍山5.2级地震前应力场的动态变化

从１９９５年９月２０日山东苍山５．２级地震前源区及其附近不同小区应力场方向的动态变化入手，分析了主应力轴方位、仰角及其矛盾符号比等参量在５．２级地震前的异常变化及其时空演变特点，简析了可能成因。

高强度聚焦超声肝脏生物学焦域及超声监控

目的 探讨在相同声强作用下 ,高强度聚焦超声经体外辐照肝脏形成的生物学焦域体积大小与辐照深度和辐照时间的关系。同时探讨超声显像法实时监控生物学焦域的图像变化规律。方法 采用重庆医科大学医学超声工程研究所自主研制的JC A型HIFU肿瘤治疗系统 ( 1MHz ,5 5 0 0W·cm-2 ) ,对 18只山羊的肝脏组织进行体外定点脉冲辐照 ,辐照深度为距皮肤 3cm和 4cm ,辐照时间为 5s、10s、15s和 2 0s。辐照过程中系列测量靶区超声灰度和强回声区面积的变化。辐照后 3～ 5天处死动物 ,剖腹观察并测量所形成的肝脏HIFU生物学焦域的体积。结果 肝脏经体外HIFU辐照后即刻 ,靶区内出现明显的回声增强并随观测时间延长而逐渐降低。强回声区面积随辐照时间增加而增大。辐照时间为 5s、10s、15s和 2 0s ,辐照深度为 3cm时 ,形成的生物学焦域体积分别为 ( 85± 2 8.0 )mm3 、( 2 74± 5 5 .0 )mm3 、( 4 10± 90 .0 )mm3 和 ( 694± 13 1.0 )mm3 ;而辐照深度为 4cm时 ,肝脏HIFU生物学焦域体积则分别为 :( 63± 7.0 )mm3 、( 167± 2 5 .0 )mm3 、( 2 73± 5 6.0 )mm3 和 ( 4 72± 10 4.0 )mm3 。结论 在相同辐照声强作用下 ,肝脏HIFU生物学焦域体积随辐照时间的增加而增加 ,随辐照深度的增加而减小。

高强度聚焦超声形成生物学焦域的剂量学研究

目的 研究辐照剂量对高强度聚焦超声生物学焦域形状、大小的影响 ,探讨高强度聚焦超声 (highintensityfo cusedultrasound ,HIFU)形成生物学焦域的剂量学。方法 运用JC A型Haifu聚焦超声肿瘤治疗系统 ,使用 1.6MHz、焦距12 0mm聚焦超声换能器 ,以 7× 10 3～ 2 7.7× 10 3W cm2 、辐照时间 1～ 2 0s的剂量定点辐照深度为 2 0mm的新鲜离体牛肝脏 ,辐照结束后沿凝固性坏死最大面剖开 ,测量生物学焦域的长、短轴和体积。结果 HIFU生物学焦域不等于声焦域。随着声强和辐照时间的增加 ,HIFU生物学焦域体积增加 ,其形态亦由椭圆体演变成圆锥体 ,且当声强增加时 ,圆锥体HIFU生物学焦域出现的更早。当声强一定 ,随着辐照时间的增加 ,HIFU生物学焦域形态指数 (K)逐渐减小。结论 辐照剂量影响HIFU生物学焦域的形状和大小 。

热状态对地震发生的影响

考虑地震是由于震源材料软化导致的一种基本机制,假设区域构造应力场在地震孕育过程中基本不变,震源区震前存在着热异常.我们根据热弹塑性增量理论,提出了两种材料模型,用弹塑性有限单元法模拟热状态对地震发生的影响. 模型1用来模拟断层外部区域的物质,其强度只和塑性变形有关而与热状态无关;模型2用来模拟断层物质,其强度只同热状态有关而与塑性变形无关.断层外部地震的发生被认为是岩石应变软化的结果;而断层内部地震的发生被认为是断层热软化的结果. 本文用上述模型分析了只有单一断层的热软化情况,并且得到了相应的断层错距、应力降和地震距.

高斯线调频连续小波变换的时频能量衰减因子方法及其应用

本文基于高斯线调频连续小波变换 ,提出了能够反映震源区或近场区小地震波形在震源深度、震源尺度、震源破裂机制、地震波传播途径、地震波衰减等方面的差异特征信息的特征指标 ,即小波变换的时频能量衰减因子方法。为了验证该方法的有效性 ,选取了震源破裂机制有明显差异特性的天然地震、爆破或塌方资料以及非强地震孕震区同一地点发生的多次小震资料。研究结果表明 ,天然地震与爆破或塌方记录的连续小波变换时频能量衰减因子有明显区别 ;正常地震活动背景下地震记录的连续小波变换时频能量衰减因子变化比较稳定 ;利用该方法 ,通过对某一地区的连续观测 ,可望为强震预测提供有效判据。

2013年4月20日四川芦山M_S7.0地震:一个高角度逆冲地震

利用中国地震台网和IRIS数据中心提供的近远震数字地震波形记录,首先读取P波初动方向,在考虑深度误差和速度模型引起的离源矢量误差基础上,利用网格搜索方法,计算了2013年4月20日四川芦山MS7.0地震断层面解,其断层面走向/倾角/滑动角依次为212°/44°/92°.然后采用近远震波形联合反演方法(CAPjoint),反演了地震矩心深度和点源近似下双力偶解,表明地震发生在12km深度,发震断层面参数为212°/47°/93°.通过分析波形反演中深度和震源区地震波速度模型对断层面倾角的影响,并结合短期余震机制解,认为芦山MS7.0地震是一个高角度逆冲地震.

汶川8.0级特大地震震源断裂特征及其动力学分析

笔者根据地壳表层地质构造和地震地质研究与地震测深和大地电磁测深成果,运用现代构造解析理论与方法,论证了汶川8.0级特大地震的深部构造环境,探讨了汶川8.0级特大地震震源区的地震断裂和震源断裂基本特征与相互关系,及其形成的地球动力学问题。笔者认为龙门山碰撞造山带深处隐伏壳幔韧性剪切带可能是汶川8.0级特大地震主震区的震源断裂,而地壳表层发育的映秀断裂带、北川断裂带和彭县—灌县断裂带等可能是汶川8.0级特大地震主震区的地震断裂,该区震源断裂与地震断裂既有显著区别,又有密切联系。研究表明,在印度板块与太平洋板块和菲律宾海板块对欧亚板块俯冲碰撞的动力学作用下,形成上扬子地块向青藏高原东缘碰撞—楔入以及青藏高原东缘向东仰冲,深部向东俯冲的动力学态势,造成龙门山碰撞造山带切割莫霍界面的壳幔韧性剪切带向中上地壳扩展,应力高度集中与能量快速释放破裂,从而引起汶川8.0级特大地震的发生,以及大型同震地表破裂带的形成。探索震源断裂与地震断裂区别与联系,对进一步研究地震机制与发震动力学以及防震减灾有重要意义。

山西地区震源机制一致性参数时空特征分析

利用山西数字地震台网记录到的中小地震波形资料,采用层状介质中点源位错模型的广义透射系数的快速算法和理论地震图拟合直达波最大振幅比来求取小震震源机制解的方法,计算了2001年—2012年山西地区281个中小地震震源机制解,根据优势分布得到山西地区现今平均构造应力场分布,计算震源机制解应力主轴与相应的区域构造应力场主轴之间的震源机制一致性参数,分析一致性参数时空分布与中等地震活动的关系。结果显示,2001年以来山西5次ML≥5.0地震前均有震源机制趋于一致性现象,震中分布在一致性参数低值附近或高低值过渡区域。