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一种新的ACE抑制剂:Fosinopril
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作者 C.Dash 李志雄 《德国医学》 CAS 1994年第2期71-71,共1页
八十年代初 Captopril 的临床使用开创了 ACE抑制剂应用的新纪元。目前一种新的 ACE 抑制剂Fosinopril 已在临床应用。本文阐述此药的药理学特点和应用。药理学特点 Fosinopril 结构上的特点是分子中有一个磷化氢基因(O-P-O^-)。ACE
关键词 ACE 抑制剂 FOSINOPRIL 临床应用
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Fosinopril对原发性高血压病人即刻及短期...
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作者 郑敏秀 陈红 《中国新药杂志》 CAS CSCD 1993年第1期17-20,共4页
<正> 血管紧张素转换酶抑制剂(ACEI)治疗原发性高血压是安全有效的,它可以逆转某些与疾病相关的病理生理改变。Fosinopril 是第一个含磷的 ACEI。它是一个前体药,需在肝及胃肠道脱脂后,才能形成为有活性的二酸 Fosino-prilat,其... <正> 血管紧张素转换酶抑制剂(ACEI)治疗原发性高血压是安全有效的,它可以逆转某些与疾病相关的病理生理改变。Fosinopril 是第一个含磷的 ACEI。它是一个前体药,需在肝及胃肠道脱脂后,才能形成为有活性的二酸 Fosino-prilat,其后被肝及肾脏代谢。本研究是评价 Fosinopril(SQ28,555)对轻。 展开更多
关键词 FOSINOPRIL 高血压 心血管效应
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Effects of fosinopril and valsartan on expressions of ICAM-1 and NO in human umbilical vein endothelial cells 被引量:12
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作者 管思明 王斌 《Chinese Medical Journal》 SCIE CAS CSCD 2003年第6期923-927,共5页
Objective To investigate the effects of fosinopril and valsartan on the expression of intercellular adhesion molecule-1 (ICAM-1) and nitric oxide (NO) induced by oxidized low-density lipoprotein (ox-LDL) in human umbi... Objective To investigate the effects of fosinopril and valsartan on the expression of intercellular adhesion molecule-1 (ICAM-1) and nitric oxide (NO) induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells.Methods The levels of NO, ICAM-1, and nitric oxide synthase (NOS) were determined using the nitrate reductase method, ELISA, immunohistochemical and image analyses.Results The ox-LDL can significantly increase the expression of ICAM-1 and inhibit the expression of NO and NOS in a dose-dependent manner. Fosinopril and valsartan can significantly inhibit these roles of ox-LDL. The roles of fosinopril and valsartan were not significantly different.Conclusion Fosinopril and valsartan inhibit oxidized LDL-induced expression of ICAM-1 and increase the expression of NO in human umbilical vein endothelial cells, which is one of the mechanisms of antiatherosclerosis. 展开更多
关键词 fosinopril·valsartan·atherosclerosis·ICAM-1·nitric oxide
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