Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

This study focuses on the dynamics of drug concentration in the blood.In general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential equation.More precisely,it is solved through an initial value problem.We proposed a newmodeling technique for studying drug concentration in blood dynamics.This technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio derivatives.We first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing solution.The proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point techniques.Stability via theUlam-Hyers(UH)technique was also investigated.The application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this study.Indeed,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of 1.00360.Caputo-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of 0.43532.For the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of 0.07299.Another interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

Three Kinds of Discrete Formulae for the Caputo Fractional Derivative

In this paper,three kinds of discrete formulae for the Caputo fractional derivative are studied,including the modified L1 discretisation forα∈(O,1),and L2 discretisation and L2C discretisation forα∈(1,2).The truncation error estimates and the properties of the coeffcients of all these discretisations are analysed in more detail.Finally,the theoretical analyses areverifiedby thenumerical examples.

Fractional cyclic integrals and Routh equations of fractional Lagrange system with combined Caputo derivatives

In this paper, we develop a fractional cyclic integral and a Routh equation for fractional Lagrange system defined in terms of fractional Caputo derivatives. The fractional Hamilton principle and the fractional Lagrange equations of the system are obtained under a combined Caputo derivative. Furthermore, the fractional cyclic integrals based on the Lagrange equations are studied and the associated Routh equations of the system are presented. Finally, two examples are given to show the applications of the results.

A High Order Formula to Approximate the Caputo Fractional Derivative

We present here a high-order numerical formula for approximating the Caputo fractional derivative of order𝛼for 0<α<1.This new formula is on the basis of the third degree Lagrange interpolating polynomial and may be used as a powerful tool in solving some kinds of fractional ordinary/partial diff erential equations.In comparison with the previous formulae,the main superiority of the new formula is its order of accuracy which is 4−α,while the order of accuracy of the previous ones is less than 3.It must be pointed out that the proposed formula and other existing formulae have almost the same computational cost.The eff ectiveness and the applicability of the proposed formula are investigated by testing three distinct numerical examples.Moreover,an application of the new formula in solving some fractional partial diff erential equations is presented by constructing a fi nite diff erence scheme.A PDE-based image denoising approach is proposed to demonstrate the performance of the proposed scheme.

A New Scheme of the ARA Transform for Solving Fractional-Order Waves-Like Equations Involving Variable Coefficients

The goal of this research is to develop a new,simplified analytical method known as the ARA-residue power series method for obtaining exact-approximate solutions employing Caputo type fractional partial differential equations(PDEs)with variable coefficient.ARA-transform is a robust and highly flexible generalization that unifies several existing transforms.The key concept behind this method is to create approximate series outcomes by implementing the ARA-transform and Taylor’s expansion.The process of finding approximations for dynamical fractional-order PDEs is challenging,but the ARA-residual power series technique magnifies this challenge by articulating the solution in a series pattern and then determining the series coefficients by employing the residual component and the limit at infinity concepts.This approach is effective and useful for solving a massive class of fractional-order PDEs.Five appealing implementations are taken into consideration to demonstrate the effectiveness of the projected technique in creating solitary series findings for the governing equations with variable coefficients.Additionally,several visualizations are drawn for different fractional-order values.Besides that,the estimated findings by the proposed technique are in close agreement with the exact outcomes.Finally,statistical analyses further validate the efficacy,dependability and steady interconnectivity of the suggested ARA-residue power series approach.

A Hybrid ESA-CCD Method for Variable-Order Time-Fractional Diffusion Equations

In this paper, we study the solutions for variable-order time-fractional diffusion equations. A three-point combined compact difference (CCD) method is used to discretize the spatial variables to achieve sixth-order accuracy, while the exponential-sum-approximation (ESA) is used to approximate the variable-order Caputo fractional derivative in the temporal direction, and a novel spatial sixth-order hybrid ESA-CCD method is implemented successfully. Finally, the accuracy of the proposed method is verified by numerical experiments.

Fuzzy computational study on the generalized fractional smoking model with caputo gH-type derivatives

This work considers a generalized fuzzy fractional smoking model with Caputo gHtypes fractional derivatives upon considering the case of uncertainty quantification.The disease-free equilibrium point and stability of the equilibrium point have been discussed for the fuzzy nonlinear fractional smoking model.The analytical proofs for the existence and uniqueness of the proposed model are concerned with the help of the fixed-point theorem,Banach contraction,and Schauder theorem.A robust double parametric approach with a generalized transform is used to study the behavior of the fuzzy fractional model in an uncertain context and obtain the convergence analysis of the study in a crisp context.Finally,the obtained results of the proposed model have been validated with the Runge-Kutta method of fourth order in crisp case(s=1,l=O).

A NONLOCAL HYBRID BOUNDARY VALUE PROBLEM OF CAPUTO FRACTIONAL INTEGRO-DIFFERENTIAL EQUATIONS

In this paper, we discuss the existence of solutions for a nonlocal hybrid boundary value problem of Caputo fractional integro-differential equations. Our main result is based on a hybrid fixed point theorem for a sum of three operators due to Dhage, and is well illustrated with the aid of an example.

Fractional derivative multivariable grey model for nonstationary sequence and its application

Most of the existing multivariable grey models are based on the 1-order derivative and 1-order accumulation, which makes the parameters unable to be adjusted according to the data characteristics of the actual problems. The results about fractional derivative multivariable grey models are very few at present. In this paper, a multivariable Caputo fractional derivative grey model with convolution integral CFGMC(q, N) is proposed. First, the Caputo fractional difference is used to discretize the model, and the least square method is used to solve the parameters. The orders of accumulations and differential equations are determined by using particle swarm optimization(PSO). Then, the analytical solution of the model is obtained by using the Laplace transform, and the convergence and divergence of series in analytical solutions are also discussed. Finally, the CFGMC(q, N) model is used to predict the municipal solid waste(MSW). Compared with other competition models, the model has the best prediction effect. This study enriches the model form of the multivariable grey model, expands the scope of application, and provides a new idea for the development of fractional derivative grey model.

ON A COUPLED INTEGRO-DIFFERENTIAL SYSTEM INVOLVING MIXED FRACTIONAL DERIVATIVES AND INTEGRALS OF DIFFERENT ORDERS

By applying the standard fixed point theorems,we prove the existence and uniqueness results for a system of coupled differential equations involving both left Caputo and right Riemann-Liouville fractional derivatives and mixed fractional integrals,supplemented with nonlocal coupled fractional integral boundary conditions.An example is also constructed for the illustration of the obtained results.

Analysis of anomalous transport with temporal fractional transport equations in a bounded domain

Anomalous transport in magnetically confined plasmas is investigated using temporal fractional transport equations.The use of temporal fractional transport equations means that the order of the partial derivative with respect to time is a fraction. In this case, the Caputo fractional derivative relative to time is utilized, because it preserves the form of the initial conditions. A numerical calculation reveals that the fractional order of the temporal derivative α(α ∈(0, 1), sub-diffusive regime) controls the diffusion rate. The temporal fractional derivative is related to the fact that the evolution of a physical quantity is affected by its past history, depending on what are termed memory effects. The magnitude of α is a measure of such memory effects. When α decreases, so does the rate of particle diffusion due to memory effects. As a result,if a system initially has a density profile without a source, then the smaller the α is, the more slowly the density profile approaches zero. When a source is added, due to the balance of the diffusion and fueling processes, the system reaches a steady state and the density profile does not evolve. As α decreases, the time required for the system to reach a steady state increases. In magnetically confined plasmas, the temporal fractional transport model can be applied to off-axis heating processes. Moreover, it is found that the memory effects reduce the rate of energy conduction and hollow temperature profiles can be sustained for a longer time in sub-diffusion processes than in ordinary diffusion processes.

A Study on the Nonlinear Caputo-Type Snakebite Envenoming Model with Memory

In this article,we introduce a nonlinear Caputo-type snakebite envenoming model with memory.The well-known Caputo fractional derivative is used to generalize the previously presented integer-order model into a fractionalorder sense.The numerical solution of the model is derived from a novel implementation of a finite-difference predictor-corrector(L1-PC)scheme with error estimation and stability analysis.The proof of the existence and positivity of the solution is given by using the fixed point theory.From the necessary simulations,we justify that the first-time implementation of the proposedmethod on an epidemicmodel shows that the scheme is fully suitable and time-efficient for solving epidemic models.This work aims to show the novel application of the given scheme as well as to check how the proposed snakebite envenoming model behaves in the presence of the Caputo fractional derivative,including memory effects.

Approximate solutions to fractional differential equations

In this paper, the time-fractional coupled viscous Burgers' equation(CVBE)and Drinfeld-Sokolov-Wilson equation(DSWE) are solved by the Sawi transform coupled homotopy perturbation method(HPM). The approximate series solutions to these two equations are obtained. Meanwhile, the absolute error between the approximate solution given in this paper and the exact solution given in the literature is analyzed. By comparison of the graphs of the function when the fractional order α takes different values, the properties of the equations are given as a conclusion.

Impact of vaccination on the dynamics of COVID-19:A mathematical study using fractional derivatives

Arrival of a new disease marks a yearlong destruction of human lives and economy in general,and if the disease turns out to be a pandemic the loss is frightening.COVID-19 is one such pandemic that has claimed millions of lives till date.There is a suffering throughout the world due to various factors associated with the pandemic,be it loss of livelihoods because of sudden shutdown of companies and lockdown,or loss of lives due to lack of medical aid and inadequate vaccination supplies.In this study,we develop a six-compartmental epidemiological model incorporating vaccination.The motivation behind the study is to analyze the significance of higher vaccination efficacy and higher rate of population getting vaccinated in controlling the rise in infectives and thereby the untimely demise of various individuals.The work begins with an ordinary differential equation model followed by stability analysis of the same,after which a fractional-order derivative model of the same is formulated and the existence of uniformly stable solution for the system is proved.In addition to this,we present the stability of the equilibria in general for the fractional model framed.The sensitivity analysis of the basic reproduction number along with its correlation with various parameters is presented.In addition to this,sensitivity of certain state variables in the fractional model with respect to different.fractional orders as well with respect to different infection rate is exhibited in this work.Factors related to lockdown and usage of face shields are incorporated in the entire study,and importance of these is highlighted in the study as well.The major takeaway from the study is that mere vaccination will not sufice in eradication of the virus.The vaccine efficacy plays a major role along with other intervention included in the model.The numerical simulations are carried out in MATLAB software using ode45 and fdel2.

EXISTENCE OF SOLUTION FOR BOUNDARY VALUE PROBLEM OF NONLINEAR FRACTIONAL DIFFERENTIAL EQUATION

This paper is concerned with the boundary value problem of a nonlinear fractional differential equation. By means of Schauder fixed-point theorem, an existence result of solution is obtained.

FRACTIONAL INTEGRAL INEQUALITIES AND THEIR APPLICATIONS TO FRACTIONAL DIFFERENTIAL EQUATIONS

In this paper, first we obtain some new fractional integral inequalities. Then using these inequalities and fixed point theorems, we prove the existence of solutions for two different classes of functional fractional differential equations.

Fractional Cattaneo heat equation in a semi-infinite medium

To better describe the phenomenon of non-Fourier heat conduction, the fractional Cattaneo heat equation is introduced from the generalized Cattaneo model with two fractional derivatives of different orders. The anomalous heat conduction under the Neumann boundary condition in a semi-infinity medium is investigated. Exact solutions are obtained in series form of the H-function by using the Laplace transform method. Finally, numerical examples are presented graphically when different kinds of surface temperature gradient are given. The effects of fractional parameters are also discussed.

General solutions to a class of time fractional partial differential equations

A class of time fractional partial differential equations is considered, which in- cludes a time fractional diffusion equation, a time fractional reaction-diffusion equation, a time fractional advection-diffusion equation, and their corresponding integer-order partial differential equations. The fundamental solutions to the Cauchy problem in a whole-space domain and the signaling problem in a half-space domain are obtained by using Fourier- Laplace transforms and their inverse transforms. The appropriate structures of the Green functions are provided. On the other hand, the solutions in the form of a series to the initial and boundary value problems in a bounded-space domain are derived by the sine- Laplace or cosine-Laplace transforms. Two examples are presented to show applications of the present technique.

New approximate solution for time-fractional coupled KdV equations by generalised differential transform method

In this paper, the genera]ised two-dimensiona] differentia] transform method （DTM） of solving the time-fractiona] coupled KdV equations is proposed. The fractional derivative is described in the Caputo sense. The presented method is a numerical method based on the generalised Taylor series expansion which constructs an analytical solution in the form of a polynomial. An illustrative example shows that the genera]ised two-dimensional DTM is effective for the coupled equations.

Dynamic behavior of fractional order Duffing chaotic system and its synchronization via singly active control

With the increasingly deep studies in physics and technology, the dynamics of fractional order nonlinear systems and the synchronization of fractional order chaotic systems have become the focus in scientific research. In this paper, the dynamic behavior including the chaotic properties of fractional order Duffing systems is extensively inves- tigated. With the stability criterion of linear fractional systems, the synchronization of a fractional non-autonomous system is obtained. Specifically, an effective singly active control is proposed and used to synchronize a fractional order Duffing system. The nu- merical results demonstrate the effectiveness of the proposed methods.