Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s block.Cataract surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local anaesth...Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s block.Cataract surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local anaesthesia.This can be done with sub-Tenon’s,retrobulbar,peribulbar,intracameral or topical anaesthesia[1].Sub-Tenon’s anaesthesia involves opening the conjunctiva and tenon’s展开更多
Through the investigation of children’s picture book market,the understanding of the development of picture book design in Chinese and Western countries,the research on the picture book status of Guangxi’s“Zhuang F...Through the investigation of children’s picture book market,the understanding of the development of picture book design in Chinese and Western countries,the research on the picture book status of Guangxi’s“Zhuang Folk Story”and the combing and induction of relevant theories,the reasons for the blank phenomenon in the research of Guangxi Zhuang Folk Story Picture Book are understood.Through the research and analysis of the present situation,it is necessary to solve the problems such as unclear national characteristics of picture images in picture books,insufficient literariness and interest of picture books to attract readers,and lagging development of related cultural communication and cultural industry.展开更多
Objective Intrauterine growth restriction followed by postnatal catch-up growth(CG-IUGR)increases the risk of insulin resistance-related diseases.Low-density lipoprotein receptor-related protein 6(LRP6)plays a substan...Objective Intrauterine growth restriction followed by postnatal catch-up growth(CG-IUGR)increases the risk of insulin resistance-related diseases.Low-density lipoprotein receptor-related protein 6(LRP6)plays a substantial role in glucose metabolism.However,whether LRP6 is involved in the insulin resistance of CG-IUGR is unclear.This study aimed to explore the role of LRP6 in insulin signaling in response to CG-IUGR.Methods The CG-IUGR rat model was established via a maternal gestational nutritional restriction followed by postnatal litter size reduction.The mRNA and protein expression of the components in the insulin pathway,LRP6/β-catenin and mammalian target of rapamycin(mTOR)/S6 kinase(S6K)signaling,was determined.Liver tissues were immunostained for the expression of LRP6 andβ-catenin.LRP6 was overexpressed or silenced in primary hepatocytes to explore its role in insulin signaling.Results Compared with the control rats,CG-IUGR rats showed higher homeostasis model assessment for insulin resistance(HOMA-IR)index and fasting insulin level,decreased insulin signaling,reduced mTOR/S6K/insulin receptor substrate-1(IRS-1)serine307 activity,and decreased LRP6/β-catenin in the liver tissue.The knockdown of LRP6 in hepatocytes from appropriate-for-gestational-age(AGA)rats led to reductions in insulin receptor(IR)signaling and mTOR/S6K/IRS-1 serine307 activity.In contrast,LRP6 overexpression in hepatocytes of CG-IUGR rats resulted in elevated IR signaling and mTOR/S6K/IRS-1 serine307 activity.Conclusion LRP6 regulated the insulin signaling in the CG-IUGR rats via two distinct pathways,IR and mTOR-S6K signaling.LRP6 may be a potential therapeutic target for insulin resistance in CG-IUGR individuals.展开更多
There was an outpouring of grief across China on October 30 when fans of legendary wuxia （master of martial arts） novelist Jin Yong heard of his passing at age 94.
There are more and more exchanges between countries as we go global.Cross-cultural knowledge is coming to play a vital role in effective communications between people of different nations.As a language facilitator,lea...There are more and more exchanges between countries as we go global.Cross-cultural knowledge is coming to play a vital role in effective communications between people of different nations.As a language facilitator,learning from my own experience offers me a deeper insight into another culture and custom,thus shedding light on proper and well-accepted communications.展开更多
Objective: To review the records of cases of Bartholin’s Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. Methods: Bartholin’s Gland Carcinoma case da...Objective: To review the records of cases of Bartholin’s Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. Methods: Bartholin’s Gland Carcinoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences 11.0. Results: Of the 12 cases four died of their disease, seven are still alive and disease free and one is alive with recurrent disease. The mean age at diagnosis was 52.8 years. Time from onset of symptoms to diagnosis averaged 5.8 months. All diagnoses were confirmed histologically. Presenting symptoms included a lump and pain. The most common presenting complaint was a lump. Treatment included surgical excision, occasional biopsy followed by radiotherapy with or without chemotherapy. In some cases radiation and chemotherapy was followed by vulvectomy of various extent. Conclusions: Bartholin’s Gland Carcinoma is a rare condition with outcome dependent on duration of symptoms, including delay in diagnosis, cell-type, cellular differentiation and the International Federation of Gynecology and Obstetrics (FIGO) classification. A Bartholin’s gland mass in a woman aged 40 years or more should be considered malignant until a biopsy proves otherwise.The incidence of Bartholin’s Gland Carcinoma in Queensland is less than that reported elsewhere but a higher proportion of squamous cell carcinomas was found in this small series.展开更多
This essay analyses Paul Green's use of music in his first long play In Abraham's Bosom and finds that music,especially the folk songs not only created authentic background for the story,but also strengthened ...This essay analyses Paul Green's use of music in his first long play In Abraham's Bosom and finds that music,especially the folk songs not only created authentic background for the story,but also strengthened the play's themes—black people's different attitudes toward tradition and the great difficulties for a black man to change his own and his people's fate.展开更多
文摘Dear Sir,We write to report a case of new onset atrial fibrillation following sub-Tenon’s block.Cataract surgery is nowadays mostly performed as a day case procedure with 95.5%of surgery performed under local anaesthesia.This can be done with sub-Tenon’s,retrobulbar,peribulbar,intracameral or topical anaesthesia[1].Sub-Tenon’s anaesthesia involves opening the conjunctiva and tenon’s
文摘Through the investigation of children’s picture book market,the understanding of the development of picture book design in Chinese and Western countries,the research on the picture book status of Guangxi’s“Zhuang Folk Story”and the combing and induction of relevant theories,the reasons for the blank phenomenon in the research of Guangxi Zhuang Folk Story Picture Book are understood.Through the research and analysis of the present situation,it is necessary to solve the problems such as unclear national characteristics of picture images in picture books,insufficient literariness and interest of picture books to attract readers,and lagging development of related cultural communication and cultural industry.
基金supported by the National Natural Science Foundation of China(No.82001651 and No.81660268).
文摘Objective Intrauterine growth restriction followed by postnatal catch-up growth(CG-IUGR)increases the risk of insulin resistance-related diseases.Low-density lipoprotein receptor-related protein 6(LRP6)plays a substantial role in glucose metabolism.However,whether LRP6 is involved in the insulin resistance of CG-IUGR is unclear.This study aimed to explore the role of LRP6 in insulin signaling in response to CG-IUGR.Methods The CG-IUGR rat model was established via a maternal gestational nutritional restriction followed by postnatal litter size reduction.The mRNA and protein expression of the components in the insulin pathway,LRP6/β-catenin and mammalian target of rapamycin(mTOR)/S6 kinase(S6K)signaling,was determined.Liver tissues were immunostained for the expression of LRP6 andβ-catenin.LRP6 was overexpressed or silenced in primary hepatocytes to explore its role in insulin signaling.Results Compared with the control rats,CG-IUGR rats showed higher homeostasis model assessment for insulin resistance(HOMA-IR)index and fasting insulin level,decreased insulin signaling,reduced mTOR/S6K/insulin receptor substrate-1(IRS-1)serine307 activity,and decreased LRP6/β-catenin in the liver tissue.The knockdown of LRP6 in hepatocytes from appropriate-for-gestational-age(AGA)rats led to reductions in insulin receptor(IR)signaling and mTOR/S6K/IRS-1 serine307 activity.In contrast,LRP6 overexpression in hepatocytes of CG-IUGR rats resulted in elevated IR signaling and mTOR/S6K/IRS-1 serine307 activity.Conclusion LRP6 regulated the insulin signaling in the CG-IUGR rats via two distinct pathways,IR and mTOR-S6K signaling.LRP6 may be a potential therapeutic target for insulin resistance in CG-IUGR individuals.
文摘There was an outpouring of grief across China on October 30 when fans of legendary wuxia （master of martial arts） novelist Jin Yong heard of his passing at age 94.
文摘There are more and more exchanges between countries as we go global.Cross-cultural knowledge is coming to play a vital role in effective communications between people of different nations.As a language facilitator,learning from my own experience offers me a deeper insight into another culture and custom,thus shedding light on proper and well-accepted communications.
文摘Objective: To review the records of cases of Bartholin’s Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. Methods: Bartholin’s Gland Carcinoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences 11.0. Results: Of the 12 cases four died of their disease, seven are still alive and disease free and one is alive with recurrent disease. The mean age at diagnosis was 52.8 years. Time from onset of symptoms to diagnosis averaged 5.8 months. All diagnoses were confirmed histologically. Presenting symptoms included a lump and pain. The most common presenting complaint was a lump. Treatment included surgical excision, occasional biopsy followed by radiotherapy with or without chemotherapy. In some cases radiation and chemotherapy was followed by vulvectomy of various extent. Conclusions: Bartholin’s Gland Carcinoma is a rare condition with outcome dependent on duration of symptoms, including delay in diagnosis, cell-type, cellular differentiation and the International Federation of Gynecology and Obstetrics (FIGO) classification. A Bartholin’s gland mass in a woman aged 40 years or more should be considered malignant until a biopsy proves otherwise.The incidence of Bartholin’s Gland Carcinoma in Queensland is less than that reported elsewhere but a higher proportion of squamous cell carcinomas was found in this small series.
文摘This essay analyses Paul Green's use of music in his first long play In Abraham's Bosom and finds that music,especially the folk songs not only created authentic background for the story,but also strengthened the play's themes—black people's different attitudes toward tradition and the great difficulties for a black man to change his own and his people's fate.
