AIM To assess the efficacy and safety of fourth-generation quinolones for helicobacter pylori(h. pylori) eradication, we conducted this systematic review and metaanalysis of randomized clinical trials. METHODS Major l...AIM To assess the efficacy and safety of fourth-generation quinolones for helicobacter pylori(h. pylori) eradication, we conducted this systematic review and metaanalysis of randomized clinical trials. METHODS Major literature databases(Pub Med, EMBASE and the Cochrane Central Register of Controlled Trials) were searched for relevant articles published prior to February 2018. We performed a meta-analysis of all randomized clinical trials that examined the efficacy of h. pylori eradication therapies and included fourthgeneration quinolones in the experimental arm. Subgroup analyses by regions and different types of fourth-generation quinolones were also performed.RESULTS Ten studies including a total of 2198 patients were assessed. A meta-analysis of randomized controlled trials showed that the eradication rate of therapies containing non-fourth-generation quinolones was significantly lower than that of therapies containing fourth-generation quinolones by intention-to-treat(ITT) analysis [75.4% vs 81.8%; odds ratio(OR) = 0.661; 95% confidence interval(CI): 0.447-0.977; P = 0.038]. This analysis also showed that the eradication rate of the therapies containing non-fourth-generation quinolones was inferior to that of therapies containing fourth-generation quinolones by perprotocol analysis(79.1% vs 84.7%; OR = 0.663; 95%CI: 0.433-1.016; P = 0.059). Moreover, the occurrence of side effects was significantly different between the control and experimental groups by ITT analysis(30.6% vs 19.5%; OR = 1.874; 95%CI: 1.120-3.137; P = 0.017). The sub-analyses also showed significant differences in moxifloxacin therapies vs other fourth-generation quinolone therapies(84.3% vs 71.9%) and in Asian vs European groups(76.7% vs 89.1%).CONCLUSION Therapies containing fourth-generation quinolones achieved a poor eradication rate in the treatment of h. pylori infection. Such regimens might be useful as a rescue treatment based on antimicrobial susceptibility testing. Different antibiotics should be chosen in different regions.展开更多
We retrospectively evaluated the efficacy and safety of the combination drug piperacillin/tazobactam (PIPC/TAZ) in comparison with those of fourth-generation cephalosporins (4th Cephs) as initial empirical treatment i...We retrospectively evaluated the efficacy and safety of the combination drug piperacillin/tazobactam (PIPC/TAZ) in comparison with those of fourth-generation cephalosporins (4th Cephs) as initial empirical treatment in hematological malignancies patients with febrile neutropenia (FN). Among 200 patients assessed in this study, 49 had received PIPC/TAZ and 151 4th Cephs. Patient background characteristics were comparable between the two treatment groups. The overall efficacy rate in those receiving 4th Cephs and PIPC/TAZ was 57.0% (86/151 patients) and 59.2% (29/49 patients), respectively, with no significant difference detected between the two treatment regimens (P = 0.78). Treat-ment did not need to be discontinued or interrupted due to development of adverse drug reactions in any of the patients. Therefore in this study the efficacy and safety of PIPC/TAZ as initial antimicrobial treatment for FN in patients with hematological malignancies were not inferior to those of 4th Cephs. Based on the preliminary data obtained in this study, we propose to conduct a multicenter, prospective, controlled study to compare PIPC/TAZ versus CFPM given as empirical antimicrobial treatment against FN in patients with hematological malignancies.展开更多
From May 25 to October 7,2024,L’éCOLE China,School of Jewelry Arts(supported by Van Cleef & Arpels) presents the "Garden of Emeralds" exhibition in its Shanghai campus.As part of the "Discover...From May 25 to October 7,2024,L’éCOLE China,School of Jewelry Arts(supported by Van Cleef & Arpels) presents the "Garden of Emeralds" exhibition in its Shanghai campus.As part of the "Discover the Gemstones" series,the exhibition gives pride to this green precious mineral and explores its history in many regions of the world,from Asia to Europe including the Middle East.Gathering both raw stones and pieces of jewelry from museum collections and private lenders,it addresses the topic through the three main pillars of L’éCOLE:gemmology,savoir-faire and the history of jewelry.展开更多
THRONGS of shoppers,in a department store adorned with colorful Spring Festival posters,vying to try their hand either at Chinese calligraphy or traditional Chinese lantern-making,might seem incongruous in a European ...THRONGS of shoppers,in a department store adorned with colorful Spring Festival posters,vying to try their hand either at Chinese calligraphy or traditional Chinese lantern-making,might seem incongruous in a European setting.The background to this vibrant scenario was The Point,Malta’s largest shopping mall,as part of the island country’s 2023 Chinese New Year celebrations,courtesy of the China Cultural Center in Malta.展开更多
Turning five years old,the Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences(CAS)strives to play a pivotal role in boosting interdisciplinary research on the interface between innovation and medical scie...Turning five years old,the Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences(CAS)strives to play a pivotal role in boosting interdisciplinary research on the interface between innovation and medical science.As we peel back the layers of this cutting-edge institution,who better to guide us than its visionary director,Prof.TAN Weihong?In this exclusive interview with HIM Director Prof.TAN Weihong,who is also a CAS Member,we can grasp an idea of its unique position in China’s scientific landscape,its major achievements,and its ambitious roadmap to excellence.展开更多
This research aims to measure the current gender representation in membership of boards of directors,and to study the factors affecting the presence of women on boards.The results of the study will support the decisio...This research aims to measure the current gender representation in membership of boards of directors,and to study the factors affecting the presence of women on boards.The results of the study will support the decision makers and policy makers at all levels by providing knowledge that contributes to bridging the current gap in participation of women boards.The methodology used in this research is the descriptive analytical approach,which relies on quantitative methods in the process of collecting and analyzing data.This study represents the boards of directors in the three sectors(public,private,and non-profit)in the Kingdom of Saudi Arabia,The study sample contained 350 targets,where a random sample of 150 people in the public sector,100 people in the private sector,and 100 people in the non-profit sector were selected.The research result found that the majority of the responses believe that the lack of experience and training,and social factors,are the most impact areas of explaining the reasons for the existence of a gap in women’s membership in boards of directors in the three sectors.And the most important reasons for the existence of a gender gap in board membership are:there is no statutory minimum percentage for women’s representation on boards of directors,and scarcity of female competencies in general,and the lack of women occupying leadership positions.展开更多
基金Supported by the Graduate Innovation Project of Nanchang University,No.CX2017213 and No.CX2017251the National Natural Science Foundation of China,No.81460115the Science and Technology Projects of Jiangxi Province,No.2014BBG70019
文摘AIM To assess the efficacy and safety of fourth-generation quinolones for helicobacter pylori(h. pylori) eradication, we conducted this systematic review and metaanalysis of randomized clinical trials. METHODS Major literature databases(Pub Med, EMBASE and the Cochrane Central Register of Controlled Trials) were searched for relevant articles published prior to February 2018. We performed a meta-analysis of all randomized clinical trials that examined the efficacy of h. pylori eradication therapies and included fourthgeneration quinolones in the experimental arm. Subgroup analyses by regions and different types of fourth-generation quinolones were also performed.RESULTS Ten studies including a total of 2198 patients were assessed. A meta-analysis of randomized controlled trials showed that the eradication rate of therapies containing non-fourth-generation quinolones was significantly lower than that of therapies containing fourth-generation quinolones by intention-to-treat(ITT) analysis [75.4% vs 81.8%; odds ratio(OR) = 0.661; 95% confidence interval(CI): 0.447-0.977; P = 0.038]. This analysis also showed that the eradication rate of the therapies containing non-fourth-generation quinolones was inferior to that of therapies containing fourth-generation quinolones by perprotocol analysis(79.1% vs 84.7%; OR = 0.663; 95%CI: 0.433-1.016; P = 0.059). Moreover, the occurrence of side effects was significantly different between the control and experimental groups by ITT analysis(30.6% vs 19.5%; OR = 1.874; 95%CI: 1.120-3.137; P = 0.017). The sub-analyses also showed significant differences in moxifloxacin therapies vs other fourth-generation quinolone therapies(84.3% vs 71.9%) and in Asian vs European groups(76.7% vs 89.1%).CONCLUSION Therapies containing fourth-generation quinolones achieved a poor eradication rate in the treatment of h. pylori infection. Such regimens might be useful as a rescue treatment based on antimicrobial susceptibility testing. Different antibiotics should be chosen in different regions.
文摘We retrospectively evaluated the efficacy and safety of the combination drug piperacillin/tazobactam (PIPC/TAZ) in comparison with those of fourth-generation cephalosporins (4th Cephs) as initial empirical treatment in hematological malignancies patients with febrile neutropenia (FN). Among 200 patients assessed in this study, 49 had received PIPC/TAZ and 151 4th Cephs. Patient background characteristics were comparable between the two treatment groups. The overall efficacy rate in those receiving 4th Cephs and PIPC/TAZ was 57.0% (86/151 patients) and 59.2% (29/49 patients), respectively, with no significant difference detected between the two treatment regimens (P = 0.78). Treat-ment did not need to be discontinued or interrupted due to development of adverse drug reactions in any of the patients. Therefore in this study the efficacy and safety of PIPC/TAZ as initial antimicrobial treatment for FN in patients with hematological malignancies were not inferior to those of 4th Cephs. Based on the preliminary data obtained in this study, we propose to conduct a multicenter, prospective, controlled study to compare PIPC/TAZ versus CFPM given as empirical antimicrobial treatment against FN in patients with hematological malignancies.
文摘From May 25 to October 7,2024,L’éCOLE China,School of Jewelry Arts(supported by Van Cleef & Arpels) presents the "Garden of Emeralds" exhibition in its Shanghai campus.As part of the "Discover the Gemstones" series,the exhibition gives pride to this green precious mineral and explores its history in many regions of the world,from Asia to Europe including the Middle East.Gathering both raw stones and pieces of jewelry from museum collections and private lenders,it addresses the topic through the three main pillars of L’éCOLE:gemmology,savoir-faire and the history of jewelry.
文摘THRONGS of shoppers,in a department store adorned with colorful Spring Festival posters,vying to try their hand either at Chinese calligraphy or traditional Chinese lantern-making,might seem incongruous in a European setting.The background to this vibrant scenario was The Point,Malta’s largest shopping mall,as part of the island country’s 2023 Chinese New Year celebrations,courtesy of the China Cultural Center in Malta.
文摘Turning five years old,the Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences(CAS)strives to play a pivotal role in boosting interdisciplinary research on the interface between innovation and medical science.As we peel back the layers of this cutting-edge institution,who better to guide us than its visionary director,Prof.TAN Weihong?In this exclusive interview with HIM Director Prof.TAN Weihong,who is also a CAS Member,we can grasp an idea of its unique position in China’s scientific landscape,its major achievements,and its ambitious roadmap to excellence.
文摘This research aims to measure the current gender representation in membership of boards of directors,and to study the factors affecting the presence of women on boards.The results of the study will support the decision makers and policy makers at all levels by providing knowledge that contributes to bridging the current gap in participation of women boards.The methodology used in this research is the descriptive analytical approach,which relies on quantitative methods in the process of collecting and analyzing data.This study represents the boards of directors in the three sectors(public,private,and non-profit)in the Kingdom of Saudi Arabia,The study sample contained 350 targets,where a random sample of 150 people in the public sector,100 people in the private sector,and 100 people in the non-profit sector were selected.The research result found that the majority of the responses believe that the lack of experience and training,and social factors,are the most impact areas of explaining the reasons for the existence of a gap in women’s membership in boards of directors in the three sectors.And the most important reasons for the existence of a gender gap in board membership are:there is no statutory minimum percentage for women’s representation on boards of directors,and scarcity of female competencies in general,and the lack of women occupying leadership positions.
