Two new Mannich and Schiff base ligands namely： （1-（3＇-amino-methyl-1＇（H）-1＇,2＇,4＇-triazole）-3-（1＇（H）-l＇,2＇,4＇- triazole-3＇-yl） iminoisatin （Lt） and l-morpholinomethyl-3-（1＇（H）-1＇,2＇,4＇-tr...Two new Mannich and Schiff base ligands namely： （1-（3＇-amino-methyl-1＇（H）-1＇,2＇,4＇-triazole）-3-（1＇（H）-l＇,2＇,4＇- triazole-3＇-yl） iminoisatin （Lt） and l-morpholinomethyl-3-（1＇（H）-1＇,2＇,4＇-triazolyl）iminoisatin （LII） were prepared from condensation reaction of the new Schiff base 3-（l＇（H）-l＇,2＇,4＇-triazole-3＇-yl）iminoisatin （SBH） （0.01 mol） with formaldehyde and 3-amino-l,2,4-triazole （3-At） or with formaldehyde and morpholine （0.01 mole each） respectively. Structures were characterized by tH NMR, CHN analyses, mass spectra and IR spectra. Metal complexes were synthesized by heating each ligand （0.02 mo with metal salts （0.01 moo in ethanol or ethanol： acetone mixture respectively. The formula of metal complexes were suggested depending on CHN and thermal analyses, metal and chloride contents, IR and UV-visible spectra, magnetic moments （laefr） and conductivity measurements. All complexes were of octahedral geometry except palladium （II） complexes which were square planar. The two ligands and some selected metal complexes showed various antibacterial and cytotoxic effects.展开更多
A series of Mannich bases were synthesized by a three-component Mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential an...A series of Mannich bases were synthesized by a three-component Mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential antibacterial effects of the synthesized compounds were investigated using standard bacterial strains： Gram-positive and Gram-negative bacteria. Interestingly, all the synthesized compounds were observed to be promising leads, possessing moderate to significant inhibitory activity as compared to standard.展开更多
A series of new methyl-4-（（substituted phenyl）[6H-indolo（2,3-b）quinoxalin-6yl]methylamino）benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial strains....A series of new methyl-4-（（substituted phenyl）[6H-indolo（2,3-b）quinoxalin-6yl]methylamino）benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial strains.Among the screened compounds 2e-2g exhibited potent inhibitory activity compared to standard drug employed,worth further investigation.展开更多
文摘Two new Mannich and Schiff base ligands namely： （1-（3＇-amino-methyl-1＇（H）-1＇,2＇,4＇-triazole）-3-（1＇（H）-l＇,2＇,4＇- triazole-3＇-yl） iminoisatin （Lt） and l-morpholinomethyl-3-（1＇（H）-1＇,2＇,4＇-triazolyl）iminoisatin （LII） were prepared from condensation reaction of the new Schiff base 3-（l＇（H）-l＇,2＇,4＇-triazole-3＇-yl）iminoisatin （SBH） （0.01 mol） with formaldehyde and 3-amino-l,2,4-triazole （3-At） or with formaldehyde and morpholine （0.01 mole each） respectively. Structures were characterized by tH NMR, CHN analyses, mass spectra and IR spectra. Metal complexes were synthesized by heating each ligand （0.02 mo with metal salts （0.01 moo in ethanol or ethanol： acetone mixture respectively. The formula of metal complexes were suggested depending on CHN and thermal analyses, metal and chloride contents, IR and UV-visible spectra, magnetic moments （laefr） and conductivity measurements. All complexes were of octahedral geometry except palladium （II） complexes which were square planar. The two ligands and some selected metal complexes showed various antibacterial and cytotoxic effects.
文摘A series of Mannich bases were synthesized by a three-component Mannich reaction. The newly synthesized compounds were well characterized by elemental analyses, IR, NMR and mass spectroscopic studies. The potential antibacterial effects of the synthesized compounds were investigated using standard bacterial strains： Gram-positive and Gram-negative bacteria. Interestingly, all the synthesized compounds were observed to be promising leads, possessing moderate to significant inhibitory activity as compared to standard.
文摘A series of new methyl-4-（（substituted phenyl）[6H-indolo（2,3-b）quinoxalin-6yl]methylamino）benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial strains.Among the screened compounds 2e-2g exhibited potent inhibitory activity compared to standard drug employed,worth further investigation.
