目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中...目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中医院的MS患者90例,根据随机数字表法将其分为禁食组和对照组,每组各45例,同期选取90例健康体检者纳入正常组。对照组患者予正常饮食及运动处方干预,禁食组患者予中医禁食疗法干预,两组患者均干预10d。比较正常组体检时与禁食组、对照组干预前后体质量指数(body mass index,BMI)、血压、血脂、血糖指标、AIP和FRS,分析禁食组、对照组干预疗效,应用Pearson相关性分析探讨MS患者AIP、FRS与临床指标的关系。结果干预前后,禁食组、对照组患者的BMI、收缩压、舒张压、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、AIP、FRS均显著高于正常组,高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平显著低于正常组(P<0.05);干预后,禁食组患者的BMI、收缩压、舒张压、LDL-C、TG、TC、FPG、AIP、FRS均显著低于本组干预前和对照组(P<0.05),HDL-C水平显著高于本组干预前和对照组(P<0.05)。禁食组患者干预后的总有效率显著高于对照组(P<0.05)。MS患者的AIP与BMI、TG水平呈正相关,与HDL-C水平呈负相关(P<0.05),FRS与BMI、收缩压、舒张压、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关(P<0.05)。结论MS患者的AIP、FRS显著增高,且与BMI、血脂等指标有关,应用中医禁食疗法可显著降低AIP、FRS,改善临床指标及疗效,有利于降低心血管疾病风险。展开更多
Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou ha...Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou had higher rates of CVD risk factors, but their impacts on cardiovascular events have rarely been studied. The Framingham risk score (FRS) is an algorithm that considers CVD risk factors and estimates the risk of developing CVD in the next 10 years. Our objectives were to assess the 10-year CVD risk predicted by the FRS, and to examine the relationships of 10-year CVD risk with plasma iron and potassium levels among TMDs. We included 134 TMDs (22 - 59 years old) who had no prior diagnosis of CVD or T2D, and not taking medications affecting iron and potassium homeostasis. Conventional cardiovascular risk factors were used to calculate the 10-year CVD risk, which was categorized as low (20%). FRS > 2%, which corresponded to the 75th percentile of FRS distribution in our study population, was used as a cut-off value to classify participants into two groups. Plasma iron and potassium levels were segregated into tertiles and their associations with 10-year CVD risk were quantified by multivariate-adjusted logistic regression to calculate the odd ratios (ORs) to being above the 75<sup>th</sup> percentile of 10-year CVD risk with the corresponding 95% confidence intervals (CIs). We found that 62.0% of participants had at least one of cardiovascular risk factors. Approximately 97.8% of TMDs had 10-year CVD risk 4.8 mmol/L led to an 83% risk reduction of having 10-year CVD risk > 2% (OR = 0.17, 95% CI: 0.04 - 0.82, P = 0.027). In conclusion, our findings showed that high plasma potassium levels associate with reduced 10-year CVD risk among TMDs. Interventions focused on monitoring of plasma potassium, particularly in those with existing cardiovascular risk factors, may help prevent CVD.展开更多
目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因...目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因素。结果:研究人群未来10 a CVD高发生风险的比例为40.6%,且男性高于女性(47.1%vs 37.6%,P<0.001)。Logistic回归分析显示,男性(B=0.524,OR=1.690,95%CI为1.377~2.073)、腹型肥胖(B=0.709,OR=2.031,95%CI为1.632~2.529)、TG(B=0.097,OR=1.102,95%CI为1.023~1.187)、尿白蛋白异常(B=0.670,OR=1.955,95%CI为1.486~2.572)均是CVD高发生风险的危险因素。结论:郑州市中老年人群未来10 a CVD的发生风险很高;加强对中老年人群尤其是男性,合并腹型肥胖、高血脂、高血压、糖尿病以及糖尿病高危人群的CVD一级预防和管理,可能有效降低CVD的发生风险。展开更多
目的检测血液透析患者内皮祖细胞数量(EPCs)和功能的改变,并探讨其与Framingham危险评分的关系。方法采用密度梯度离心法分离培养慢性肾功能衰竭长期血液透析患者和对照组外周血单个核细胞,将其接种在人纤维连接蛋白包被培养板,7 d后取...目的检测血液透析患者内皮祖细胞数量(EPCs)和功能的改变,并探讨其与Framingham危险评分的关系。方法采用密度梯度离心法分离培养慢性肾功能衰竭长期血液透析患者和对照组外周血单个核细胞,将其接种在人纤维连接蛋白包被培养板,7 d后取贴壁细胞进行Di-LDL和FITC-UEA-I双染色.并通过流式细胞仪检测其表面标志CD34、CD133、KDR,以鉴定EPCs。采用改良的Boyden小室、黏附功能检测评价其迁移和黏附能力,并与10 a Framingham危险评分进行统计学分析。结果长期血液透析患者EPCs的数量和迁移、黏附功能均低于对照组,差别有统计学意义(P<0.05);10 a Framingham危险评分与患者EPCs的数量和迁移、黏附功能分别呈负相关(r=-0.623,-0.658,-0.625,P<0.05)。结论长期血液透析患者的EPCs数量和功能降低,存在血管新生和内皮修复的缺陷,增加了患冠心病的风险。展开更多
文摘目的观察中医禁食疗法对代谢综合征(metabolic syndrome,MS)患者血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)、Framingham风险评分(Framingham risk score,FRS)的干预作用。方法选取2021年8月至2022年5月就诊于温州市中医院的MS患者90例,根据随机数字表法将其分为禁食组和对照组,每组各45例,同期选取90例健康体检者纳入正常组。对照组患者予正常饮食及运动处方干预,禁食组患者予中医禁食疗法干预,两组患者均干预10d。比较正常组体检时与禁食组、对照组干预前后体质量指数(body mass index,BMI)、血压、血脂、血糖指标、AIP和FRS,分析禁食组、对照组干预疗效,应用Pearson相关性分析探讨MS患者AIP、FRS与临床指标的关系。结果干预前后,禁食组、对照组患者的BMI、收缩压、舒张压、低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)、三酰甘油(triglyceride,TG)、总胆固醇(total cholesterol,TC)、空腹血糖(fasting plasma glucose,FPG)、AIP、FRS均显著高于正常组,高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平显著低于正常组(P<0.05);干预后,禁食组患者的BMI、收缩压、舒张压、LDL-C、TG、TC、FPG、AIP、FRS均显著低于本组干预前和对照组(P<0.05),HDL-C水平显著高于本组干预前和对照组(P<0.05)。禁食组患者干预后的总有效率显著高于对照组(P<0.05)。MS患者的AIP与BMI、TG水平呈正相关,与HDL-C水平呈负相关(P<0.05),FRS与BMI、收缩压、舒张压、LDL-C、TC水平呈正相关,与HDL-C水平呈负相关(P<0.05)。结论MS患者的AIP、FRS显著增高,且与BMI、血脂等指标有关,应用中医禁食疗法可显著降低AIP、FRS,改善临床指标及疗效,有利于降低心血管疾病风险。
文摘Hypertension, obesity, smoking, dyslipidemia, and type 2 diabetes (T2D) are the major risk factors for developing cardiovascular diseases (CVD). Recent studies revealed that taxi-motorbike drivers (TMDs) in Cotonou had higher rates of CVD risk factors, but their impacts on cardiovascular events have rarely been studied. The Framingham risk score (FRS) is an algorithm that considers CVD risk factors and estimates the risk of developing CVD in the next 10 years. Our objectives were to assess the 10-year CVD risk predicted by the FRS, and to examine the relationships of 10-year CVD risk with plasma iron and potassium levels among TMDs. We included 134 TMDs (22 - 59 years old) who had no prior diagnosis of CVD or T2D, and not taking medications affecting iron and potassium homeostasis. Conventional cardiovascular risk factors were used to calculate the 10-year CVD risk, which was categorized as low (20%). FRS > 2%, which corresponded to the 75th percentile of FRS distribution in our study population, was used as a cut-off value to classify participants into two groups. Plasma iron and potassium levels were segregated into tertiles and their associations with 10-year CVD risk were quantified by multivariate-adjusted logistic regression to calculate the odd ratios (ORs) to being above the 75<sup>th</sup> percentile of 10-year CVD risk with the corresponding 95% confidence intervals (CIs). We found that 62.0% of participants had at least one of cardiovascular risk factors. Approximately 97.8% of TMDs had 10-year CVD risk 4.8 mmol/L led to an 83% risk reduction of having 10-year CVD risk > 2% (OR = 0.17, 95% CI: 0.04 - 0.82, P = 0.027). In conclusion, our findings showed that high plasma potassium levels associate with reduced 10-year CVD risk among TMDs. Interventions focused on monitoring of plasma potassium, particularly in those with existing cardiovascular risk factors, may help prevent CVD.
文摘目的:探讨郑州市中老年人群心血管病(CVD)的发生风险。方法:2014年8月至2015年12月,从河南省郑州市6个社区筛选年龄40~74岁的常驻居民1993人。采用Framingham10年冠心病风险评分标准评估CVD的发生风险,采用logistic回归分析CVD的危险因素。结果:研究人群未来10 a CVD高发生风险的比例为40.6%,且男性高于女性(47.1%vs 37.6%,P<0.001)。Logistic回归分析显示,男性(B=0.524,OR=1.690,95%CI为1.377~2.073)、腹型肥胖(B=0.709,OR=2.031,95%CI为1.632~2.529)、TG(B=0.097,OR=1.102,95%CI为1.023~1.187)、尿白蛋白异常(B=0.670,OR=1.955,95%CI为1.486~2.572)均是CVD高发生风险的危险因素。结论:郑州市中老年人群未来10 a CVD的发生风险很高;加强对中老年人群尤其是男性,合并腹型肥胖、高血脂、高血压、糖尿病以及糖尿病高危人群的CVD一级预防和管理,可能有效降低CVD的发生风险。
文摘目的检测血液透析患者内皮祖细胞数量(EPCs)和功能的改变,并探讨其与Framingham危险评分的关系。方法采用密度梯度离心法分离培养慢性肾功能衰竭长期血液透析患者和对照组外周血单个核细胞,将其接种在人纤维连接蛋白包被培养板,7 d后取贴壁细胞进行Di-LDL和FITC-UEA-I双染色.并通过流式细胞仪检测其表面标志CD34、CD133、KDR,以鉴定EPCs。采用改良的Boyden小室、黏附功能检测评价其迁移和黏附能力,并与10 a Framingham危险评分进行统计学分析。结果长期血液透析患者EPCs的数量和迁移、黏附功能均低于对照组,差别有统计学意义(P<0.05);10 a Framingham危险评分与患者EPCs的数量和迁移、黏附功能分别呈负相关(r=-0.623,-0.658,-0.625,P<0.05)。结论长期血液透析患者的EPCs数量和功能降低,存在血管新生和内皮修复的缺陷,增加了患冠心病的风险。
