Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the c...Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by im- munohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxO1 is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.展开更多
叉头框蛋白M1 （forkhead box protein M1,FoxM1）是Fox蛋白家族的成员,是典型的增殖相关转录因子.已有大量的研究证实,FoxM1在多种肿瘤的发生、细胞增殖、侵袭、转移和血管生成等诸多方面发挥重要作用.胰腺癌是目前所知恶性程度最高的...叉头框蛋白M1 （forkhead box protein M1,FoxM1）是Fox蛋白家族的成员,是典型的增殖相关转录因子.已有大量的研究证实,FoxM1在多种肿瘤的发生、细胞增殖、侵袭、转移和血管生成等诸多方面发挥重要作用.胰腺癌是目前所知恶性程度最高的肿瘤之一,近年来,其发病率逐年上升,在肿瘤相关性死因中居第4位.展开更多
基金Project supported by the National Basic Research Program (973) of China (No. 2004CB117500) and the National Natural Science Foun-dation of China (Nos. 30571335 and 330471253)
文摘Forkhead box (Fox) proteins play critical roles in the regulation of differentiation, proliferation, immunity and aging of cells. Most studies on Fox proteins are limited to cultured cells and rodent. The aim of the current study is to detect by im- munohistrochemistry whether FoxO1, FoxO3a and FoxO4 proteins are localized in the stomach and intestine of the pig. The results showed that FoxO4 exists in the mucosa in all parts of the stomach and intestine; FoxO3a exists mainly in the lamina propria and muscularis of some parts. However, FoxO1 is not detectable in all parts of the stomach and intestine. Collectively, the results of the present study indicate that there exists a distinct expression pattern of Fox proteins, and that FoxO4 is a primary forkhead transcriptional factor localized in the gastrointestinal tracts of the pig.
文摘叉头框蛋白M1 （forkhead box protein M1,FoxM1）是Fox蛋白家族的成员,是典型的增殖相关转录因子.已有大量的研究证实,FoxM1在多种肿瘤的发生、细胞增殖、侵袭、转移和血管生成等诸多方面发挥重要作用.胰腺癌是目前所知恶性程度最高的肿瘤之一,近年来,其发病率逐年上升,在肿瘤相关性死因中居第4位.
