We report a very rare case of endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar. A 47-year-old woman visited the surgical department, since she had a gradually growing and ...We report a very rare case of endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar. A 47-year-old woman visited the surgical department, since she had a gradually growing and painful tumor both in an appendectomy scar and at an umbilical site. She underwent appendectomy at age 18 years, and noticed the tumor at age 22 years. Partial tumor resection was performed in that department, and the pathology revealed endometrioid adenocarcinoma. She was referred to our department for radical therapy. Tumors in the both sites were dissected together with some swelling lymph nodes in our department. A pathological diagnosis of the tumor in the umbilical site showed only benign endometriosis. In contrast, the tumor in the appendectomy scar showed benign endometriosis, atypical endometriosis and well differentiated endometrioid adenocarcinoma. Resected lymph nodes also contained endometrioid adenocarcinoma, and were diagnosed as metastases. It was concluded that the endometrioid adenocarcinoma in the tumor of the appendectomy scar was a malignant transformation arising from abdominal wall endometriosis from the pathological findings. Since the operation, adjuvant and maintenance chemotherapy with paclitaxel and carboplatin had been administered for 3 years. She is free of disease 3.5 years after the operation.展开更多
Endometriosis is a chronic and destructive developmental gynecologic condition that affects approximately 10%percent of females worldwide,and is one of the most frequent causes of extreme pelvic pain.The endometriumli...Endometriosis is a chronic and destructive developmental gynecologic condition that affects approximately 10%percent of females worldwide,and is one of the most frequent causes of extreme pelvic pain.The endometriumlike tissue,glands,and stroma outside the uterine cavity are often affected by endometriosis.It is estrogendependent and frequently affects the ovaries,fallopian tubes,and pelvic peritoneum.Symptoms such as chronic pelvic pain,infertility,dyspareunia,as well as digestive and urinary symptoms often accompany endometriosis.The overall condition shares characteristics with ovarian carcinoma such as enhanced vascular activation of the endothelial growth factor,local invasion,lymph angiogenesis,neoangiogenic,mechanism tolerance to apoptosis,and genome instability.Genetic studies have shown that endometriotic lesions contain gene mutations related directly to malignancies,particularly the ARID1A,p53,KRAS,and PTEN genes.However,women with endometriosis have a lower risk of ovarian cancer than the general population,where endometriosis was seen in only 1.3%,and did not diagnose ovarian cancer progression among them.We need to look into the connection between endometriosis and uterine carcinomas,as well as the common lesions and correlations in the uterine microenvironment,which may play a role in mutations and malignant exchanges.Although endometriosis is a risk factor of ovarian cancer,malignant cells from the uterus can migrate to the ovary and cause endometriosis-related ovarian cancer.The purpose of this article is to examine current data on genetic phenomena and molecular changes for endometriosis associated with ovarian cancer,focusing primarily on the proliferation of uterine and precise cell biomarkers.展开更多
文摘We report a very rare case of endometrioid adenocarcinoma arising from abdominal wall endometriosis in the appendectomy scar. A 47-year-old woman visited the surgical department, since she had a gradually growing and painful tumor both in an appendectomy scar and at an umbilical site. She underwent appendectomy at age 18 years, and noticed the tumor at age 22 years. Partial tumor resection was performed in that department, and the pathology revealed endometrioid adenocarcinoma. She was referred to our department for radical therapy. Tumors in the both sites were dissected together with some swelling lymph nodes in our department. A pathological diagnosis of the tumor in the umbilical site showed only benign endometriosis. In contrast, the tumor in the appendectomy scar showed benign endometriosis, atypical endometriosis and well differentiated endometrioid adenocarcinoma. Resected lymph nodes also contained endometrioid adenocarcinoma, and were diagnosed as metastases. It was concluded that the endometrioid adenocarcinoma in the tumor of the appendectomy scar was a malignant transformation arising from abdominal wall endometriosis from the pathological findings. Since the operation, adjuvant and maintenance chemotherapy with paclitaxel and carboplatin had been administered for 3 years. She is free of disease 3.5 years after the operation.
文摘Endometriosis is a chronic and destructive developmental gynecologic condition that affects approximately 10%percent of females worldwide,and is one of the most frequent causes of extreme pelvic pain.The endometriumlike tissue,glands,and stroma outside the uterine cavity are often affected by endometriosis.It is estrogendependent and frequently affects the ovaries,fallopian tubes,and pelvic peritoneum.Symptoms such as chronic pelvic pain,infertility,dyspareunia,as well as digestive and urinary symptoms often accompany endometriosis.The overall condition shares characteristics with ovarian carcinoma such as enhanced vascular activation of the endothelial growth factor,local invasion,lymph angiogenesis,neoangiogenic,mechanism tolerance to apoptosis,and genome instability.Genetic studies have shown that endometriotic lesions contain gene mutations related directly to malignancies,particularly the ARID1A,p53,KRAS,and PTEN genes.However,women with endometriosis have a lower risk of ovarian cancer than the general population,where endometriosis was seen in only 1.3%,and did not diagnose ovarian cancer progression among them.We need to look into the connection between endometriosis and uterine carcinomas,as well as the common lesions and correlations in the uterine microenvironment,which may play a role in mutations and malignant exchanges.Although endometriosis is a risk factor of ovarian cancer,malignant cells from the uterus can migrate to the ovary and cause endometriosis-related ovarian cancer.The purpose of this article is to examine current data on genetic phenomena and molecular changes for endometriosis associated with ovarian cancer,focusing primarily on the proliferation of uterine and precise cell biomarkers.
