Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study t...Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.展开更多
The performance of clay-pile-pier system under earthquake shaking was comprehensively examined via three-dimensional finite element analyses,in which the complex stress-strain relationships of a clay and piled pier sy...The performance of clay-pile-pier system under earthquake shaking was comprehensively examined via three-dimensional finite element analyses,in which the complex stress-strain relationships of a clay and piled pier system were depicted by a hyperbolic-hysteretic and an equivalent elastoplastic model,respectively.One hundred twenty ground motions with varying peak accelerations were considered,along with the variations in bridge superstructure mass and pile flexural rigidity.Comprehensive comparison studies suggested that peak pile-cap acceleration and peak pile-cap velocity are the optimal ground motion intensity measures for seismic responses of the pier and the pile,respectively.Furthermore,based on two optimal ground motion intensity measures and using curvature ductility to quantify different damage states,seismic fragility analyses were performed.The pier generally had no evident damage except when the bridge girder mass was equal to 960 t,which seemed to be comparatively insensitive to the varying pile flexural rigidity.In comparison,the pile was found to be more vulnerable to seismic damage and its failure probabilities tended to clearly reduce with the increment of pile flexural rigidity,while the influence of the bridge girder mass was relatively minor.展开更多
Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen,leading to the accumulation of advanced glycation end-products(AGEs)cross-links in collagenous tissues.More recently,A...Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen,leading to the accumulation of advanced glycation end-products(AGEs)cross-links in collagenous tissues.More recently,AGEs content has been related to loss of bone quality,independent of bone mass,and increased fracture risk with aging and diabetes.Loss of bone quality is mostly attributed to changes in material properties,structural organization,or cellular remodeling.Though all these factors play a role in bone fragility disease,some common recurring patterns can be found between diabetic and age-related bone fragility.The main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE accumulation.This study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales,collagen deformation mechanisms at the nanoscale,and resistance to bone fracture at the macroscale.展开更多
The deterioration of the performance of offshore bridges is particularly prominent due to the complex natural environment,including the coupling effects of earthquake and seawater erosion.In particular,bridge piers ar...The deterioration of the performance of offshore bridges is particularly prominent due to the complex natural environment,including the coupling effects of earthquake and seawater erosion.In particular,bridge piers are the main energy-consuming and load-bearing components,so that excellent seismic capacity of bridge piers is the key to avoiding bridge damage.Although earthquake resistant behavior of ordinary reinforced concrete bridge piers(ordinary pier)can be improved by increasing the section size and reinforcement ratio of piers,the improvement of the earthquake resistant behavior is limited.To further improve the earthquake resistant behavior of bridge piers,high-tensile reinforcement engineered cementitious composite(ECC)bridge piers are utilized and time-varying seismic fragility analysis are conducted in this study.The refined model of a bridge pier is built by OpenSees.First,the influence of ECC replacement height on pier curvature is analyzed to determine the reasonable ECC height.Then,the time-varying fragility analysis of high-tensile reinforcement ECC piers(ECC composite piers)with durability damage are evaluated considering the time-varying law of materials.Four damage states,slight damage,moderate damage,extensive damage and complete collapse,are utilized in the study.These fragility curves indicate the durability damage can debase the earthquake resistant behavior of piers continually,the exceedance probability of the same state of destruction increases with the increase of peak ground acceleration(PGA)and service time of pier.The results also indicate that the corrosion level of chloride ion to pier is small during the early service period,and the bridge pier vulnerable curve is similar to that of the new bridge pier.As the level of chlorine ion corrosion deepens,transcendental probability is increased.Compared with the ordinary pier,the exceedance probability in each limit state of ECC composite piers is significantly reduced.The proposed ECC composite pies leads to better realistic time-varying earthquake resistant behavior.展开更多
This study focuses on the seismic fragility analysis of arch dams.The multiple stripe analysis(MSA),cloud analysis(CLA),and incremental dynamic analysis(IDA)methods are compared.A comprehensive dam-reservoir-foundatio...This study focuses on the seismic fragility analysis of arch dams.The multiple stripe analysis(MSA),cloud analysis(CLA),and incremental dynamic analysis(IDA)methods are compared.A comprehensive dam-reservoir-foundation rock system,which considers the opening of contraction joints,the nonlinearity of dam concrete and foundation rock,the radiation damping effect of semi-unbounded foundation,and the compressibility of reservoir water,is used as a numerical example.225,80,and 15 earthquake records are selected for MSA,CLA,and IDA,respectively.The results show that MSA provides satisfactory fragility analysis,while both CLA and IDA have assumptions that may lead to deviations.Therefore,MSA is the most reliable method among the three methods and is recommended for the fragility analysis of arch dams.It is also shown that the choice of demand level affects the reliability of fragility curves and the effect of the material uncertainty on the fragility of the dam is not significant.展开更多
The design of columns relies heavily on the basis of Leonhard Euler’s Theory of Elastic Buckling.However,to increase the accuracy in determining the maximum critical load a column can withstand before buckling,a cons...The design of columns relies heavily on the basis of Leonhard Euler’s Theory of Elastic Buckling.However,to increase the accuracy in determining the maximum critical load a column can withstand before buckling,a constant was introduced.This dimensionless coefficient is K,also known as the effective-length factor.This constant is often found in building design codes and varies in value depending on the type of column support that is applied.This paper presents experimental and analytical studies on the determination of the effective-length factor in the buckling stability of columns with partially-fixed support conditions.To this end,the accurate K value of the columns tested by the Instron Testing Machine(ITM)at California State University,Northridge’s(CSUN’s)Mechanics Laboratory is determined.The ITM is used in studying the buckling of columns where the supports are neither pinned nor fixed,and the material cross-section rather rests upon the machine while loading is applied axially.Several column specimens were tested and the experimental data were analyzed in order to estimation of the accurate effective-length factor.The calculations from the tested results as well as the conducted probabilistic analysis shed light on how a fragility curve may aid in predicting the effective-length value of future tests.展开更多
Zr-Al-Ni-Cu bulk metallic glasses (BMGs) were developed and their fragility parameters (m) were calculated by Arrhenius and Vogel-Fulcher-Tammann (VFT) equations. The results show that the m values of the Zr-Al-...Zr-Al-Ni-Cu bulk metallic glasses (BMGs) were developed and their fragility parameters (m) were calculated by Arrhenius and Vogel-Fulcher-Tammann (VFT) equations. The results show that the m values of the Zr-Al-Ni-Cu BMGs derived by Arrhenius equation are in agreement with the corresponding m values derived by VFT equation. These Zr-Al-Ni-Cu BMGs characterize in low m values. The low m values for these BMGs would be due to their network microstructures. In addition, the m values of Zr-Al-Cu-Ni BMGs could be obtained by regulating Zr content. The composition of Zr-Al-Cu-Ni BMGs with the lowest m value would be near 54%Zr (mole fraction) because the m value about 13 of Zr 54 Al 13 Cu 18 Ni 15 BMG is the lowest among these Zr-Al-Ni-Cu BMGs developed.展开更多
Background:Global spread and impact of the coronavirus disease 2019(COVID-19)pandemic are determined to a large extent,by resistance to the pandemic and public response of all countries in the world;while a country...Background:Global spread and impact of the coronavirus disease 2019(COVID-19)pandemic are determined to a large extent,by resistance to the pandemic and public response of all countries in the world;while a country's resistance and response are in turn determined by its political and socio economic conditions.To inform future disease prevention and control,we analyzed global data to exam the relationship between state vulnerabilities and COVID-19 incidences and deaths.Methods:Vulnerability was measured using the Fragile States Index(FSI).FSI is created by the Fund for Peace to assess levels of fragility for individual countries.Total FSI score and scores for 12 specific indicators were used as the predictor variables.Outcome variables were national cumulative COVID-19 cases and deaths up to September 16,2020,derived from the World Health Organization.Cumulative incidence rates were computed using 2019 National population derived from the World Bank,and case fatality rates were computed as the ratio of deaths/COVID-19 cases.Countries with incomplete data were excluded,yielding a final sample of 146 countries.Multivariate regression was used to examine the association between the predictor and the outcome measures.Results:There were dramatic cross-country variations in both FSI and COVID-19 epidemiological measurements.FSI total scores were negatively associated with both COVID-19 cumulative incidence rates(β=-0.0135,P<0.001)and case fatality rates(β=-0.0147,P<0.05).Of the 12 FSI indicators,three negatively associated with COVID-19 incidences were E1(Economic Decline and Poverty),E3(Human Flight and Brain Drain),and S2(Refugees and Internally Displaced Persons);two positively associated were P1(State Legitimacy)and X1(External Intervention).With regard to association with case fatality rates,C1(Security Apparatus)was positive,and P3(Human Rights and Rule of Law)and X1 was negative.Conclusion:With FSI measures by the Fund of Peace,overall,more fragile countries are less likely to be affected by the COVID-19 pandemic,and even if affected,death rates were lower.However,poor in state legitimacy and lack of external intervention are risk for COVID-19 infection and lack of security apparatus is risky for COVID-19 death.Implications of the study findings are discussed and additional studies are needed to examine the mechanisms underpinning these relationships.展开更多
Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide....Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence.展开更多
Fragility analysis for highway bridges has become increasingly important in the risk assessment of highway transportation networks exposed to seismic hazards. This study introduces a methodology to calculate fragility...Fragility analysis for highway bridges has become increasingly important in the risk assessment of highway transportation networks exposed to seismic hazards. This study introduces a methodology to calculate fragility that considers multi-dimensional performance limit state parameters and makes a first attempt to develop fragility curves for a multi-span continuous (MSC) concrete girder bridge considering two performance limit state parameters: column ductility and transverse deformation in the abutments. The main purpose of this paper is to show that the performance limit states, which are compared with the seismic response parameters in the calculation of fragility, should be properly modeled as randomly interdependent variables instead of deterministic quantities. The sensitivity of fragility curves is also investigated when the dependency between the limit states is different. The results indicate that the proposed method can be used to describe the vulnerable behavior of bridges which are sensitive to multiple response parameters and that the fragility information generated by this method will be more reliable and likely to be implemented into transportation network loss estimation.展开更多
Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete (RC) building sand studying the vulnerability of existing buildings. The Chinese C...Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete (RC) building sand studying the vulnerability of existing buildings. The Chinese Code for Seismic Design of Buildings (CCSDB) has evolved over time, however, there is still reported earthquake induced damage of newly designed RC buildings. Thus, to investigate modern Chinese seismic design code, three low-, mid- and high-rise RC frames were designed according to the 2010 CCSDB and the corresponding vulnerability curves were derived by computing a probabilistic seismic demand model (PSDM).The PSDM was computed by carrying out nonlinear time history analysis using thirty ground motions obtained from the Pacific Earthquake Engineering Research Center. Finally, the PSDM was used to generate fragility curves for immediate occupancy, significant damage, and collapse prevention damage levels. Results of the vulnerability assessment indicate that the seismic demands on the three different frames designed according to the 2010 CCSDB meet the seismic requirements and are almost in the same safety level.展开更多
The Northridge earthquake inflicted various levels of damage upon a large number of Caltrans' bridges not retrofitted by column jacketing.In this respect,this study represents results of fragility curve developmen...The Northridge earthquake inflicted various levels of damage upon a large number of Caltrans' bridges not retrofitted by column jacketing.In this respect,this study represents results of fragility curve development for two (2) sample bridges typical in southern California,strengthened for seismic retrofit by means of steel jacketing of bridge columns.Monte Carlo simulation is performed to study nonlinear dynamic responses of the bridges before and after column retrofit.Fragility curves in this study are represented by lognormal distribution functions with two parameters and developed as a function of PGA.The sixty (60) ground acceleration time histories for the Los Angeles area developed for the Federal Emergency Management Agency (FEMA) SAC (SEAOC-ATC CUREe) steel project are used for the dynamic analysis of the bridges. The improvement in the fragility with steel jacketing is quantified by comparing fragility curves of the bridge before and after column retrofit.In this first attempt to formulate the problem of fragility enhancement,the quantification is made by comparing the median values of the fragility curves before and after the retrofit.Under the hypothesis that this quantification also applies to empirical fragility curves developed on the basis of Northridge earthquake damage,the enhanced version of the empirical curves is developed for the ensuing analysis to determine the enhancement of transportation network performance due to the retrofit.展开更多
Flexible pipelines are often used to connect hard pipes from a foundation to a superstructure to accommodate large deformation in the base isolation layer during an earthquake. Although Chinese seismic design guidelin...Flexible pipelines are often used to connect hard pipes from a foundation to a superstructure to accommodate large deformation in the base isolation layer during an earthquake. Although Chinese seismic design guidelines suggest several confi gurations, they are diff erent from the designs that have been proven in practice, e.g., Japanese styles, and extensive experimental investigation into their seismic performance is required. Three types of seals, rubber-, metal- and asbestinebased, were tested quasi-statically with infi lled pressurized water at 2.5 MPa. The asbestine-based seal leaked at a smaller deformation than the other two types of seals. Based on the test results, three damage states were defi ned and the deformation capacity was estimated. To evaluate their performance, a three-dimensional model of a base-isolated medical building was developed using OpenSees, with the fl exible pipelines simulated by a mechanical model calibrated from the experimental data. A probabilistic seismic demand model and the fragility function of the fl exible pipelines were then developed to evaluate the seismic performance.展开更多
This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations ...This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations in terms of superstructure type, connection, continuity at support and foundation type, etc. render different damage resistant capability. Six classes of bridges are established based on their anticipated failure mechanisms under earthquake shaking. The numerical models that are capable of simulating the complex soil-structure interaction effects, nonlinear behavior of columns and connections are developed for each bridge class. The dynamic responses are obtained using nonlinear time history analyses for a suite of 250 earthquake motions with increasing intensity. An equivalent static analysis procedure is also implemented to evaluate the vulnerability of the bridges when subjected to liquefaction-induced lateral spreading. Fragility functions for each bridge class are derived and compared for both seismic shaking (based on nonlinear dynamic analyses) and lateral spreading (based on equivalent static analyses) for different performance states. The study finds that the fragility functions due to either ground shaking or lateral spreading show significant correlation with the structural characterizations, but differences emerge for ground shaking and lateral spreading conditions. Structural properties that will mostly affect the bridges' damage resistant capacity are also identified.展开更多
This paper presents a copula technique to develop time-variant seismic fragility curves for corroded bridges at the system level and considers the realistic time-varying dependence among component seismic demands. Bas...This paper presents a copula technique to develop time-variant seismic fragility curves for corroded bridges at the system level and considers the realistic time-varying dependence among component seismic demands. Based on material deterioration mechanisms and incremental dynamic analysis, the time-evolving seismic demands of components were obtained in the form of marginal probability distributions. The time-varying dependences among bridge components were then captured with the best fitting copula function, which was selected from the commonly used copula classes by the empirical distribution based analysis method. The system time-variant fragility curves at different damage states were developed and the effects of time-varying dependences among components on the bridge system fragility were investigated. The results indicate the time-varying dependence among components significantly affects the time-variant fragility of the bridge system. The copula technique captures the nonlinear dependence among component seismic demands accurately and easily by separating the marginal distributions and the dependence among them.展开更多
The lack of knowledge concerning modelling existing buildings leads to significant variability in fragility curves for single or grouped existing buildings. This study aims to investigate the uncertainties of fragilit...The lack of knowledge concerning modelling existing buildings leads to significant variability in fragility curves for single or grouped existing buildings. This study aims to investigate the uncertainties of fragility curves, with special consideration of the single-building sigma. Experimental data and simplified models are applied to the BRD tower in Bucharest, Romania, a RC building with permanent instrumentation. A three-step methodology is applied: (1) adjustment of a linear MDOF model for experimental modal analysis using a Timoshenko beam model and based on Anderson's criteria, (2) computation of the structure's response to a large set of accelerograms simulated by SIMQKE software, considering twelve ground motion parameters as intensity measurements (IM), and (3) construction of the fragility curves by comparing numerical interstory drift with the threshold criteria provided by the Hazus methodology for the slight damage state. By introducing experimental data into the model, uncertainty is reduced to 0.02 considering Sd ) as seismic intensity IM and uncertainty related to the model is assessed at 0.03. These values must be compared with the total uncertainty value of around 0.7 provided by the Hazus methodology.展开更多
This study deals with the seismic fragility of elastic structural systems equipped with single concave sliding(friction pendulum system(FPS)) isolators considering different soil conditions. The behavior of these ...This study deals with the seismic fragility of elastic structural systems equipped with single concave sliding(friction pendulum system(FPS)) isolators considering different soil conditions. The behavior of these systems is analyzed by employing a two-degree-of-freedom model, whereas the FPS response is described by means of a velocity-dependent model. The uncertainty in the seismic inputs is taken into account by considering artificial seismic excitations modelled as timemodulated filtered Gaussian white noise random processes of different intensity within the power spectral density method. In particular, the filter parameters, which control the frequency content of the random excitations, are calibrated to describe stiff, medium and soft soil conditions. The sliding friction coefficient at large velocity is also considered as a random variable modelled through a uniform probability density function. Incremental dynamic analyses are developed in order to evaluate the probabilities of exceeding different limit states related to both the reinforced concrete(RC) superstructure and isolation level, defining the seismic fragility curves within an extensive parametric study carried out for different structural system properties and soil conditions. The abovementioned seismic fragility curves are useful to evaluate the seismic reliability of base-isolated elastic systems equipped with FPS and located in any site for any soil condition.展开更多
In Yunnan, 8 major aspects of biodiversity and fragility in landforms, ecosystems, distribution populations, alien invasion, segregation, pollution and maladministration with various menace factors causing biodiversit...In Yunnan, 8 major aspects of biodiversity and fragility in landforms, ecosystems, distribution populations, alien invasion, segregation, pollution and maladministration with various menace factors causing biodiversity loss have been described. It is revealed that the facts that the biodiversity and fragility coexists in this paper. Accordingly, 6 major countermeasures for effective conservation and rational utilization of the provincial biodiversity were suggested on the basis of the scientific development concepts, principles of nature protection, conservation biology, resource management and ethnobotany and present status in Yunnan with rich intangible resources such as climatic, ethnical and cultural diversity, etc.展开更多
Numerical studies have been conducted for low- and medium-rise rocking structures to investigate their efficiency as earthquake-resisting systems in comparison with conventional structures. Several non-linear time-his...Numerical studies have been conducted for low- and medium-rise rocking structures to investigate their efficiency as earthquake-resisting systems in comparison with conventional structures. Several non-linear time-history analyses have been performed to evaluate seismic performance of selected cases at desired ground shaking levels, based on key parameters such as total and flexural story drifts and residual deformations. The Far-field record set is selected as input ground motions and median peak values of key parameters are taken as best estimates of system response. In addition, in order to evaluate the probability of exceeding relevant damage states, analytical fragility curves have been developed based on the results of the incremental dynamic analysis procedure. Small exceedance probabilities and acceptable margins against collapse, together with minor associated damages in main structural members, can be considered as superior seismic performance for medium-rise rocking systems. Low-rise rocking systems could provide significant performance improvement over their conventional counterparts notwithstanding certain weaknesses in their seismic response.展开更多
基金National Key R&D Program of China under Grant No.2022YFC3003603。
文摘Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.
基金National Natural Science Foundation of China under Grant Nos.52178353,51808421the Fundamental Research Funds for the Central Universities(WUT:2020III043)。
文摘The performance of clay-pile-pier system under earthquake shaking was comprehensively examined via three-dimensional finite element analyses,in which the complex stress-strain relationships of a clay and piled pier system were depicted by a hyperbolic-hysteretic and an equivalent elastoplastic model,respectively.One hundred twenty ground motions with varying peak accelerations were considered,along with the variations in bridge superstructure mass and pile flexural rigidity.Comprehensive comparison studies suggested that peak pile-cap acceleration and peak pile-cap velocity are the optimal ground motion intensity measures for seismic responses of the pier and the pile,respectively.Furthermore,based on two optimal ground motion intensity measures and using curvature ductility to quantify different damage states,seismic fragility analyses were performed.The pier generally had no evident damage except when the bridge girder mass was equal to 960 t,which seemed to be comparatively insensitive to the varying pile flexural rigidity.In comparison,the pile was found to be more vulnerable to seismic damage and its failure probabilities tended to clearly reduce with the increment of pile flexural rigidity,while the influence of the bridge girder mass was relatively minor.
基金supported by the National Institutes of Health under Award Number 1R21AR077881.
文摘Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen,leading to the accumulation of advanced glycation end-products(AGEs)cross-links in collagenous tissues.More recently,AGEs content has been related to loss of bone quality,independent of bone mass,and increased fracture risk with aging and diabetes.Loss of bone quality is mostly attributed to changes in material properties,structural organization,or cellular remodeling.Though all these factors play a role in bone fragility disease,some common recurring patterns can be found between diabetic and age-related bone fragility.The main pattern we will discuss in this viewpoint is the increase of fibrillar collagen stiffness and loss of collagen-induced plasticity with AGE accumulation.This study focused on recent related experimental studies and discusses the correlation between fluorescent AGEs content at the molecular and fibrillar scales,collagen deformation mechanisms at the nanoscale,and resistance to bone fracture at the macroscale.
基金National Natural Science Foundation of China under Grant No.51608488Scientific and Technological Project of Henan Province,China under Grant No.222102320006+1 种基金Zhengzhou University 2022 Annual Basic Research Foundation for Young Teachers,China under Grant No.JC22547025Postdoctoral Research Grant in Henan Province。
文摘The deterioration of the performance of offshore bridges is particularly prominent due to the complex natural environment,including the coupling effects of earthquake and seawater erosion.In particular,bridge piers are the main energy-consuming and load-bearing components,so that excellent seismic capacity of bridge piers is the key to avoiding bridge damage.Although earthquake resistant behavior of ordinary reinforced concrete bridge piers(ordinary pier)can be improved by increasing the section size and reinforcement ratio of piers,the improvement of the earthquake resistant behavior is limited.To further improve the earthquake resistant behavior of bridge piers,high-tensile reinforcement engineered cementitious composite(ECC)bridge piers are utilized and time-varying seismic fragility analysis are conducted in this study.The refined model of a bridge pier is built by OpenSees.First,the influence of ECC replacement height on pier curvature is analyzed to determine the reasonable ECC height.Then,the time-varying fragility analysis of high-tensile reinforcement ECC piers(ECC composite piers)with durability damage are evaluated considering the time-varying law of materials.Four damage states,slight damage,moderate damage,extensive damage and complete collapse,are utilized in the study.These fragility curves indicate the durability damage can debase the earthquake resistant behavior of piers continually,the exceedance probability of the same state of destruction increases with the increase of peak ground acceleration(PGA)and service time of pier.The results also indicate that the corrosion level of chloride ion to pier is small during the early service period,and the bridge pier vulnerable curve is similar to that of the new bridge pier.As the level of chlorine ion corrosion deepens,transcendental probability is increased.Compared with the ordinary pier,the exceedance probability in each limit state of ECC composite piers is significantly reduced.The proposed ECC composite pies leads to better realistic time-varying earthquake resistant behavior.
基金National Natural Science Foundation of China under Grant Nos.51725901 and 52022047the State Key Laboratory of Hydroscience and Hydraulic Engineering under Grant No.2021-KY-04。
文摘This study focuses on the seismic fragility analysis of arch dams.The multiple stripe analysis(MSA),cloud analysis(CLA),and incremental dynamic analysis(IDA)methods are compared.A comprehensive dam-reservoir-foundation rock system,which considers the opening of contraction joints,the nonlinearity of dam concrete and foundation rock,the radiation damping effect of semi-unbounded foundation,and the compressibility of reservoir water,is used as a numerical example.225,80,and 15 earthquake records are selected for MSA,CLA,and IDA,respectively.The results show that MSA provides satisfactory fragility analysis,while both CLA and IDA have assumptions that may lead to deviations.Therefore,MSA is the most reliable method among the three methods and is recommended for the fragility analysis of arch dams.It is also shown that the choice of demand level affects the reliability of fragility curves and the effect of the material uncertainty on the fragility of the dam is not significant.
基金The authors would like to express their great appreciation for funding made possible in support of this research endeavor through the CSU-LSAMP(California State University Louis Stokes Alliance for Minority Participation)program via the NSF(National Science Foundation)grant#HRD-1302873the Chancellor’s Office of the California State University。
文摘The design of columns relies heavily on the basis of Leonhard Euler’s Theory of Elastic Buckling.However,to increase the accuracy in determining the maximum critical load a column can withstand before buckling,a constant was introduced.This dimensionless coefficient is K,also known as the effective-length factor.This constant is often found in building design codes and varies in value depending on the type of column support that is applied.This paper presents experimental and analytical studies on the determination of the effective-length factor in the buckling stability of columns with partially-fixed support conditions.To this end,the accurate K value of the columns tested by the Instron Testing Machine(ITM)at California State University,Northridge’s(CSUN’s)Mechanics Laboratory is determined.The ITM is used in studying the buckling of columns where the supports are neither pinned nor fixed,and the material cross-section rather rests upon the machine while loading is applied axially.Several column specimens were tested and the experimental data were analyzed in order to estimation of the accurate effective-length factor.The calculations from the tested results as well as the conducted probabilistic analysis shed light on how a fragility curve may aid in predicting the effective-length value of future tests.
基金Project(50874045)supported by the National Natural Science Foundation of ChinaProjects(200902472,20080431021)supported by the China Postdoctoral Science FoundationProject(10A044)supported by the Research Foundation of Education Bureau of Hunan Province of China
文摘Zr-Al-Ni-Cu bulk metallic glasses (BMGs) were developed and their fragility parameters (m) were calculated by Arrhenius and Vogel-Fulcher-Tammann (VFT) equations. The results show that the m values of the Zr-Al-Ni-Cu BMGs derived by Arrhenius equation are in agreement with the corresponding m values derived by VFT equation. These Zr-Al-Ni-Cu BMGs characterize in low m values. The low m values for these BMGs would be due to their network microstructures. In addition, the m values of Zr-Al-Cu-Ni BMGs could be obtained by regulating Zr content. The composition of Zr-Al-Cu-Ni BMGs with the lowest m value would be near 54%Zr (mole fraction) because the m value about 13 of Zr 54 Al 13 Cu 18 Ni 15 BMG is the lowest among these Zr-Al-Ni-Cu BMGs developed.
基金This paper was supported by the National Natural Science Foundation of China(No.72042014).
文摘Background:Global spread and impact of the coronavirus disease 2019(COVID-19)pandemic are determined to a large extent,by resistance to the pandemic and public response of all countries in the world;while a country's resistance and response are in turn determined by its political and socio economic conditions.To inform future disease prevention and control,we analyzed global data to exam the relationship between state vulnerabilities and COVID-19 incidences and deaths.Methods:Vulnerability was measured using the Fragile States Index(FSI).FSI is created by the Fund for Peace to assess levels of fragility for individual countries.Total FSI score and scores for 12 specific indicators were used as the predictor variables.Outcome variables were national cumulative COVID-19 cases and deaths up to September 16,2020,derived from the World Health Organization.Cumulative incidence rates were computed using 2019 National population derived from the World Bank,and case fatality rates were computed as the ratio of deaths/COVID-19 cases.Countries with incomplete data were excluded,yielding a final sample of 146 countries.Multivariate regression was used to examine the association between the predictor and the outcome measures.Results:There were dramatic cross-country variations in both FSI and COVID-19 epidemiological measurements.FSI total scores were negatively associated with both COVID-19 cumulative incidence rates(β=-0.0135,P<0.001)and case fatality rates(β=-0.0147,P<0.05).Of the 12 FSI indicators,three negatively associated with COVID-19 incidences were E1(Economic Decline and Poverty),E3(Human Flight and Brain Drain),and S2(Refugees and Internally Displaced Persons);two positively associated were P1(State Legitimacy)and X1(External Intervention).With regard to association with case fatality rates,C1(Security Apparatus)was positive,and P3(Human Rights and Rule of Law)and X1 was negative.Conclusion:With FSI measures by the Fund of Peace,overall,more fragile countries are less likely to be affected by the COVID-19 pandemic,and even if affected,death rates were lower.However,poor in state legitimacy and lack of external intervention are risk for COVID-19 infection and lack of security apparatus is risky for COVID-19 death.Implications of the study findings are discussed and additional studies are needed to examine the mechanisms underpinning these relationships.
基金FESR P.O.Apulia Region 2007-2013-Action 1.2.4,No.3Q5AX31
文摘Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence.
基金National Natural Science Foundation of China Under Award Number 50878184National High Technology Research and Development Program (863 Program) of China Under Grant No. 2006AA04Z437Graduate Starting Seed Fund of Northwestern Polytechnical University Under the Grant No. Z2012059
文摘Fragility analysis for highway bridges has become increasingly important in the risk assessment of highway transportation networks exposed to seismic hazards. This study introduces a methodology to calculate fragility that considers multi-dimensional performance limit state parameters and makes a first attempt to develop fragility curves for a multi-span continuous (MSC) concrete girder bridge considering two performance limit state parameters: column ductility and transverse deformation in the abutments. The main purpose of this paper is to show that the performance limit states, which are compared with the seismic response parameters in the calculation of fragility, should be properly modeled as randomly interdependent variables instead of deterministic quantities. The sensitivity of fragility curves is also investigated when the dependency between the limit states is different. The results indicate that the proposed method can be used to describe the vulnerable behavior of bridges which are sensitive to multiple response parameters and that the fragility information generated by this method will be more reliable and likely to be implemented into transportation network loss estimation.
基金National Natural Science Foundation of China Under Grant No.51108105,90815029,50938006 Research Fund for the Doctoral Program of Higher Education of China Under Grant No.20094410120002+3 种基金 Major Program of National Natural Science Foundation of China Under Grant No.90815027Key Projects in the National Science&Technology Pillar Program during the Eleventh Five-Year Plan Period Under Grant No.2009BAJ28B03Fund for High School in Guangzhou (10A057)the Open Foundation of State Key Laboratory of Subtropical Building Science(2011KB15)
文摘Following several damaging earthquakes in China, research has been devoted to find the causes of the collapse of reinforced concrete (RC) building sand studying the vulnerability of existing buildings. The Chinese Code for Seismic Design of Buildings (CCSDB) has evolved over time, however, there is still reported earthquake induced damage of newly designed RC buildings. Thus, to investigate modern Chinese seismic design code, three low-, mid- and high-rise RC frames were designed according to the 2010 CCSDB and the corresponding vulnerability curves were derived by computing a probabilistic seismic demand model (PSDM).The PSDM was computed by carrying out nonlinear time history analysis using thirty ground motions obtained from the Pacific Earthquake Engineering Research Center. Finally, the PSDM was used to generate fragility curves for immediate occupancy, significant damage, and collapse prevention damage levels. Results of the vulnerability assessment indicate that the seismic demands on the three different frames designed according to the 2010 CCSDB meet the seismic requirements and are almost in the same safety level.
基金MCEER/FHWA under Contract No.DTFH 61-98-C-00094Caltrans under Contract No.59A0304
文摘The Northridge earthquake inflicted various levels of damage upon a large number of Caltrans' bridges not retrofitted by column jacketing.In this respect,this study represents results of fragility curve development for two (2) sample bridges typical in southern California,strengthened for seismic retrofit by means of steel jacketing of bridge columns.Monte Carlo simulation is performed to study nonlinear dynamic responses of the bridges before and after column retrofit.Fragility curves in this study are represented by lognormal distribution functions with two parameters and developed as a function of PGA.The sixty (60) ground acceleration time histories for the Los Angeles area developed for the Federal Emergency Management Agency (FEMA) SAC (SEAOC-ATC CUREe) steel project are used for the dynamic analysis of the bridges. The improvement in the fragility with steel jacketing is quantified by comparing fragility curves of the bridge before and after column retrofit.In this first attempt to formulate the problem of fragility enhancement,the quantification is made by comparing the median values of the fragility curves before and after the retrofit.Under the hypothesis that this quantification also applies to empirical fragility curves developed on the basis of Northridge earthquake damage,the enhanced version of the empirical curves is developed for the ensuing analysis to determine the enhancement of transportation network performance due to the retrofit.
基金Scientific Research Fund of Institute of Engineering Mechanics,CEA under Grant Nos.2016A05 and 2016A06the International Science and Technology Cooperation Program of China under Grant No.2014DFA70950the National Natural Science Foundation of China under Grant No.51378478
文摘Flexible pipelines are often used to connect hard pipes from a foundation to a superstructure to accommodate large deformation in the base isolation layer during an earthquake. Although Chinese seismic design guidelines suggest several confi gurations, they are diff erent from the designs that have been proven in practice, e.g., Japanese styles, and extensive experimental investigation into their seismic performance is required. Three types of seals, rubber-, metal- and asbestinebased, were tested quasi-statically with infi lled pressurized water at 2.5 MPa. The asbestine-based seal leaked at a smaller deformation than the other two types of seals. Based on the test results, three damage states were defi ned and the deformation capacity was estimated. To evaluate their performance, a three-dimensional model of a base-isolated medical building was developed using OpenSees, with the fl exible pipelines simulated by a mechanical model calibrated from the experimental data. A probabilistic seismic demand model and the fragility function of the fl exible pipelines were then developed to evaluate the seismic performance.
基金Supported by:Pacific Earthquake Engineering Research Center Lifelines Program Under Project Task No.9C
文摘This paper evaluates the seismic vulnerability of different classes of typical bridges in California when subjected to seismic shaking or liquefaction-induced lateral spreading. The detailed structural configurations in terms of superstructure type, connection, continuity at support and foundation type, etc. render different damage resistant capability. Six classes of bridges are established based on their anticipated failure mechanisms under earthquake shaking. The numerical models that are capable of simulating the complex soil-structure interaction effects, nonlinear behavior of columns and connections are developed for each bridge class. The dynamic responses are obtained using nonlinear time history analyses for a suite of 250 earthquake motions with increasing intensity. An equivalent static analysis procedure is also implemented to evaluate the vulnerability of the bridges when subjected to liquefaction-induced lateral spreading. Fragility functions for each bridge class are derived and compared for both seismic shaking (based on nonlinear dynamic analyses) and lateral spreading (based on equivalent static analyses) for different performance states. The study finds that the fragility functions due to either ground shaking or lateral spreading show significant correlation with the structural characterizations, but differences emerge for ground shaking and lateral spreading conditions. Structural properties that will mostly affect the bridges' damage resistant capacity are also identified.
基金Natural Science Foundation of China under Grant No.51808376
文摘This paper presents a copula technique to develop time-variant seismic fragility curves for corroded bridges at the system level and considers the realistic time-varying dependence among component seismic demands. Based on material deterioration mechanisms and incremental dynamic analysis, the time-evolving seismic demands of components were obtained in the form of marginal probability distributions. The time-varying dependences among bridge components were then captured with the best fitting copula function, which was selected from the commonly used copula classes by the empirical distribution based analysis method. The system time-variant fragility curves at different damage states were developed and the effects of time-varying dependences among components on the bridge system fragility were investigated. The results indicate the time-varying dependence among components significantly affects the time-variant fragility of the bridge system. The copula technique captures the nonlinear dependence among component seismic demands accurately and easily by separating the marginal distributions and the dependence among them.
基金the ANR National Research Agency as Part of Its RiskNat Program(URBASIS project)under Grant No.ANR-09-RISK-009the Rh ne-Alpes Regional Council(Programme Vulnerabilitédes Ouvrages aux Risques)and the Joseph Fourier Université(Grenoble 1)
文摘The lack of knowledge concerning modelling existing buildings leads to significant variability in fragility curves for single or grouped existing buildings. This study aims to investigate the uncertainties of fragility curves, with special consideration of the single-building sigma. Experimental data and simplified models are applied to the BRD tower in Bucharest, Romania, a RC building with permanent instrumentation. A three-step methodology is applied: (1) adjustment of a linear MDOF model for experimental modal analysis using a Timoshenko beam model and based on Anderson's criteria, (2) computation of the structure's response to a large set of accelerograms simulated by SIMQKE software, considering twelve ground motion parameters as intensity measurements (IM), and (3) construction of the fragility curves by comparing numerical interstory drift with the threshold criteria provided by the Hazus methodology for the slight damage state. By introducing experimental data into the model, uncertainty is reduced to 0.02 considering Sd ) as seismic intensity IM and uncertainty related to the model is assessed at 0.03. These values must be compared with the total uncertainty value of around 0.7 provided by the Hazus methodology.
文摘This study deals with the seismic fragility of elastic structural systems equipped with single concave sliding(friction pendulum system(FPS)) isolators considering different soil conditions. The behavior of these systems is analyzed by employing a two-degree-of-freedom model, whereas the FPS response is described by means of a velocity-dependent model. The uncertainty in the seismic inputs is taken into account by considering artificial seismic excitations modelled as timemodulated filtered Gaussian white noise random processes of different intensity within the power spectral density method. In particular, the filter parameters, which control the frequency content of the random excitations, are calibrated to describe stiff, medium and soft soil conditions. The sliding friction coefficient at large velocity is also considered as a random variable modelled through a uniform probability density function. Incremental dynamic analyses are developed in order to evaluate the probabilities of exceeding different limit states related to both the reinforced concrete(RC) superstructure and isolation level, defining the seismic fragility curves within an extensive parametric study carried out for different structural system properties and soil conditions. The abovementioned seismic fragility curves are useful to evaluate the seismic reliability of base-isolated elastic systems equipped with FPS and located in any site for any soil condition.
基金This work was supported by a grant from the National Natural Science Foundation of China (No.30560127/C020608)
文摘In Yunnan, 8 major aspects of biodiversity and fragility in landforms, ecosystems, distribution populations, alien invasion, segregation, pollution and maladministration with various menace factors causing biodiversity loss have been described. It is revealed that the facts that the biodiversity and fragility coexists in this paper. Accordingly, 6 major countermeasures for effective conservation and rational utilization of the provincial biodiversity were suggested on the basis of the scientific development concepts, principles of nature protection, conservation biology, resource management and ethnobotany and present status in Yunnan with rich intangible resources such as climatic, ethnical and cultural diversity, etc.
基金International Institute of Earthquake Engineering and Seismology(IIEES)under the research project No.7143
文摘Numerical studies have been conducted for low- and medium-rise rocking structures to investigate their efficiency as earthquake-resisting systems in comparison with conventional structures. Several non-linear time-history analyses have been performed to evaluate seismic performance of selected cases at desired ground shaking levels, based on key parameters such as total and flexural story drifts and residual deformations. The Far-field record set is selected as input ground motions and median peak values of key parameters are taken as best estimates of system response. In addition, in order to evaluate the probability of exceeding relevant damage states, analytical fragility curves have been developed based on the results of the incremental dynamic analysis procedure. Small exceedance probabilities and acceptable margins against collapse, together with minor associated damages in main structural members, can be considered as superior seismic performance for medium-rise rocking systems. Low-rise rocking systems could provide significant performance improvement over their conventional counterparts notwithstanding certain weaknesses in their seismic response.