The effect of Fructus Mume formula and its separated prescription extract on insulin resis- tance in type 2 diabetic rats was investigated. The rat model of type 2 diabetes was established by feed- ing on a high-fat d...The effect of Fructus Mume formula and its separated prescription extract on insulin resis- tance in type 2 diabetic rats was investigated. The rat model of type 2 diabetes was established by feed- ing on a high-fat diet for 8 weeks and by subsequently intravenous injection of small doses of strepto- zotocin. Rats in treatment groups, including the Fructus Mume formula treatment group （FM）, the cold property herbs of Fructus Mume formula treatment group （CFM）, the warm property herbs of Fructus Mume formula treatment group （WFM）, were administrated with Fructus Mume formula and its sepa- rated prescription extract by gavage, while the rats in diabetic model group （DM） and metformin group （MET） were given by gavage with normal saline and metformin correspondingly. The body weight be- fore and after treatment was measured, and the oral glucose tolerance test （OGTT） and the insulin re- lease test （IRT） were performed. The homeostasis model assessment-insulin resistance index （HOMA-IR） was calculated. The protein and mRNA expression levels of Insr, β-arrestin-2, Its-1 and Glut-4 in the liver, skeletal muscle and fat tissues were detected by using Western blotting and RT-PCR respectively. The results demonstrated that, as compared with DM group, OGTT, IRT （0 h, 1 h） levels and HOMR-IR in treatment groups were all reduced, meanwhile their protein and mRNA expression levels of Insr, Irs-1 and Glut-4 in the liver, skeletal muscle and fat tissues were obviously increased, and their protein and mRNA expression levels of β-arrestin-2 in the liver and skeletal muscle tissues were also markedly increased. It was suggested that the Fructus Mume formula and its separated prescription extracts could effectively improve insulin resistance in type 2 diabetic rats, which might be related to the up-regulated expression of Insr, Irs-1 and Glut-4 in the liver, skeletal muscle and fat tissues, and β-arrestin-2 in the liver and skeletal muscle tissues.展开更多
Under the foundation of Cauchy integral formula on certain distinguished boundary for functions with values in universal Clifford algebra, we define the Cauchy type integral with values in a universal Clifford algebra...Under the foundation of Cauchy integral formula on certain distinguished boundary for functions with values in universal Clifford algebra, we define the Cauchy type integral with values in a universal Clifford algebra, obtain its Cauchy principal value and Plemelj formula on certain distinguished boundary.展开更多
A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some resul...A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some results on the related Jacobi interpolation are established. A pseudospectral scheme is proposed for the Kuramoto-Sivashisky equation. A skew symmetric decomposition is used for dealing with the nonlinear convection term. The stability and convergence of the proposed scheme are proved. The error estimates are obtained. Numerical results show the efficiency of this approach.展开更多
Let D be a bounded domain with piecewise C^（1） smooth orientable boundary on Stein manifolds, and let Φ（z） be a Cauchy type integral with Bochner-Martinelli kernel Ω（φ^V, S^-, S） and Holder continuous density...Let D be a bounded domain with piecewise C^（1） smooth orientable boundary on Stein manifolds, and let Φ（z） be a Cauchy type integral with Bochner-Martinelli kernel Ω（φ^V, S^-, S） and Holder continuous density function φ（ζ）, the authors define a solid angular coefficient α（t） at the point t∈δD, prove that there exist the interior and outer limit values Φ^±（t） under the meaning of the Cauchy principal value, and obtain the more general Plemelj formula and jump formula.展开更多
We investigate the highest weight representations of the q-deformed Virasoro algebra of Hom-type. In order to determine its unitarity and irreducible highest weight representations, we present its Kac determinant form...We investigate the highest weight representations of the q-deformed Virasoro algebra of Hom-type. In order to determine its unitarity and irreducible highest weight representations, we present its Kac determinant formula when q is nonzero and non-root of unity.展开更多
To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined. By means of the power series expansion of the s...To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined. By means of the power series expansion of the solution, this method can construct an approximate solution to solve the given integral equation. On the basis of the orthogonal polynomials, two useful determinant expressions of the numerator polynomial and the denominator polynomial for Padé-type approximation are explicitly given.展开更多
目的:基于上皮细胞-间充质细胞转分化(EMT)学说观察化纤Ⅳ号方、艾灸以及二者相配合治疗肺纤维化大鼠Collagen TypeⅢ(Ⅲ-C)和PDGF的变化,探讨其治疗效应及生物学机制。方法:将鼠龄约为6周的SD大鼠随机分为空白组、模型组、化纤Ⅳ号方...目的:基于上皮细胞-间充质细胞转分化(EMT)学说观察化纤Ⅳ号方、艾灸以及二者相配合治疗肺纤维化大鼠Collagen TypeⅢ(Ⅲ-C)和PDGF的变化,探讨其治疗效应及生物学机制。方法:将鼠龄约为6周的SD大鼠随机分为空白组、模型组、化纤Ⅳ号方组、艾灸组、化纤Ⅳ号方与艾灸配合治疗组(简称为"灸药组"),治疗30 d后处死观察其肺组织病理改变,并检测其Collagen TypeⅢ、PDGF的基因和蛋白表达情况。结果:实时荧光定量结果显示:与空白组相比,各组Ⅲ-C和PDGF m RNA表达增高(P<0.05)。与模型组相比,各组的Ⅲ-C和PDGF m RNA表达有明显降低(P<0.01)。而各组中,灸药组疗效最明显,Ⅲ-C和PDGF的表达最低。蛋白免疫印迹法检测结果显示:与模型组相比各组的Ⅲ-C蛋白表达有差异。结论:1艾灸、化纤Ⅳ号方均可减轻博莱霉素诱导肺纤维化大鼠的肺纤维化程度。2艾灸配合化纤Ⅳ号方可减轻博莱霉素诱导肺纤维化大鼠的肺纤维化程度,且其效果优于单用艾灸或单用化纤Ⅳ号方。3艾灸、化纤Ⅳ号方及其二者配合使用不同程度阻抑博莱霉素诱导肺纤维化大鼠肺纤维化进程的效应机制,可能与通过调控其EMT过程中的Ⅲ-C和PDGF表达环节紧密相关。展开更多
In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauch...In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauchy-type integral taken over a smooth surface by rather simple method.展开更多
With the aid of Mullin-Rota's substitution rule, we show that the Sheffertype differential operators together with the delta operators ? and D could be used to construct a pair of expansion formulas that imply a w...With the aid of Mullin-Rota's substitution rule, we show that the Sheffertype differential operators together with the delta operators ? and D could be used to construct a pair of expansion formulas that imply a wide variety of summation formulas in the discrete analysis and combinatorics. A convergence theorem is established for a fruitful source formula that implies more than 20 noted classical fomulas and identities as consequences. Numerous new formulas are also presented as illustrative examples. Finally, it is shown that a kind of lifting process can be used to produce certain chains of(∞~m) degree formulas for m ≥ 3 with m ≡ 1(mod 2) and m ≡ 1(mod 3), respectively.展开更多
Background: Postprandial hyperglycemia is an independent risk factor for diabetes-associated complications in individuals with type 2 diabetes. Dietary modification plays an important role in glycemic control. This st...Background: Postprandial hyperglycemia is an independent risk factor for diabetes-associated complications in individuals with type 2 diabetes. Dietary modification plays an important role in glycemic control. This study was to examine the efficacy of a diabetes specific formula (DSF) during a 4-hour postprandial meal tolerance test (MTT) in Russian subjects with type 2 diabetes receiving oral hypoglycemic medication. Methods: In a randomized, cross-over design, 168 eligible subjects from 11 study centers consumed, in a random order, the DSF (230 mL) or a common light hospital breakfast (i.e. standard meal) on two different occasions. The amounts of macronutrients were similar between the two meals providing ~200 kcal, 11 g protein, 26 g carbohydrate and 8 g fat. Capillary glucose levels were measured at baseline (before meal consumption), and post-meal consumption at 30, 60, 90, 120, 180 and 240 min. Results: The DSF was well tolerated in all subjects. There were 111 subjects completed the study per protocol (mean ± SEM: age: 58.6 ± 0.8 yr, BMI: 31.8 ± 0.42 kg/m2, waist circumference: 101 ± 1.3 cm, HbA1c: 8.0% ± 0.1%). Glucose levels reached peak values at 60 min (median) and the lowest levels at the end of the 240-min MTT test. The mean positive area under the curve (PAUC), the primary outcome, was significantly smaller after DSF consumption (mean ± SEM: 183.02 ± 18.74, median: 132.55) than the PAUC after consumption of the standard meal (mean ± SEM: 239.95 ± 23.11, median: 166.89;p = 0.027). The actual and adjusted peak glucose concentrations were similar between the two treatments. Conclusions: In patients with type 2 diabetes receiving oral hypoglycemic agents, compared to a hospital meal, the DSF improves postprandial glucose control. Combining results from earlier studies, long-term use of DSF may be beneficial to improve glucose management and decrease diabetes-associated complications.展开更多
There is quite abundant resource of ludwigite ore in Liaoning Province of China. Content of MgO in the slag of pyrometallurgical separation of boron from iron is much higher than that in the ordinary slags. Through th...There is quite abundant resource of ludwigite ore in Liaoning Province of China. Content of MgO in the slag of pyrometallurgical separation of boron from iron is much higher than that in the ordinary slags. Through the equilibrium partition ratio of sulfur L S between the metal and the slag in an atmosphere of CO N 2, the acidic coefficients for B 2O 3 and the basic coefficients for MgO were estimated. The basic formulae were given for the blast furnace type slag containing B 2O 3 and high MgO.展开更多
基金supported by grants from the National Natural Science Foundation of China(No.81273683)the Foundation of Hubei Provincial Health Department(No.2012Z-Y04)
文摘The effect of Fructus Mume formula and its separated prescription extract on insulin resis- tance in type 2 diabetic rats was investigated. The rat model of type 2 diabetes was established by feed- ing on a high-fat diet for 8 weeks and by subsequently intravenous injection of small doses of strepto- zotocin. Rats in treatment groups, including the Fructus Mume formula treatment group （FM）, the cold property herbs of Fructus Mume formula treatment group （CFM）, the warm property herbs of Fructus Mume formula treatment group （WFM）, were administrated with Fructus Mume formula and its sepa- rated prescription extract by gavage, while the rats in diabetic model group （DM） and metformin group （MET） were given by gavage with normal saline and metformin correspondingly. The body weight be- fore and after treatment was measured, and the oral glucose tolerance test （OGTT） and the insulin re- lease test （IRT） were performed. The homeostasis model assessment-insulin resistance index （HOMA-IR） was calculated. The protein and mRNA expression levels of Insr, β-arrestin-2, Its-1 and Glut-4 in the liver, skeletal muscle and fat tissues were detected by using Western blotting and RT-PCR respectively. The results demonstrated that, as compared with DM group, OGTT, IRT （0 h, 1 h） levels and HOMR-IR in treatment groups were all reduced, meanwhile their protein and mRNA expression levels of Insr, Irs-1 and Glut-4 in the liver, skeletal muscle and fat tissues were obviously increased, and their protein and mRNA expression levels of β-arrestin-2 in the liver and skeletal muscle tissues were also markedly increased. It was suggested that the Fructus Mume formula and its separated prescription extracts could effectively improve insulin resistance in type 2 diabetic rats, which might be related to the up-regulated expression of Insr, Irs-1 and Glut-4 in the liver, skeletal muscle and fat tissues, and β-arrestin-2 in the liver and skeletal muscle tissues.
基金Supported by the National Natural Science Foundation of China (10471107)
文摘Under the foundation of Cauchy integral formula on certain distinguished boundary for functions with values in universal Clifford algebra, we define the Cauchy type integral with values in a universal Clifford algebra, obtain its Cauchy principal value and Plemelj formula on certain distinguished boundary.
文摘A generalized Gauss-type quadrature formula is introduced, which assists in selection of collocation points in pseudospectral method for differential equations with two-point derivative boundary conditions. Some results on the related Jacobi interpolation are established. A pseudospectral scheme is proposed for the Kuramoto-Sivashisky equation. A skew symmetric decomposition is used for dealing with the nonlinear convection term. The stability and convergence of the proposed scheme are proved. The error estimates are obtained. Numerical results show the efficiency of this approach.
文摘Let D be a bounded domain with piecewise C^（1） smooth orientable boundary on Stein manifolds, and let Φ（z） be a Cauchy type integral with Bochner-Martinelli kernel Ω（φ^V, S^-, S） and Holder continuous density function φ（ζ）, the authors define a solid angular coefficient α（t） at the point t∈δD, prove that there exist the interior and outer limit values Φ^±（t） under the meaning of the Cauchy principal value, and obtain the more general Plemelj formula and jump formula.
基金Supported by the National Natural Science Foundation of China(11047030)Supported by the Science and Technology Program of Henan Province(152300410061)
文摘We investigate the highest weight representations of the q-deformed Virasoro algebra of Hom-type. In order to determine its unitarity and irreducible highest weight representations, we present its Kac determinant formula when q is nonzero and non-root of unity.
基金Project supported by the National Natural Science Foundation of China (No. 10271074)
文摘To solve Fredholm integral equations of the second kind, a generalized linear functional is introduced and a new function-valued Padé-type approximation is defined. By means of the power series expansion of the solution, this method can construct an approximate solution to solve the given integral equation. On the basis of the orthogonal polynomials, two useful determinant expressions of the numerator polynomial and the denominator polynomial for Padé-type approximation are explicitly given.
文摘目的:基于上皮细胞-间充质细胞转分化(EMT)学说观察化纤Ⅳ号方、艾灸以及二者相配合治疗肺纤维化大鼠Collagen TypeⅢ(Ⅲ-C)和PDGF的变化,探讨其治疗效应及生物学机制。方法:将鼠龄约为6周的SD大鼠随机分为空白组、模型组、化纤Ⅳ号方组、艾灸组、化纤Ⅳ号方与艾灸配合治疗组(简称为"灸药组"),治疗30 d后处死观察其肺组织病理改变,并检测其Collagen TypeⅢ、PDGF的基因和蛋白表达情况。结果:实时荧光定量结果显示:与空白组相比,各组Ⅲ-C和PDGF m RNA表达增高(P<0.05)。与模型组相比,各组的Ⅲ-C和PDGF m RNA表达有明显降低(P<0.01)。而各组中,灸药组疗效最明显,Ⅲ-C和PDGF的表达最低。蛋白免疫印迹法检测结果显示:与模型组相比各组的Ⅲ-C蛋白表达有差异。结论:1艾灸、化纤Ⅳ号方均可减轻博莱霉素诱导肺纤维化大鼠的肺纤维化程度。2艾灸配合化纤Ⅳ号方可减轻博莱霉素诱导肺纤维化大鼠的肺纤维化程度,且其效果优于单用艾灸或单用化纤Ⅳ号方。3艾灸、化纤Ⅳ号方及其二者配合使用不同程度阻抑博莱霉素诱导肺纤维化大鼠肺纤维化进程的效应机制,可能与通过调控其EMT过程中的Ⅲ-C和PDGF表达环节紧密相关。
基金Project supported by NNSF of China(10471107)RFDP of Higher Eduction of China(20060486001)
文摘In this article,the authors discussed the boundary behavior for the Cauchy- type integrals with values in a Clifford algebra,obtained some Sochocki–Plemelj formulae and Privalov–Muskhelishvili theorems for the Cauchy-type integral taken over a smooth surface by rather simple method.
文摘With the aid of Mullin-Rota's substitution rule, we show that the Sheffertype differential operators together with the delta operators ? and D could be used to construct a pair of expansion formulas that imply a wide variety of summation formulas in the discrete analysis and combinatorics. A convergence theorem is established for a fruitful source formula that implies more than 20 noted classical fomulas and identities as consequences. Numerous new formulas are also presented as illustrative examples. Finally, it is shown that a kind of lifting process can be used to produce certain chains of(∞~m) degree formulas for m ≥ 3 with m ≡ 1(mod 2) and m ≡ 1(mod 3), respectively.
文摘Background: Postprandial hyperglycemia is an independent risk factor for diabetes-associated complications in individuals with type 2 diabetes. Dietary modification plays an important role in glycemic control. This study was to examine the efficacy of a diabetes specific formula (DSF) during a 4-hour postprandial meal tolerance test (MTT) in Russian subjects with type 2 diabetes receiving oral hypoglycemic medication. Methods: In a randomized, cross-over design, 168 eligible subjects from 11 study centers consumed, in a random order, the DSF (230 mL) or a common light hospital breakfast (i.e. standard meal) on two different occasions. The amounts of macronutrients were similar between the two meals providing ~200 kcal, 11 g protein, 26 g carbohydrate and 8 g fat. Capillary glucose levels were measured at baseline (before meal consumption), and post-meal consumption at 30, 60, 90, 120, 180 and 240 min. Results: The DSF was well tolerated in all subjects. There were 111 subjects completed the study per protocol (mean ± SEM: age: 58.6 ± 0.8 yr, BMI: 31.8 ± 0.42 kg/m2, waist circumference: 101 ± 1.3 cm, HbA1c: 8.0% ± 0.1%). Glucose levels reached peak values at 60 min (median) and the lowest levels at the end of the 240-min MTT test. The mean positive area under the curve (PAUC), the primary outcome, was significantly smaller after DSF consumption (mean ± SEM: 183.02 ± 18.74, median: 132.55) than the PAUC after consumption of the standard meal (mean ± SEM: 239.95 ± 23.11, median: 166.89;p = 0.027). The actual and adjusted peak glucose concentrations were similar between the two treatments. Conclusions: In patients with type 2 diabetes receiving oral hypoglycemic agents, compared to a hospital meal, the DSF improves postprandial glucose control. Combining results from earlier studies, long-term use of DSF may be beneficial to improve glucose management and decrease diabetes-associated complications.
文摘There is quite abundant resource of ludwigite ore in Liaoning Province of China. Content of MgO in the slag of pyrometallurgical separation of boron from iron is much higher than that in the ordinary slags. Through the equilibrium partition ratio of sulfur L S between the metal and the slag in an atmosphere of CO N 2, the acidic coefficients for B 2O 3 and the basic coefficients for MgO were estimated. The basic formulae were given for the blast furnace type slag containing B 2O 3 and high MgO.
